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3. The role of macrophages in the host response to radiation

Author

Jones, Keaton and Muschel, Ruth

Subjects
616.99
Abstract

Emerging pre-clinical data suggests a role for radiation in eliciting antitumor immunity. Effective anti-tumour responses can be hindered by highly immunosuppressive tumour microenvironments. We aimed to investigate the role of macrophages in the immune response to radiation. We used the murine colorectal cancer cell line MC38 and the pancreatic cell line KPC for in vitro and in vivo work. To examine the immune response following irradiation, subcutaneous xenografts were analysed by flow cytometry. Further characterisation of macrophages was carried out by gene expression analyses of RNA from isolated cells, along with ex-vivo functional assays. To determine the effect of macrophage depletion, we used an antibody targeting macrophage colony stimulating factor (CSF-1). Single dose 10Gy irradiation to murine tumors, generated from colorectal (MC38) and pancreatic (KPC) cell lines induced Colony Stimulating Factor 1 (CSF-1). Coincident with the elevation in CSF1, CD11b+ F480+ macrophages increased in the tumors, peaking five days following irradiation. These tumor-associated macrophages (TAMs) from irradiated tumors were skewed toward an immunosuppressive phenotpye (CD206hi iNOSlo) and were more effective in suppressing CD8 T cell expansion ex vivo. Macrophage depletion via anti-CSF (aCSF) reduced macrophage numbers yet only achieved tumor growth delay when combined with radiation. The tumor growth delay from aCSF after radiation was abrogated by depletion of CD8 T cells. There was enhanced recognition of tumor cell antigens by T cells isolated from irradiated tumors, consistent with increased antigen priming. Radiation stimulated increased expression of PD-L1 on tumor cells, limiting antitumor responses. The addition of anti-PD-L1 resulted in improved tumor suppression and even regression in the highly resistant murine pancreatic cancer model. In summary we show that adaptive immunity induced by radiation is limited by the recruitment of highly M2 polarised immunosuppressive macrophages. Macrophage depletion with aCSF partly reduced the immunosuppression after radiation, but additional treatment with anti-PD-L1 was required to achieve tumor regression.

Published
2018

6. Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus.

Author

Adu-Gyamfi, Emmanuel, Johnson, Kristen A, Fraser, Mark E, Scott, Jordan L, Soni, Smita P, Jones, Keaton R, Digman, Michelle A, Gratton, Enrico, Tessier, Charles R, and Stahelin, Robert V

Subjects
CHO Cells, Cell Membrane, Animals, Humans, Cricetulus, Hemorrhagic Fever, Ebola, Phosphatidylserines, Viral Matrix Proteins, Virus Assembly, Ebolavirus, Virus Release, HEK293 Cells, Chlorocebus aethiops, Vaccine Related, Biodefense, Immunization, Emerging Infectious Diseases, Prevention, Infectious Diseases, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

UnlabelledLipid-enveloped viruses replicate and bud from the host cell where they acquire their lipid coat. Ebola virus, which buds from the plasma membrane of the host cell, causes viral hemorrhagic fever and has a high fatality rate. To date, little has been known about how budding and egress of Ebola virus are mediated at the plasma membrane. We have found that the lipid phosphatidylserine (PS) regulates the assembly of Ebola virus matrix protein VP40. VP40 binds PS-containing membranes with nanomolar affinity, and binding of PS regulates VP40 localization and oligomerization on the plasma membrane inner leaflet. Further, alteration of PS levels in mammalian cells inhibits assembly and egress of VP40. Notably, interactions of VP40 with the plasma membrane induced exposure of PS on the outer leaflet of the plasma membrane at sites of egress, whereas PS is typically found only on the inner leaflet. Taking the data together, we present a model accounting for the role of plasma membrane PS in assembly of Ebola virus-like particles.ImportanceThe lipid-enveloped Ebola virus causes severe infection with a high mortality rate and currently lacks FDA-approved therapeutics or vaccines. Ebola virus harbors just seven genes in its genome, and there is a critical requirement for acquisition of its lipid envelope from the plasma membrane of the human cell that it infects during the replication process. There is, however, a dearth of information available on the required contents of this envelope for egress and subsequent attachment and entry. Here we demonstrate that plasma membrane phosphatidylserine is critical for Ebola virus budding from the host cell plasma membrane. This report, to our knowledge, is the first to highlight the role of lipids in human cell membranes in the Ebola virus replication cycle and draws a clear link between selective binding and transport of a lipid across the membrane of the human cell and use of that lipid for subsequent viral entry.

Published
2015

11. Bed-load measurements on large, sand-bed rivers in the United States

Author

Abraham David, McAlpin Tate, and Jones Keaton

Subjects
Environmental sciences, GE1-350
Abstract

The movement of bed forms (sand dunes) in large sand-bed rivers is being used to determine the transport rate of bed load. The ISSDOTv2 (Integrated Section Surface Difference Over Time version 2) methodology uses time sequenced differences of measured bathymetric surfaces to compute the bed-load transport rate. The method was verified using flume studies [1]. In general, the method provides very consistent and repeatable results, and also shows very good fidelity with most other measurement techniques. Over the last 7 years we have measured, computed and compiled what we believe to be the most extensive data set anywhere of bed-load measurements on large, sand bed rivers. Most of the measurements have been taken on the Mississippi, Missouri, Ohio and Snake Rivers in the United States. For cases where multiple measurements were made at varying flow rates, bed-load rating curves have been produced. This paper will provide references for the methodology, but is intended more to discuss the measurements, the resulting data sets, and current and potential uses for the bed-load data.

