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1. Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate

Author

Caroline Andrews, Brian Fortier, Amy Hayward, Ruth Lederman, Lindsay Petersen, Jo McBride, Desiree C. Petersen, Olabode Ajayi, Paidamoyo Kachambwa, Moleboheng Seutloali, Aubrey Shoko, Mamokhosana Mokhosi, Reinhard Hiller, Marcia Adams, Chrissie Ongaco, Elizabeth Pugh, Jane Romm, Tameka Shelford, Frank Chinegwundoh, Ben Adusei, Sunny Mante, Nana Yaa Snyper, Ilir Agalliu, David W. Lounsbury, Thomas Rohan, Alex Orfanos, Yuri Quintana, Judith S. Jacobson, Alfred I. Neugut, Edward Gelmann, Joseph Lachance, Cherif Dial, Thierno Amadou Diallo, Mohamed Jalloh, Serigne Magueye Gueye, Papa Moussa Sène Kane, Halimatou Diop, Anna Julienne Ndiaye, Amina Sow Sall, Ndeye Coumba Toure-Kane, Ezenwa Onyemata, Alash’le Abimiku, Andrew A. Adjei, Richard Biritwum, Richard Gyasi, Mathew Kyei, James E. Mensah, Julian Okine, Vicky Okyne, Isabella Rockson, Evelyn Tay, Yao Tettey, Edward Yeboah, Wenlong C. Chen, Elvira Singh, Michael B. Cook, Christine N. Duffy, Ann Hsing, Cassandra Claire Soo, Pedro Fernandez, Hayley Irusen, Oseremen Aisuodionoe-Shadrach, Abubakar Mustapha Jamda, Peter Oluwole Olabode, Maxwell Madueke Nwegbu, Olalekan Hafees Ajibola, Olushola Jeremiah Ajamu, Yakubu Garba Ambuwa, Akindele Olupelumi Adebiyi, Michael Asuzu, Olufemi Ogunbiyi, Olufemi Popoola, Olayiwola Shittu, Olukemi Amodu, Emeka Odiaka, Ifeoluwa Makinde, Maureen Joffe, Audrey Pentz, and Timothy R. Rebbeck

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods: We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results: We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. Conclusion: We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.

Published
2018
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2. Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate

Author

Michael B. Cook, Alex Orfanos, Marcia Adams, Olayiwola B. Shittu, Lindsay Petersen, Olufemi Ogunbiyi, Amy Hayward, Maxwell M. Nwegbu, Jo McBride, Moleboheng Seutloali, Paidamoyo Kachambwa, Andrew A. Adjei, Hayley Irusen, Evelyn Tay, Peter Oluwole Olabode, Elvira Singh, Julian Okine, Reinhard Hiller, Ruth Lederman, Serigne Magueye Gueye, Yao Tettey, Cherif Dial, Anna Julienne Ndiaye, Michael C. Asuzu, Edward P. Gelmann, Vicky Okyne, Olalekan Hafees Ajibola, David W. Lounsbury, Brian Fortier, Ezenwa Onyemata, Jane Romm, Halimatou Diop, Mohamed Jalloh, Alfred I. Neugut, Audrey Pentz, Yuri Quintana, Yakubu Garba Ambuwa, Elizabeth W. Pugh, Ilir Agalliu, R. K. Gyasi, Isabella Rockson, Ben Adusei, Frank Chinegwundoh, Akindele Olupelumi Adebiyi, E D Yeboah, Olushola Jeremiah Ajamu, Pedro L. Fernández, Thierno Amadou Diallo, James E. Mensah, Tameka Shelford, Caroline Andrews, Ndeye Coumba Toure-Kane, Maureen Joffe, Olufemi Popoola, Richard B. Biritwum, Christine N. Duffy, Thomas E. Rohan, Mamokhosana Mokhosi, Timothy R. Rebbeck, Oseremen I. Aisuodionoe-Shadrach, Abubakar Mustapha Jamda, Sunny Mante, Desiree C. Petersen, Joseph Lachance, Emeka Odiaka, Aubrey Shoko, Ann W. Hsing, Cassandra Soo, Chrissie M. Ongaco, Ifeoluwa Makinde, Alash’le Abimiku, Nana Yaa Snyper, Olukemi K. Amodu, Judith S. Jacobson, Amina Sow Sall, Papa Moussa Sene Kane, Olabode Ajayi, Mathew Yamoah Kyei, and Wenlong C. Chen

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Genotype, African descent, Black People, lcsh:RC254-282, 03 medical and health sciences, South Africa, 0302 clinical medicine, Prostate, Internal medicine, Carcinoma, Medicine, Humans, Original Report, Extramural, business.industry, Pan african, Cancer, Prostatic Neoplasms, Genomics, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Baltimore, business
Abstract

Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. Conclusion We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.

Published
2018
Full Text
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3. Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate.

Author

Andrews C, Fortier B, Hayward A, Lederman R, Petersen L, McBride J, Petersen DC, Ajayi O, Kachambwa P, Seutloali M, Shoko A, Mokhosi M, Hiller R, Adams M, Ongaco C, Pugh E, Romm J, Shelford T, Chinegwundoh F, Adusei B, Mante S, Snyper NY, Agalliu I, Lounsbury DW, Rohan T, Orfanos A, Quintana Y, Jacobson JS, Neugut AI, Gelmann E, Lachance J, Dial C, Diallo TA, Jalloh M, Gueye SM, Kane PMS, Diop H, Ndiaye AJ, Sall AS, Toure-Kane NC, Onyemata E, Abimiku A, Adjei AA, Biritwum R, Gyasi R, Kyei M, Mensah JE, Okine J, Okyne V, Rockson I, Tay E, Tettey Y, Yeboah E, Chen WC, Singh E, Cook MB, Duffy CN, Hsing A, Soo CC, Fernandez P, Irusen H, Aisuodionoe-Shadrach O, Jamda AM, Olabode PO, Nwegbu MM, Ajibola OH, Ajamu OJ, Ambuwa YG, Adebiyi AO, Asuzu M, Ogunbiyi O, Popoola O, Shittu O, Amodu O, Odiaka E, Makinde I, Joffe M, Pentz A, and Rebbeck TR

Subjects
Baltimore, Black People, Carcinoma pathology, Genomics, Genotype, Humans, Male, Prostate pathology, Prostatic Neoplasms pathology, South Africa epidemiology, Black or African American, Carcinoma epidemiology, Carcinoma genetics, Prostatic Neoplasms epidemiology, Prostatic Neoplasms genetics
Abstract

Purpose: Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA., Methods: We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array., Results: We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories., Conclusion: We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.

Published
2018
Full Text
View/download PDF

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