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1. IS HOME-BASED MONITORING OF OVULATION TO TIME FROZEN EMBRYO TRANSFER AN EFFECTIVE ALTERNATIVE FOR HOSPITAL-BASED MONITORING OF OVULATION?

Author

Zaat, Tjitske, primary, De Bruin, Jan Peter P., additional, Groenewoud, Eva, additional, Baart, Esther B., additional, Van Baal, Wilhelmina, additional, Brandes, Monique, additional, Cantineau, Astrid E.P., additional, Broekmans, Frank, additional, Gielen, Susanne, additional, Goddijn, Mariette, additional, Van Disseldorp, Jeroen, additional, van Heusden, Arne M., additional, Kaaijk, Eugenie M., additional, Klijn, Nicole, additional, Koks, Carolien A.M., additional, De Koning, Cornelia, additional, Van Der Linden, Paul J.Q., additional, Manger, Petra, additional, Moolenaar, Lobke, additional, Van Oppenraaij, Robbert, additional, Pieterse, Quirine, additional, Smeenk, Jesper M.J., additional, Visser, Jantien, additional, Van Wely, Madelon, additional, and Mol, Femke, additional

Published
2022
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3. Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort study

Author

Wang, Zheng, primary, Groen, Henk, additional, Van Zomeren, Koen C, additional, Cantineau, Astrid E P, additional, Van Oers, Anne, additional, Van Montfoort, Aafke P A, additional, Kuchenbecker, Walter K H, additional, Pelinck, Marie J, additional, Broekmans, Frank J M, additional, Klijn, Nicole F, additional, Kaaijk, Eugenie M, additional, Mol, Ben W J, additional, Hoek, Annemieke, additional, and Van Echten-Arends, Jannie, additional

Published
2021
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4. Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort study

Author

MS VPG/Gynaecologie, Child Health, Wang, Zheng, Groen, Henk, Van Zomeren, Koen C, Cantineau, Astrid E P, Van Oers, Anne, Van Montfoort, Aafke P A, Kuchenbecker, Walter K H, Pelinck, Marie J, Broekmans, Frank J M, Klijn, Nicole F, Kaaijk, Eugenie M, Mol, Ben W J, Hoek, Annemieke, Van Echten-Arends, Jannie, MS VPG/Gynaecologie, Child Health, Wang, Zheng, Groen, Henk, Van Zomeren, Koen C, Cantineau, Astrid E P, Van Oers, Anne, Van Montfoort, Aafke P A, Kuchenbecker, Walter K H, Pelinck, Marie J, Broekmans, Frank J M, Klijn, Nicole F, Kaaijk, Eugenie M, Mol, Ben W J, Hoek, Annemieke, and Van Echten-Arends, Jannie

Published
2021

5. The inSIGHT study: costs and effects of routine hysteroscopy prior to a first IVF treatment cycle. A randomised controlled trial

Author

Smit Janine G, Kasius Jenneke C, Eijkemans Marinus JC, Koks Carolien AM, Van Golde Ron, Oosterhuis Jurjen GE, Nap Annemiek W, Scheffer Gabrielle J, Manger Petra AP, Hoek Annemiek, Kaplan Mesrure, Schoot Dick BC, van Heusden Arne M, Kuchenbecker Walter KH, Perquin Denise AM, Fleischer Kathrin, Kaaijk Eugenie M, Sluijmer Alexander, Friederich Jaap, Laven Joop SE, van Hooff Marcel, Louwe Leonie A, Kwee Janet, Boomgaard Jantien J, de Koning Corry H, Janssen Ineke CAH, Mol Femke, Mol Ben WJ, Torrance Helen L, and Broekmans Frank JM

Subjects
Hysteroscopy, Subfertility, IVF, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background In in vitro fertilization (IVF) and intracytoplasmatic sperm injection (ICSI) treatment a large drop is present between embryo transfer and occurrence of pregnancy. The implantation rate per embryo transferred is only 30%. Studies have shown that minor intrauterine abnormalities can be found in 11–45% of infertile women with a normal transvaginal sonography or hysterosalpingography. Two randomised controlled trials have indicated that detection and treatment of these abnormalities by office hysteroscopy after two failed IVF cycles leads to a 9–13% increase in pregnancy rate. Therefore, screening of all infertile women for intracavitary pathology prior to the start of IVF/ICSI is increasingly advocated. In absence of a scientific basis for such a policy, this study will assess the effects and costs of screening for and treatment of unsuspected intrauterine abnormalities by routine office hysteroscopy, with or without saline infusion sonography (SIS), prior to a first IVF/ICSI cycle. Methods/design Multicenter randomised controlled trial in asymptomatic subfertile women, indicated for a first IVF/ICSI treatment cycle, with normal findings at transvaginal sonography. Women with recurrent miscarriages, prior hysteroscopy treatment and intermenstrual blood loss will not be included. Participants will be randomised for a routine fertility work-up with additional (SIS and) hysteroscopy with on-the-spot-treatment of predefined intrauterine abnormalities versus the regular fertility work-up without additional diagnostic tests. The primary study outcome is the cumulative ongoing pregnancy rate resulting in live birth achieved within 18 months of IVF/ICSI treatment after randomisation. Secondary study outcome parameters are the cumulative implantation rate; cumulative miscarriage rate; patient preference and patient tolerance of a SIS and hysteroscopy procedure. All data will be analysed according to the intention-to-treat principle, using univariate and multivariate logistic regression and cox regression. Cost-effectiveness analysis will be performed to evaluate the costs of the additional tests as routine procedure. In total 700 patients will be included in this study. Discussion The results of this study will help to clarify the significance of hysteroscopy prior to IVF treatment. Trial registration NCT01242852

