Search

Your search keyword '"Kaakoush, Nadeem O."' showing total 338 results
Start Over Author "Kaakoush, Nadeem O." Search Limiters Full Text
338 results on '"Kaakoush, Nadeem O."'

1. Gut microbiota strain richness is species specific and affects engraftment

Author

Chen-Liaw, Alice, Aggarwala, Varun, Mogno, Ilaria, Haifer, Craig, Li, Zhihua, Eggers, Joseph, Helmus, Drew, Hart, Amy, Wehkamp, Jan, Lamousé-Smith, Esi S. N., Kerby, Robert L., Rey, Federico E., Colombel, Jean Frédéric, Kamm, Michael A., Olle, Bernat, Norman, Jason M., Menon, Rajita, Watson, Andrea R., Crossette, Emily, Terveer, Elisabeth M., Keller, Josbert J., Borody, Thomas J., Grinspan, Ari, Paramsothy, Sudarshan, Kaakoush, Nadeem O., Dubinsky, Marla C., and Faith, Jeremiah J.

Published
2025
Full Text
View/download PDF

4. Author Correction: Gut microbiota strain richness is species specific and affects engraftment

Author

Chen-Liaw, Alice, Aggarwala, Varun, Mogno, Ilaria, Haifer, Craig, Li, Zhihua, Eggers, Joseph, Helmus, Drew, Hart, Amy, Wehkamp, Jan, Lamousé-Smith, Esi S. N., Kerby, Robert L., Rey, Federico E., Colombel, Jean Frédéric, Kamm, Michael A., Olle, Bernat, Norman, Jason M., Menon, Rajita, Watson, Andrea R., Crossette, Emily, Terveer, Elisabeth M., Keller, Josbert J., Borody, Thomas J., Grinspan, Ari, Paramsothy, Sudarshan, Kaakoush, Nadeem O., Dubinsky, Marla C., and Faith, Jeremiah J.

Published
2025
Full Text
View/download PDF

6. Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome

Author

Mathur, Anukriti, Kay, Callum, Xue, Yansong, Pandey, Abhimanu, Lee, Jiwon, Jing, Weidong, Enosi Tuipulotu, Daniel, Lo Pilato, Jordan, Feng, Shouya, Ngo, Chinh, Zhao, Anyang, Shen, Cheng, Rug, Melanie, Miosge, Lisa A, Atmosukarto, Ines I, Price, Jason D, Ali, Sidra A, Gardiner, Elizabeth E, Robertson, Avril AB, Awad, Milena M, Lyras, Dena, Kaakoush, Nadeem O, and Man, Si Ming

Published
2023
Full Text
View/download PDF

7. High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study)

Author

Ong, Kwok Leung, Hui, Nicholas, Januszewski, Andrzej S, Kaakoush, Nadeem O, Xu, Aimin, Fayyad, Rana, DeMicco, David A, Jenkins, Alicia J, Keech, Anthony C, Waters, David D, Barter, Philip J, and Rye, Kerry-Anne

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Heart Disease, Clinical Trials and Supportive Activities, Cardiovascular, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Aged, Anticholesteremic Agents, Atorvastatin, Biomarkers, Cardiovascular Diseases, Coronary Artery Disease, Female, Fibroblast Growth Factors, Humans, Male, Middle Aged, Predictive Value of Tests, Endocrinology & Metabolism, Clinical sciences
Abstract