Published
2018
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12. Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model

Author

Philippou, Yiannis, primary, Sjoberg, Hanna T., additional, Murphy, Emma, additional, Alyacoubi, Said, additional, Jones, Keaton I., additional, Gordon-Weeks, Alex N., additional, Phyu, Su, additional, Parkes, Eileen E., additional, Gillies McKenna, W., additional, Lamb, Alastair D., additional, Gileadi, Uzi, additional, Cerundolo, Vincenzo, additional, Scheiblin, David A., additional, Lockett, Stephen J., additional, Wink, David A., additional, Mills, Ian G., additional, Hamdy, Freddie C., additional, Muschel, Ruth J., additional, and Bryant, Richard J., additional

Published
2020
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13. Effectiveness of building-level sewage surveillance during both community-spread and sporadic-infection phases of SARS-CoV-2 in a university campus population.

Author

Johnson, William, Reeves, Katelyn, Liebig, Jennifer, Feula, Antonio, Butler, Claire, Alkire, Michaela, Singh, Samiha, Litton, Shelby, O'Conor, Kerry, Jones, Keaton, Ortega, Nikolas, Shimek, Trace, Witteman, Julia, Bjorkman, Kristen K., and Mansfeldt, Cresten

Subjects
SARS-CoV-2, PUBLIC health, MICROBIAL communities, SEWAGE, NOROVIRUSES
Abstract

Pathogen surveillance within wastewater rapidly progressed during the SARS-CoV-2 pandemic and informed public health management. In addition to the successful monitoring of entire sewer catchment basins at the treatment facility scale, subcatchment or building-levelmonitoring enabled targeted support of resource deployment. However, optimizing the temporal and spatial resolution of these monitoring programs remains complex due to population dynamics and within-sewer physical, chemical, and biological processes. To address these limitations, this study explores the advancement of the building-scale network that monitored the oncampus residential population at the University of Colorado Boulder between August 2020 and May 2021 through a daily SARS-CoV-2 surveillance campaign. During the study period, SARS-CoV-2 infection prevalence transitioned from robust community spread in Fall 2020 to sporadic infections in Spring 2021. Temporally, these distinct phases enabled investigating the effectiveness of resource commitment by exploring subsets of the original daily sampling data. Spatially, select sampling sites were installed along the flow path of the pipe network, enabling the exploration of the conservation of viral concentrations within the wastewater. Infection prevalence and resource commitment for informed action displayed an inverted relationship: higher temporal and spatial resolution surveillance is more imperative during sporadic infection phases than during high prevalence periods. This relationship was reinforced when norovirus (two minor clusters) and influenza (primarily absent) were additionally surveilled at a weekly frequency. Overall, resource commitment should scale to meet the objectives of the monitoring campaign--providing a general prevalence estimate requires fewer resources than an early-warning and targeted-action monitoring framework. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Students' participation in collaborative research should be recognised