Published
2012
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6. The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial

Author

Koks Carolien AM, Brinkhuis Egbert A, Broekmans Frank J, Nap Annemiek W, van Kasteren Yvonne M, Schierbeek Jaap M, Bouckaert Peter XJM, Oosterhuis Gerrit JE, Kaaijk Eugenie M, Klijn Nicole F, Maas Jacques WM, van der Veen Fulco, Stolk Ronald P, Macklon Nick S, Hompes Peter GA, Kuchenbecker Walter KH, Bemelmans Wanda JE, Land Jolande A, Bolster Johanna HT, ter Bogt Nancy CW, Groen Henk, Mutsaerts Meike AQ, Burggraaff Jan M, Blankhart Adrienne S, Perquin Denise AM, Gerards Marie H, Mulder Robert JAB, Gondrie Ed TCM, Mol Ben WJ, and Hoek Annemieke

Subjects
Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background In the Netherlands, 30% of subfertile women are overweight or obese, and at present there is no agreement on fertility care for them. Data from observational and small intervention studies suggest that reduction of weight will increase the chances of conception, decrease pregnancy complications and improve perinatal outcome, but this has not been confirmed in randomised controlled trials. This study will assess the cost and effects of a six-months structured lifestyle program aiming at weight reduction followed by conventional fertility care (intervention group) as compared to conventional fertility care only (control group) in overweight and obese subfertile women. We hypothesize that the intervention will decrease the need for fertility treatment, diminish overweight-related pregnancy complications, and will improve perinatal outcome. Methods/Design Multicenter randomised controlled trial in subfertile women (age 18-39 year) with a body mass index between 29 and 40 kg/m2. Exclusion criteria are azoospermia, use of donor semen, severe endometriosis, premature ovarian failure, endocrinopathies or pre-existent hypertensive disorders. In the intervention group the aim is a weight loss of at least 5% to10% in a six-month period, to be achieved by the combination of a diet, increase of physical activity and behavioural modification. After six months, in case no conception has been achieved, these patients will start fertility treatment according to the Dutch fertility guidelines. In the control group treatment will be started according to Dutch fertility guidelines, independently of the patient's weight. Outcome measures and analysis The primary outcome measure is a healthy singleton born after at least 37 weeks of gestation after vaginal delivery. Secondary outcome parameters including pregnancy outcome and complications, percentage of women needing fertility treatment, clinical and ongoing pregnancy rates, body weight, quality of life and costs. Data will be analysed according to the intention to treat principle, and cost-effectiveness analysis will be performed to compare the costs and health effects in the intervention and control group. Discussion The trial will provide evidence for costs and effects of a lifestyle intervention aiming at weight reduction in overweight and obese subfertile women and will offer guidance to clinicians for the treatment of these patients. Trial registration Dutch Trial Register NTR1530

Published
2010
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7. Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN) : A randomised, two-by-two factorial trial

Author

Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen G E, Smeenk, Jesper M J, Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M, Laven, Joop S E, Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A J, Bourdrez, Petra, Gianotten, Judith, Koks, Carolien A M, Lambalk, Cornelis B., Hompes, Peter G A, van der Veen, Fulco, Mol, Ben Willem J., van Wely, Madelon, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen G E, Smeenk, Jesper M J, Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M, Laven, Joop S E, Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A J, Bourdrez, Petra, Gianotten, Judith, Koks, Carolien A M, Lambalk, Cornelis B., Hompes, Peter G A, van der Veen, Fulco, Mol, Ben Willem J., and van Wely, Madelon

Published
2018

8. Association between periconceptional weight loss and maternal and neonatal outcomes in obese infertile women

Author

van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, on behalf of the LIFEstyle study group, van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, and on behalf of the LIFEstyle study group

Published
2018

9. Influence of endometrial thickness on pregnancy rates in modified natural cycle frozen-thawed embryo transfer

Author

Groenewoud, Eva R., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van Dool, Grada, Fleisher, Katrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M., Koks, Caroliene A.M., Laven, Joop S.E., van der Linden, Paul J.Q., Manger, A. Petra, van Rumste, Minouche, Spinder, Taeke, Macklon, Nick S., Groenewoud, Eva R., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van Dool, Grada, Fleisher, Katrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M., Koks, Caroliene A.M., Laven, Joop S.E., van der Linden, Paul J.Q., Manger, A. Petra, van Rumste, Minouche, Spinder, Taeke, and Macklon, Nick S.

Published
2018

10. Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): A randomised, two-by-two factorial trial

Author

UMC Utrecht, MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen G E, Smeenk, Jesper M J, Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M, Laven, Joop S E, Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A J, Bourdrez, Petra, Gianotten, Judith, Koks, Carolien A M, Lambalk, Cornelis B., Hompes, Peter G A, van der Veen, Fulco, Mol, Ben Willem J., van Wely, Madelon, UMC Utrecht, MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen G E, Smeenk, Jesper M J, Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M, Laven, Joop S E, Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A J, Bourdrez, Petra, Gianotten, Judith, Koks, Carolien A M, Lambalk, Cornelis B., Hompes, Peter G A, van der Veen, Fulco, Mol, Ben Willem J., and van Wely, Madelon

Published
2018

11. Influence of endometrial thickness on pregnancy rates in modified natural cycle frozen-thawed embryo transfer

Author

MS VPG/Gynaecologie, Child Health, Circulatory Health, Groenewoud, Eva R., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van Dool, Grada, Fleisher, Katrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M., Koks, Caroliene A.M., Laven, Joop S.E., van der Linden, Paul J.Q., Manger, A. Petra, van Rumste, Minouche, Spinder, Taeke, Macklon, Nick S., MS VPG/Gynaecologie, Child Health, Circulatory Health, Groenewoud, Eva R., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van Dool, Grada, Fleisher, Katrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M., Koks, Caroliene A.M., Laven, Joop S.E., van der Linden, Paul J.Q., Manger, A. Petra, van Rumste, Minouche, Spinder, Taeke, and Macklon, Nick S.

