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Rationale and Objectives The aim of this study was to determine whether resident performance in head ultrasound on neonates improves following brain phantom simulation training. Materials and Methods Ten junior radiology residents with at least one year of radiology training were divided into two equal groups. Both groups received a detailed head ultrasound protocol sheet and observed a technologist perform a head ultrasound on a neonatal patient at the beginning of their first pediatric radiology rotation. Both groups of residents also received teaching with a brain phantom model. Group A residents independently performed one head ultrasound exam, subsequently received phantom simulation training, and then performed a post-training head ultrasound exam. Group B residents received phantom simulation training prior to their first head ultrasound exam. Three pediatric radiologists independently and blindly reviewed the ultrasound images of each head ultrasound exam for proficiency of image acquisition using a validated scoring system. Scores of Group A residents prior to phantom training were compared to their scores after phantom training as well as to scores of Group B residents using simple linear regression. Results There was a statistically significant improvement in the performance of head ultrasound on neonates when comparing the same residents pre- and postphantom training (p = 0.003). Residents who initially trained with the phantom performed significantly better on their first head ultrasound examination on a neonate than those residents who did not (p = 0.005). Conclusion Our novel head ultrasound phantom training model significantly improves radiology resident performance of head ultrasound on neonates and may, therefore, be beneficial for residency education.

The present work deals with the experimental and numerical investigation of melting process of phase change material used for low temperature thermal energy storage applications. Thermal energy storage is a good solution to bridge the gap between energy supply and energy demand. The unconstrained melting of paraffin wax having melting range of 570C to 610C was studied in simple spherical glass capsule. The objective of the subject work is to perform the experimental and numerical analysis of melting process in spherical capsule subjected to constant wall temperature. Ansys Fluent 18 is used for computation purpose. In experimental analysis, melting process was observed through visual capturing of interface between solid and liquid. Melting fraction and temperature at the centre of PCM capsule are monitored both experimentally and numerically. Good consistency in results were observed.

The destabilization of endothelial nitric-oxide synthase (eNOS) mRNA in hypoxic endothelial cells may be important in the etiology of vascular diseases, such as pulmonary hypertension. Recently, an overlapping antisense transcript to eNOS/NOS3 was implicated in the post-transcriptional regulation of eNOS. We demonstrate here that expression of sONE, also known as eNOS antisense (NOS3AS) or autophagy 9-like 2 (APG9L2), is robustly induced by hypoxia or functional deficiency of von Hippel-Lindau protein. sONE is also up-regulated in the aortas of hypoxic rats. In hypoxic endothelial cells, sONE expression negatively correlates with eNOS expression. Blocking the hypoxic induction of sONE by RNA interference attenuates the fall in both eNOS RNA and protein. We provide evidence that the induction of sONE primarily involves transcript stabilization rather than increased transcriptional activity and is von Hippel-Lindaubut not hypoxia-inducible factor 2alpha-dependent. We also demonstrate that sONE transcripts are enriched in the nucleus of normoxic cells and that hypoxia promotes an increase in the level of cytoplasmic and polyribosome-associated, sONE mRNA. The finding that eNOS expression can be regulated by an overlapping cis-antisense transcript in a stimulus-dependent fashion provides evidence that sense/antisense interactions may play a previously unappreciated role in vascular disease pathogenesis.

[Figure][1] Image courtesy of ©2010 Jupiterimages Corp. > I try and spy with my little eye, > > Your age, your sex, the name you go by, > > The type of exam, position you’re in, > > Comparison films? Oh good, let’s begin. > Next time can you take a bigger “big breath?” > > I