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Utilising Abbott’s work on professions and disciplines we trace the broad development of Social Policy in UK universities over the past 50 years. As with all subjects, Social Policy is enmeshed in continuous boundary protection, and at the same time may seek to extend jurisdiction by laying claim to areas and activities undertaken by others. We draw on a range of sources to inform our analysis including: overviews of contributions to Journal of Social Policy; reviews of selected available UK Social Policy Association documents such as newsletters; reviews of research quality (Research Assessment Exercise/Research Excellence Framework) submissions; and student numbers data. In conclusion we consider whether reassessment of some of the jurisdictional battles of the past 50 years might provide routes forward for the subject to flourish in the current environment.

Since 2000, robotic-assisted surgery has rapidly expanded into almost every surgical sub-specialty. Despite the popularity of robotic surgery across the United States, a national consensus for standardized training and education of robotic surgeons or surgical teams remains absent. In this quality improvement initiative, a novel, stepwise iterative Robotic Assistant Surgical Training (RAST) curriculum was developed to broaden and standardize robotic bedside assistant training. Thirteen voluntary participants, capable of fulfilling the bedside assistant role, were evaluated to determine if RAST enhanced the learner’s self-perceived level of confidence and comfort in their role as bedside assistant. A pre- and post-RAST training survey and a between-stages repeated-measures survey were conducted. All learner participants reported statistically significant increases in confidence and comfort after RAST training, (p =

Common Law, Civil Law, and Colonial Law builds upon the legal historian F.W. Maitland's famous observation that history involves comparison, and that those who ignore every system but their own 'hardly came in sight of the idea of legal history'. The extensive introduction addresses the intellectual challenges posed by comparative approaches to legal history. This is followed by twelve essays derived from papers delivered at the 24th British Legal History Conference. These essays explore patterns in legal norms, processes, and practice across an exceptionally broad chronological and geographical range. Carefully selected to provide a network of inter-connections, they contribute to our better understanding of legal history by combining depth of analysis with historical contextualization. This title is also available as Open Access on Cambridge Core.

Le droit prend une place toujours plus importante dans notre société, et il pose à l’Europe entière un problème difficile qu’il est pourtant urgent de résoudre : comment construire un droit, un système judiciaire - ou du moins un ensemble cohérent de systèmes judiciaires - alors que la plupart des droits européens ont une longue histoire, qui n’est pas seulement une histoire de doctrines ou de normes, mais aussi celle de la symbiose dans laquelle ces droits ont vécu avec les sociétés qui les ont créés, appliqués ou subis. Le Groupe de recherche France-Îles Britanniques a choisi de consacrer son premier colloque à une confrontation entre la France et l’Angleterre sur le thème « Droit et société », car on peut dans ce domaine comparer terme à terme la situation anglaise (puis britannique) avec celle de la France sur un millénaire : des questions diverses y sont abordées, de la production des lois et de l’idéologie qui l’inspire, à la représentation que se fait la société du droit, de la justice et des juges, en passant par la fonction et le statut sociaux des hommes de loi. La vision et la perception des pauvres et des marginaux n’ont pas été oubliées dans un ouvrage qui se veut un tremplin vers de futures recherches.

Introduction In this paper, I compare certain aspects of the ideals and practices of royal approaches to crime in England in the tenth and the later twelfth centuries. In the latter, the Angevin period, the birth of the English Common Law is traditionally found ; in the former Patrick Wormaid has recently located what he calls the Making of English Law. My central concern is to make comparisons regarding the conceptualization and treatment of offences and offenders. I aim to set the issues in...