Published
2018

12. Gonadotrophins Versus Clomifene Citrate with or Without Intrauterine Insemination in Women with Normogonadotropic Anovulation and Clomifene Failure (M-OVIN): A Randomized, Two-by-Two Factorial Trial

Author

MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen E., Smeenk, Jesper M.J., Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, De Bruin, Jan Peter, Kaaijk, Eugenie M., Laven, Joop S.E., Hendriks, Dave J., Gerards, Marie H., Van Rooij, Ilse A.J., Bourdrez, Petra, Gianotten, Judith, Koks, Carolien, Lambalk, Cornelis B., Hompes, Peter G., Van Der Veen, Fulco, Mol, Ben Willem J., Van Wely, Madelon, MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen E., Smeenk, Jesper M.J., Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, De Bruin, Jan Peter, Kaaijk, Eugenie M., Laven, Joop S.E., Hendriks, Dave J., Gerards, Marie H., Van Rooij, Ilse A.J., Bourdrez, Petra, Gianotten, Judith, Koks, Carolien, Lambalk, Cornelis B., Hompes, Peter G., Van Der Veen, Fulco, Mol, Ben Willem J., and Van Wely, Madelon

Published
2018

13. Influence of endometrial thickness on pregnancy rates in modified natural cycle frozen-thawed embryo transfer

Author

Groenewoud, Eva R, Cohlen, Ben J, Al-Oraiby, Amani, Brinkhuis, Egbert A, Broekmans, Frank J M, de Bruin, Jan-Peter, van Dool, Grada, Fleisher, Katrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A, Kaaijk, Eugenie M, Koks, Caroliene A M, Laven, Joop S E, van der Linden, Paul J Q, Manger, A Petra, van Rumste, Minouche, Spinder, Taeke, Macklon, Nick S, Groenewoud, Eva R, Cohlen, Ben J, Al-Oraiby, Amani, Brinkhuis, Egbert A, Broekmans, Frank J M, de Bruin, Jan-Peter, van Dool, Grada, Fleisher, Katrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A, Kaaijk, Eugenie M, Koks, Caroliene A M, Laven, Joop S E, van der Linden, Paul J Q, Manger, A Petra, van Rumste, Minouche, Spinder, Taeke, and Macklon, Nick S

Abstract

INTRODUCTION: Pregnancy after frozen-thawed embryo transfer (FET) is a multifactorial process. Although embryo quality is a key factor in determining pregnancy, other factors, including maternal determinants, are also considered to be predictive. Even though an association between endometrial thickness measured by transvaginal ultrasound and pregnancy rates has been reported in patients undergoing various assisted reproductive technology treatments, whether endometrial thickness predicts achieving pregnancy after natural cycle FET (NC-FET) remains unclear.MATERIAL AND METHODS: In this cohort study, 463 patients allocated to the modified NC-FET (mNC-FET) arm of a previously published randomized controlled trial were included. Monitoring in mNC-FET cycles consisted of regular ultrasound scans, measuring both dominant follicle and endometrial thickness. When the dominant follicle reached a size of 16-20 mm, an injection of human chorionic gonadotrophin was administered and embryo thawing and transfer planned. No minimal endometrial thickness was defined below which transfer was to be deferred. The primary endpoint was ongoing pregnancy rate.RESULTS: Overall, the ongoing pregnancy rate per started FET cycle was 12.5%. Multivariate regression analyses showed that embryo quality was the only significant predictor for ongoing pregnancy. Mean endometrial thickness did not differ between patients achieving ongoing pregnancy and those who did not (9.0 vs. 8.8 mm, p = 0.4). Comparable results were obtained with regard to clinical pregnancy, live birth and miscarriage rates. The area under the receiver operator curve was 0.5, indicating little discriminatory value of endometrial thickness.CONCLUSIONS: Given that endometrial thickness was not found to be predictive of pregnancy after mNC-FET, cancellation based on endometrial thickness alone may not be justified.

Published
2018

14. Association between periconceptional weight loss and maternal and neonatal outcomes in obese infertile women

Author

MS VPG/Gynaecologie, Child Health, Circulatory Health, van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, on behalf of the LIFEstyle study group, MS VPG/Gynaecologie, Child Health, Circulatory Health, van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, and on behalf of the LIFEstyle study group

Published
2018

15. Cost-effectiveness analysis of lifestyle intervention in obese infertile women

Author

Van Oers, Anne M., Mutsaerts, Meike A Q, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, van Golde, R., Kaaijk, Eugenie M, Schierbeek, Jaap M., Klijn, Nicole F., Van Kasteren, Yvonne M., Land, Jolande A, Mol, B. W J, Hoek, A., Groen, H., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, Niels E A, Lambalk, Cornelis B., Verberg, Marieke F G, Mercelina, Patricia E A M, van der Veen, F, Nap, Annemiek W., Gondrie, Ed T C M, Mulder, Robert J A B, Bruin, Jacob P, Reproductive Origins of Adult Health and Disease (ROAHD), Methods in Medicines evaluation & Outcomes research (M2O), Value, Affordability and Sustainability (VALUE), Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), ACS - Atherosclerosis & ischemic syndromes, Plastic, Reconstructive and Hand Surgery, Afdeling Onderwijs FHML, Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), and RS: GROW - R4 - Reproductive and Perinatal Medicine

