1. Assessing central and peripheral respiratory chemoreceptor interaction in humans
- Author
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Kristin M. Milloy, Matthew G. White, Janelle O. C. Chicilo, Kevin J. Cummings, Jamie R. Pfoh, and Trevor A. Day
- Subjects
Oxygen ,Carotid Body ,Nutrition and Dietetics ,Respiratory Rate ,Physiology ,Respiration ,Physiology (medical) ,Tidal Volume ,Humans ,General Medicine ,Carbon Dioxide ,Hypoxia ,Chemoreceptor Cells - Abstract
What is the central question of this study? We investigated the interaction between central and peripheral respiratory chemoreceptors in healthy, awake human participants by using a background of step increases in steady-state normoxic fraction of inspired carbon dioxide to alter central chemoreceptor activation and by using the transient hypoxia test to target the peripheral chemoreceptors. What is the main finding and its importance? Our data suggest that the interaction between central and peripheral respiratory chemoreceptors is additive in minute ventilation and respiratory rate, but hypo-additive in tidal volume. Our study adds important new data in reconciling chemoreceptor interaction in awake healthy humans and is consistent with previous reports of simple addition in intact rodents and humans.Arterial blood gas levels are maintained through respiratory chemoreflexes, mediated by central chemoreceptors in the CNS and peripheral chemoreceptors located in the carotid bodies. The interaction between central and peripheral chemoreceptors is controversial, and few studies have investigated this interaction in awake, healthy humans, owing, in part, to methodological challenges. We investigated the interaction between the central and peripheral chemoreceptors in healthy humans using a transient hypoxia test (three consecutive breaths of 100% N
- Published
- 2022