15 results on '"Keogh I"'
Search Results
2. Treating Rhinitis with Topical Nasal Sprays: Patient Knowledge, Use and Satisfaction.
- Author
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Corbett, M., Garry, S., Gloughlin, E. Mc, Hinchion, K., and Keogh, I.
- Published
- 2020
3. Human Papilloma Virus- Associated Head and Neck Cancer: A 21st Century Pandemic; Assessing Student Awareness and Knowledge.
- Author
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Kavanagh, F. G., McNamara, A. T., Fopohunda, O., and Keogh, I. J.
- Published
- 2018
4. Missense mutations in the BCS1L gene as a cause of the Bjornstad syndrome
- Author
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Hinson, J.T., Fantin, V.R., Schonberger, J., Breivik, N., Siem, G., McDonough, B., Sharma, P., Keogh, I., Godinho, R., Santos, F., Esparza, A., Nicolau, Y., Selvaag, E., Cohen, B.H., Hoppel, C.L., Tranebjærg, Lisbeth, Eavey, R.D., Seidman, J.G., Seidman, C.E., Hinson, J.T., Fantin, V.R., Schonberger, J., Breivik, N., Siem, G., McDonough, B., Sharma, P., Keogh, I., Godinho, R., Santos, F., Esparza, A., Nicolau, Y., Selvaag, E., Cohen, B.H., Hoppel, C.L., Tranebjærg, Lisbeth, Eavey, R.D., Seidman, J.G., and Seidman, C.E.
- Abstract
Udgivelsesdato: 2007/2/22
- Published
- 2007
5. High-flow nasal oxygen as an adjunct for the safe removal of impacted metallic upper airway foreign bodies.
- Author
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van den Berg N, Aly M, Callaghan M, and Keogh I
- Abstract
Foreign body airway obstruction is considered an airway emergency and is a challenging clinical scenario for both the otolaryngologist and the anaesthetist. We present three cases of impacted upper airway metallic foreign bodies. Supra-glottic airways were obstructed and precarious. Apnoeic oxygenation utilizing high-flow nasal oxygen (HFNO), a form of tubeless anaesthetic, was used in all three cases, leading to the safe removal of the foreign bodies. Increased training, awareness and equipment availability to provide HFNO apnoeic oxygenation in the emergency setting for otolaryngology airway procedures will lead to better outcomes for patients and decreases the risk of a potential surgical airway., Competing Interests: No conflicts of interest. Informed patient consents obtained., (Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2023.)
- Published
- 2023
- Full Text
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6. Instrumentation failure during microlaryngoscopy.
- Author
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van den Berg N, Corbett M, Cleere E, and Keogh I
- Abstract
Equipment failure can be a cause of morbidity during surgical procedures. We present two cases where a broken surgical instrument, a heart-shaped curved micro-grasper, colloquially termed 'sweetheart' micro-forceps, compromised patient safety during microlaryngoscopy. We discuss the importance of thorough safety protocols and communication between team members to mitigate this risk. Microinstruments used during microlaryngoscopy are at risk of failure or breakage due to their small size. Surgeons must be alert to the risk of equipment failure during surgery as a potential cause of patient morbidity. In our patient, loss of the broken instrument in the respiratory tract could have resulted in iatrogenic aspiration, respiratory infection and would have necessitated rigid bronchoscopy for removal. Instruments and equipment must checked and communicated by the surgical team before and after use to prevent potential patient morbidity., (Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2022.)
- Published
- 2022
- Full Text
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7. 'A Down and Out Eye': Case Report of a Primary Ethmoid Mucocele.
- Author
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James D, Garry S, Corbett M, and Keogh I
- Abstract
Paranasal sinus mucoceles are benign, locally expansile masses of the paranasal sinuses that are lined by epithelial cells. They result from obstruction of sinus ostia. The close proximity of paranasal sinus mucoceles to the orbit and skull base predisposing the patient to significant morbidity. We describe the case of a previously healthy 23-year-old gentleman presenting with a five-day history of unilateral (left) eye pain and swelling with an obvious deformity. There was also no history of trauma or prior surgery. He underwent a CT sinus, which showed near complete opacification of the left anterior ethmoid sinus with bony destruction and obvious displacement of the orbit both laterally and anteriorly. This was assessed as to be in keeping with an ethmoid mucocele. Endoscopic marsupialization has become the preferred surgical approach over obliterative procedures for the treatment of paranasal sinus mucoceles. Primary ethmoid mucocele is an uncommon entity, especially in the absence of prior ear, nose and throat (ENT) complaints, and therefore should remain an important differential when a patient presents with a unilateral swelling causing proptosis., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, James et al.)
