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7 results on '"Kim, Jusong"'

1. A Method of Data Augmentation to Train a Small Area Fingerprint Recognition Deep Neural Network with a Normal Fingerprint Database

Author

Kim, JuSong

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract

Fingerprints are popular among the biometric based systems due to ease of acquisition, uniqueness and availability. Nowadays it is used in smart phone security, digital payment and digital locker. The traditional fingerprint matching methods based on minutiae are mainly applicable for large-area fingerprint and the accuracy rate would reduce significantly when dealing with small-area fingerprint from smart phone. There are many attempts to using deep learning for small-area fingerprint recognition, and there are many successes. But training deep neural network needs a lot of datasets for training. There is no well-known dataset for small-area, so we have to make datasets ourselves. In this paper, we propose a method of data augmentation to train a small-area fingerprint recognition deep neural network with a normal fingerprint database (such as FVC2002) and verify it via tests. The experimental results showed the efficiency of our method.

Published
2022

3. A Novel Kinase Inhibitor AX-0085 Inhibits Interferon-γ-Mediated Induction of PD-L1 Expression and Promotes Immune Reaction to Lung Adenocarcinoma Cells

Author

Kim, Jusong, primary, Jang, Haeyeon, additional, Lee, Gyu Jin, additional, Hur, Yelim, additional, Keum, Juhee, additional, Jo, Jung Ki, additional, Yun, Si-Eun, additional, Park, Sung Jun, additional, Park, Young Jun, additional, Choi, Myeong Jun, additional, Kim, Kye-Seong, additional, and Kim, Jaesang, additional

Published
2021
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7. A Novel Kinase Inhibitor AX-0085 Inhibits Interferon-γ-Mediated Induction of PD-L1 Expression and Promotes Immune Reaction to Lung Adenocarcinoma Cells.

Author

Kim, Jusong, Jang, Haeyeon, Lee, Gyu Jin, Hur, Yelim, Keum, Juhee, Jo, Jung Ki, Yun, Si-Eun, Park, Sung Jun, Park, Young Jun, Choi, Myeong Jun, Kim, Kye-Seong, and Kim, Jaesang

Subjects
*KINASE inhibitors, *PROGRAMMED death-ligand 1, *PROGRAMMED cell death 1 receptors, *ADENOCARCINOMA, *LUNGS, *T cells, *ANAPLASTIC lymphoma kinase
Abstract

In this study, we describe a novel kinase inhibitor AX-0085 which can suppress the induction of PD-L1 expression by Interferon-γ (IFN-γ) in lung adenocarcinoma (LUAD) cells. AX-0085 effectively blocks JAK2/STAT1 signaling initiated by IFN-γ treatment and prevents nuclear localization of STAT1. Importantly, we demonstrate that AX-0085 reverses the IFN-γ-mediated repression of T cell activation in vitro and enhances the anti-tumor activity of anti-PD-1 antibody in vivo when used in combination. Finally, transcriptomic analyses indicated that AX-0085 is highly specific in targeting the IFN-γ-pathway, thereby raising the possibility of applying this reagent in combination therapy with checkpoint inhibitor antibodies. It may be particularly relevant in cases in which PD-L1-mediated T cell exhaustion leads to immunoevasive phenotypes. [ABSTRACT FROM AUTHOR]

Published
2022
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