Chimeric antigen receptor (CAR) T cells have revolutionized blood cancer immunotherapy; however, their efficacy against solid tumors has been limited. A common mechanism of tumor escape from single target therapies is downregulation or mutational loss of the nominal epitope. Targeting multiple antigens may thus improve the effectiveness of CAR immunotherapies. We generated dual CAR-T cells targeting two tumor antigens: TAG-72 (tumor-associated glycoprotein 72) and CD47. TAG-72 is a pan-adenocarcinoma oncofetal antigen, highly expressed in ovarian cancers, with increased expression linked to disease progression. CD47 is ubiquitously overexpressed in multiple tumor types, including ovarian cancer; it is a macrophage “don’t eat me” signal. However, CD47 is also expressed on many normal cells. To avoid this component of the dual CAR-T cells killing healthy tissue, we designed a truncated CD47 CAR devoid of intracellular signaling domains. The CD47 CAR facilitates binding to CD47+ cells, increasing the prospect of TAG-72+ cell elimination via the TAG-72 CAR. Furthermore, we could reduce the damage to normal tissue by monomerizing the CD47 CAR. Our results indicate that the co-expression of the TAG-72 CAR and the CD47-truncated monomer CAR on T cells could be an effective, dual CAR-T cell strategy for ovarian cancer, also applicable to other adenocarcinomas., Graphical Abstract, Tumors often escape immunotherapy by mutational downregulation of the nominal target antigen. Use of CAR-T cells with dual antigen specificity can mitigate this problem. Adenocarcinomas expressing low levels of TAG-72 are not killed by single specificity TAG-72 CAR-T cells, but they are killed by dual CAR-T cells targeting TAG-72 and CD47.

The aim of this study is to determine the nature of the relationship between house prices of different types of housing across the UK regions. We use an Autoregressive Distributed Lag bounds testing approach to determine the long-run relationships between house prices as well as an error correction model to estimate the short-run dynamics between house prices. The data include house prices across the regions of Great Britain and for new, old and modern houses. The results suggest that house price shocks ripple across regions, although the nature of the relationship varies across housing types. We further simulate the impact of house price shocks and reveal a complex structure whereby a house price shock in region A impacts upon prices in other regions, which in turn feedback into region A in a recursive ripple.

We present here the complete genomes of two Streptomyces bacteriophages, Satis and JustBecause. Both phages were isolated directly from soil samples collected in St. Louis, MO, and present with an unusual prolate head morphology and large genome lengths of over 180 kb.

Jensen and Tyler (2015) have powerfully argued that 'anti-welfare commonsense', fuelled by negative political and media discourse stressing welfare dependency and deception, has buttressed support for social security reform in recent years. Along with many other academics they point to the hardening of public attitudes towards welfare state provision and how notions of the 'deserving' and 'undeserving poor' have been reintroduced into popular debates. We identify four distinct threads within this scholarship. First, there is an argument that public attitudes have shifted from an earlier post-war welfare imaginary and settlement to an anti-welfare consensus. Second, this hardening includes a growing prevalence of 'othering'. The third thread is the broadening of this moral and disciplinary gaze to include groups, such as disabled people, who until recently were not subject to the same amount of stigma as other types of benefit recipients. Fourth, is the impact of pejorative welfare discourses on the self-identity and attitudes of disadvantaged groups. While a growing body of evidence makes it increasingly difficult to argue against suggestions that there is a hostile body of anti-welfare sentiment in the UK, what is often implicit in the analysis of pejorative contemporary attitudes to welfare is the view that there was once a 'golden age' of the welfare state when public support was more fully behind a strong set of social security benefits provided as a social right of citizenship. Whether this was the case is a moot point however. Few studies have tried to piece together the attitudes to welfare of the general public during the consensus era. We attempt to undertake such a task here, drawing on ad hoc attitudes surveys and polling data in particular. Specifically, we focus on how notions of the 'deserving' and 'undeserving poor' play out in this data, pointing to some key continuities found in contemporary and historical public attitudes to welfare.

It is commonly argued that public support for the welfare state is in long-term decline in the UK. Evidence from the British Social Attitudes Survey (BSA) is typically cited to support this claim, but it only stretches back to 1983. Few would disagree that the Thatcher years offered an unusual socio-political-economic context, which raises a question over whether the BSA's early 1980s baseline provides a misleading view on support for the welfare state over the longue duree. In this article, we explore this issue, piecing together data from the Beveridge era through to the present day, drawing on data from contemporary studies and surveys; opinion polls; and historical government surveys and reports. Our method is undoubtedly a ‘second best approach’, making use of often limited historical data, which means we remain cautious in offering bold findings. However, we argue there is some evidence to suggest the 1980s were an unusual moment, suggesting the decline in support for welfare is less dramatic than analysis of the BSA might make it seem, but also that support for the welfare state during the postwar consensus years was likely more equivocal than we often believe it to be from today's perspective, perhaps reflecting a tendency to reify this period as a ‘golden age’ of welfare and so underplaying the complexity of the politics of social policy in the pre-BSA period.

