15 results on '"Kaufmann, Brigitte C."'
Search Results
2. Intracortical recordings reveal vision-to-action cortical gradients driving human exogenous attention
- Author
-
Seidel Malkinson, Tal, Bayle, Dimitri J., Kaufmann, Brigitte C., Liu, Jianghao, Bourgeois, Alexia, Lehongre, Katia, Fernandez-Vidal, Sara, Navarro, Vincent, Lambrecq, Virginie, Adam, Claude, Margulies, Daniel S., Sitt, Jacobo D., and Bartolomeo, Paolo
- Published
- 2024
- Full Text
- View/download PDF
3. Severity-dependent interhemispheric white matter connectivity predicts post-stroke neglect recovery
- Author
-
Kaufmann, Brigitte C, primary, Pastore-Wapp, Manuela, additional, Bartolomeo, Paolo, additional, Geiser, Nora, additional, Nyffeler, Thomas, additional, and Cazzoli, Dario, additional
- Published
- 2024
- Full Text
- View/download PDF
4. Severity-Dependent Interhemispheric White Matter Connectivity Predicts Poststroke Neglect Recovery.
- Author
-
Kaufmann, Brigitte C., Pastore-Wapp, Manuela, Bartolomeo, Paolo, Geiser, Nora, Nyffeler, Thomas, and Cazzoli, Dario
- Subjects
- *
UNILATERAL neglect , *DIFFUSION tensor imaging , *STROKE patients , *NEUROREHABILITATION , *WHITE matter (Nerve tissue) - Abstract
Left-sided spatial neglect is a very common and challenging issue after right-hemispheric stroke, which strongly and negatively affects daily living behavior and recovery of stroke survivors. The mechanisms underlying recovery of spatial neglect remain controversial, particularly regarding the involvement of the intact, contralesional hemisphere, with potential contributions ranging from maladaptive to compensatory. In the present prospective, observational study, we assessed neglect severity in 54 right-hemispheric stroke patients (32 male; 22 female) at admission to and discharge from inpatient neurorehabilitation. We demonstrate that the interaction of initial neglect severity and spared white matter (dis)connectivity resulting from individual lesions (as assessed by diffusion tensor imaging, DTI) explains a significant portion of the variability of poststroke neglect recovery. In mildly impaired patients, spared structural connectivity within the lesioned hemisphere is sufficient to attain good recovery. Conversely, in patients with severe impairment, successful recovery critically depends on structural connectivity within the intact hemisphere and between hemispheres. These distinct patterns, mediated by their respective white matter connections, may help to reconcile the dichotomous perspectives regarding the role of the contralesional hemisphere as exclusively compensatory or not. Instead, they suggest a unified viewpoint wherein the contralesional hemisphere can - but must not necessarily - assume a compensatory role. This would depend on initial impairment severity and on the available, spared structural connectivity. In the future, our findings could serve as a prognostic biomarker for neglect recovery and guide patient-tailored therapeutic approaches. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Causal evidence for the multiple-demand brain network: it takes three to tango
- Author
-
Kaufmann, Brigitte C, primary, Cazzoli, Dario, additional, Nyffeler, Thomas, additional, and Bartolomeo, Paolo, additional
- Published
- 2023
- Full Text
- View/download PDF
6. A case study of left visual neglect after right pontine lesion: pathophysiological evidence for the infratentorial involvement in human visual attention
- Author
-
Cazzoli, Dario, primary, Kaufmann, Brigitte C, additional, Rühe, Henrik, additional, Geiser, Nora, additional, Vanbellingen, Tim, additional, and Nyffeler, Thomas, additional
- Published
- 2023
- Full Text
- View/download PDF
7. Joint impact on attention, alertness and inhibition of lesions at a frontal white matter crossroad
- Author
-
Kaufmann, Brigitte C, primary, Cazzoli, Dario, additional, Pastore-Wapp, Manuela, additional, Vanbellingen, Tim, additional, Pflugshaupt, Tobias, additional, Bauer, Daniel, additional, Müri, René M, additional, Nef, Tobias, additional, Bartolomeo, Paolo, additional, and Nyffeler, Thomas, additional
