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1. Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance.

Author

Elahpour, Nafise, Niesner, Isabella, Abdellaoui, Nora, Holzapfel, Boris Michael, Gritsch, Lukas, Jallot, Edouard, Mayer‐Wagner, Susanne, and Lao, Jonathan

Subjects
BIOACTIVE glasses, DRUG resistance in bacteria, DRUG resistance in microorganisms, BACTERIAL diseases, METAL ions
Abstract

This work focuses on combating bacterial infections in bone tissue using metal elements embedded in bioactive glass. While there is an urgent need for alternative methods with a shrinking number of effective treatment options untouched by antimicrobial resistance, it is crucial to first understand the mechanisms of pathogenesis, persistence, and bacterial resistance in skeletal infection, and then develop effective counterstrategies and innovative alternatives. This review considers the role of antimicrobial metal ions, their mechanism of action, and their incorporation into bioactive glass formulations as these materials can serve as delivery platforms with the least possible complexities. Furthermore, the bacterial infection risk in bone is also examined with specific attention to antibiotic resistance and biofilm formation. This review sheds light on the most promising materials as novel antibacterial agents by presenting a wide range of possible bioactive glass formulations equipped with potential antibacterial ions and in vitro/ in vivo insights, and it also reinforces the importance of continuing studies to develop multi‐faceted antibacterial bioactive glasses. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds Manufactured by Direct and Indirect 3D Printing Methods for Bone Regeneration

Author

Elahpour, Nafise, primary, Niesner, Isabella, additional, Bossard, Cédric, additional, Abdellaoui, Nora, additional, Montouillout, Valérie, additional, Fayon, Franck, additional, Taviot-Guého, Christine, additional, Frankenbach, Tina, additional, Crispin, Alexander, additional, Khosravani, Pardis, additional, Holzapfel, Boris Michael, additional, Jallot, Edouard, additional, Mayer-Wagner, Susanne, additional, and Lao, Jonathan, additional

Published
2023
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12. In vitro and in vivo evaluation of the inflammatory potential of various nanoporous calcium phosphate biomaterials

Author

Velard, Frédéric, Schlaubitz, Silke, Fricain, Jean-Christophe, Guillaume, Christine, Laurent-Maquin, Dominique, Möller-Siegert, Janina, Vidal, Loïc, Jallot, Edouard, Sayen, Stéphanie, Raissle, Olivier, Nedelec, J.-M., Vix-Guterl, Cathie, Anselme, Karine, Amédée, Joëlle, Laquerrière, Patrice, Biomatériaux et inflammation en site osseux - EA 4691 (BIOS), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), INSERM UMR-S1026, Bioingénierie Tissulaire, Université Bordeaux, CHU Bordeaux [Bordeaux], Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
nanoporous hydroxyapatite biomaterials, inflammatory potential, [CHIM]Chemical Sciences
Abstract

International audience; Aim: To discriminate the most important physicochemical parameters for bone reconstruction, the inflammatory potential of seven nanoporous hydroxyapatite powders synthesized by hard or soft templating was evaluated both in vitro and in vivo. Materials & methods: After physical and chemical characterization of the powders, we studied the production of inflammatory mediators by human primary monocytes after 4 and 24 h in contact with powders, and the host response after 2 weeks implantation in a mouse critical size defect model. Results: In vitro results highlighted increases in the secretion of TNF-α, IL-1, -8, -10 and proMMP-2 and -9 and decreases in the secretion of IL-6 only for powders prepared by hard templating. In vivo observations confirmed an extensive inflammatory tissue reaction and a strong resorption for the most inflammatory powder in vitro. Conclusion: These findings highlight that the most critical physicochemical parameters for these nanoporous hydroxyapatite are, the crystallinity that controls dissolution potential, the specific surface area and the size and shape of crystallites.