Author

Borakati, Aditya, McLean, Kenneth, Drake, Thomas M., Harrison, Ewen M., Kamarajah, Sivesh K., Khatri, Chetan, Nepogodiev, Dmitri, Abbas, Minaam, Abdalkoddus, Muhammad, Abdel-Fattah, Areej, Abdelgalil, Reem, Abdikadir, Haweya, Adams, Ryan, Adams, Sarah, Adelaja, Inioluwa, Adeogun, Abiola, Adjei, Helena, Adlan, Amirul, Adwan, Hussamuddin, Aeyad, Sara, Aftab, Raiyyan, Afzul, Amir, Agarwal, Vani, Aglan, Hosam, Agrawal, Medha, Agrawal, Rishi, Ahmed, Fiza, Akhtar, Sobia, Akpenyi, Onyinye, Al-Attar, Maithem, Al-Ausi, Muhammed, Al-Khyatt, Waleed, Al-Mousawi, Alia, Al-Nasser, Zainab, Alagappan, Anand, Alberts, Justin, Alfa-Wali, Maryam, Ali, Abdulmajid, Ali, Adnan, Ali, Tamara, Alkhaffaf, Bilal, Allen, Rachael, Alubaidi, Kassem, Andah, Edemanwan, Anderson, Richard, Andrew, Kirstine, Ang, Andrew, Ang, Eshen, Anyomih, Theophilus, Archer, James, Archer, Matt, Arnell, Steven, Arnold, Matthew, Arora, Esha, Ashraf, Nadeem, Ashraf, Raees, Ashwood, Jordan, Asif, Usama, Atayi, Andrew, Auckburally, Sameera, Austin, Ralph, Azam, Sultana, Yahaya, Aishah Azri, Babatunde, Fiyin, Bach, Simon, Bachar, Roudi, Badran, Abdul, Baillie, Caroline, Balai, Edward, Baldwin, Alexander, Balian, Vartan, Banfield, Danielle, Bannard-Smith, Jonathan, Barker, Connor, Barmayehvar, Behrad, Barnfield, Jane, Bartlett, David, Bartlett, Richard, Baryeh, Kwaku, Basetti, Siddharth, Bateman, Kellie, Bath, Michael, Beamish, Andrew, Beasley, William, Beecroft, Simon, Begaj, Ardit, Beghal, Gurpreet, Belchos, Jessica, Bera, Katarzyna, Bergara, Tara, Betts, Anna, Bhangu, Aneel, Bhaskaran, Gayathri, Bhatti, Amina, Bica, Mihai, Billyard, Caitlin, Birkin, Emily, Blazeby, Jane, Blege, Harry, Blencowe, Natalie, Blore, Christopher, Boddy, Alex, Boissaud-Cooke, Matthew, Bolina, Anita, Bolton, William, Bosanquet, David, Bowley, Doug, Boyce, Kathryn, Branagan, Graham, Brayley, Jessica, Brecher, Joanna, Bresges, Kristina, Briggs, Emily, Broll, Ryan, Brown, Damien, Brown, Elliot, Brown, Leo, Brown, Robin, Brown, Rory, Bruce, Connor, Bruce, Pepa, Buckle, Rory, Budd, Emily, Buka, Richard, Burke, Dermot, Burke, Joshua, Burman, Alisha, Burney, Laura, Burrows, Amy, Bux, Mohammed, Cahill, Ronan, Calabria, Clementina, Camilleri-Brennan, Julian, Campbell, Amy, Campbell, Bill, Cant, Matthew, Cao, Yun, Carlson, Sophie, Carr, Grace, Carr, Luke, Carr, Rebecca, Carr, Richard, Cartwright, Eleanor, Castle, Alice, Cattle, Kirsty, Cave, Daniel, Chapman, Stephen, Charalabopoulos, Alexandros, Chaudhri, Sanjay, Chaudhry, Ahmad, Chauhan, Paresh, Chauhan, Priyesh, Chebbout, Ryad, Chen, Yunzi, Chenciner, Louisa, Cheng, Jingjie, Cheng, Natalie, Chew, Lin, China, Zenab, Chitnis, Abhishek, Chitsabesan, Praminthra, Choi, Paul, Choi, Sarah, Choudhry, Mariam, Choy, Chern, Ciurleo, Claudia, Claireaux, Henry, Coe, Peter, Cole, Simon, Concannon, Katy, Cope, Edward, Corbridge, Olivia, Court, Jessica, Cox, Louise, Craig-Mcquaide, Anna, Cresswell, Ben, Crozier, Lauren, Cruickshank, Neil, Cuckow, Lucy, Cui, Helen, Cumber, Elspeth, Cumming, Sarah, Cundy, Olivia, Cunha, Melissa, Cunha, Pedro, Cunliffe, Laura, Dada, Jazleen, Daliya, Prita, Dalli, Jeffrey, Daniels, Ian, Daniels, James, Daoub, Ahmed, Dar, Sabeera, Das, Emma, Das, Kaustuv, Davies, Emily, Davies, Gareth, Davies, Kirsty, Davies, Kristen, Davies, Rachel, Dawe, Victoria, Lucas de Carvalho, Joshua, De Jong, Katie, Deasy, Katherine, Deekonda, Praveena, Deepak, Sahil, Desai, Henal, Desai, Karishma, Devlin, Ryan, Dewan, Nishat, Dhillon, Akashdeep, Dhillon, Priya, Dhir, Tanya, Di Saverio, Salomone, Diamond, Julia, Dib, Peter, Dimitriadis, Panagiotis A., Dindyal, Shiva, Doe, Matthew, Doehrty, Ciaran, Dogra, Tara, Doshi, Arpan, Downey, Alison, Doyle, Joseph, Draper, Ashleigh, Duff, Sarah, Duncumb, Joseph, Dupre, Sophie, Durno, Justine, Dzieweczynski, Michal, Eardley, Nicola, Easby, Sarah, Easdon, Sam, Ebdewi, Hamdi, Eccles, Lydon, Edwards, Jacob, Eedarapalli, Padma, Elbuzidi, Mohamed, Elder, Patrick, Elliott, Lucy, Elsaddig, Malaz, Embury-Young, Ysabelle, Emesih, Sophie, Engledow, Alec, English, William, Episkopos, Christos, Epstein, Jonathan, Esmail, Rahim, Fatayer, Taher, Favero, Nicolò, Fearnhead, Nicola, Feldman, Maxine, Fennelly, Evelyn, Fenwick, Stephen, Ferguson, Lucie, Fergusson, Stuart, Fessas, Petros, FitzGerald, Isabel, Fitzgerald, J. Edward, Fitzpatrick, Harry, Fletcher, Daniel, Forjoe, Tonia, Forte, Beniamino, Fowler, Alex, France, Benjamin, Francis, Abraham, Francis, Niroshan, Francis, Sunil, Freeman, Sam, Fretwell, Vicky, Fung, Teresa, Furness, Hugh, Gallagher, Michael, Gallagher, Stuart, Gao, Chuanyu, Garard, Lothaire, Gardner, Shona, Gaukroger, Andrew, George, Daniel, George, Simi, Ghaddar, Jamal, Ghaffar, Ali, Ghouse, Shamira, Gilbert, Amanda, Gill, Ashveen, Giovinazzo, Francesco, Girling, Carey, Giwa, Lolade, Glasbey, James, Glen, Paul, Goble, Mary, Godfrey, Jenna, Goel, Shreya, Goh, Wenn, Gohil, Kajal, Gokani, Shyam, Gold, David, Golding, David, Gonzalez-Ciscar, Andrea, Goodson, Ross, Gough, Melissa, Govil, Shubhangi, Gower, Thomas, Graham, Christopher, Gray, Sam, Green, Patrick, Greenhalgh, Samuel, Gregoriou, Kyriacos, Gribbell, Rhiannon, Gribbon, Mary