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The results on the effect of three decade long term application of chemical fertilizers and amendments on the yield of continuous maize-wheat crop rotation in an acid alfisol at Palampur revealed that continuous omission of essential nutrients in a maize-wheat sequence resulted in an appreciable decline in the grain yield of maize and wheat crops. A remarkable reduction in crop yield was noticed in plots where nitrogen was applied alone. Use of recommended level of N alone through urea had deleterious effect on crop productivity. The continuous exhaustionof native pools of K in 100% NP treated plots appreciably reduced percent grain yield. Application of farmyard manure (FYM) and lime along with NPK fertilizers increased the crop yield. The integrated use of optimal dose of NPK and FYM give better and more sustainable yields.