- Published
- 2022
- Full Text
- View/download PDF
8. Joint impact on attention, alertness and inhibition of lesions at a frontal white matter crossroad.
- Author
-
Kaufmann, Brigitte C, Cazzoli, Dario, Pastore-Wapp, Manuela, Vanbellingen, Tim, Pflugshaupt, Tobias, Bauer, Daniel, Müri, René M, Nef, Tobias, Bartolomeo, Paolo, and Nyffeler, Thomas
- Subjects
- *
WHITE matter (Nerve tissue) , *COGNITION , *WAKEFULNESS , *LARGE-scale brain networks , *PRINCIPAL components analysis , *CRANIOPHARYNGIOMA , *ECOLOGICAL momentary assessments (Clinical psychology) - Abstract
In everyday life, information from different cognitive domains—such as visuospatial attention, alertness and inhibition—needs to be integrated between different brain regions. Early models suggested that completely segregated brain networks control these three cognitive domains. However, more recent accounts, mainly based on neuroimaging data in healthy participants, indicate that different tasks lead to specific patterns of activation within the same, higher-order and 'multiple-demand' network. If so, then a lesion to critical substrates of this common network should determine a concomitant impairment in all three cognitive domains. The aim of the present study was to critically investigate this hypothesis, i.e. to identify focal stroke lesions within the network that can concomitantly affect visuospatial attention, alertness and inhibition. We studied an unselected sample of 60 first-ever right-hemispheric, subacute stroke patients using a data-driven, bottom-up approach. Patients performed 12 standardized neuropsychological and oculomotor tests, four per cognitive domain. A principal component analysis revealed a strong relationship between all three cognitive domains: 10 of 12 tests loaded on a first, common component. Analysis of the neuroanatomical lesion correlates using different approaches (i.e. voxel-based and tractwise lesion-symptom mapping, disconnectome maps) provided convergent evidence on the association between severe impairment of this common component and lesions at the intersection of superior longitudinal fasciculus II and III, frontal aslant tract and, to a lesser extent, the putamen and inferior fronto-occipital fasciculus. Moreover, patients with a lesion involving this region were significantly more impaired in daily living cognition, which provides an ecological validation of our results. A probabilistic functional atlas of the multiple-demand network was performed to confirm the potential relationship between patients' lesion substrates and observed cognitive impairments as a function of the multiple-demand network connectivity disruption. These findings show, for the first time, that a lesion to a specific white matter crossroad can determine a concurrent breakdown in all three considered cognitive domains. Our results support the multiple-demand network model, proposing that different cognitive operations depend on specific collaborators and their interaction, within the same underlying neural network. Our findings also extend this hypothesis by showing (i) the contribution of superior longitudinal fasciculus and frontal aslant tract to the multiple-demand network; and (ii) a critical neuroanatomical intersection, crossed by a vast amount of long-range white matter tracts, many of which interconnect cortical areas of the multiple-demand network. The vulnerability of this crossroad to stroke has specific cognitive and clinical consequences; this has the potential to influence future rehabilitative approaches. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
9. Video-Oculography During Free Visual Exploration to Detect Right Spatial Neglect in Left-Hemispheric Stroke Patients With Aphasia: A Feasibility Study
- Author
-
Kaufmann, Brigitte C., Cazzoli, Dario, Koenig-Bruhin, Monica, Müri, René M., Nef, Tobias, Nyffeler, Thomas, University of Bern, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Luzerner Kantonsspital [Lucerne, Switzerland], Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Gestionnaire, Hal Sorbonne Université
- Subjects
video-oculography ,General Neuroscience ,[SDV]Life Sciences [q-bio] ,610 Medicine & health ,aphasia ,[SDV] Life Sciences [q-bio] ,right spatial visual neglect ,mean gaze position ,visual exploration behaviour ,570 Life sciences ,biology ,left-hemispheric stroke ,Neuroscience ,Original Research ,free visual exploration - Abstract
International audience; Spatial neglect has been shown to occur in 17-65% of patients after acute left-hemispheric stroke. One reason for this varying incidence values might be that left-hemispheric stroke is often accompanied by aphasia, which raises difficulties in assessing attention deficits with conventional neuropsychological tests entailing verbal instructions. Video-oculography during free visual exploration (FVE) requires only little understanding of simple non-verbal instruction and has been shown to be a sensitive and reliable tool to detect spatial neglect in patients with right-hemispheric stroke. In the present study, we aimed to investigate the feasibility of FVE to detect neglect in 10 left-hemispheric stroke patients with mild to severe aphasia as assessed by means of the Token Test, Boston Naming Test and Aachener Aphasie Test. The patient's individual deviation between eye movement calibration and validation was recorded and compared to 20 age-matched healthy controls. Furthermore, typical FVE parameters such as the landing point of the first fixation, the mean gaze position (in ° of visual angle), the number and duration of visual fixations and the mean visual exploration area were compared between groups. In addition, to evaluate for neglect, the Bells cancellation test was performed and neglect severity in daily living was measured by means of the Catherine Bergego Scale (CBS). Our results showed that the deviation between calibration and validation did not differ between aphasia patients and healthy controls highlighting its feasibility. Furthermore, FVE revealed the typical neglect pattern with a significant leftward shift in visual exploration bahaviour, which highly correlated with neglect severity as assessed with CBS. The present study provides evidence that FVE has the potential to be used as a neglect screening tool in left-hemispheric stroke patients with aphasia in which compliance with verbal test instructions may be compromised by language deficits.