Published
2015
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14. Effect of strontium substituted hydroxyapatite on inflammatory mediator production by human monocytes

Author

Buache, Emilie, Velard, F., Bauden, E., Guillaume, C., Jallot, Edouard, Nedelec, Jean-Marie, Laurent-Maquin, D., Laquerriere, P., Biomatériaux et inflammation en site osseux - EA 4691 (BIOS), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), MI, Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Bonnefoy, Stéphanie

Subjects
Calcium phosphate Cytokines Inflammation Strontium Matrix metalloproteinases
Abstract

International audience; Calcium phosphate materials are widely used as bone substitutes because of their properties close to those of the mineral phase of bones. Nevertheless, after several months, calcium phosphate-based materials release particles that may be phagocytosed by monocytes, leading to an inflammatory reaction. Strontium is well known to counteract the osteoporosis process, but little is known about its effect on inflammatory processes. The purpose of this work was to study the effect of biphasic calcium phosphate (BCP) particles substituted with strontium on the inflammatory reaction. Human primary monocytes stimulated or not by lipopolysaccharide (LPS) were exposed to BCP particles containing strontium for 6 and 24 h. Inflammatory mediators (cytokines and matrix metalloproteinases (MMPs)) production was then quantified by ELISA and zymography. We observed that the presence of strontium had few effects on unstimulated cells, but it decreased the production of pro-inflammatory cytokines and the chemokine interleukin 8 in LPS-stimulated cell-conditioned medium. This work suggests for the first time that strontium may be involved in the control of inflammatory processes following BCP phagocytosis by human monocytes.

Published
2012

15. Influence des propriétés physicochimiques d'hydroxyapatites sur le comportement cellulaire. Effect of the physicochemical characteristics of hydroxyapatite on the cell behaviour

Author

Laquerriere, Patrice, Grandjean-Laquerriere, Alexia, Jallot, Edouard, Nardin, Michel, Frayssinet, Patrick, Nedelec, Jean-Marie, Laurent-Maquin, Dominique, Interfaces biomatériaux/tissus hôtes, Université de Reims Champagne-Ardenne (URCA)-IFR53-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de chimie des surfaces et interfaces de Mulhouse (ICSIM), Ecole Nationale Supérieure de Chimie de Mulhouse-Centre National de la Recherche Scientifique (CNRS), URODELIA, PRIVEE, Laboratoire des Matériaux Inorganiques (LMI), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Clermont Université-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de chimie des surfaces et interfaces (ICSI), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS), Laurent-Maquin, Dominique, and Institut de Chimie et des Surfaces et Interfaces (ICSI)

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, [SDV.IB]Life Sciences [q-bio]/Bioengineering
Abstract

soumis à ITBM; Les biocéramiques phosphocalciques sont utilisées comme substitut osseux depuis de nombreuses décennies. Le descellement aseptique après une arthroplastir totale est un problème majeur en chirurgie orthopédique. Les particules d'hydroxyapatite issues du biomatériau ont été identifiées comme cause majeure de l'échec de l'implantation. Pour cette raison et afin d'augmenter la longévité des implants aprés une arthroplastie, des recherches dans le domaine de ces particules relarguées sont donc nécessaires. Dans cet article, nous discutons de la réponse cellulaire (principalement des monocytes/macrophages qui sont parmi les premières cellules à coloniser le site inflammatoire) après exposition à des particules ayant des caractéristiques différentes (taille, forme, température de traitement et composition chimique). Les caractéristiques les plus importantes sont d'abord la forme puis la taille des particules. En effets, les particules sous forme d'aiguille induisent une plus grande production de médiateurs de l'inflammation et elles sont plus toxiques pour les cellules. La température de traitement semble être moins importante même si elle joue un rôle important dans les processus de dissolution/précipitation. Peu de choses sont connues sur l'effet d'ions dopant l'hydroxyapatite (comme le zinc, le strontium,...) sur la réponse cellulaire. Les premières données montrent que le dopage semble bénéfique pour les cellules.