The paper examines several aspects of developed countries with a particular focus on Europe. It argues that despite problems and qualifications, Europe is still in many respects a desirable part of the world in which to live, where people can fulfill their aspirations with a degree of safety. Having said that, Europe faces many problems. Any solution to Europe’s problems must encompass innovation. In this respect Europe’s record is better than many argue, but still there is a need to do better and to place innovation at the very core of policy making. High quality research institutions are valuable here, but too often their work is taken up by non-European multinationals. This is a time of enormous change and issues such as quantitative easing and robotics are also briefly touched upon, in particular their economic and societal impact.

Our study examines the effect of water utilization together with the effect of water quality on economic growth across countries. We constructed a panel of 177 countries covering the period of 1960–2009. We analyse two dependent variables, gross domestic product per capita and the average of five years of growth. The analysis is conducted using a fixed effects model and fixed effects with instrumental variables. We find that although water utilization affects growth, water quality also proves to be highly significant and affects growth in both the short and long run to a greater degree than water quantity.

Psychosocial hazards in mental healthcare contribute to the development of compassion fatigue in mental health professionals. Compassion fatigue has a negative impact on the mental health and wellbeing of professionals that can impair the quality of services provided to clients. The majority of research on compassion fatigue has focused on individual-level variables such as gender, history of trauma and age, among others. It is also imperative to understand the role played by alterable work-related characteristics in contributing to the development of compassion fatigue in order to attenuate its impact on mental health professionals and their clients. The present review examined articles exploring work-related factors associated with compassion fatigue. Fifteen quantitative studies were included and their quality was assessed using a checklist. An inductive content-analysis approach was adopted to synthesise the themes emerging from the data. The results suggested a theoretical model consistent with the Job Demands-Resources model, wherein job demands (such as workplace trauma, workload and therapeutic settings) are associated with compassion fatigue, and job resources (such as supervisors’, coworkers’ and organisational support) mitigate the impact of job demands. In addition to person-oriented factors, work-related factors are critical for the prevention of compassion fatigue.

Purpose: The paper examines the potential effects of academic publications on patenting and the share of high technology exports. We test the short-run and the long-run causalities among high technology exports, the number of academic publications and the number of patents in three separate models.Methodology/Approach: Our sample consists of panel data for 61 countries and 20 years. The panel Granger causality and vector error correction model have been used in order to capture the short-run causalities. Furthermore, panel cointegration regressions have been applied to test for long-run causalities.Findings: Our results strongly suggest that there is a positive long-run effect of academic publications on both patenting and the share of high technology exports. This suggests that the outcomes of basic science in the form publications strongly support technological development, and thus emphasises the importance of basic research. In addition the effect of patents on high technology exports is mostly insignificant when controlling for academic publications and GDP.Research Limitation/implication: First, the variables used in the analysis are only proxies. The scope of the data has been significantly limited by the data availability. This leads also to limited the number of control variables.Originality/Value of paper: There are still only a very limited number of studies testing the effect of academic outcomes on the technological development of the economy. Our research brings new empirical insights into this problem.

Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited. Objectives: To evaluate the efficacy and safety of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor with robust wake-promoting effects, for the treatment of excessive sleepiness in participants with obstructive sleep apnea with current or prior sleep apnea treatment. Methods: This was a double-blind, randomized, placebo-controlled, parallel-group, 12-week trial comparing solriamfetol, 37.5, 75, 150, and 300 mg, with placebo. Measurements and Main Results: Of 476 randomized participants, 459 were included in the prespecified efficacy analyses. Coprimary endpoints (Maintenance of Wakefulness Test sleep latency and Epworth Sleepiness Scale score) were met at all solriamfetol doses (P

In the paper we study the variables influencing attitudes to the use of two biotechnologies related to gene transfer within apples. Using Eurobarometer 73.1 survey data on biotechnology, science and technology, with 15,650 respondents, we study the extent these attitudes are determined by socio-economic and other variables. We found that attitudes to the risks and gains are determined by socio-economic variables and also by the individual's knowledge, scientific background, their parent's education in science and their religion. Perceptions of naturalness and of environmental impact combined with perceived risks and gains in determining overall approval, proxied by views on whether the technologies should be encouraged, for GMTs. However there are substantial differences in attitudes to transgenesis and cisgenesis.