BackgroundHigher plasma fibroblast growth factor 21 (FGF21) levels predict incident cardiovascular events in type 2 diabetes patients. However, whether FGF21 levels predict cardiovascular events in statin-treated patients in the general population is unknown. We investigated whether FGF21 levels predict major cardiovascular event (MCVE) in the Treating to New Targets (TNT) trial participants.MethodsAfter 8-week run-in on atorvastatin 10 mg/day, 10,001 patients with stable coronary disease in the TNT trial were randomized to 10 mg or 80 mg/day of atorvastatin for a median of 4.9 years. We analyzed data from 1996 patients with plasma FGF21 levels measured at randomization. Among them, 1835 patients had FGF21 measured one-year post-randomization.ResultsHigher ln-transformed FGF21 levels at randomization were associated with higher risk of incident MCVE (adjusted hazards ratio per SD increase = 1.18, P = 0.019). At 1-year post-randomization, FGF21 levels were lower in patients randomized to receive 80 mg versus 10 mg atorvastatin (186.9 versus 207.5 pg/mL respectively, P = 0.006). Higher ln-transformed FGF21 levels at 1-year post-randomization were also associated with higher subsequent risk of MCVEs (adjusted hazards ratio per SD increase = 1.24, P = 0.009). However, changes in FGF21 levels over 1-year were not related to subsequent MCVE risk. FGF21 levels had significant incremental value in net reclassification improvement in MCVE risk prediction.ConclusionsHigher plasma FGF21 levels are associated with higher CVD risk in statin-treated high-risk patients. Higher dose atorvastatin is associated with a reduction in FGF21 levels. FGF21 provides incremental value in CVD risk prediction in statin-treated patients.

Published
2019

8. Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐NLRP3 inflammasomes

Author

Enosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan, and Man, Si Ming

Published
2023
Full Text
View/download PDF

10. Defined microbiota transplant restores Th17/RORγt⁺ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas

Author

Britton, Graham J., Contijoch, Eduardo J., Spindler, Matthew P., Aggarwala, Varun, Dogan, Belgin, Bongers, Gerold, San Mateo, Lani, Baltus, Andrew, Das, Anuk, Gevers, Dirk, Borody, Thomas J., Kaakoush, Nadeem O., Kamm, Michael A., Mitchell, Hazel, Paramsothy, Sudarshan, Clemente, Jose C., Colombel, Jean-Frederic, Simpson, Kenneth W., Dubinsky, Marla C., Grinspan, Ari, and Faith, Jeremiah J.

Published
2020

11. Dietary Determinants of Metabolic and Gut Microbial Health in Patients with Inflammatory Bowel Disease.

Author

Wark, Gabrielle, Kaakoush, Nadeem O., Samocha-Bonet, Dorit, Ghaly, Simon, and Danta, Mark

Abstract

Background: Diet has been linked to gut dysbiosis and the onset, course, and response to treatment of patients with IBD and metabolic disease. Methods: This single-centre prospective case-control study investigated the relationship between dietary intake, metabolic profile, and stool microbial composition in 57 individuals with IBD in clinical remission and 24 healthy individuals (HC). Participants' baseline anthropometric measurements, serum metabolic parameters, lipid profiles, and oral and stool samples for microbiota testing were collected. Their dietary intake and physical activity were documented. A partially corrected correlation was performed to examine the associations between variables and p-values adjusted for multiple comparisons using the Benjamini–Hochberg equation (adj-p). Results: In participants with IBD, the intake of saturated fat correlated positively, and the intake of dietary fibre correlated negatively with anthropometric indices (saturated fat and BMI: r = 0.37, adj-p = 0.04, fibre and BMI: r = −0.45, adj-p = 0.01). Higher anthropometric indices were associated with poorer glucose control and a less favourable serum lipid profile (BMI and insulin: r = 0.48, p < 0.01, WHR and triglycerides: r = 0.57, p < 0.01). The stool microbiota of participants in the IBD group was less diverse and more similar to their oral microbiota than was observed in the HC group (Mann–Whitney U test p = 0.03). Within the IBD group, a higher intake of added sugar and processed meat and a higher serum insulin level was associated with lower stool microbial alpha diversity (processed meat intake and Shannon's diversity: r = −0.43, adj-p = 0.02; added sugar and Shannon's diversity: r = −0.39, adj-p = 0.03; insulin and Shannon's diversity: r = −0.45, adj-p = 0.02). Neither the dietary intake nor stool microbial composition correlated with the risk of disease flaring. Conclusions: Our findings suggest that dietary intake is associated with the metabolic health and gut microbial composition of IBD patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis

Author

Paramsothy, Sudarshan, Nielsen, Shaun, Kamm, Michael A., Deshpande, Nandan P., Faith, Jeremiah J., Clemente, Jose C., Paramsothy, Ramesh, Walsh, Alissa J., van den Bogaerde, Johan, Samuel, Douglas, Leong, Rupert W.L., Connor, Susan, Ng, Watson, Lin, Enmoore, Borody, Thomas J., Wilkins, Marc R., Colombel, Jean-Frederic, Mitchell, Hazel M., and Kaakoush, Nadeem O.

