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3. Adaptive radiotherapy: The Elekta Unity MR-linac concept

Author

Winkel, Dennis, Bol, Gijsbert H., Kroon, Petra S., van Asselen, Bram, Hackett, Sara S., Werensteijn-Honingh, Anita M., Intven, Martijn P.W., Eppinga, Wietse S.C., Tijssen, Rob H.N., Kerkmeijer, Linda G.W., de Boer, Hans C.J., Mook, Stella, Meijer, Gert J., Hes, Jochem, Willemsen-Bosman, Mirjam, de Groot-van Breugel, Eline N., Jürgenliemk-Schulz, Ina M., and Raaymakers, Bas W.

Published
2019
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5. An ESTRO-ACROP guideline on quality assurance and medical physics commissioning of online MRI guided radiotherapy systems based on a consensus expert opinion

Author

Klinische Fysica RT, Cancer, Tanadini-Lang, Stephanie, Budgell, Geoff, Bohoudi, Omar, Corradini, Stefanie, Cusumano, Davide, Güngör, Görkem, Kerkmeijer, Linda G.W., Mahmood, Faisal, Nill, Simeon, Palacios, Miguel A., Reiner, Michael, Thorwarth, Daniela, Wilke, Lotte, Wolthaus, Jochem, Klinische Fysica RT, Cancer, Tanadini-Lang, Stephanie, Budgell, Geoff, Bohoudi, Omar, Corradini, Stefanie, Cusumano, Davide, Güngör, Görkem, Kerkmeijer, Linda G.W., Mahmood, Faisal, Nill, Simeon, Palacios, Miguel A., Reiner, Michael, Thorwarth, Daniela, Wilke, Lotte, and Wolthaus, Jochem

Published
2023

6. Genomic classifiers in personalized prostate cancer radiation therapy approaches: a systematic review and future perspectives based on international consensus

Author

Tilki, Derya, Spohn, Simon K.B.; Draulans, Cédric; Kishan, Amar U.; Spratt, Daniel; Ross, Ashley; Maurer, Tobias; Berlin, Alejandro; Blanchard, Pierre; Collins, Sean; Bronsert, Peter; Chen, Ronald; Pra, Alan Dal; de Meerleer, Gert; Eade, Thomas; Haustermans, Karin; Hölscher, Tobias; Höcht, Stefan; Ghadjar, Pirus; Davicioni, Elai; Heck, Matthias; Kerkmeijer, Linda G.W.; Kirste, Simon; Tselis, Nikolaos; Tran, Phuoc T.; Pinkawa, Michael; Pommier, Pascal; Deltas, Constantinos; Schmidt-Hegemann, Nina-Sophie; Wiegel, Thomas; Zilli, Thomas; Tree, Alison C.; Qiu, Xuefeng; Murthy, Vedang; Epstein, Jonathan I.; Graztke, Christian; Gao, Xin; Grosu, Anca L.; Kamran, Sophia C.; Zamboglou, Constantinos, Koç University Hospital, School of Medicine, Tilki, Derya, Spohn, Simon K.B.; Draulans, Cédric; Kishan, Amar U.; Spratt, Daniel; Ross, Ashley; Maurer, Tobias; Berlin, Alejandro; Blanchard, Pierre; Collins, Sean; Bronsert, Peter; Chen, Ronald; Pra, Alan Dal; de Meerleer, Gert; Eade, Thomas; Haustermans, Karin; Hölscher, Tobias; Höcht, Stefan; Ghadjar, Pirus; Davicioni, Elai; Heck, Matthias; Kerkmeijer, Linda G.W.; Kirste, Simon; Tselis, Nikolaos; Tran, Phuoc T.; Pinkawa, Michael; Pommier, Pascal; Deltas, Constantinos; Schmidt-Hegemann, Nina-Sophie; Wiegel, Thomas; Zilli, Thomas; Tree, Alison C.; Qiu, Xuefeng; Murthy, Vedang; Epstein, Jonathan I.; Graztke, Christian; Gao, Xin; Grosu, Anca L.; Kamran, Sophia C.; Zamboglou, Constantinos, Koç University Hospital, and School of Medicine