Catherine, Grieco, Charlotte, Griffiths, Emma, Griffiths, Ewen, Griffiths, Nathan, Griffiths, Sara, Grossart, Cathleen, Guerero, Daniel, Guillotte, Christianne, Gupta, Rishi, Guy, Claire, Gwozdz, Adam, Haddow, James, Hafiz, Shazia, Halkias, Constantine, Hall, Elisabeth, Hamid, Hasseb, Hamilton, Emma, Harbhajan Singh, Gurvinder Singh, Hardman, John, Harries, Rhiannon, Harris, Rhydian, Harrogate, Suzanne, Harty, Megan, Harvey, Jessica, Hashemi, Rahima, Hassane, Ahmed, Hawkins, Helen, Hawthorne, Thomas, Hayes, John, Hazenberg, Phoebe, Heath, Harry, Hebbar, Madhusoodhana, Heer, R., Hegarty O'Dowd, Roisin, Henshall, David, Herrod, Philip, Hester, Elizabeth, Heywood, Emily, Heywood, Nick, Hill, Frances, Hill, James, Hill, Kirsty, Ho, May, Hollyman, Marianne, Holroyd, David, Home, Joseph, Hornby, Steve, Horne, Laura, Horseman, Charlotte, Hosamuddin, Huma, Hough, Amy, Hourston, George, Hudson-Peacock, Nathan, Hughes, Belinda, Hughes, Katie, Huppatz, Isabel, Hurst, Penelope, Hussain, Mahrukh, Hussain, Shoaib Fahad, Hussain, Syeda, Hutchings, Imogen, Ibrahim, Bilal, Imam, Lema, Ingham, Rory, Ingleton, Rose, Iqbal, Rizwan, Isherwood, Jenny, Islim, Abdurrahman, Ismail, Omar, Iyer, Shashank, Jackman, Toby, Jain, Prashant, Jamal, Nadeem, Jamal, Sabine, James, Ellen, Jayaratne, Nirmitha, Jeffreys, Nathan, Jhala, Hiral, Johnson, Courtney, Johnston, Zoe, Jones, Conor, Jones, Emma-Jane, Jones, Keaton, Jones, Victor, Joseph, Roshan, Joshi, Dilan, Joyce, Holly, Joyner, Claire, Kale, Aditya, Kanabar, Sagar, Kanapeckaite, Lina, Kankam, Hadyn, Kaptanis, Sarantos, Karam, Edward, Karponis, Dimitrios, Karunatilleke, Anne, Kasivisvanathan, Veeru, Kaur, Geeta, Kauser, Samina, Keelty, Nigel, Kelly, Denise, Kennett, Jessica, Kerr, Molly, Kerwan, Ahmed, Khajuria, Apoorva, Khalil, Mostafa, Khaliq, Mehnoor, Khan, Ayushah, Khan, Hamzah, Khan, Haroon, Khan, Maaz, Khan, Maria, Khan, Shahab, Khan, Kaywaan, Khaw, Rachel, Kheterpal, Ashni, Khonsari, Parisa, Kiandee, Miraen, Kim, Samuel, Kim, Suji, Kim, Sung-Hee, King, Harry, Kinsella, Anna, Kishore, Ajit, Klimach, Stefan, Kolias, Angelos G., Kolodziejczyk, Anna, Kong, Chia Yew, Kong, Tseun Han James, Kouli, Omar, Kukran, Sebi, Kukran, Sevi, Kumaran, Geev, Kutuzov, Vladislav, Laing, Chris, Laing, Georgina, Lal, Kulvinder, Lalor, Peter, Lambert, Joel, Lambotharan, Sai Geethan, Lancaster, Eve, Latter, Jasmine, Latter, Michelle, Lau, Kenny, Lazarou, Alexa, Leadon, Madeline, Lee, Gabriel, Lee, Jeyoung, Lee, Kathryn, Lee, Matthew, Lee, Samuel, Lee, Zong, Leung, Edward, Lewis, Thomas, Li, Hansen, Li, Mimi, Liew, Wan Jane, Liew, Yao Ren, Light, Alexander, Lilis, Lydia, Lim, Diana, Lim, Hui, Lim, Joseph, Lim, Zhi, Liu, Siyin, Lloyd, James, Logan, Andrew, Loganathan, Priya, Long, M., Longstaff, Lydia, Rojas, Luisa Lopez, Lovegrove, Richard, Lowe-Zinola, Jack, Morrell, Byron Lu, Luck, Joshua, Luhmann, Andreas, Lunawat, Surabhika, Lund, Jon, Luo, Cong, Luo, Lorna, Lyell, Iona, Lykoudis, Panagis, Macdonald, Jonathan, Mackenzie, Aliya, Magee, Conor, Mahankali-Rao, Pooja, Mahawar, Kamal, Mahfooz, Mehreen, Mahmood, Faisal, Makwana, Samir, Malik, Tom, Mallick, Sohaib, Manalayil, Jyothis, Mandishona, Tinaye, Mangam, Sudhakar, Manimaran, Maniragav, Manimaran, Natarajan, Manson, Chris, Mansoor, Sufyan, Mansour, Fatima, Marcos Rodrigo, Alejandro, Markham, Nicholas, Marks, Maria, Marriott, Paul, Marsden, Hannah, Martin, Laura, Martins, Tiago, Mason, John, Mason, Luke, Masood, Mariam, Math, Nikhil, Mathew, Ginimol, Matthews, Jacob, Mayes, Jonathan, Mc Gee, Ursula, Mcallister, Ross, Mcallister, Sandra, Mccain, Scott, Mccann, Conor, Mccann, Emmet, McCarthy, Cathal, Mccoll, Gillian, Mcconaghie, Greg, Mcdermott, Ace, McDermott, Frank, Mcdougall, Rachel, McDowell, Mark, McFarlane, Gordon, McGregor, Richard, McKechnie, Doug, McKenna, Jillian, McKinstry, Scott, Mclachlan, Georgia, Mclean, E., McLennan, Elizabeth, McNair, Angus, Mealy, Kenneth, Mecia, Lauren, Mehta, Alexander, Mellan, Aidan, Menon, Arathi, Menzies, Donald, Mesbah, Zhubene, Messenger, David, Miller, George, Mishra, Aseem, Mistry, Sona, Mohamed, Tahira, Mushaini, Nisha Mohamed, Mohan, Midhun, Mohd Azmilssss, Ameerah, Mohite, Ajay, Moorthy, Krishna, Moradzadeh, Jalal, Morgan, Richard, Morley, Gabriella, Mortimer, Alice, Mownah, Hannah, Moxey, Paul, Mudalige, Gagira, Muhammad, Umarah, Munday, Samuel, Murphy, Ben, Murphy, Ciaran, Murray, Caoimhe, Murray, Hannah, Murray, Michael, Murtaza, Mohammed Ibrar, Mushtaq, Jameel, Mustafa, Ameer, Mustafa, Shams, Myers, Laura, Myers, Sam, Naasan, Adeeb, Nadeem, Kiran, Naeem, Hanzla, Naik, Prashant, Nair, Arun, Nambiar, Keshav K., Naqi, Muhammad, Naqvi, Zehra, Neo, Yan Ning, Neophytou, Georgia Irene, Neville, Jonathan, Newman, Tom, Ng, Benjamin, Ng, Guat, Ng, Jing Qi, Ng, Vincent, Ng, Zhan Herr, Ni