We used natural abundance δ13C, δ15N, and Δ14C to compare trophic linkages between potential carbon sources (leaf litter, epilithic biofilm, and particulate organic matter) and consumers (aquatic macroinvertebrates and fish) in a nonglacial stream and two reaches of the heavily glaciated Herbert River. We tested the hypothesis that proglacial stream food webs are sustained by organic carbon released from glacial ecosystems. Carbon sources and consumers in the nonglacial stream had carbon isotope values that ranged from −30‰ to −25‰ for δ13C and from −14‰ to 53‰ for Δ14C reflecting a food web sustained mainly on contemporary primary production. In contrast, biofilm in the two glacial stream sites was highly Δ14C-depleted (−215‰ to 175‰) relative to the nonglacial stream consistent with the assimilation of ancient glacier organic carbon. IsoSource modeling showed that in upper Herbert River, macroinvertebrates (Δ14C = −171‰ to 22‰) and juvenile salmonids (Δ14C = −102‰ to 17‰) reflected a feeding history of both biofilm (∼ 56%) and leaf litter (∼ 40%). We estimate that in upper Herbert River on average 36% of the carbon incorporated into consumer biomass is derived from the glacier ecosystem. Thus, 14C-depleted glacial organic carbon was likely transferred to higher trophic levels through a feeding history of bacterial uptake of dissolved organic carbon and subsequent consumption of 14C-depleted biofilm by invertebrates and ultimately fish. Our findings show that the metazoan food web is sustained in part by glacial organic carbon such that future changes in glacial runoff could influence the stability and trophic structure of proglacial aquatic ecosystems.

Item does not contain fulltext Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because of high renal radiometal retention. Therefore, we developed and evaluated a pretargeting strategy using click chemistry in vivo to reduce kidney uptake and avoid unwanted radiation toxicity. We focused on the bioorthogonal reaction between a trans-cyclooctene (TCO)-functionalized TAG72 targeting diabody, AVP04-07, and a low-molecular-weight radiolabeled tetrazine probe that was previously shown to have low kidney retention and relatively fast renal clearance. METHODS: AVP04-07 diabodies were functionalized with TCO tags, and in vitro immunoreactivity toward bovine submaxillary mucin and tetrazine reactivity were assessed. Next, pretargeting biodistribution studies were performed in LS174T tumor-bearing mice with AVP04-07-TCO(n) (where n indicates the number of TCO groups per diabody) and radiolabeled tetrazine to optimize the TCO modification grade (0, 1.8, or 4.7 TCO groups per diabody) and the (177)Lu-tetrazine dose (0.1, 1.0, or 10 Eq with respect to the diabody). Radiolabeled tetrazine was injected at 47 h after diabody injection, and mice were euthanized 3 h later. A pretargeting SPECT/CT study with (111)In-tetrazine was performed with the optimized conditions. RESULTS: Immunoreactivity for native AVP04-07 was similar to that for TCO-functionalized AVP04-07, and the latter reacted efficiently with radiolabeled tetrazine in vitro. The combination of the pretargeting component AVP04-07 functionalized with 4.7 TCO groups and 1 Eq of (177)Lu-tetrazine with respect to the diabody showed the most promising biodistribution. Specifically, high (177)Lu-tetrazine tumor uptake (6.9 percentage injected dose/g) was observed with low renal retention, yielding a tumor-to-kidney ratio of 5.7. SPECT/CT imaging confirmed the predominant accumulation of radiolabeled tetrazine in the tumor and low nontumor retention. CONCLUSION: Pretargeting provides an alternative radioimmunotherapy and nuclear imaging strategy by overcoming the high renal retention of low-molecular-weight radiometal tumor-homing agents through the separate administration of a tumor-homing agent and a radioactive probe with fast clearance.

The commercial fisheries of the United States and Canadian Great Lakes are in a long period of decline. Detailed statistics kept for well over a century document a fluctuating pattern of harvests o...