Published
2019
Full Text
View/download PDF

16. Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome

Author

Pandey, Abhimanu, primary, Shen, Cheng, additional, Feng, Shouya, additional, Enosi Tuipulotu, Daniel, additional, Ngo, Chinh, additional, Liu, Cheng, additional, Kurera, Melan, additional, Mathur, Anukriti, additional, Venkataraman, Shweta, additional, Zhang, Jing, additional, Talaulikar, Dipti, additional, Song, Renhua, additional, Wong, Justin J.-L., additional, Teoh, Narci, additional, Kaakoush, Nadeem O., additional, and Man, Si Ming, additional

Published
2024
Full Text
View/download PDF

22. Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

Author

Fox, Daniel, Mathur, Anukriti, Xue, Yansong, Liu, Yunqi, Tan, Wei Hong, Feng, Shouya, Pandey, Abhimanu, Ngo, Chinh, Hayward, Jenni A., Atmosukarto, Ines I., Price, Jason D., Johnson, Matthew D., Jessberger, Nadja, Robertson, Avril A. B., Burgio, Gaetan, Tscharke, David C., Fox, Edward M., Leyton, Denisse L., Kaakoush, Nadeem O., Märtlbauer, Erwin, Leppla, Stephen H., and Man, Si Ming

Published
2020
Full Text
View/download PDF

40. Additional file 2 of Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett’s esophagus

Author

Deshpande, Nandan P., Riordan, Stephen M., Gorman, Claire J., Nielsen, Shaun, Russell, Tonia L., Correa-Ospina, Carolina, Fernando, Bentotage S. M., Waters, Shafagh A., Castaño-Rodríguez, Natalia, Man, Si Ming, Tedla, Nicodemus, Wilkins, Marc R., and Kaakoush, Nadeem O.

Abstract

Additional file 2: Figure S1. Splicing events within the esophageal transcriptome. Figure S2. Exon skipping events within the esophageal transcriptome. Figure S3. Circular RNAs and gene fusion within the esophageal transcriptome. Figure S4. Saliva and esophageal microbiota in the early stages of the EAC cascade. Figure S5. Esophageal microbiota in the early stages of the EAC cascade. Figure S6. Procrustes analysis between transcriptome and microbiome. Figure S7. Correlations between Campylobacter iOTU36 and transcript counts. Figure S8. Prevalence of regions of interest in shotgun metagenomics data.

Published
2021
Full Text
View/download PDF

41. Lyophilised Oral Faecal Microbiota Transplantation in Ulcerative Colitis - a Randomised Placebo-Controlled Trial

Author

Haifer, Craig, Paramosthy, Sudarshan, Kaakoush, Nadeem O., Saikal, Aiasha, Ghaly, Simon, Luu, Laurence DW, Borody, Thomas J, and Leong, Rupert W.

Subjects
Coronavirus, COVID-19
Abstract

Background: Colonoscopic infusion and enemas of faecal microbiota transplantation (FMT) induce remission in ulcerative colitis (UC) but whether oral FMT achieves induction and maintenance of remission in UC is unknown.Methods: A double-blind, randomised placebo-controlled trial was conducted. Following 2-weeks of amoxicillin, metronidazole and doxycycline, patients with active UC were randomised 1:1 to FMT or placebo capsules for 8-weeks. The primary outcome was steroid-free clinical remission with endoscopic remission or response. At week-8, FMT-responders were re-randomised 1:1 to continue or withdraw FMT for a further 48-weeks. Modified intention-to-treat analysis was performed and included all patients who received at least one study dose. The gastrointestinal microbiota was profiled using 16S rRNA and ITS region amplicon sequencing. This report presents the final analysis.Findings: From May 2019 to March 2020, 35 subjects were randomised (15 FMT/ 20 placebo). Recruitment was terminated early due to the SARS-COV-2 pandemic. The primary outcome was achieved in 8/15(53%) with FMT versus 3/20(15%) with placebo (difference:38·3% [95%CI: 8·6–68·0]; P =0·027; OR:5·0[95%CI: 1·8–14·1]). Ten FMT-responders entered the maintenance phase. By 56-weeks, 6/6 (100%) subjects randomised to withdraw FMT relapsed (median time to treatment escalation 24-weeks); whereas 4/4(100%) subjects on maintenance-FMT had endoscopic and histologic mucosal healing. Adverse events occurred in 10/15(67%) FMT and 18/20(85%) placebo subjects and were generally mild and self-limiting. Serious adverse events included worsening UC (2 FMT, 1 placebo) and PR bleeding (1 placebo). Antibiotics reduced pathobionts and FMT increased species richness relative to placebo (P