- Published
- 2021
- Full Text
- View/download PDF
10. Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet
- Author
-
Cazzoli, Dario, primary, Kaufmann, Brigitte C, additional, Paladini, Rebecca E, additional, Müri, René M, additional, Nef, Tobias, additional, and Nyffeler, Thomas, additional
- Published
- 2020
- Full Text
- View/download PDF
11. Immersive 3D Virtual Reality Cancellation Task for Visual Neglect Assessment: A Pilot Study
- Author
-
Knobel, Samuel E. J., Kaufmann, Brigitte C., Gerber, Stephan M., Cazzoli, Dario, Müri, René M., Nyffeler, Thomas, and Nef, Tobias
- Subjects
610 Medicine & health ,Human Neuroscience ,immersive virtual reality ,stroke ,head-mounted display ,Behavioral Neuroscience ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Neurology ,570 Life sciences ,biology ,visual neglect ,cancellation task ,Biological Psychiatry ,Original Research - Abstract
Background: Unilateral spatial neglectis an attention disorder frequently occurring after a right-hemispheric stroke. Neglect results in a reduction in qualityof life and performance in activities of daily living. With current technical improvements in virtual reality (VR) technology, trainingwith stereoscopic head-mounted displays (HMD) has become a promising new approach for the assessment and the rehabilitation of neglect. The focus of this pilot study was to develop and evaluate a simple visual search task in VR for HMD. The VR system was tested regarding feasibility, acceptance, and potential adverse effects in healthy controls and right-hemispheric stroke patients with and without neglect. Methods: The VR system consisted of two main components, a head-mounted display to present the virtual environment, and a hand-held controller for the interaction with the latter. The task followed the rationale of diagnostic paper-pencil cancellation tasks; i.e., the participants were asked to search targets among distractors. However, instead of a two-dimensional setup, the targets and distractors were arranged in three dimensions, in a sphere around the subject inside its field of view. Usability and acceptance of the task, as well as the performance in the latter, were tested in 15 right-hemispheric subacute stroke patients (10 of whom with and five of whom without unilateral spatial neglect; mean age: 67.1 ± 10.5 years) and 35 age-matched healthy controls. Results: System usability and acceptance were rated as high both in stroke patients and healthy controls, close to the maximum score of the questionnaire scale. No relevant adverse effects occurred. There was a high correlation (r = 0.854, p = 0.002) between the Center of Cancellation [an objective neglect measure) calculated from a paper-pencil cancellation task (Sensitive Neglect Test (SNT)] and the newly developed VR cancellation task. Conclusion: Overall, the developed visual search task in the tested VR system is feasible, well-accepted, enjoyable, and does not evoke any significant negative effects, both for healthy controls and for stroke patients. Findings for task performance show that the ability of the VR cancellation to detect neglect in stroke patients is similar to paper-pencil cancellation tasks.