Bhoirne, Maire, Nicholas, James, Nicholson, Gary, Ninkovic-Hall, George, Nixon, Gemma, Norwood, Mike, Noton, Toby, Nourzaie, Romman, Novell, Richard, Nyanhongo, Donald, O'Brien, James, O'Kane, Rory, O'Neill, Stephen, O'Sullivan, Hugh, Oakley, Thomas, Ogbuokiri, Chinomso, Ogunleye, Oluwafunto, Oh, Su, Okorocha, Emezie, Olivier, James, Ologunde, Rele, Omara, Sharif, Ormrod, Alice, Osborne, Caroline, Osmanska, Joanna, Owasil, Raisah, Owczarek, Sebastian, Ozcan, Ezgi, Palaniappan, Sri, Palazzo, Francesco, Palkhi, Abbas, Pandey, Gargi, Park, James, Parker, Jennifer, Parry, Anna, Parsonage, James, Passby, Lauren, Patel, Bhavi, Patel, Bhavik, Patel, Chantal, Patel, Dinisha, Patel, Kirtan, Patel, Panna, Patel, Pratiksha, Patel, Trupesh, Pathmarajah, Mariasoosai, Patil, Amogh, Patil, Pradeep, Patrick, Yusuf, Pearce, Jessica, Pearce, Lyndsay, Peirce, Colin, Peiris, Bryony, Pendrill, Amy, Periketi, Sreelata, Perry, Michael, Petrov, George, Phillips, Charlotte, Pike, Grace, Pinho-Gomes, Ana Catarina, Polly, Parhana, Ponweera, Arachchige, Poolovadoo, Yanish, Poonawala, Raunak, Popova, Petya, Pournaras, Dimitri, Powell, Brooke, Prabakaran, Praveena, Prakash, Esha, Pratumsuwan, Tapani, Prem Kumar, Anusha, Puddy, Helen, Pullinger, Michael, Punjabi, Nikita, Putt, Oliver Charles, Qadir, Omar, Qamar, Mubasher, Quinn, Patrick, Qureshi, Arham, Rabie, Mohamed, Radford, Angus, Radhakrishnan, Anand, Radotra, Ansh, Rafiq, Nasir, Rahem, Aria, Rahman, Nahim, Rahman, Syed, Rajagopal, Ramesh, Rajan, Nick, Rajaraman, Nikitha, Rajendran, Sumetha, Ramachenderam, Liandra, Ramakrishnan, Divya, Ramjas, Denisha, Rammell, James, Rampal, Ritika, Ramsay, George, Randhawa, Ratan, Rea, Ellis, Rees, Stephanie, Rehman, Saad, Rehman, Salwah, Rehnnuma, Nabila, Rejayee, Melina, Rob, Zakaria, Roberts, Charlotte, Roberts, Grace, Roberts, Ben, Robinson, Harry, Robinson, Stephen, Rogers, Ailin, Rogers, Alex, Rook, William, Ross, Talisa, Roy, Chloe, Rushd, Azelea, Rutherford, Duncan, Saat, Michael, Sadanand, Kaushik, Sagar, Rebecca, Sagoo, Harkiran, Saha, Arin, Sahnan, Kapil, Sait, Mohammed Salik, Sait, Saif, Salekin, Damien, Salem, Mostafa, Salloum, Nadia, Sanders, Emma, Sandhu, Jasmesh, Sandhu, N., Sandison, Lorna, Sandland-Taylor, Laura, Sangal, Ron, Sanghera, Chandan, Saramunda, Josephine, Satterthwaite, Lauren, Schramm, Moritz, Scott, Rupert, Searle, Chloe, Seehra, Harkiran, Segura-Sampedro, Juan Jose, Sekhon Inderjit Singh, Harpreet Kaur, Seraj, Shaikh Sanjid, Seth, Ishani, Sethi, Rajiv, Shah, Apar, Shaid, Mario, Shaikh, Shafaque, Shamali, Awad, Sharkey, Elizabeth, Sharma, Abhi, Sharma, Neil, Sharma, Sachin, Shenoy, Aniruddh, Shergill, Maleasha, Shirazi, Shahram, Siddiqui, Imran, Sim, Raykal, Simmonds, Lucy, Simon, Andrew, Simpson, William, Singh, Bharpoor, Singh, J., Singh, Prashant, Sinha, Anant, Sinha, Sidhartha, Sinnerton, Robert, Sivakumar, Chaamanti, Skelly, Brendan, Slater, Richard, Small, Samuel, Smart, Neil, Smart, Yat Wing, Smith, Alexander, Smith, Charlotte, Smith, Jason, Smith, Rebecca, Smith, Scott, Sodde, Peter, Soh, Zhi Min, Sonsale, Aniket, Soualhi, Ahmed, Spearman, John, Spencer, Robert, Spiers, Harry, Stather, Philip, Stoddart, Michael, Storey, Bradley, Stringer, Howard, Stringfellow, Thomas, Stubbs, Ben, Sukir, Niv, Sukirthan, Nivian, Suleman, Yasir, Sureshkumar, Aparnah, Suri, Ashwin, Swartbol, Timen, Tahir, Hyder, Tan, E. Tian, Tan, Huai Ling, Tan, Laura, Tang, Alethea, Taribagil, Priyal, Tay, Yao Zong, Taylor, Beth, Taylor, Zara, Thatcher, Alexandra, Thavayogan, Rachel, Thomaa, Michael, Thomas, Daniah, Thomas, Jenny, Thomas, Paul, Pinkney, Thomas, Thompson, Chris, Ting, Mag, Toner, Ethan, Tong, Godwin, Torkington, Jared, Traish, Molly, Triniman, Miles, Trotter, John, Tsang, Kwong, Turaga, Sanchit, Turley, Hannah, Turner, James, Urbonas, Tomas, Urquhart, Alexandra, Vadgama, Nimai, Vaidya, Aashay, van Boxel, Gijs, Vara, Swati, Varcada, Massimo, Varley, Rebecca, Varma, Dee, Vella-Baldacchino, Martinique, Venturini, Sara, Verma, Naina, Verma, Saurabh, Vernet, Gabrielle, Vipond, Mark, von Roon, Alex, Wadood, Qasim, Waite, Kathryn, Walker, Lewis, Walker, Nathan, Wan, Jonathan C.M., Wang, Liyang, Wang, Xue, Ward, Alex, Ward, Thomas, Warnaar, Nienke, Warren, Lloyd, Warren, Oliver, Waters, Sam, Watson, Angus, Watson, Laura Jayne, Waugh, Dominic, Weinberg, Daniel, West, Malcolm, White, Carla, White, Tim, Whitehurst, Katharine, Whitham, Robert, Wijekoon, Tharindri, Wijeyaratne, Manuk, Wilkin, Richard, Wilkins, Alex, Williams, Adam, Williams, Gethin, Williams, Luke, Williams, Robert, Williamson, Andrew, Willson, Jacinthe, Wilson, Andrew, Wilson, Holly, Wilson, James, Wilson, Lizzie, Wilson, Megan, Wilson, Michael, Wilson, Rebekah, Wilson, Tim, Woin, Evelina, Wright, Esther, Wright, Jenny, Wroe, Nicholas, Wylie, Joanne, Xu, Yiwang, Yalamarthi, Satheesh, Yan, Angela, Yang, Narisu, Yardimci, Eda, Yasin, Ibrahim, Yasin, Ismael, Yasin, Noor, Yates, Joseph, Yau, Jih Dar, Yeoh, Tricia, Yip, Joshua, Yong, Cissy, Zaver, Vasudev, Zhelezniakova, Tatiana, and Zulkifli, Adreana