Published
2021
Full Text
View/download PDF

45. Divergent Dysbiosis among Afro-Colombian and Colombian Amerindian-Mestizo Populations with Contrasting Risks of Gastric Cancer.

Author

Caguazango-Montenegro, Juan, Bedoya-urresta, Alvaro R., Vinasco-pacheco, Karla, Simovic, Isidora, Yepez-caicedo, Yomaira, Coral-bedoya, Marino, Kaakoush, Nadeem O., and Castano-rodriguez, Natalia

Subjects
HELICOBACTER pylori, PRECANCEROUS conditions, ECOLOGICAL models, MICROBIAL diversity, DISEASE risk factors
Abstract

Background/Aims Gastric dysbiosis linked to Helicobacter pylori is a key but not definitive factor in the development of gastric cancer (GC). Other microorganisms involved in gastric dysbiosis may further influence malignancy progression, especially in high-risk GC populations. To characterise the gastric microbiota associated with H.pylori infection and assess its impact on the transition from non-atrophic gastritis (NACG) to gastric premalignant lesions (GPL) in two populations from Nariño, Colombia with opposite risk of GC, Barbacoas low-risk (LR; Afro-Colombians) and Cumbal high-risk (HR; Amerindian- Mestizos). Methods We analysed 200 individuals from these populations, categorised into NACG or GPL based on histopathology. Total DNA from gastric biopsies was used to sequence the 16S rRNA gene-V4 using the Illumina MiSeq platform. Microbial diversity and composition was assessed based on municipality, histopathological grouping and H.pylori infection status. Results Barbacoas showed greater microbial richness, evenness, and Shannon’s diversity compared to Cumbal in the absence of H.pylori reads (p<0.001). In Barbacoas (LR), alpha diversity metrics were stable from NACG to GPL, while in Cumbal (HR), richness significantly increased in GPL (p<0.0001). Beta diversity analysis revealed significant differences in microbial composition based on municipality, explaining 26.2% of the variation (p<0.0001). The main taxa contributing to the compositional differences between Barbacoas and Cumbal were Streptococcus, Lacticaseibacillus, Pseudomonas, and Staphylococcus. H.pylori infection was more prevalent in Barbacoas (83.8%) than Cumbal (69.7%) (p<0.05). Differences in microbial composition were also observed between H.pylori positive and negative individuals in both populations (p<0.05). Conclusion The dysbiotic patterns from NACG to GPL associated with H.pylori infection followed an ecological model in both populations. Barbacoas showed stable gastric microbiota during histological transition, whereas Cumbal exhibited disturbed microbiota with increased richness. Streptococcus, Lacticaseibacillus, Pseudomonas, and Staphylococcus, may impact GC risk. [ABSTRACT FROM AUTHOR]

Published
2024

48. Defined microbiota transplant restores Th17/RORγt+regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas

Author

Britton, Graham J., primary, Contijoch, Eduardo J., additional, Spindler, Matthew P., additional, Aggarwala, Varun, additional, Dogan, Belgin, additional, Bongers, Gerold, additional, San Mateo, Lani, additional, Baltus, Andrew, additional, Das, Anuk, additional, Gevers, Dirk, additional, Borody, Thomas J., additional, Kaakoush, Nadeem O., additional, Kamm, Michael A., additional, Mitchell, Hazel, additional, Paramsothy, Sudarshan, additional, Clemente, Jose C., additional, Colombel, Jean-Frederic, additional, Simpson, Kenneth W., additional, Dubinsky, Marla C., additional, Grinspan, Ari, additional, and Faith, Jeremiah J., additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results