Abstract

Current risk-stratification systems for prostate cancer (PCa) do not sufficiently reflect the disease heterogeneity. Genomic classifiers (GC) enable improved risk stratification after surgery, but less data exist for patients treated with definitive radiation therapy (RT) or RT in oligo-/metastatic disease stages. To guide future perspectives of GCs for RT, we conducted (1) a systematic review on the evidence of GCs for patients treated with RT and (2) a survey of experts using the Delphi method, addressing the role of GCs in personalized treatments to identify relevant fields of future clinical and translational research. We performed a systematic review and screened ongoing clinical trials on ClinicalTrials.gov. Based on these results, a multidisciplinary international team of experts received an adapted Delphi method survey. Thirty-one and 30 experts answered round 1 and round 2, respectively. Questions with ?75% agreement were considered relevant and included in the qualitative synthesis. Evidence for GCs as predictive biomarkers is mainly available to the postoperative RT setting. Validation of GCs as prognostic markers in the definitive RT setting is emerging. Experts used GCs in patients with PCa with extensive metastases (30%), in postoperative settings (27%), and in newly diagnosed PCa (23%). Forty-seven percent of experts do not currently use GCs in clinical practice. Expert consensus demonstrates that GCs are promising tools to improve risk-stratification in primary and oligo-/metastatic patients in addition to existing classifications. Experts were convinced that GCs might guide treatment decisions in terms of RT-field definition and intensification/deintensification in various disease stages. This work confirms the value of GCs and the promising evidence of GC utility in the setting of RT. Additional studies of GCs as prognostic biomarkers are anticipated and form the basis for future studies addressing predictive capabilities of GCs to optimize RT and, European Union (EU); Horizon 2020; Research and Innovation Programme; German Federal Ministry of Education and Research (BMBF); ERA PER Joint Funding Call 2019; A.T. acknowledges support from Cancer Research UK (C33589/A28284 and C7224/A28724 CRUK RadNet). This project represents independent research supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at the Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. We thank Fotini Miltiadous for administrative support. ; Funding text 3: Disclosures: A.U.K. reports funding support from grant P50CA09213 from the Prostate Cancer National Institutes of Health Specialized Programs of Research Excellence and grant W81XWH-22-1-0044 from the Department of Defense, as well as grant RSD1836 from the Radiologic Society of North America, the STOP Cancer organization, the Jonsson Comprehensive Cancer Center, and the Prostate Cancer Foundation. C.Z. received funding from the Klaus Tschira foundation, Naslund Medical, and from the German Research Foundation. C.Z. received speaker fees from Johnson & Johnson and Novocure, all outside the submitted work. E.D. is an employee of Veracyte, manufacturer of Decipher. A.R. is a consultant and/or speaker for Astellas, Bayer, Pfizer, Blue Earth, Lantheus, Janssen, Tempus, and Veracyte. X.G. is on the consulting/advisory board for Bayer, Myovant, and Guardant Health.

Published
2023

8. Patterns of Failure Following External Beam Radiotherapy With or Without an Additional Focal Boost in the Randomized Controlled FLAME Trial for Localized Prostate Cancer

Author

Trialbureau Beeld, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, MS Radiotherapie, Groen, Veerle H., Haustermans, Karin, Pos, Floris J., Draulans, Cédric, Isebaert, Sofie, Monninkhof, Evelyn M., Smeenk, Robert J., Kunze-Busch, Martina, de Boer, Johannes C.J., van der Voort van Zijp, Jochem, Kerkmeijer, Linda G.W., van der Heide, Uulke A., Trialbureau Beeld, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, MS Radiotherapie, Groen, Veerle H., Haustermans, Karin, Pos, Floris J., Draulans, Cédric, Isebaert, Sofie, Monninkhof, Evelyn M., Smeenk, Robert J., Kunze-Busch, Martina, de Boer, Johannes C.J., van der Voort van Zijp, Jochem, Kerkmeijer, Linda G.W., and van der Heide, Uulke A.

Published
2022

9. Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Author

Trialbureau Beeld, Cancer, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Radiotherapie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Divisie Beeld, Groen, Veerle H., Zuithoff, Nicolaas P.A., van Schie, Marcel, Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Hans C.J., van der Voort van Zyp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., Kerkmeijer, Linda G.W., Trialbureau Beeld, Cancer, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Radiotherapie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Divisie Beeld, Groen, Veerle H., Zuithoff, Nicolaas P.A., van Schie, Marcel, Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Hans C.J., van der Voort van Zyp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., and Kerkmeijer, Linda G.W.