Southeastern Alaska is a remote coastal-maritime ecosystem that is experiencing increased deposition of mercury (Hg) as well as rapid glacier loss. Here we present the results of the first reported survey of total and methyl Hg (MeHg) concentrations in regional streams and biota. Overall, streams draining large wetland areas had higher Hg concentrations in water, mayflies, and juvenile salmon than those from glacially-influenced or recently deglaciated watersheds. Filtered MeHg was positively correlated with wetland abundance. Aqueous Hg occurred predominantly in the particulate fraction of glacier streams but in the filtered fraction of wetland-rich streams. Colonization by anadromous salmon in both glacier and wetland-rich streams may be contributing additional marine-derived Hg. The spatial distribution of Hg in the range of streams presented here shows that watersheds are variably, yet fairly predictably, sensitive to atmospheric and marine inputs of Hg.

League tables ranking performance outcomes within or between countries have become commonplace in most policy sectors in recent decades and there are numerous examples to be found in practice. UNICEF's 2007 Overview of Child Well-Being in Rich Countries offered a comprehensive and widely cited comparative analysis of children's well being in 21 of the richest countries of the world. Utilising an additive index the authors distilled a large amount of quantitative data relating to children's well being and were able to provide the most comprehensive snapshot of outcomes to date. Whilst an advantage of the method — and certainly a key factor in generating media coverage — was the way it allowed for a ranking of nations, recent debates in the comparative policy analysis literature have pointed to the advantages of methods that aim to classify nations into qualitatively distinct types rather than ranking them in league tables. These debates have particular force when multiple components of analysis are conceptually distinct or cases have widely varying contexts. Fuzzy set ideal type analysis (FSITA) has become an increasingly popular alternative approach to the additive index, precisely because it addresses these concerns. In this paper we explore the potential for using FSITA for the comparative analysis of children's well-being. Drawing on the same data and conceptual foundations as the 2007 UNICEF study we explore the potential advantages of utilising a diversity oriented method such as FSITA as tool for policy evaluation that eschews ranking in favour of classifying.

QCA based methods have grown in popularity in recent years. Standing between quantitative and qualitative research, in principle they help balance the breadth of analysis provided by quantitative data with the depth of case study knowledge provided by qualitative analysis. The challenge of mixing depth and breadth has always been a particularly acute one for policy based research. Proponents of QCA techniques suggest they are better placed to handle the diversity of policy provision found in different spatial entities than standard linear quantitative methods, while also able to allow for hypothesis testing based upon a fine grained analysis that is more systematic in approach than the techniques typically employed in standard qualitative analyses. The full potential of these methods for policy analysis has yet to be realised however. Partly this is because knowledge of these methods remains at the margins of the policy analysis community, particularly amongst practitioners undertaking applied policy analyses such as policy evaluations. In the introduction to this volume we first outline some of the key principles of QCA research before moving on to identify some of its key advantages. We round off by highlighting key themes explored by the papers included within the volume.

The article analyses conditional β-convergence among the low income countries using a panel data framework covering the period 1960 to 2008. The estimation of conditional income convergence is based on the augmented Solow model with system GMM technique for the dynamic panel data. More importantly, the article assesses the role of initial human capital stock and the rule of law in the income convergence of poor countries by considering further categorizations of the poor countries based on these two variables. This is the first study on the comparative properties of human capital and the rule of law in the income convergence of poor countries utilizing a dynamic panel framework. The full sample of low income countries does not show any evidence of conditional income convergence. The categorizations on the basis of initial human capital stock do not alter the conclusion of no income convergence. However, the subsample of low income countries with a better rule of law exhibits positive evidence of convergence towards the steady states. The article concludes that there exists a greater role of the rule of law, than initial human capital stock, in the income convergence of poor countries and vice versa for the high and middle income countries.

We use an updated form of an old database to examine aid predictability, i.e. the relationship between commitments and disbursements. In contrast to the existing literature, the regression results suggest that on average almost all commitments tend to be met within two years, with the overwhelming majority met immediately. But the situation is different with respect to individual sectors. Some such as infrastructure have very long lags. For some sectors too it seems likely that commitments will never be fully met. Debt aid, however, tends to be disbursed in full almost immediately. There are also substantial differences between countries.