- Published
- 2020
- Full Text
- View/download PDF
12. The right anterior temporal lobe critically contributes to magnitude knowledge
- Author
-
Pflugshaupt, Tobias, primary, Bauer, Daniel, additional, Frey, Julia, additional, Vanbellingen, Tim, additional, Kaufmann, Brigitte C, additional, Bohlhalter, Stephan, additional, and Nyffeler, Thomas, additional
- Published
- 2020
- Full Text
- View/download PDF
13. Theta burst stimulation in neglect after stroke: functional outcome and response variability origins
- Author
-
Nyffeler, Thomas, primary, Vanbellingen, Tim, additional, Kaufmann, Brigitte C, additional, Pflugshaupt, Tobias, additional, Bauer, Daniel, additional, Frey, Julia, additional, Chechlacz, Magdalena, additional, Bohlhalter, Stephan, additional, Müri, René M, additional, Nef, Tobias, additional, and Cazzoli, Dario, additional
- Published
- 2019
- Full Text
- View/download PDF
14. Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet
- Author
-
Cazzoli, Dario, Kaufmann, Brigitte C., Paladini, Rebecca E., Müri, René M., Nef, Tobias, and Nyffeler, Thomas
- Subjects
570 Life sciences ,biology ,10. No inequality ,610 Medicine & health - Abstract
The clinical link between spatial and non-spatial attentional aspects in patients with hemispatial neglect is well known; in particular, an increase in alerting can transitorily help to allocate attention towards the contralesional side. In models of attention, this phenomenon is postulated to rely on an interaction between ventral and dorsal cortical networks, subtending non-spatial and spatial attentional aspects, respectively. However, the exact neural underpinnings of the interaction between these two networks are still poorly understood. In the present study, we included 80 right-hemispheric patients with subacute stroke (50% women; age range: 24–96), 33 with and 47 without neglect, as assessed by paper–pencil cancellation tests. The patients performed a computerized task in which they were asked to respond as quickly as possible by button-press to central targets, which were either preceded or not preceded by non-spatial, auditory warning tones. Reaction times in the two different conditions were measured. In neglect patients, a warning tone, enhancing activity within the ventral attentional ‘alerting’ network, could boost the reaction (in terms of shorter reaction times) of the dorsal attentional network to a visual stimulus up to the level of patients without neglect. Critically, using voxel-based lesion-symptom mapping analyses, we show that this effect significantly depends on the integrity of the right anterior insula and adjacent inferior frontal gyrus, i.e., right-hemispheric patients with lesions involving these areas were significantly less likely to show shorter reaction times when a warning tone was presented prior to visual target appearance. We propose that the right anterior insula and inferior frontal gyrus are a critical hub through which the ventral attentional network can ‘alert’ and increase the efficiency of the activity of the dorsal attentional network.
15. The right anterior temporal lobe critically contributes to magnitude knowledge
- Author
-
Pflugshaupt, Tobias, Bauer, Daniel, Frey, Julia, Vanbellingen, Tim, Kaufmann, Brigitte C., Bohlhalter, Stephan, and Nyffeler, Thomas
- Subjects
10. No inequality ,610 Medicine & health - Abstract
Cognitive estimation is a mental ability applied to solve numerical problems when precise facts are unknown, unavailable or impractical to calculate. It has been associated with several underlying cognitive components, most often with executive functions and semantic memory. Little is known about the neural correlates of cognitive estimation. To address this issue, the present cross-sectional study applied lesion-symptom mapping in a group of 55 patients with left hemineglect due to right-hemisphere stroke. Previous evidence suggests a high prevalence of cognitive estimation impairment in these patients, as they might show a general bias towards large magnitudes. Compared to 55 age- and gender-matched healthy controls, the patient group demonstrated impaired cognitive estimation. However, the expected large magnitude bias was not found. Lesion-symptom mapping related their general estimation impairment predominantly to brain damage in the right anterior temporal lobe. Also critically involved were the right uncinate fasciculus, the anterior commissure and the right inferior frontal gyrus. The main findings of this study emphasize the role of semantic memory in cognitive estimation, with reference to a growing body of neuroscientific literature postulating a transmodal hub for semantic cognition situated in the bilateral anterior temporal lobe. That such semantic hub function may also apply to numerical knowledge is not undisputed. We here propose a critical contribution of the right anterior temporal lobe to at least one aspect of number processing, i.e. the knowledge about real-world numerical magnitudes.
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.