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27 results on '"Kabir, Shaila"'

4. An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity

Author

Tithi, Tanzia Islam, primary, Tahsin, Md. Rafat, additional, Anjum, Juhaer, additional, Zaman, Tasnuva Sharmin, additional, Aktar, Fahima, additional, Bahar, Nasiba Binte, additional, Tasnim, Sabiha, additional, Sultana, Arifa, additional, Jahan, Ishrat, additional, Afrin, Syeda Sadia, additional, Akter, Tahmina, additional, Sen, Priyanka, additional, Koly, Fahima Jannat, additional, Reza, Md. Selim, additional, Chowdhury, Jakir Ahmed, additional, Kabir, Shaila, additional, Chowdhury, Abu Asad, additional, and Amran, Md. Shah, additional

Published
2023
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9. Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment

Author

Rasel, Md. Shamiul Islam, primary, Mohona, Farhana Afrin, additional, Akter, Wahida, additional, Kabir, Shaila, additional, Chowdhury, Abu Asad, additional, Chowdhury, Jakir Ahmed, additional, Hassan, Md. Abul, additional, Al Mamun, Abdullah, additional, Ghose, Dipayon Krisna, additional, Ahmad, Zubair, additional, Khan, Farhat S., additional, Bari, Md. Fazlul, additional, Rahman, Md. Sohanur, additional, and Amran, Md. Shah, additional

Published
2022
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12. In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

Author

Tahsin, Md. Rafat, Tithi, Tanzia Islam, Mim, Sabiha Rahman, Haque, Ehfazul, Sultana, Arifa, Bahar, Nasiba Binte, Ahmed, Raju, Chowdhury, Jakir Ahmed, Chowdhury, Abu Asad, Kabir, Shaila, Aktar, Fahima, Uddin, Md. Sahab, Amran, Md. Shah, Tahsin, Md. Rafat, Tithi, Tanzia Islam, Mim, Sabiha Rahman, Haque, Ehfazul, Sultana, Arifa, Bahar, Nasiba Binte, Ahmed, Raju, Chowdhury, Jakir Ahmed, Chowdhury, Abu Asad, Kabir, Shaila, Aktar, Fahima, Uddin, Md. Sahab, and Amran, Md. Shah

Abstract

Background: Diabetes mellitus is one of the most notable health dilemmas. Analyzing plants for new antidiabetic remedies has become an impressive territory for life science researchers. Gynura procumbens has long been used to treat diabetes. Thus, we strived to ascertain the hypoglycemic potentiality of extract of leaves of G. procumbens by in vivo and in silico approaches. Methods: Fresh leaves of G. procumbens were collected and shade-dried to prepare ethanolic extracts to evaluate pharmacological parameters. Diabetes was induced in rats via injecting alloxan through the intraperitoneal route at a dose of 150 mg/kg body weight. Humalyzer 3000 was used to perform a biochemical assay of collected samples from rats. Anti-hyperglycemic activity study along with overdose toxicity test was performed. The pharmacological activity of this plant was also evaluated through a molecular docking study. This in silico study investigated the binding affinity of natural ligands from G. procumbens against glycoside hydrolase enzymes. Results: We detected a peak plasma concentration of G. procumbens at 3 hours 45 minutes that is roughly similar to the peak plasma concentration of metformin. Again, in OGTT and anti-hyperglycemic tests, it has been ascertained that both plant extract and metformin can exert significant P < 0.05 and highly significant P < 0.01 hypoglycemic activity in a dose-dependent manner. Metformin exhibited better therapeutic efficacy than that of plant extract, but it possessed null statistical significance. Also, our safety profile expressed that, similar to metformin, the plant extract can restore the disturbed pathological state in a dose-oriented approach with a wide safety margin. In silico study also validated the potentialities of natural constituents of G. procumbens. Conclusion: This study suggested that G. procumbens can be considered as potential antidiabetic plant. Robust and meticulous investigation regarding plant chemistry and pharmacology i

Published
2022
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13. In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

Author

Tahsin, Md. Rafat, primary, Tithi, Tanzia Islam, additional, Mim, Sabiha Rahman, additional, Haque, Ehfazul, additional, Sultana, Arifa, additional, Bahar, Nasiba Binte, additional, Ahmed, Raju, additional, Chowdhury, Jakir Ahmed, additional, Chowdhury, Abu Asad, additional, Kabir, Shaila, additional, Aktar, Fahima, additional, Uddin, Md. Sahab, additional, and Amran, Md. Shah, additional

Published
2022
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14. A Retrospective Cross-Sectional Study Assessing Self-Reported Adverse Events following Immunization (AEFI) of the COVID-19 Vaccine in Bangladesh