Published
2021

10. Lutetium-177-PSMA-617 in Low-Volume Hormone-Sensitive Metastatic Prostate Cancer: A Prospective Pilot Study

Author

Privé, Bastiaan M., primary, Peters, Steffie M.B., additional, Muselaers, Constantijn H.J., additional, van Oort, Inge M., additional, Janssen, Marcel J.R., additional, Sedelaar, J.P. Michiel, additional, Konijnenberg, Mark W., additional, Zámecnik, Patrik, additional, Uijen, Maike J.M., additional, Schilham, Melline G.M., additional, Eek, Annemarie, additional, Scheenen, Tom W.J., additional, Verzijlbergen, J. Fred, additional, Gerritsen, Winald R., additional, Mehra, Niven, additional, Kerkmeijer, Linda G.W., additional, Smeenk, Robert J., additional, Somford, Diederik M., additional, van Basten, Jean-Paul A., additional, Heskamp, Sandra, additional, Barentsz, Jelle O., additional, Gotthardt, Martin, additional, Witjes, J. Alfred, additional, and Nagarajah, James, additional

Published
2021
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11. Delivered dose quantification in prostate radiotherapy using online 3D cine imaging and treatment log files on a combined 1.5T magnetic resonance imaging and linear accelerator system

Author

Klinische Fysica RT, Kwaliteit Radiotherapie, Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Onderzoek Radiotherapie, Experimentele klinische fysica, Kontaxis, Charis, de Muinck Keizer, Daan M., Kerkmeijer, Linda G.W., Willigenburg, Thomas, den Hartogh, Mariska D., van der Voort van Zyp, Jochem R.N., de Groot-van Breugel, Eline N., Hes, Jochem, Raaymakers, Bas W., Lagendijk, Jan J.W., de Boer, Hans C.J., Klinische Fysica RT, Kwaliteit Radiotherapie, Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Onderzoek Radiotherapie, Experimentele klinische fysica, Kontaxis, Charis, de Muinck Keizer, Daan M., Kerkmeijer, Linda G.W., Willigenburg, Thomas, den Hartogh, Mariska D., van der Voort van Zyp, Jochem R.N., de Groot-van Breugel, Eline N., Hes, Jochem, Raaymakers, Bas W., Lagendijk, Jan J.W., and de Boer, Hans C.J.

Published
2020

12. Planning feasibility of extremely hypofractionated prostate radiotherapy on a 1.5 T magnetic resonance imaging guided linear accelerator

Author

Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Experimentele klinische fysica, den Hartogh, Mariska D., de Boer, Hans C.J., de Groot-van Breugel, Eline N., van der Voort van Zyp, Jochem R.N., Hes, Jochem, van der Heide, Uulke A., Pos, Floris, Haustermans, Karin, Depuydt, Tom, Jan Smeenk, Robert, Kunze-Busch, Martina, Raaymakers, Bas W., Kerkmeijer, Linda G.W., Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Experimentele klinische fysica, den Hartogh, Mariska D., de Boer, Hans C.J., de Groot-van Breugel, Eline N., van der Voort van Zyp, Jochem R.N., Hes, Jochem, van der Heide, Uulke A., Pos, Floris, Haustermans, Karin, Depuydt, Tom, Jan Smeenk, Robert, Kunze-Busch, Martina, Raaymakers, Bas W., and Kerkmeijer, Linda G.W.

Published
2019

13. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Vollenbrock, Sophie E., primary, Nowee, Marlies E., additional, Voncken, Francine E.M., additional, Kotte, Alexis N.T.J., additional, Goense, Lucas, additional, van Rossum, Peter S.N., additional, van Lier, Astrid L.H.M.W., additional, Heijmink, Stijn W., additional, Bartels-Rutten, Annemarieke, additional, Wessels, Frank J., additional, Aleman, Berthe M.P., additional, Dewit, Luc, additional, Kerkmeijer, Linda G.W., additional, Jansen, Edwin P.M., additional, Intven, Martijn, additional, Lips, Irene M., additional, Meijer, Gert J., additional, and Nijkamp, Jasper, additional

Published
2019
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14. Standard whole prostate gland radiotherapy with and without lesion boost in prostate cancer : Toxicity in the FLAME randomized controlled trial