Subjects
Male, obesity, Cost effectiveness, Cost-Benefit Analysis, Overweight, Body Mass Index, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Obstetrics and Gynaecology, 030212 general & internal medicine, Birth Rate, Netherlands, Family Characteristics, OUTCOMES, 030219 obstetrics & reproductive medicine, Obstetrics, SUBFERTILE, Rehabilitation, Obstetrics and Gynecology, Cost-effectiveness analysis, scenario analysis, Weight Reduction Programs, PREGNANCY, Female, medicine.symptom, Live birth, infertility, Infertility, Female, Adult, Infertility, medicine.medical_specialty, Patient Dropouts, Reproductive medicine, WEIGHT-LOSS, Fertilization in Vitro, Direct Service Costs, 03 medical and health sciences, DELIVERY, Ovulation Induction, Intervention (counseling), Weight Loss, medicine, Journal Article, Humans, Infant Health, FERTILITY TREATMENT, Healthy Lifestyle, cost-effectiveness, Infertility, Male, COUPLES, Cryopreservation, OVERWEIGHT, business.industry, lifestyle intervention, LIVE BIRTH, Embryo Transfer, medicine.disease, BODY-MASS INDEX, Reproductive Medicine, anovulation, Physical therapy, Lost to Follow-Up, business, Follow-Up Studies
Abstract

STUDY QUESTION What is the cost-effectiveness of lifestyle intervention preceding infertility treatment in obese infertile women? SUMMARY ANSWER Lifestyle intervention preceding infertility treatment as compared to prompt infertility treatment in obese infertile women is not a cost-effective strategy in terms of healthy live birth rate within 24 months after randomization, but is more likely to be cost-effective using a longer follow-up period and live birth rate as endpoint. WHAT IS KNOWN ALREADY In infertile couples, obesity decreases conception chances. We previously showed that lifestyle intervention prior to infertility treatment in obese infertile women did not increase the healthy singleton vaginal live birth rate at term, but increased natural conceptions, especially in anovulatory women. Cost-effectiveness analyses could provide relevant additional information to guide decisions regarding offering a lifestyle intervention to obese infertile women. STUDY DESIGN, SIZE, DURATION The cost-effectiveness of lifestyle intervention preceding infertility treatment compared to prompt infertility treatment was evaluated based on data of a previous RCT, the LIFEstyle study. The primary outcome for effectiveness was the vaginal birth of a healthy singleton at term within 24 months after randomization (the healthy live birth rate). The economic evaluation was performed from a hospital perspective and included direct medical costs of the lifestyle intervention, infertility treatments, medication and pregnancy in the intervention and control group. In addition, we performed exploratory cost-effectiveness analyses of scenarios with additional effectiveness outcomes (overall live birth within 24 months and overall live birth conceived within 24 months) and of subgroups, i.e. of ovulatory and anovulatory women, women

Published
2017
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17. The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles

Author

Groenewoud, Eva R., Macklon, Nick S., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van der Dool, Grada, Fleisher, Kathrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M, Koks, Carolina A.M., Laven, Joop S E, van der Linden, Paul J.Q., Manger, Petra A P, van Rumpste, Minouche, Spinder, Taeke, ANTARCTICA Study Group, Groenewoud, Eva R., Macklon, Nick S., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van der Dool, Grada, Fleisher, Kathrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M, Koks, Carolina A.M., Laven, Joop S E, van der Linden, Paul J.Q., Manger, Petra A P, van Rumpste, Minouche, Spinder, Taeke, and ANTARCTICA Study Group

Published
2017

18. The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles

Author

MS VPG/Gynaecologie, UMC Utrecht, Circulatory Health, Child Health, Groenewoud, Eva R., Macklon, Nick S., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van der Dool, Grada, Fleisher, Kathrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M, Koks, Carolina A.M., Laven, Joop S E, van der Linden, Paul J.Q., Manger, Petra A P, van Rumpste, Minouche, Spinder, Taeke, ANTARCTICA Study Group, MS VPG/Gynaecologie, UMC Utrecht, Circulatory Health, Child Health, Groenewoud, Eva R., Macklon, Nick S., Cohlen, Ben J., Al-Oraiby, Amani, Brinkhuis, Egbert A., Broekmans, Frank J.M., de Bruin, Jan Peter, van der Dool, Grada, Fleisher, Kathrin, Friederich, Jaap, Goddijn, Mariëtte, Hoek, Annemieke, Hoozemans, Diederik A., Kaaijk, Eugenie M, Koks, Carolina A.M., Laven, Joop S E, van der Linden, Paul J.Q., Manger, Petra A P, van Rumpste, Minouche, Spinder, Taeke, and ANTARCTICA Study Group

Published
2017

19. Cost-effectiveness analysis of lifestyle intervention in obese infertile women

Author

MS VPG/Gynaecologie, Circulatory Health, Child Health, Van Oers, Anne M., Mutsaerts, Meike A Q, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, van Golde, R., Kaaijk, Eugenie M, Schierbeek, Jaap M., Klijn, Nicole F., Van Kasteren, Yvonne M., Land, Jolande A, Mol, B. W J, Hoek, A., Groen, H., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, Niels E A, Lambalk, Cornelis B., Verberg, Marieke F G, Mercelina, Patricia E A M, van der Veen, F, Nap, Annemiek W., Gondrie, Ed T C M, Mulder, Robert J A B, Bruin, Jacob P, behalf of the LIFEstyle study group, MS VPG/Gynaecologie, Circulatory Health, Child Health, Van Oers, Anne M., Mutsaerts, Meike A Q, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, van Golde, R., Kaaijk, Eugenie M, Schierbeek, Jaap M., Klijn, Nicole F., Van Kasteren, Yvonne M., Land, Jolande A, Mol, B. W J, Hoek, A., Groen, H., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, Niels E A, Lambalk, Cornelis B., Verberg, Marieke F G, Mercelina, Patricia E A M, van der Veen, F, Nap, Annemiek W., Gondrie, Ed T C M, Mulder, Robert J A B, Bruin, Jacob P, and behalf of the LIFEstyle study group