Published
2017
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16. Silver Creek: A study of stream velocities and erosion along the Ohio River near Clarksville, Indiana

Author

Jones, Keaton E.; Abraham, David D.; Bell, Gary L.; Clifton, Nate D., United States. Army. Corps of Engineers. Louisville District; United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.), Jones, Keaton E.; Abraham, David D.; Bell, Gary L.; Clifton, Nate D., and United States. Army. Corps of Engineers. Louisville District; United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.)

Abstract

ERDC /CHL TR-18-4 Silver Creek: A Study of Stream Velocities and Erosion along the Ohio River near Clarksville, Indiana McAlpine Lock and Dam Numerical Model Coastal and Hydraulics Laboratory Keaton E. Jones, David D. Abraham, Gary L. Bell, and Nate D. Clifton April 2018 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and military engineering, geospatial sciences, water resources, and environmental sciences for the Army, the Department of Defense, civilian agencies, and our nation’s public good. Find out more at www.erdc.usace.army.mil. To search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. ERDC/CHL TR-18-4 April 2018 Silver Creek: A Study of Stream Velocities and Erosion along the Ohio River near Clarksville, Indiana McAlpine Lock and Dam Numerical Model Keaton E. Jones, David D. Abraham, Gary L. Bell, and Nate D. Clifton Coastal and Hydraulics Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Rd Vicksburg, MS 39180-6199 Final report Approved for public release; distribution is unlimited. Prepared for U.S. Army Corps of Engineers, Louisville District Mazzoli Federal Building 600 Dr. Martin Luther King Jr. Place Louisville, KY 40201-0059 Under Project No. 455010, “The Silver Creek Floodplain Management Services Project: A Study of Stream Velocities and Erosion along the Ohio River near Clarksville, Indiana” ERDC/CHL TR-18-4 ii Abstract The River Engineering Branch of the Coastal and Hydraulics Laboratory conducted a two-dimensional numerical model investigation of the Ohio River immediately downstream of McAlpine Lock and Dam. The right bank between river mile 605.5 and 606.5 (opposite the dam’s downstream set of tainter gates) has historically experienced stability issues. Condit

Published
2018

17. Bed-load and water surface measurements during the 2011 Mississippi River Flood at Vicksburg, Mississippi

Author

Jones, Keaton E.; Abraham, David D.; McAlpin, Tate O., United States. Army. Corps of Engineers. Mississippi Valley Division; United States. Mississippi River Commission; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.); Mississippi River Geomorphology and Potamology Program (U.S.), Jones, Keaton E.; Abraham, David D.; McAlpin, Tate O., and United States. Army. Corps of Engineers. Mississippi Valley Division; United States. Mississippi River Commission; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.); Mississippi River Geomorphology and Potamology Program (U.S.)