- Published
- 2021
- Full Text
- View/download PDF
8. A fifteen-year review of skin allergy testing in Irish patients with symptomatic rhinitis.
- Author
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Nae A, Hinchion K, and Keogh IJ
- Abstract
Objective: Our objective was to review skin prick allergy testing (SPAT) results in patients with symptomatic rhinitis in an Irish population., Methods: A fifteen-year retrospective review of our database of symptomatic patients with rhinitis was performed. All patients who had SPAT performed during this interval were included. Data was analysed in terms of demographics and dominant allergens., Results: 1158 patients were included. 617 Females vs 541 Males. Age range five to eighty-five years old. Mean age thirty-four years. 49% of our patients tested positive to at least one aeroallergen. The most common allergens were dust mites (23%) and timothy grass (22%). Patients born during the Irish pollen season (April-July) were between 5 and 7 times more likely to be sensitive to timothy and ryegrass pollens compared to others tested. 241 patients had both SPAT and serum allergen specific IgE testing (SASIgET) performed; positive results were consistent between both groups., Conclusion: Results demonstrated that half of our patients with symptomatic rhinitis had allergen sensitisation. Dust mites and grass were the main allergens in our area. Our nurse led clinic has allowed efficient patient education and the development of a unique Irish SPAT database. Retesting a patient with a known allergy test result it is not indicated., Competing Interests: Authors have no funding, financial or other conflicts of interest, including competing interests to disclose. This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors., (© 2020 The Authors.)
- Published
- 2020
- Full Text
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9. Human Papilloma Virus- Associated Head and Neck Cancer: A 21st Century Pandemic; Assessing Student Awareness and Knowledge
- Author
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Kavanagh FG, McNamara AT, Fopohunda O, and Keogh IJ
- Subjects
- Adolescent, Adult, Female, Head and Neck Neoplasms prevention & control, Humans, Ireland epidemiology, Male, Middle Aged, Papillomavirus Infections prevention & control, Papillomavirus Infections virology, Surveys and Questionnaires, Universities statistics & numerical data, Vaccination, Young Adult, Awareness, Head and Neck Neoplasms etiology, Head and Neck Neoplasms virology, Immunization Programs, Knowledge, Papillomaviridae pathogenicity, Papillomavirus Infections complications, Papillomavirus Vaccines, Students psychology, Students statistics & numerical data
- Abstract
Background The Human Papillomavirus (HPV) is a causal agent in a subset of Head and Neck Cancers (HNC) being diagnosed in younger patients without significant tobacco and alcohol use. This survey assessed the awareness level of HNC and HPV vaccinations in university students. Methods An anonymous, questionnaire-based survey of registered students of the National University of Ireland, Galway (NUIG) was carried out. Results 1,550 responded, 1,494 completed the survey; 1,018 female (68.1%), 476 male (31.9%). 63% had never heard the term HNC. 45% had never heard the term HPV. 69% were unaware of how one would be exposed to HPV. 84% were unaware of the association between HNC and HPV. Conclusions There are poor levels of awareness of HNC, HPV and HPV vaccination. HPV vaccination needs to be appreciated as a major cancer breakthrough. However the public health benefits of increased awareness of HPV, HNC and HPV vaccination have yet to be realised., Competing Interests: The authors have no conflicts of interest to declare.