Author

Monninkhof, Evelyn M., van Loon, Juliette W.L., van Vulpen, Marco, Kerkmeijer, Linda G.W., Pos, Floris J., Haustermans, Karin, van den Bergh, Laura, Isebaert, Sofie, McColl, Gill M., Jan Smeenk, Robert, Noteboom, Juus, Walraven, Iris, Peeters, Petra H.M., van der Heide, Uulke A., Monninkhof, Evelyn M., van Loon, Juliette W.L., van Vulpen, Marco, Kerkmeijer, Linda G.W., Pos, Floris J., Haustermans, Karin, van den Bergh, Laura, Isebaert, Sofie, McColl, Gill M., Jan Smeenk, Robert, Noteboom, Juus, Walraven, Iris, Peeters, Petra H.M., and van der Heide, Uulke A.

Published
2018

15. Characterization of the first RF coil dedicated to 1.5 T MR guided radiotherapy

Author

Hoogcarspel, Stan J., Zijlema, Stefan E., Tijssen, Rob H.N., Kerkmeijer, Linda G.W., Jürgenliemk-Schulz, Ina M., Lagendijk, Jan J.W., Raaymakers, Bas W., Hoogcarspel, Stan J., Zijlema, Stefan E., Tijssen, Rob H.N., Kerkmeijer, Linda G.W., Jürgenliemk-Schulz, Ina M., Lagendijk, Jan J.W., and Raaymakers, Bas W.

Published
2018

16. Standard whole prostate gland radiotherapy with and without lesion boost in prostate cancer: Toxicity in the FLAME randomized controlled trial

Author

Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Onderzoek Radiotherapie, MS Radiotherapie, Arts-assistenten Radiotherapie, Monninkhof, Evelyn M., van Loon, Juliette W.L., van Vulpen, Marco, Kerkmeijer, Linda G.W., Pos, Floris J., Haustermans, Karin, van den Bergh, Laura, Isebaert, Sofie, McColl, Gill M., Jan Smeenk, Robert, Noteboom, Juus, Walraven, Iris, Peeters, Petra H.M., van der Heide, Uulke A., Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Onderzoek Radiotherapie, MS Radiotherapie, Arts-assistenten Radiotherapie, Monninkhof, Evelyn M., van Loon, Juliette W.L., van Vulpen, Marco, Kerkmeijer, Linda G.W., Pos, Floris J., Haustermans, Karin, van den Bergh, Laura, Isebaert, Sofie, McColl, Gill M., Jan Smeenk, Robert, Noteboom, Juus, Walraven, Iris, Peeters, Petra H.M., and van der Heide, Uulke A.

Published
2018

17. Characterization of the first RF coil dedicated to 1.5 T MR guided radiotherapy

Author

Experimentele klinische fysica, Cancer, Computational Imaging, Fysica Radiotherapie Research, Klinische Fysica RT, MS Radiotherapie, Hoogcarspel, Stan J., Zijlema, Stefan E., Tijssen, Rob H.N., Kerkmeijer, Linda G.W., Jürgenliemk-Schulz, Ina M., Lagendijk, Jan J.W., Raaymakers, Bas W., Experimentele klinische fysica, Cancer, Computational Imaging, Fysica Radiotherapie Research, Klinische Fysica RT, MS Radiotherapie, Hoogcarspel, Stan J., Zijlema, Stefan E., Tijssen, Rob H.N., Kerkmeijer, Linda G.W., Jürgenliemk-Schulz, Ina M., Lagendijk, Jan J.W., and Raaymakers, Bas W.

Published
2018

18. Superior target delineation for stereotactic body radiotherapy of bone metastases from renal cell carcinoma on MRI compared to CT

Author

Prins, Fieke M., Van Der Velden, Joanne M., Gerlich, Anne S., Kotte, Alexis N.T.J., Eppinga, Wietse S.C., Kasperts, Nicolien, Verlaan, Jorrit J., Pameijer, Frank A., Kerkmeijer, Linda G.W., Prins, Fieke M., Van Der Velden, Joanne M., Gerlich, Anne S., Kotte, Alexis N.T.J., Eppinga, Wietse S.C., Kasperts, Nicolien, Verlaan, Jorrit J., Pameijer, Frank A., and Kerkmeijer, Linda G.W.