Abstract

Mississippi Valley Division Engineer Research and Development Center Bed-Load and Water Surface Measurements during the 2011 Mississippi River Flood at Vicksburg, Mississippi MRG&P Report No. 18 • April 2018 MRG&P Report No. 18 April 2018 Bed-Load and Water Surface Measurements during the 2011 Mississippi River Flood at Vicksburg, Mississippi Keaton E. Jones, David D. Abraham, and Tate O. McAlpin Coastal and Hydraulics Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199 Final report Approved for public release; distribution is unlimited. Prepared for U.S. Army Corps of Engineers, Mississippi Valley Division Mississippi River Geomorphology & Potamology Program 1400 Walnut Street Vicksburg, MS 39180 Under Project 127672, “Bedload Measurement” MRG&P Report No. 18 ii Abstract The U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory, Field Data Collection and Analysis Branch collected bathymetry data and water surface elevations during the 2011 Flood. According to the gage at Vicksburg, MS, the flood peaked at a stage of 57.1 and a flow of 2,310,000 cubic feet per second (cfs) on 17 May 2011, both the highest of record. The reported water surface data include a continuous water surface profile from river mile (RM) 597 to RM 362 and water surface measurements in the vicinity of the Yazoo Backwater levee and Vicksburg, MS. Bathymetry data were also collected and include five sets of surveys, compatible with the Integrated Section Surface Difference over Time Version 2 (ISSDOTv2) method of measuring bed-load transport. These five sets were surveyed at flow rates between 1.6 million and 2.3 million cfs. ISSDOTv2 was used to calculate bed-load transport for the five sets of data. These new bed-load data populate the Lower Mississippi River bed-load rating curve at higher flows and provide a higher level of confidence in the higher-flow portions of the curve. The resulting curve can be a

Published
2018

18. Modeled sedimentation in the Lower White River countyline levee setback, Washington state: Comparison of 1D (HEC-RAS) and 2D (AdH) results

Author

Jones, Keaton E.; Dahl, Travis A.; Corum, Zachary P., United States. Army. Corps of Engineers. Seattle District; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.); Flood and Coastal Systems Research and Development Program (U.S.), Jones, Keaton E.; Dahl, Travis A.; Corum, Zachary P., and United States. Army. Corps of Engineers. Seattle District; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.); Flood and Coastal Systems Research and Development Program (U.S.)

Abstract

ERDC /CHL TR-18-9 Flood and Coastal Systems Research and Development Program Modeled Sedimentation in the Lower White River Countyline Levee Setback, Washington State Comparison of 1D (HEC-RAS) and 2D (AdH) Results Coastal and Hydraulics Laboratory Keaton E. Jones, Travis A. Dahl, and Zachary P. Corum July 2018 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and military engineering, geospatial sciences, water resources, and environmental sciences for the Army, the Department of Defense, civilian agencies, and our nation’s public good. Find out more at www.erdc.usace.army.mil. To search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. Flood and Coastal Systems Research and Development Program ERDC/CHL TR-18-9 July 2018 Modeled Sedimentation in the Lower White River Countyline Levee Setback, Washington State Comparison of 1D (HEC-RAS) and 2D (AdH) Results Keaton E. Jones, Travis A. Dahl Coastal and Hydraulics Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Rd Vicksburg, MS 39180-6199 Zachary P. Corum U.S. Army Corps of Engineers, Seattle District 4735 E. Marginal Way South Seattle, WA 98134 Final report Approved for public release; distribution is unlimited. Prepared for U.S. Army Corps of Engineers Washington, DC 20314-1000 Under Project 454633, “Evaluation of Levee Setbacks and River Restoration Projects for Flood Risk Reduction” ERDC/CHL TR-18-9 ii Abstract The design of the Lower White River Countyline Setback Project in Washington State includes lowering an existing levee and constructing a new setback levee to allow the river to reconnect to an existing wetland. This study used two hydrodynamic and sediment transport models, Hydrologic Engineering Center-River Analysis System (

Published
2018

21. Sediment and hydraulic measurements with computed bed load on the Missouri River, Sioux City to Hermann, 2014

Author

Abraham, David D.; Ramos-Villanueva, Marielys; Pratt, Thad C.; Ganesh, Naveen B.; May, David P.; Butler, William C.; McAlpin, Tate O.; Jones, Keaton E.; Shelley, John E.; Pridal, Dan, United States. Army. Corps of Engineers. Kansas City District; United States. Army. Corps of Engineers. Omaha District; United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.), Abraham, David D.; Ramos-Villanueva, Marielys; Pratt, Thad C.; Ganesh, Naveen B.; May, David P.; Butler, William C.; McAlpin, Tate O.; Jones, Keaton E.; Shelley, John E.; Pridal, Dan, and United States. Army. Corps of Engineers. Kansas City District; United States. Army. Corps of Engineers. Omaha District; United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Coastal and Hydraulics Laboratory (U.S.)