Published
2005
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16. In vitro and in vivo evaluation of the inflammatory potential of various nanoporous hydroxyapatite biomaterials

Author

Velard, Frédéric, primary, Schlaubitz, Silke, additional, Fricain, Jean-Christophe, additional, Guillaume, Christine, additional, Laurent-Maquin, Dominique, additional, Möller-Siegert, Janina, additional, Vidal, Loïc, additional, Jallot, Edouard, additional, Sayen, Stéphanie, additional, Raissle, Olivier, additional, Nedelec, Jean-Marie, additional, Vix-Guterl, Cathie, additional, Anselme, Karine, additional, Amédée, Joëlle, additional, and Laquerrière, Patrice, additional

Published
2015
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17. Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications

Author

Hoppe, Alexander, Jokić, Bojan, Janaćković, Đorđe, Fey, Tobias, Greil, Peter, Romeis, Stefan, Schmidt, Jochen, Peukert, Wolfgang, Lao, Jonathan, Jallot, Edouard, Boccaccini, Aldo R., Hoppe, Alexander, Jokić, Bojan, Janaćković, Đorđe, Fey, Tobias, Greil, Peter, Romeis, Stefan, Schmidt, Jochen, Peukert, Wolfgang, Lao, Jonathan, Jallot, Edouard, and Boccaccini, Aldo R.

Abstract

Loading biomaterials with angiogenic therapeutics has emerged as a promising approach for developing superior biomaterials for engineering bone constructs. In this context, cobalt-releasing materials are of interest as Co is a known angiogenic agent. In this study, we report on cobalt-releasing three-dimensional (3D) scaffolds based on a silicate bioactive glass. Novel melt-derived "1393" glass (53 wt % SiO2, 6 wt % Na2O, 12 wt % K2O, wt % MgO, 20 wt % CaO, and 4 wt % P2O5) with CoO substituted for CaO was fabricated and was used to produce a 3D porous scaffold by the foam replica technique. Glass structural and thermal properties as well as scaffold macrostructure, compressive strength, acellular bioactivity, and Co release in simulated body fluid (SBF) were investigated. In particular, detailed insights into the physicochemical reactions occurring at the scaffold-fluid interface were derived from advanced micro-particle-induced X-ray emission/Rutherford backscattering spectrometry analysis. CoO is shown to act in a concentration-dependent manner as both a network former and a network modifier. At a concentration of 5 wt % CoO, the glass transition point (T-g) of the glass was reduced because of the replacement of stronger Si-O bonds with Co-O bonds in the glass network. Compressive strengths of gt 2 MPa were measured for Co-containing 1393-derived scaffolds, which are comparable to values of human spongy bone. SBF studies showed that all glass scaffolds form a calcium phosphate (CaP) layer, and for 1393-1Co and 1393-5Co, CaP layers with incorporated traces of Co were observed. The highest Co concentrations of similar to 12 ppm were released in SBF after reaction for 21 days, which are known to be within therapeutic ranges reported for Co2+ ions.

Published
2014

18. Sr Solid-State NMR as a Structurally Sensitive Tool for the Investigation of Materials:Antiosteoporotic Pharmaceuticals and Bioactive Glasses

Author

Bonhomme, Christian, Gervais, Christel, Folliet, Nicolas, Pourpoint, Frédérique, Coelho Diogo, Cristina, Lao, Jonathan, Jallot, Edouard, Lacroix, Joséphine, Nedelec, Jean-Marie, Iuga, Dinu, Hanna, John V., Smith, Mark E., Xiang, Ye, Du, Jincheng, Laurencin, Danielle, Bonhomme, Christian, Gervais, Christel, Folliet, Nicolas, Pourpoint, Frédérique, Coelho Diogo, Cristina, Lao, Jonathan, Jallot, Edouard, Lacroix, Joséphine, Nedelec, Jean-Marie, Iuga, Dinu, Hanna, John V., Smith, Mark E., Xiang, Ye, Du, Jincheng, and Laurencin, Danielle