Published
2017

20. Effect of intra-fraction motion on the accumulated dose for free-breathing MR-guided stereotactic body radiation therapy of renal-cell carcinoma

Author

Stemkens, Bjorn, Glitzner, Markus, Kontaxis, Charis, De Senneville, Baudouin Denis, Prins, Fieke M, Crijns, Sjoerd P.M., Kerkmeijer, Linda G.W., Lagendijk, Jan J.W., Van Den Berg, Cornelis A.T., Tijssen, Rob H.N., Stemkens, Bjorn, Glitzner, Markus, Kontaxis, Charis, De Senneville, Baudouin Denis, Prins, Fieke M, Crijns, Sjoerd P.M., Kerkmeijer, Linda G.W., Lagendijk, Jan J.W., Van Den Berg, Cornelis A.T., and Tijssen, Rob H.N.

Published
2017

21. Superior target delineation for stereotactic body radiotherapy of bone metastases from renal cell carcinoma on MRI compared to CT

Author

Onderzoek Radiotherapie, Cancer, Arts-assistenten Radiotherapie, Klinische Fysica RT, MS Radiotherapie, MS Orthopaedie Spine, Regenerative Medicine and Stem Cells, MS Radiologie, Prins, Fieke M., Van Der Velden, Joanne M., Gerlich, Anne S., Kotte, Alexis N.T.J., Eppinga, Wietse S.C., Kasperts, Nicolien, Verlaan, Jorrit J., Pameijer, Frank A., Kerkmeijer, Linda G.W., Onderzoek Radiotherapie, Cancer, Arts-assistenten Radiotherapie, Klinische Fysica RT, MS Radiotherapie, MS Orthopaedie Spine, Regenerative Medicine and Stem Cells, MS Radiologie, Prins, Fieke M., Van Der Velden, Joanne M., Gerlich, Anne S., Kotte, Alexis N.T.J., Eppinga, Wietse S.C., Kasperts, Nicolien, Verlaan, Jorrit J., Pameijer, Frank A., and Kerkmeijer, Linda G.W.

Published
2017

22. Effect of intra-fraction motion on the accumulated dose for free-breathing MR-guided stereotactic body radiation therapy of renal-cell carcinoma

Author

Kwaliteit Radiotherapie, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, Researchgr. Beeldg. Moleculaire Interv., Onderzoek Radiotherapie, MS Radiotherapie, Stemkens, Bjorn, Glitzner, Markus, Kontaxis, Charis, De Senneville, Baudouin Denis, Prins, Fieke M, Crijns, Sjoerd P.M., Kerkmeijer, Linda G.W., Lagendijk, Jan J.W., Van Den Berg, Cornelis A.T., Tijssen, Rob H.N., Kwaliteit Radiotherapie, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, Researchgr. Beeldg. Moleculaire Interv., Onderzoek Radiotherapie, MS Radiotherapie, Stemkens, Bjorn, Glitzner, Markus, Kontaxis, Charis, De Senneville, Baudouin Denis, Prins, Fieke M, Crijns, Sjoerd P.M., Kerkmeijer, Linda G.W., Lagendijk, Jan J.W., Van Den Berg, Cornelis A.T., and Tijssen, Rob H.N.

Published
2017

23. Renal Cell Carcinoma: Alternative Nephron-Sparing Treatment Options for Small Renal Masses, a Systematic Review

Author

Onderzoek Radiotherapie, Cancer, MS Radiotherapie, MS Radiologie, Circulatory Health, Zorgeenheid Urologie Zorg, MS Urologische Oncologie, Urologie Medisch volwassenen, Prins, Fieke M., Kerkmeijer, Linda G.W., Pronk, Anne A, Vonken, Evert Jan P.A., Meijer, Richard P., Bex, Axel, Barendrecht, Maurits M, Onderzoek Radiotherapie, Cancer, MS Radiotherapie, MS Radiologie, Circulatory Health, Zorgeenheid Urologie Zorg, MS Urologische Oncologie, Urologie Medisch volwassenen, Prins, Fieke M., Kerkmeijer, Linda G.W., Pronk, Anne A, Vonken, Evert Jan P.A., Meijer, Richard P., Bex, Axel, and Barendrecht, Maurits M

Published
2017

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