Published
2017

21. Hysteroscopy before In-Vitro Fertilisation (inSIGHT) : A Multicentre, Randomised Controlled Trial

Author

Smit, Janine G., Kasius, Jenneke C., Eijkemans, Marinus J C, Koks, Carolien A M, Van Golde, Ronald, Nap, Annemiek W., Scheffer, Gabrielle J., Manger, Petra A P, Hoek, Annemieke, Schoot, Benedictus C., Van Heusden, Arne M., Kuchenbecker, Walter K H, Perquin, Denise A M, Fleischer, Kathrin, Kaaijk, Eugenie M., Sluijmer, Alexander, Friederich, Jaap, Dykgraaf, Ramon H M, Van Hooff, Marcel, Louwe, Leonie A., Kwee, Janet, De Koning, Corry H., Janssen, Ineke C A H, Mol, Femke, Mol, Ben W J, Broekmans, Frank J M, Torrance, Helen L., Smit, Janine G., Kasius, Jenneke C., Eijkemans, Marinus J C, Koks, Carolien A M, Van Golde, Ronald, Nap, Annemiek W., Scheffer, Gabrielle J., Manger, Petra A P, Hoek, Annemieke, Schoot, Benedictus C., Van Heusden, Arne M., Kuchenbecker, Walter K H, Perquin, Denise A M, Fleischer, Kathrin, Kaaijk, Eugenie M., Sluijmer, Alexander, Friederich, Jaap, Dykgraaf, Ramon H M, Van Hooff, Marcel, Louwe, Leonie A., Kwee, Janet, De Koning, Corry H., Janssen, Ineke C A H, Mol, Femke, Mol, Ben W J, Broekmans, Frank J M, and Torrance, Helen L.

Published
2016

22. PROMISE : first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation

Author

Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E, Atik, Ruth Bender, Bloemenkamp, Kitty Wm, Brady, Rebecca, Briley, Annette, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin, Eapen, Abey, Essex, Holly, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Parrott, Steve, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Trépel, Dominic, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark David, Khalaf, Yacoub, Goddijn, Mariëtte, Regan, Lesley, Rai, Rajendra, Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E, Atik, Ruth Bender, Bloemenkamp, Kitty Wm, Brady, Rebecca, Briley, Annette, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin, Eapen, Abey, Essex, Holly, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Parrott, Steve, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Trépel, Dominic, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark David, Khalaf, Yacoub, Goddijn, Mariëtte, Regan, Lesley, and Rai, Rajendra

Published
2016

23. Randomized trial of a lifestyle program in obese infertile women

Author

Mutsaerts, Meike A Q, Van Oers, Anne M., Groen, Henk, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, Van Golde, Ron, Kaaijk, Eugenie M., Schierbeek, Jaap M., Oosterhuis, Gerrit J E, Broekmans, Frank J., Bemelmans, Wanda J E, Lambalk, Cornelis B., Verberg, Marieke F G, Van Der Veen, Fulco, Klijn, Nicole F., Mercelina, Patricia E A M, Van Kasteren, Yvonne M., Nap, Annemiek W., Brinkhuis, Egbert A., Vogel, Niels E A, Mulder, Robert J A B, Gondrie, Ed T C M, De Bruin, Jan P., Sikkema, J. Marko, De Greef, Mathieu H G, Ter Bogt, Nancy C W, Land, Jolande A., Mol, Ben W J, Hoek, Annemieke, Mutsaerts, Meike A Q, Van Oers, Anne M., Groen, Henk, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, Van Golde, Ron, Kaaijk, Eugenie M., Schierbeek, Jaap M., Oosterhuis, Gerrit J E, Broekmans, Frank J., Bemelmans, Wanda J E, Lambalk, Cornelis B., Verberg, Marieke F G, Van Der Veen, Fulco, Klijn, Nicole F., Mercelina, Patricia E A M, Van Kasteren, Yvonne M., Nap, Annemiek W., Brinkhuis, Egbert A., Vogel, Niels E A, Mulder, Robert J A B, Gondrie, Ed T C M, De Bruin, Jan P., Sikkema, J. Marko, De Greef, Mathieu H G, Ter Bogt, Nancy C W, Land, Jolande A., Mol, Ben W J, and Hoek, Annemieke

