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Herein, a wide range of mono- and di-arylated products were efficiently prepared from C–N coupling of 2-halobenzothiazoles and primary aromatic amines, and representative compounds 3b and 4b were further confirmed by X-ray crystallography. It was noteworthy that the di-arylated products, denoted as di(benzothiazolyl)amines, are new chemical entities which have not yet been reported. Moreover, the ligand-controlled protocol was extended to the synthesis of target molecules bearing a diphenyl ether or diphenyl amine scaffold. To our delight, several compounds exhibited good inhibitory activity against succinate-cytochrome c reductase (SCR), which revealed the practical application of this protocol. Notably, selective mono- and di-arylation could be switched simply by varying the ligand from Xantphos to a pyridine-functionalized N-heterocyclic carbene (NHC) ligand, and further investigations were carried out to elucidate the possible reason for this new finding.

BACKGROUND: High breast density is significantly associated with an increased risk of breast diseases. Presently, suspected breast masses assessed as Breast Imaging-Reporting and Data System (BI-RADS) grade 4 provide a wide range of positive predictive values. Moreover, subcategories (4a, 4b, and 4c) are still under consideration as the diagnostic criteria are neither comprehensive nor objective. However, whether mammography breast density (MBD) has any impact on the accurate grading of BI-RADS 4 assessed by ultrasound (US) remains unknown. METHODS: A total of 1,086 women with 1,293 breast masses were included and assessed as BI-RADS 3–5 by US. The subcategories of MBD (from the ACR-a to the ACR-d group) were assessed by mammography according to the criteria of the American College of Radiology (ACR). The clinicopathological characteristics of these patients were reviewed retrospectively. The malignancy rates of breast masses among different subgroups assessed by BI-RADS were re-estimated with MBD. RESULTS: Almost all BI-RADS 3 masses were classified as benign and nearly all BI-RADS 5 masses were identified as malignant. Significant inverse associations between MBD and malignancy rates were detected between the BI-RADS 4a and BI-RADS 4b groups. Moreover, malignancy rates decreased significantly from ACR-a to ACR-d for BI-RADS 4a and 4b breast lesions (P

C26H27ClN8NiO7, triclinic, P1̄ (no. 2), a = 9.893(2) Å, b = 11.503(2) Å, c = 13.295(3) Å, α = 78.77(3)°, β = 70.52(3)°, γ = 83.40(3)°, V = 1397.0(6) Å3, Z = 2, R gt(F) = 0.0423, wR ref(F 2) = 0.1032, T = 153.15 K.

C33H39Cl2N9NiO12, monoclinic, P21/c (no. 14), a = 9.7478(4) Å, b = 20.6247(7) Å, c = 19.0897(11) Å, β = 92.767(5)°, V = 3833.4(3) Å3, Z = 4, R gt(F) = 0.0527, wR ref(F 2) = 0.1143, T = 108.4(2) K.

Objective: To compare pre- and post-therapy symptom scores reported on the National Institute of Health Chronic Prostatitis Symptom Index (NIHCPSI) after trans-rectal antibiotic injections therapy for men suffering from chronic prostatitis. Materials and methods: Retrospective analysis of NIHCPSI symptom scores obtained from chart reviews of 77 treated males suffering from chronic prostatitis before and after trans rectal injections for the treatment of chronic prostatitis. Results: Most patients reported a 40% to 60% improvement in symptom scores. In subgroups comparing scores in patients with less than 5 injections, the improvement was less than in patients who received 10 or more injections. Patients’ responses after a shorter (3 months) follow up showed better pain scores than patient’s scores after longer, over one-year or more, follow- up periods. Conclusion: Our findings show that direct antibiotic injection for chronic prostatitis is a viable addition to standard therapies. Improvements in symptom scores are long lasting. Discomfort is minimal and side effects are rare and avoidable

The introduction of the AQC boiler has complex effects on the temperature of Tertiary air, traditional PID is difficult to achieve the effective control. Combined the method of the conventional PID with the fuzzy control theory, a fuzzy self-tuning PID controller is designed. Compared with traditional PID, results of simulation show that the fuzzy PID controller improves not only the adaptability and robustness of the system, but also the system's static and dynamic performance.

In this paper, we consider the q-difference analogue of the Clunie theorem. We obtain there is no zero-order entire solution of f n ( z ) + ( ∇ q f ( z ) ) n = 1 when n ≥ 2 ; there is no zero-order transcendental entire solution of f n ( z ) + P ( z ) ( ∇ q f ( z ) ) m = Q ( z ) when n > m ≥ 0 ; and the equation f n + P ( z ) ∇ q f ( z ) = h ( z ) has at most one zero-order transcendental entire solution f if f is not the solution of ∇ q f ( z ) = 0 , when n ≥ 4 . MSC:30D35, 30D30, 39A13, 39B12.