- Published
- 2018
10. Identifying and reducing risks in functional endoscopic sinus surgery through a hierarchical task analysis.
- Author
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Corbett M, O'Connor P, Byrne D, Thornton M, and Keogh I
- Abstract
Objective: To develop a hierarchical task listing of steps required to perform successful Functional Endoscopic Sinus Surgery (FESS). To complete a technical and human factor analysis of tasks resulting in the identification of errors, frequency of occurrence, severity, and reduction through remediation., Methods: A triangulation of methods was used in order to derive the steps required to complete a FESS: 1) a literature review was carried out of published descriptions of FESS techniques; 2) observations of three FESS; 3) interviews with surgeons on FESS techniques. Data sets were combined to develop a task analysis of a correct approach to conducting FESS. A review by 12 surgeons, and observation of 25 FESS resulted in refinement of the task analysis. With input from five consultant surgeons and one consultant anesthetist, a Systematic Human Error Reduction and Prediction Approach (SHERPA) was used to identify the risks and mitigating steps in FESS., Results: Ten tasks and 49 subtasks required for a correct approach to completing FESS were identified based on literature review and expert consensus. A risk score for each subtask was calculated from a suitable risk matrix. Risk reduction methods at each subtask were detailed. High-scoring subtasks were evaluated and varying strategies examined to reduce the likelihood and mitigate the impact of error. The study demonstrates the usefulness of the HTA and SHERPA approach in standardization and optimization of clinical practice in order to improve patient safety., Conclusion: Hierarchical Task Analysis and SHERPA are valuable tools to deconstruct expert performance and to highlight potential errors in FESS. The HTA and SHERPA approach to surgical procedures are useful learning and assessment tools for novice surgeons. The information derived offers the opportunity to improve surgical training and enhance patient safety by identifying high-risk steps in the procedure, and how risk can be mitigated., Level of Evidence: 2c Outcomes Research.
- Published
- 2018
- Full Text
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11. Dual plasmonic gold nanostars for photoacoustic imaging and photothermal therapy.
- Author
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Raghavan V, O'Flatharta C, Dwyer R, Breathnach A, Zafar H, Dockery P, Wheatley A, Keogh I, Leahy M, and Olivo M
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- Animals, Cell Line, Tumor, Gold chemistry, Humans, Metal Nanoparticles chemistry, Mice, Neoplasms diagnosis, Neoplasms diagnostic imaging, Xenograft Model Antitumor Assays, Metal Nanoparticles therapeutic use, Neoplasms therapy, Photoacoustic Techniques, Phototherapy
- Abstract
Aim: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer., Materials & Methods: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice., Results & Conclusion: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS. The in vivo photothermal capability of DPGNS resulted in a significant decrease in the tumor cellular area. DPGNS exhibited potential for single node diagnosis and therapy with longer wavelength facilitating deeper imaging and therapy.
- Published
- 2017
- Full Text
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12. Eosinophilic Angiocentric Fibrosis as a Stenosing Lesion in the Subglottis.
- Author
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Keogh I, O'Connell R, Hynes S, and Lang J
- Abstract
Subglottic Eosinophilic Angiocentric Fibrosis (EAF) is an extremely rare disease of an elusive aetiology. It is chronically progressive benign condition that causes narrowing of the subglottic region leading to dysphonia and airway compromise. The diagnosis is historical and imaging is nonspecific. We report a case xc of 56-year-old lady referred to our institution with globus sensation, hoarseness, and mild stridor. Incidental subglottic mass was found at time of diagnostic microlaryngoscopy and biopsy confirmed subglottic EAF. All laboratory investigations were unremarkable. Lesion was removed with laryngeal microdebrider and three courses of intravenous dexamethasone were administered. Patient's postoperative period was uneventful and had remained disease free for 1 year. To date, no consensus has been reached on the optimal treatment of subglottic EAF. We recommend regular follow-up to detect early recurrence., Competing Interests: The authors declare that they have no competing interests.
- Published
- 2017
- Full Text
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13. Appraisal of the peri-hospital management and evolving microbiology of peritonsillar abscess disease.
- Author
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Ryan S, Papanikolaou V, and Keogh I
- Subjects
- Adolescent, Adult, Child, Community Health Services, Female, Hospitalization, Humans, Incidence, Ireland epidemiology, Male, Middle Aged, Peritonsillar Abscess diagnosis, Practice Patterns, Physicians', Referral and Consultation, Retrospective Studies, Young Adult, Peritonsillar Abscess microbiology, Peritonsillar Abscess therapy, Primary Health Care
- Abstract
Objectives: Peritonsillar abscess (PTA) is a common complication of tonsillitis, yet there is limited consensus regarding its management and epidemiology. Current issues include pre-hospital care provided by general practitioners (GP) in the community (ii) the lack of standardized protocols for in-patient management and (iii) the role of routine microbiology studies in patients with PTA. We performed a retrospective review of confirmed cases of PTA presenting to a west of Ireland tertiary referral center to evaluate the peri-hospital management and role of microbiology studies in such cases., Methodology: Retrospective chart review of 200 confirmed cases of peritonsillar abscess., Results: The annual incidence of PTA in the west of Ireland population was 14/100,000. Pre-hospital treatment given by Primary Care Physicians (PCP) was often deficient with 84 (42%) patients receiving no treatment prior to hospital referral. Needle aspiration was the most common technique used to drain the PTA 142 (71%). Anaerobes were isolated in 54 (27%) of cases demonstrating an increasing importance of these bacteria in PTA disease. Metronidazole with either benzylpenicillin 72 (36%), or co-amoxiclav 82 (41%), was the most common empiric antibiotics used. Successful treatment of all cases of PTA with the use of empiric antibiotics was achieved before results arising from microbiology became available., Conclusion: The epidemiology of PTA is not well described. We have described the epidemiology for PTA disease in the west of Ireland population for the first time. Needle aspiration was the most common drainage technique used. Empiric antibiotic treatment based on clinical response is advised with antibiotics effective against aerobic and anaerobic bacteria recommended.