Published
2016

24. Hysteroscopy before In-Vitro Fertilisation (inSIGHT): A Multicentre, Randomised Controlled Trial

Author

MS VPG/Gynaecologie, Arts-assistenten DV&B, Biostatistiek Onderzoek, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Child Health, Fertiliteitartsen, Smit, Janine G., Kasius, Jenneke C., Eijkemans, Marinus J C, Koks, Carolien A M, Van Golde, Ronald, Nap, Annemiek W., Scheffer, Gabrielle J., Manger, Petra A P, Hoek, Annemieke, Schoot, Benedictus C., Van Heusden, Arne M., Kuchenbecker, Walter K H, Perquin, Denise A M, Fleischer, Kathrin, Kaaijk, Eugenie M., Sluijmer, Alexander, Friederich, Jaap, Dykgraaf, Ramon H M, Van Hooff, Marcel, Louwe, Leonie A., Kwee, Janet, De Koning, Corry H., Janssen, Ineke C A H, Mol, Femke, Mol, Ben W J, Broekmans, Frank J M, Torrance, Helen L., MS VPG/Gynaecologie, Arts-assistenten DV&B, Biostatistiek Onderzoek, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Child Health, Fertiliteitartsen, Smit, Janine G., Kasius, Jenneke C., Eijkemans, Marinus J C, Koks, Carolien A M, Van Golde, Ronald, Nap, Annemiek W., Scheffer, Gabrielle J., Manger, Petra A P, Hoek, Annemieke, Schoot, Benedictus C., Van Heusden, Arne M., Kuchenbecker, Walter K H, Perquin, Denise A M, Fleischer, Kathrin, Kaaijk, Eugenie M., Sluijmer, Alexander, Friederich, Jaap, Dykgraaf, Ramon H M, Van Hooff, Marcel, Louwe, Leonie A., Kwee, Janet, De Koning, Corry H., Janssen, Ineke C A H, Mol, Femke, Mol, Ben W J, Broekmans, Frank J M, and Torrance, Helen L.

Published
2016

25. Randomized trial of a lifestyle program in obese infertile women

Author

MS VPG/Gynaecologie, Circulatory Health, Child Health, HAG Netwerken, Epidemiology & Health Economics, Mutsaerts, Meike A Q, Van Oers, Anne M., Groen, Henk, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, Van Golde, Ron, Kaaijk, Eugenie M., Schierbeek, Jaap M., Oosterhuis, Gerrit J E, Broekmans, Frank J., Bemelmans, Wanda J E, Lambalk, Cornelis B., Verberg, Marieke F G, Van Der Veen, Fulco, Klijn, Nicole F., Mercelina, Patricia E A M, Van Kasteren, Yvonne M., Nap, Annemiek W., Brinkhuis, Egbert A., Vogel, Niels E A, Mulder, Robert J A B, Gondrie, Ed T C M, De Bruin, Jan P., Sikkema, J. Marko, De Greef, Mathieu H G, Ter Bogt, Nancy C W, Land, Jolande A., Mol, Ben W J, Hoek, Annemieke, MS VPG/Gynaecologie, Circulatory Health, Child Health, HAG Netwerken, Epidemiology & Health Economics, Mutsaerts, Meike A Q, Van Oers, Anne M., Groen, Henk, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, Van Golde, Ron, Kaaijk, Eugenie M., Schierbeek, Jaap M., Oosterhuis, Gerrit J E, Broekmans, Frank J., Bemelmans, Wanda J E, Lambalk, Cornelis B., Verberg, Marieke F G, Van Der Veen, Fulco, Klijn, Nicole F., Mercelina, Patricia E A M, Van Kasteren, Yvonne M., Nap, Annemiek W., Brinkhuis, Egbert A., Vogel, Niels E A, Mulder, Robert J A B, Gondrie, Ed T C M, De Bruin, Jan P., Sikkema, J. Marko, De Greef, Mathieu H G, Ter Bogt, Nancy C W, Land, Jolande A., Mol, Ben W J, and Hoek, Annemieke

Published
2016

26. PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation

Author

Arts-assistenten DV&B, Geboortecentrum voorzitterschap, Child Health, Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E, Atik, Ruth Bender, Bloemenkamp, Kitty Wm, Brady, Rebecca, Briley, Annette, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin, Eapen, Abey, Essex, Holly, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Parrott, Steve, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Trépel, Dominic, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark David, Khalaf, Yacoub, Goddijn, Mariëtte, Regan, Lesley, Rai, Rajendra, Arts-assistenten DV&B, Geboortecentrum voorzitterschap, Child Health, Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E, Atik, Ruth Bender, Bloemenkamp, Kitty Wm, Brady, Rebecca, Briley, Annette, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin, Eapen, Abey, Essex, Holly, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Parrott, Steve, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Trépel, Dominic, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark David, Khalaf, Yacoub, Goddijn, Mariëtte, Regan, Lesley, and Rai, Rajendra

Published
2016

27. PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages – a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation

Author

Coomarasamy, Arri, primary, Williams, Helen, additional, Truchanowicz, Ewa, additional, Seed, Paul T, additional, Small, Rachel, additional, Quenby, Siobhan, additional, Gupta, Pratima, additional, Dawood, Feroza, additional, Koot, Yvonne E, additional, Atik, Ruth Bender, additional, Bloemenkamp, Kitty WM, additional, Brady, Rebecca, additional, Briley, Annette, additional, Cavallaro, Rebecca, additional, Cheong, Ying C, additional, Chu, Justin, additional, Eapen, Abey, additional, Essex, Holly, additional, Ewies, Ayman, additional, Hoek, Annemieke, additional, Kaaijk, Eugenie M, additional, Koks, Carolien A, additional, Li, Tin-Chiu, additional, MacLean, Marjory, additional, Mol, Ben W, additional, Moore, Judith, additional, Parrott, Steve, additional, Ross, Jackie A, additional, Sharpe, Lisa, additional, Stewart, Jane, additional, Trépel, Dominic, additional, Vaithilingam, Nirmala, additional, Farquharson, Roy G, additional, Kilby, Mark David, additional, Khalaf, Yacoub, additional, Goddijn, Mariëtte, additional, Regan, Lesley, additional, and Rai, Rajendra, additional

Published
2016
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28. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