Abstract

Strontium is an element of fundamental importance in biomedical science. Indeed, it has been demonstrated that Sr2+ ions can promote bone growth and inhibit bone resorption. Thus, the oral administration of Sr-containing medications has been used clinically to prevent osteoporosis, and Sr-containing biomaterials have been developed for implant and tissue engineering applications. The bioavailability of strontium metal cations in the body and their kinetics of release from materials will depend on their local environment. It is thus crucial to be able to characterize, in detail, strontium environments in disordered phases such as bioactive glasses, to understand their structure and rationalize their properties. In this paper, we demonstrate that 87Sr NMR spectroscopy can serve as a valuable tool of investigation. First, the implementation of high-sensitivity 87Sr solid-state NMR experiments is presented using 87Sr-labeled strontium malonate (with DFS (double field sweep), QCPMG (quadrupolar Carr–Purcell–Meiboom–Gill), and WURST (wideband, uniform rate, and smooth truncation) excitation). Then, it is shown that GIPAW DFT (gauge including projector augmented wave density functional theory) calculations can accurately compute 87Sr NMR parameters. Last and most importantly, 87Sr NMR is used for the study of a (Ca,Sr)-silicate bioactive glass of limited Sr content (only 9 wt %). The spectrum is interpreted using structural models of the glass, which are generated through molecular dynamics (MD) simulations and relaxed by DFT, before performing GIPAW calculations of 87Sr NMR parameters. Finally, changes in the 87Sr NMR spectrum after immersion of the glass in simulated body fluid (SBF) are reported and discussed.

Published
2012

19. Sr Solid-State NMR as a Structurally Sensitive Tool for the Investigation of Materials : Antiosteoporotic Pharmaceuticals and Bioactive Glasses

Author

Bonhomme, Christian, Gervais, Christel, Folliet, Nicolas, Pourpoint, Frédérique, Coelho Diogo, Cristina, Lao, Jonathan, Jallot, Edouard, Lacroix, Joséphine, Nedelec, Jean-Marie, Iuga, Dinu, Hanna, John V., Smith, Mark E., Xiang, Ye, Du, Jincheng, Laurencin, Danielle, Bonhomme, Christian, Gervais, Christel, Folliet, Nicolas, Pourpoint, Frédérique, Coelho Diogo, Cristina, Lao, Jonathan, Jallot, Edouard, Lacroix, Joséphine, Nedelec, Jean-Marie, Iuga, Dinu, Hanna, John V., Smith, Mark E., Xiang, Ye, Du, Jincheng, and Laurencin, Danielle

Abstract

Strontium is an element of fundamental importance in biomedical science. Indeed, it has been demonstrated that Sr2+ ions can promote bone growth and inhibit bone resorption. Thus, the oral administration of Sr-containing medications has been used clinically to prevent osteoporosis, and Sr-containing biomaterials have been developed for implant and tissue engineering applications. The bioavailability of strontium metal cations in the body and their kinetics of release from materials will depend on their local environment. It is thus crucial to be able to characterize, in detail, strontium environments in disordered phases such as bioactive glasses, to understand their structure and rationalize their properties. In this paper, we demonstrate that 87Sr NMR spectroscopy can serve as a valuable tool of investigation. First, the implementation of high-sensitivity 87Sr solid-state NMR experiments is presented using 87Sr-labeled strontium malonate (with DFS (double field sweep), QCPMG (quadrupolar Carr–Purcell–Meiboom–Gill), and WURST (wideband, uniform rate, and smooth truncation) excitation). Then, it is shown that GIPAW DFT (gauge including projector augmented wave density functional theory) calculations can accurately compute 87Sr NMR parameters. Last and most importantly, 87Sr NMR is used for the study of a (Ca,Sr)-silicate bioactive glass of limited Sr content (only 9 wt %). The spectrum is interpreted using structural models of the glass, which are generated through molecular dynamics (MD) simulations and relaxed by DFT, before performing GIPAW calculations of 87Sr NMR parameters. Finally, changes in the 87Sr NMR spectrum after immersion of the glass in simulated body fluid (SBF) are reported and discussed.

Published
2012

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