- Published
- 2014
14. Surgical checklists: the human factor.
- Author
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O'Connor P, Reddin C, O'Sullivan M, O'Duffy F, and Keogh I
- Abstract
Background: Surgical checklists has been shown to improve patient safety and teamwork in the operating theatre. However, despite the known benefits of the use of checklists in surgery, in some cases the practical implementation has been found to be less than universal. A questionnaire methodology was used to quantitatively evaluate the attitudes of theatre staff towards a modified version of the World Health Organisation (WHO) surgical checklist with relation to: beliefs about levels of compliance and support, impact on patient safety and teamwork, and barriers to the use of the checklist., Methods: Using the theory of planned behaviour as a framework, 14 semi-structured interviews were conducted with theatre personnel regarding their attitudes towards, and levels of compliance with, a checklist. Based upon the interviews, a 27-item questionnaire was developed and distribute to all theatre personnel in an Irish hospital., Results: Responses were obtained from 107 theatre staff (42.6% response rate). Particularly for nurses, the overall attitudes towards the effect of the checklist on safety and teamworking were positive. However, there was a lack of rigour with which the checklist was being applied. Nurses were significantly more sensitive to the barriers to the use of the checklist than anaesthetists or surgeons. Moreover, anaesthetists were not as positively disposed to the surgical checklist as surgeons and nurse. This finding was attributed to the tendency for the checklist to be completed during a period of high workload for the anaesthetists, resulting in a lack of engagement with the process., Conclusion: In order to improve the rigour with which the surgical checklist is applied, there is a need for: the involvement of all members of the theatre team in the checklist process, demonstrated support for the checklist from senior personnel, on-going education and training, and barriers to the implementation of the checklist to be addressed.
- Published
- 2013
- Full Text
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15. Advances in bio-optical imaging for the diagnosis of early oral cancer.
- Author
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Olivo M, Bhuvaneswari R, and Keogh I
- Abstract
Oral cancer is among the most common malignancies worldwide, therefore early detection and treatment is imperative. The 5-year survival rate has remained at a dismal 50% for the past several decades. The main reason for the poor survival rate is the fact that most of the oral cancers, despite the general accessibility of the oral cavity, are not diagnosed until the advanced stage. Early detection of the oral tumors and its precursor lesions may be the most effective means to improve clinical outcome and cure most patients. One of the emerging technologies is the use of non-invasive in vivo tissue imaging to capture the molecular changes at high-resolution to improve the detection capability of early stage disease. This review will discuss the use of optical probes and highlight the role of optical imaging such as autofluorescence, fluorescence diagnosis (FD), laser confocal endomicroscopy (LCE), surface enhanced Raman spectroscopy (SERS), optical coherence tomography (OCT) and confocal reflectance microscopy (CRM) in early oral cancer detection. FD is a promising method to differentiate cancerous lesions from benign, thus helping in the determination of adequate resolution of surgical resection margin. LCE offers in vivo cellular imaging of tissue structures from surface to subsurface layers and has demonstrated the potential to be used as a minimally invasive optical biopsy technique for early diagnosis of oral cancer lesions. SERS was able to differentiate between normal and oral cancer patients based on the spectra acquired from saliva of patients. OCT has been used to visualize the detailed histological features of the oral lesions with an imaging depth down to 2-3 mm. CRM is an optical tool to noninvasively image tissue with near histological resolution. These comprehensive diagnostic modalities can also be used to define surgical margin and to provide a direct assessment of the therapeutic effectiveness.
- Published
- 2011
- Full Text
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