Author

Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E M, Bender Atik, Ruth, Bloemenkamp, Kitty W M, Brady, Rebecca, Briley, Annette L, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin J, Eapen, Abey, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A M, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark D, Khalaf, Yacoub, Goddijn, Mariette, Regan, Lesley, Rai, Rajendra, Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E M, Bender Atik, Ruth, Bloemenkamp, Kitty W M, Brady, Rebecca, Briley, Annette L, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin J, Eapen, Abey, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A M, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark D, Khalaf, Yacoub, Goddijn, Mariette, Regan, Lesley, and Rai, Rajendra

Published
2015

29. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

Author

Arts-assistenten DV&B, Geboortecentrum voorzitterschap, Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E M, Bender Atik, Ruth, Bloemenkamp, Kitty W M, Brady, Rebecca, Briley, Annette L, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin J, Eapen, Abey, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A M, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark D, Khalaf, Yacoub, Goddijn, Mariette, Regan, Lesley, Rai, Rajendra, Arts-assistenten DV&B, Geboortecentrum voorzitterschap, Coomarasamy, Arri, Williams, Helen, Truchanowicz, Ewa, Seed, Paul T, Small, Rachel, Quenby, Siobhan, Gupta, Pratima, Dawood, Feroza, Koot, Yvonne E M, Bender Atik, Ruth, Bloemenkamp, Kitty W M, Brady, Rebecca, Briley, Annette L, Cavallaro, Rebecca, Cheong, Ying C, Chu, Justin J, Eapen, Abey, Ewies, Ayman, Hoek, Annemieke, Kaaijk, Eugenie M, Koks, Carolien A M, Li, Tin-Chiu, MacLean, Marjory, Mol, Ben W, Moore, Judith, Ross, Jackie A, Sharpe, Lisa, Stewart, Jane, Vaithilingam, Nirmala, Farquharson, Roy G, Kilby, Mark D, Khalaf, Yacoub, Goddijn, Mariette, Regan, Lesley, and Rai, Rajendra

Published
2015

30. Quadruple torsion of the fallopian tube in an 18-yearold virgin: a rare twist.

Author

Zaat, Tjitske R., Braakhekke, Miriam W. M., Kaaijk, Eugenie M., and Peters, Louisette W.

Abstract

In this report, we describe an 18-year-old nulliparous virgo, with no medical history, who presented herself at the emergency department with symptoms of lower abdominal pain and nausea with vomiting. On examination, an echogenic unilocular cyst with possible relation to the right ovary was found. The working diagnosis was an ovarian torsion. She underwent a diagnostic laparoscopy which revealed a quadruple torsion of the fallopian tube with hydrosalpinx. Detorsion of the tube was performed, and the tube was drained using diathermic incision. After the surgery, the patient recovered rapidly. Ultrasonic evaluation 38 days later showed an echogenic area measuring 2'3 cm suspected for persistent hydrosalpinx. Because of the asymptomatic postoperative period, the patient was treated conservatively, and no further treatment was performed. [ABSTRACT FROM AUTHOR]

Published
2018
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31. The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial

Author

Mutsaerts, Meike AQ, primary, Groen, Henk, additional, ter Bogt, Nancy CW, additional, Bolster, Johanna HT, additional, Land, Jolande A, additional, Bemelmans, Wanda JE, additional, Kuchenbecker, Walter KH, additional, Hompes, Peter GA, additional, Macklon, Nick S, additional, Stolk, Ronald P, additional, van der Veen, Fulco, additional, Maas, Jacques WM, additional, Klijn, Nicole F, additional, Kaaijk, Eugenie M, additional, Oosterhuis, Gerrit JE, additional, Bouckaert, Peter XJM, additional, Schierbeek, Jaap M, additional, van Kasteren, Yvonne M, additional, Nap, Annemiek W, additional, Broekmans, Frank J, additional, Brinkhuis, Egbert A, additional, Koks, Carolien AM, additional, Burggraaff, Jan M, additional, Blankhart, Adrienne S, additional, Perquin, Denise AM, additional, Gerards, Marie H, additional, Mulder, Robert JAB, additional, Gondrie, Ed TCM, additional, Mol, Ben WJ, additional, and Hoek, Annemieke, additional

Published
2010
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34. Case Report: Unilateral oophorectomy in polycystic ovary syndrome: a treatment option in highly selected cases?

Author

Kaaijk, Eugenie M., Beek, Johan F., Hamerlynck, Johan V.T.H., and van der Veen, Fulco

Abstract

We performed unilateral oophorectomy (UO) in three patients with polycystic ovary syndrome (PCOS) and longstanding infertility. The indication for performing this procedure was a combination of ovarian pathology and the long-standing infertility. All three patients were resistant to clomiphene citrate and before UO all patients had been treated unsuccessfully with gonadotrophins and in-vitro fertilization. All three patients became ovulatory within the first month after UO. Two patients conceived 11 and 12 months after surgery respectively and delivered healthy babies. Testosterone concentrations decreased in two patients to upper values of the normal range and remained unchanged in one patient. We conclude that restoration of ovulation can be a beneficial side-effect of UO in clomiphene citrate resistant patients with PCOS and long-standing infertility. [ABSTRACT FROM PUBLISHER]

Published
1997
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35. Association between periconceptional weight loss and maternal and neonatal outcomes in obese infertile women.

