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5. RACIAL AND ETHNIC DISPARITIES IN INFERIOR VENA CAVA FILTER PLACEMENT FOR DEEP VEIN THROMBOSIS IN THE UNITED STATES

Author

Juarez, Jordan Jared, primary, Khalid, Muhammad Umar, additional, Ulloa, Bianca, additional, Romero, Carlos Manuel, additional, Maruthi, Rohit, additional, Chang, Eric, additional, Shafi, Irfan, additional, Lakhter, Vladimir, additional, Zhao, Huaqing, additional, Pérez-Stable, Eliseo J., additional, and Bashir, Riyaz, additional

Published
2023
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14. A Decade of Drug Development through Phase-1 Trials; Systematic Review of Literature for Novel Drugs and Targets in Multiple Myeloma

Author

Deen, Imad Ud, Khalid, Muhammad Umar, Russ, Atlantis Dawn, Hua, Anh, Iftikhar, Ahmad, Mushtaq, Adeela, Safdar, Ahmad, McBride, Ali, and Anwer, Faiz

Abstract

Introduction:Multiple Myeloma (MM) remains an incurable malignancy but response rates are reaching 90% with induction chemotherapy. Despite improved therapy, majority of the patients still face relapse and drug resistance (Korteum KM et al, 2014). There has been significant advancement in drug development for MM with the introduction of many new classes of drugs such as proteasome inhibitors, Immunomodulatory agents, histone deacetylase (HDAC) inhibitors, surface molecule targeting antibodies, intracellular transduction inhibitors and chimeric antigen T cells (CAR-T). The purpose of our study is to systematically summarize the drugs and targets tested through phase I during the last 10 years and their potential mechanisms of actions (MOA).

Published
2017
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15. Early pandemic in-hospital outcomes and mortality risk factors in COVID-19 solid organ transplant patients.

Author

Alhuneafat L, Khalid MU, Jabri A, Deicke MD, Virk S, Jacobs MW, Hsich E, Alqarqaz M, Dunlap ME, Kassis-George H, and Link C

Abstract

Background: Solid organ transplant (SOT) recipients with COVID-19 have a higher risk of mortality than those without COVID-19. However, it is unclear how SOT patient outcomes compare to the general population without SOT who contract COVID-19., Methods: We used the National Inpatient Sample from January to December 2020 to investigate inpatient outcomes seen in SOT recipients after contracting COVID-19 compared to nontransplant patients. We identified our study sample using ICD-10 CM and excluded those <18 years of age and those with dual organ transplants. Inpatient outcomes were compared in SOT and non-SOT COVID cohorts, and we further evaluated predictors of mortality in the SOT with COVID population., Results: Out of the 1,416,445 COVID-19 admissions included in the study, 8315 (0.59%) were single SOT recipients. Our analysis that adjusted for multiple baseline characteristics and comorbidities demonstrated that COVID-19 in SOT patients was associated with higher rates of acute kidney injury (adjusted odds ratio [aOR] 2.34, 95% confidence interval [CI] 1.81-3.02, P  < 0.01), lower rates of acute respiratory distress syndrome (aOR 0.68, 95% CI 0.54-0.85, P  < 0.01), and similar rates of cardiac arrest, pulmonary embolism, circulatory shock, cerebrovascular events, and in-hospital mortality. Age >65 was associated with mortality in SOT patients., Conclusion: In this nationally representative sample, SOT patients presenting with COVID-19 experienced similar rates of mortality compared to those without SOT. SOT patients were more likely to develop acute kidney injury. Further research is needed to understand the complex relationship between transplant patient outcomes and COVID-19., Competing Interests: The authors report no funding or conflicts of interest. Central illustration:COVID-19 in-hospital outcomes of mortality in patients with solid organ transplant., (Copyright © 2024 Baylor University Medical Center.)

Published
2024
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