Abstract

ERDC /CHL TR-17-8 Sediment and Hydraulic Measurements with Computed Bed Load on the Missouri River, Sioux City to Hermann, 2014 Coastal and Hydraulics Laboratory David Abraham, Marielys Ramos-Villanueva, Thad Pratt, Naveen Ganesh, David May, William Butler, Tate McAlpin, Keaton Jones, John Shelley, and Daniel Pridal May 2017 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and military engineering, geospatial sciences, water resources, and environmental sciences for the Army, the Department of Defense, civilian agencies, and our nation’s public good. Find out more at www.erdc.usace.army.mil. To search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. ERDC/CHL TR-17-8 May 2017 Sediment and Hydraulic Measurements with Computed Bed Load on the Missouri River, Sioux City to Hermann, 2014 David Abraham, Marielys Ramos-Villanueva, Thad Pratt, Naveen Ganesh, David May, William Butler, Tate McAlpin, and Keaton Jones Coastal and Hydraulics Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199 John Shelley U.S. Army Corps of Engineers, Kansas City District 601 E 12th St. Kansas City, MO 64106 Daniel Pridal U.S. Army Corps of Engineers, Omaha District 1616 Capitol Ave., Ste. 9000 Omaha, NE 68102 Final report Approved for public release; distribution is unlimited. Prepared for U.S. Army Corps of Engineers, Kansas City District 601 E 12th St. Kansas City, MO 64106 U.S. Army Corps of Engineers, Omaha District 1616 Capitol Ave., Ste. 9000 Omaha, NE 68102 Under Work Unit HC2022 ERDC/CHL TR-17-8 ii Abstract This work was performed to assist the U.S. Army Corps of Engineers, Omaha and Kansas City Districts, in quantifying sediment bed load and suspended load at several sites on

Published
2017

22. Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer

Author

D'Costa, Zenobia, primary, Jones, Keaton, additional, Azad, Abul, additional, van Stiphout, Ruud, additional, Lim, Su Y., additional, Gomes, Ana L., additional, Kinchesh, Paul, additional, Smart, Sean C., additional, Gillies McKenna, W., additional, Buffa, Francesca M., additional, Sansom, Owen J., additional, Muschel, Ruth J., additional, O'Neill, Eric, additional, and Fokas, Emmanouil, additional

Published
2017
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25. Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma Are Not Explained by Differences in Comorbidities, Liver Disease Severity, or Tumor Burden.

Author

Dakhoul, Lara, Gawrieh, Samer, Jones, Keaton R., Ghabril, Marwan, McShane, Chelsey, Orman, Eric, Vilar‐Gomez, Eduardo, Chalasani, Naga, and Nephew, Lauren

Abstract

Black patients have higher mortality and are less likely to receive liver transplantation for hepatocellular carcinoma (HCC) than white patients. Reasons for these disparities have not been fully elucidated. Comorbid disease, liver disease severity, cirrhosis etiologies, and tumor characteristics were compared between black and white patients with HCC seen at the Indiana University Academic Medical Center from January 2000 to June 2014. Logistic regression was used to investigate the primary outcome, which was liver transplantation. Log‐rank testing was used to compare survival between the two groups. Subgroup analysis explored reasons for failure to undergo liver transplantation in patients within Milan criteria. The cohort included 1,032 (86%) white and 164 (14%) black patients. Black and white patients had similar Model for End‐Stage Liver Disease (MELD) and Child‐Pugh scores (CPSs). There was a trend toward larger tumor size (5.3 cm versus 4.7 cm; P = 0.05) in black patients; however, Barcelona Clinic Liver Cancer (BCLC) staging and Milan criteria were similar. Black patients were less likely to undergo liver transplantation than white patients; this was a disparity that was not attenuated (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.21‐0.90) on multivariable analysis. Substance abuse was more frequently cited as the reason black patients within Milan criteria failed to undergo transplantation compared to white patients. Survival was similar between the two groups. Conclusion: Racial differences in patient and tumor characteristics were small and did not explain the disparity in liver transplantation. Higher rates of substance abuse in black patients within Milan criteria who failed to undergo transplantation suggest social factors contribute to this disparity in this cohort. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity.

Author

Go S, Demetriou C, Valenzano G, Hughes S, Lanfredini S, Ferry H, Arbe-Barnes E, Sivakumar S, Bashford-Rogers R, Middleton MR, Mukherjee S, Morton J, Jones K, and Neill EO

Subjects
Animals, Mice, Humans, Tumor Microenvironment immunology, Receptors, CCR5 metabolism, Receptors, CCR5 genetics, Mice, Inbred C57BL, Cell Line, Tumor, Programmed Cell Death 1 Receptor metabolism, Programmed Cell Death 1 Receptor antagonists & inhibitors, Immunotherapy methods, NK Cell Lectin-Like Receptor Subfamily K metabolism, NK Cell Lectin-Like Receptor Subfamily K genetics, CD8-Positive T-Lymphocytes immunology, Killer Cells, Natural immunology, Pancreatic Neoplasms immunology, Pancreatic Neoplasms therapy, Pancreatic Neoplasms pathology, Carcinoma, Pancreatic Ductal immunology, Carcinoma, Pancreatic Ductal therapy, Carcinoma, Pancreatic Ductal pathology
Abstract

The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T-cell activity) have had limited success. Here, we demonstrate how inducing localized physical damage using ionizing radiation (IR) unmasks the benefit of immunotherapy by increasing tissue-resident natural killer (trNK) cells that support CD8 T activity. Our data confirms that targeting mouse orthotopic PDAC tumors with IR together with CCR5 inhibition and PD1 blockade reduces E-cadherin positive tumor cells by recruiting a hypoactive NKG2D -ve NK population, phenotypically reminiscent of trNK cells, that supports CD8 T-cell involvement. We show an equivalent population in human single-cell RNA sequencing (scRNA-seq) PDAC cohorts that represents immunomodulatory trNK cells that could similarly support CD8 T-cell levels in a cDC1-dependent manner. Importantly, a trNK signature associates with survival in PDAC and other solid malignancies revealing a potential beneficial role for trNK in improving adaptive anti-tumor responses and supporting CCR5 inhibitor (CCR5i)/αPD1 and IR-induced damage as a novel therapeutic approach., Competing Interests: SG, CD, GV, SH, SL, HF, EA, SS, RB, MM, SM, JM, KJ, EN No competing interests declared, (© 2024, Go, Demetriou, Valenzano et al.)

Published
2024
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