Author

van Oers AM, Mutsaerts MAQ, Burggraaff JM, Kuchenbecker WKH, Perquin DAM, Koks CAM, van Golde R, Kaaijk EM, Broekmans FJ, de Bruin JP, van der Veen F, Nap AW, Gondrie ETCM, Mol BWJ, Groen H, and Hoek A

Subjects
Adult, Birth Rate, Body Mass Index, Female, Humans, Infant, Newborn, Infertility, Female physiopathology, Live Birth, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy Rate, Treatment Outcome, Infertility, Female therapy, Life Style, Obesity physiopathology, Weight Loss physiology
Abstract

Background: Obesity in women of reproductive age has deleterious effects on reproductive and offspring health. In this study, we aimed to evaluate the association between the magnitude of periconceptional body-mass index (BMI) change and maternal and neonatal outcomes in obese infertile women who participated in the LIFEstyle study. The LIFEstyle study was a randomized controlled trial, evaluating if a six-month lifestyle intervention program prior to infertility treatment in obese infertile women improved birth rates, compared to prompt infertility treatment., Methods and Findings: This is an exploratory post hoc analysis of the LIFEstyle study. We recorded periconceptional BMI change in women with an ongoing pregnancy, pooling data of all women, regardless of randomization arm. Periconceptional BMI change was calculated using weight at randomization and the periconceptional weight (measured in kilograms 12 weeks before or after conception and expressed as BMI change in units BMI (kg/m2)). Subsequently, women were categorized into quartiles according to the magnitude of their periconceptional change in BMI. The odds of maternal and neonatal outcomes were calculated using logistic regression analysis, comparing women in each of the first three weight change quartiles separately, and combined, to women in the fourth quartile. The fourth quartile was chosen as reference group, since these women had the least weight loss. We adjusted for periconceptional BMI, nulliparity and smoking status. In addition, we performed a subgroup analysis for singleton pregnancies. In the LIFEstyle study, 321 obese infertile women achieved an ongoing pregnancy which was conceived within 24 months after randomization. Periconceptional BMI change was available in 244 of these women (76%). Median BMI at randomization was 35.9 kg/m2. Women in the first quartile (Q1) had a periconceptional BMI change of <-2.1 kg/m2, women in the second quartile (Q2) -2.1 to -0.9 kg/m2, women in the third quartile (Q3) -0.9 to 0.1 kg/m2 and women in the fourth quartile (Q4) gained ≥0.1 kg/m2. There were no significant differences between women in the quartiles regarding rates of excessive gestational weight gain (in term pregnancies), gestational diabetes, preterm birth, induction of labor, spontaneous vaginal birth and Caesarean section. Compared to women in Q4, the adjusted odds ratios, aOR, and 95% confidence interval for a hypertensive complication were; 0.55 (0.22-1.42) for women in Q1, 0.30 (0.12-0.78) for women in Q2, 0.39 (0.16-0.96) for women in Q3 and 0.39 (0.19-0.82) for women in Q1 to Q3 combined. In the subgroup analysis, investigating singleton pregnancies only, the statistically significant decreased rate of a hypertensive complication remained in women in Q2 (aOR 0.27, 95% CI 0.10-0.72) and Q3 (aOR 0.39, 95%CI 0.16-0.98) and when comparing women in Q1 to Q3 together to women in Q4 (aOR 0.38, 95%CI 0.18-0.80). Furthermore, there was a significantly decreased aOR (95%CI) of preterm birth in women in Q2 (0.24, 0.06-0.98) and when combining women in Q1 to Q3 (0.37, 0.14-0.97) compared to women in Q4., Conclusions: These results suggest that a periconceptional decrease in BMI in obese infertile women could lead to a decrease of the rates of hypertensive pregnancy complications and preterm birth. The results are limited by the exploratory nature of the analyses and further evidence is necessary to provide more definitive conclusions.

Published
2018
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36. Using an electrocautery strategy or recombinant follicle stimulating hormone to induce ovulation in polycystic ovary syndrome: randomised controlled trial.

Author

Bayram N, van Wely M, Kaaijk EM, Bossuyt PM, and van der Veen F

Subjects
Adult, Anovulation therapy, Chronic Disease, Female, Humans, Laparoscopy, Recurrence, Treatment Outcome, Electrocoagulation methods, Follicle Stimulating Hormone therapeutic use, Ovulation Induction methods, Polycystic Ovary Syndrome therapy, Pregnancy statistics & numerical data
Abstract

Objective: To compare the effectiveness of an electrocautery strategy with ovulation induction using recombinant follicle stimulating hormone in patients with polycystic ovary syndrome., Design: Randomised controlled trial., Setting: Secondary and tertiary hospitals in the Netherlands., Participants: 168 patients with clomiphene citrate resistant polycystic ovary syndrome: 83 were allocated electrocautery and 85 were allocated recombinant follicle stimulating hormone., Intervention: Laparoscopic electrocautery of the ovaries followed by clomiphene citrate and recombinant follicle stimulating hormone if anovulation persisted, or induction of ovulation with recombinant follicle stimulating hormone., Main Outcome Measure: Ongoing pregnancy within 12 months., Results: . The cumulative rate of ongoing pregnancy after recombinant follicle stimulating hormone was 67%. With only electrocautery it was 34%, which increased to 49% after clomiphene citrate was given. Subsequent recombinant follicle stimulating hormone increased the rate to 67% at 12 months (rate ratio 1.01, 95% confidence interval 0.81 to 1.24). No complications occurred from electrocautery with or without clomiphene citrate. Patients allocated to electrocautery had a significantly lower risk of multiple pregnancy (0.11, 0.01 to 0.86)., Conclusion: The ongoing pregnancy rate from ovulation induction with laparoscopic electrocautery followed by clomiphene citrate and recombinant follicle stimulating hormone if anovulation persisted, or recombinant follicle stimulating hormone, seems equivalent to ovulation induction with recombinant follicle stimulating hormone, but the former procedure carries a lower risk of multiple pregnancy.

Published
2004
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