Author

Sultana, Arifa, primary, Shahriar, Saimon, additional, Tahsin, Md. Rafat, additional, Mim, Sabiha Rahman, additional, Fatema, Kazi Rubiya, additional, Saha, Ananya, additional, Yesmin, Fahmida, additional, Bahar, Nasiba Binte, additional, Samodder, Mithun, additional, Mamun, Md. Ariful Haque, additional, Aknur Rahman, Md., additional, Ferdousy, Sonia, additional, Akter, Tahmina, additional, Aktar, Fahima, additional, Kuddus, Md. Ruhul, additional, Rahman, Md. Mustafizur, additional, Sarker, Md. Moklesur Rahman, additional, Büyüker, Sultan Mehtap, additional, Chowdhury, Jakir Ahmed, additional, Chowdhury, Abu Asad, additional, Kabir, Shaila, additional, Hossain, Md. Akter, additional, and Amran, Md. Shah, additional

Published
2021
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16. A Retrospective Cross-Sectional Study Assessing Self-Reported Adverse Events following Immunization (AEFI) of the COVID-19 Vaccine in Bangladesh

Author

Sultana, Arifa, Shahriar, Saimon, Tahsin, Md. Rafat, Mim, Sabiha Rahman, Fatema, Kazi Rubiya, Saha, Ananya, Yesmin, Fahmida, Bahar, Nasiba Binte, Samodder, Mithun, Mamun, Md. Ariful Haque, Aknur Rahman, Md., Ferdousy, Sonia, Akter, Tahmina, Aktar, Fahima, Kuddus, Md. Ruhul, Rahman, Md. Mustafizur, Sarker, Md. Moklesur Rahman, Buyuker, Sultan Mehtap, Chowdhury, Jakir Ahmed, Chowdhury, Abu Asad, Kabir, Shaila, Hossain, Md. Akter, Amran, Md. Shah, Sultana, Arifa, Shahriar, Saimon, Tahsin, Md. Rafat, Mim, Sabiha Rahman, Fatema, Kazi Rubiya, Saha, Ananya, Yesmin, Fahmida, Bahar, Nasiba Binte, Samodder, Mithun, Mamun, Md. Ariful Haque, Aknur Rahman, Md., Ferdousy, Sonia, Akter, Tahmina, Aktar, Fahima, Kuddus, Md. Ruhul, Rahman, Md. Mustafizur, Sarker, Md. Moklesur Rahman, Buyuker, Sultan Mehtap, Chowdhury, Jakir Ahmed, Chowdhury, Abu Asad, Kabir, Shaila, Hossain, Md. Akter, and Amran, Md. Shah

Abstract

Background: The Oxford-AstraZeneca vaccine (Covishield) was the first to be introduced in Bangladesh to fight the ongoing global COVID-19 pandemic. As this vaccine had shown some side-effects in its clinical trial, we aimed to conduct a study assessing short-term adverse events following immunization (AEFIs) in Bangladesh. Method: A cross-sectional study was conducted on social and electronic media platforms by delivering an online questionnaire among people who had taken at least one dose of the COVID-19 vaccine. The collected data were then analysed to evaluate various parameters related to the AEFIs of the respondents. Results: A total of 626 responses were collected. Of these, 623 were selected based on complete answers and used for the analysis. Most of the respondents were between 30-60 years of age, and 40.4% were female. We found that a total of 8.5% of the total respondents had been infected with the SARS-CoV-2 virus. Our survey revealed that out of 623 volunteers, 317 reported various side-effects after taking the vaccine, which is about 50.88% of the total participants. The majority of participants (37.07%, 231/623) reported swelling and pain at the injection site and fever (25.84%, 162/623); these were some of the common localized and generalized symptoms after the COVID-19 vaccine administration. Conclusion: The side-effects reported after receiving the Oxford-AstraZeneca vaccine (Covishield) are similar to those reported in clinical trials, demonstrating that the vaccines have a safe therapeutic window. Moreover, further research is needed to determine the efficacy of existing vaccines in preventing SARS-CoV-2 infections or after-infection hospitalization.

Published
2021
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27. A Survey on Antimicrobial Sensitivity Pattern of Different Antibiotics on Clinical Isolates of Escherichia coli Collected from Dhaka City, Bangladesh.

Author

Shahriar, Mohammad, Hossain, Mahboob, and Kabir, Shaila

Abstract

A study of antimicrobial sensitivity of Escherichia coli isolated from clinical sources of Medinova Diagnostic Center and Popular Diagnostic Center, Dhaka, Bangladesh was carried out to facilitate the preference of drug in the management of Escherichia coli induced symptoms. Very low sensitivity of E. coli towards ampicillin (4%), aztreonam (4%), cloxacillin (5%), nalidixic acid (5%), ciprofloxacin (7.5%), ceftriaxone (12.5%), doxycycline (12.5%), ceftazidime (16.25%), co-trimoxazole (20%), chloramphenicol (22.51%), tetracycline (25%), and netilmicin (35%) was observed. Higher sensitivity pattern was observed for gentamicin (56%) and only imipenem (95%) has shown sensitivity pattern possibly susceptible enough to consider for the management of E. coli induced cases in the area under study. The low sensitivity to different antimicrobial could be attributed to their prevailing usage and abuse in the area under study. [ABSTRACT FROM AUTHOR]

Published
2010

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