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5 results on '"Kichigin, Ilya"'

1. Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

Author

Lind, Abigail L, Lai, Yvonne YY, Mostovoy, Yulia, Holloway, Alisha K, Iannucci, Alessio, Mak, Angel CY, Fondi, Marco, Orlandini, Valerio, Eckalbar, Walter L, Milan, Massimo, Rovatsos, Michail, Kichigin, Ilya G, Makunin, Alex I, Johnson Pokorná, Martina, Altmanová, Marie, Trifonov, Vladimir A, Schijlen, Elio, Kratochvíl, Lukáš, Fani, Renato, Velenský, Petr, Rehák, Ivan, Patarnello, Tomaso, Jessop, Tim S, Hicks, James W, Ryder, Oliver A, Mendelson, Joseph R, Ciofi, Claudio, Kwok, Pui-Yan, Pollard, Katherine S, and Bruneau, Benoit G

Subjects
Climate Change Impacts and Adaptation, Biological Sciences, Environmental Sciences, Genetics, Cardiovascular, Human Genome, Acclimatization, Animals, Cardiovascular System, Chromosomes, Lizards, Ecology, Evolutionary biology, Environmental management
Abstract

Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.

Published
2019

2. Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

Author

Lind, Abigail L., Lai, Yvonne Y. Y., Mostovoy, Yulia, Holloway, Alisha K., Iannucci, Alessio, Mak, Angel C. Y., Fondi, Marco, Orlandini, Valerio, Eckalbar, Walter L., Milan, Massimo, Rovatsos, Michail, Kichigin, Ilya G., Makunin, Alex I., Johnson Pokorná, Martina, Altmanová, Marie, Trifonov, Vladimir A., Schijlen, Elio, Kratochvíl, Lukáš, Fani, Renato, Velenský, Petr, Rehák, Ivan, Patarnello, Tomaso, Jessop, Tim S., Hicks, James W., Ryder, Oliver A., Mendelson, Joseph R., Ciofi, Claudio, Kwok, Pui-Yan, Pollard, Katherine S., Bruneau, Benoit G., Lind, Abigail L., Lai, Yvonne Y. Y., Mostovoy, Yulia, Holloway, Alisha K., Iannucci, Alessio, Mak, Angel C. Y., Fondi, Marco, Orlandini, Valerio, Eckalbar, Walter L., Milan, Massimo, Rovatsos, Michail, Kichigin, Ilya G., Makunin, Alex I., Johnson Pokorná, Martina, Altmanová, Marie, Trifonov, Vladimir A., Schijlen, Elio, Kratochvíl, Lukáš, Fani, Renato, Velenský, Petr, Rehák, Ivan, Patarnello, Tomaso, Jessop, Tim S., Hicks, James W., Ryder, Oliver A., Mendelson, Joseph R., Ciofi, Claudio, Kwok, Pui-Yan, Pollard, Katherine S., and Bruneau, Benoit G.

Abstract

Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.

Published
2019

3. Additional file 1:Table S1. of Contrasting origin of B chromosomes in two cervids (Siberian roe deer and grey brocket deer) unravelled by chromosome-specific DNA sequencing

Author

Makunin, Alexey, Kichigin, Ilya, Larkin, Denis, O’Brien, Patricia, Ferguson-Smith, Malcolm, Fengtang Yang, Proskuryakova, Anastasiya, Vorobieva, Nadezhda, Chernyaeva, Ekaterina, O’Brien, Stephen, Graphodatsky, Alexander, and Trifonov, Vladimir

Abstract

Bovine BAC clone localization on grey brocket deer chromosomes. Table S2. Repeat family composition. Table S3. Major repeat clusters revealed in chromosome-specific DNA with RepeatExplorer. Figure S1. Insert length distribution for chromosome-specific DNA containing bovine chromosomes 23, 26, 28 and 29) inferred from paired-end read mapping to cattle genome. Figure S2. Fluorescence in situ hybridization of chromosome-specific DNA samples containing mixed bovine chromosomes 23, 26, 28 and 29 (red - CY3) and chromosome 10 (green - FITC) to cattle metaphase and corresponding DAPI staining. Figure S4. Fluorescence in situ hybridization of bovine BAC clone CH240-472E2 to grey brocket deer metaphase and corresponding DAPI staining. (DOC 633Â kb)

Published
2016
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4. Additional file 2: of Contrasting origin of B chromosomes in two cervids (Siberian roe deer and grey brocket deer) unravelled by chromosome-specific DNA sequencing

Author

Makunin, Alexey, Kichigin, Ilya, Larkin, Denis, O’Brien, Patricia, Ferguson-Smith, Malcolm, Fengtang Yang, Proskuryakova, Anastasiya, Vorobieva, Nadezhda, Chernyaeva, Ekaterina, O’Brien, Stephen, Graphodatsky, Alexander, and Trifonov, Vladimir

Abstract

Distance between positions plots. Plots are presented for all chromosomes of reference genomes (canFam3 for CFA12, bosTau7 for BTAMix, CPYB1, CPYB2, and MGOB). Axes: X – ln(distance between consecutive DOP-positions, bp), Y – cumulative chromosome length, bp. Black dots – individual distances, red lines – mean values. (PDF 958 kb)

Published
2016
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5. Contrasting origin of B chromosomes in two cervids (Siberian roe deer and grey brocket deer) unravelled by chromosome-specific DNA sequencing

Author

Makunin, Alexey I., primary, Kichigin, Ilya G., additional, Larkin, Denis M., additional, O’Brien, Patricia C. M., additional, Ferguson-Smith, Malcolm A., additional, Yang, Fengtang, additional, Proskuryakova, Anastasiya A., additional, Vorobieva, Nadezhda V., additional, Chernyaeva, Ekaterina N., additional, O’Brien, Stephen J., additional, Graphodatsky, Alexander S., additional, and Trifonov, Vladimir A., additional

Published
2016
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