Search

Your search keyword '"King, Melanie"' showing total 37 results
Start Over Author "King, Melanie" Search Limiters Full Text
37 results on '"King, Melanie"'

3. Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author

Farrar, Daniel S., Drouin, Olivier, Moore Hepburn, Charlotte, Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin Thibodeau, Melanie, Orkin, Julia, Ouldali, Naïm, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Proulx-Gauthier, Jean-Philippe, Purewal, Rupeena, Ricci, Christina, Sadarangani, Manish, Salvadori, Marina I., Thibeault, Roseline, Top, Karina A., Viel-Thériault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Published
2022
Full Text
View/download PDF

4. Sex-based differences in the phenotypic expression and prognosis of idiopathic non-ischaemic cardiomyopathy: a cardiovascular magnetic resonance study

Author

Mallabone, Maggie, primary, Labib, Dina, additional, Abdelhaleem, Ahmed, additional, Dykstra, Steven, additional, Thompson, Richard B, additional, Paterson, D Ian, additional, Thompson, Sam K, additional, Hasanzadeh, Fereshteh, additional, Mikami, Yoko, additional, Rivest, Sandra, additional, Flewitt, Jacqueline, additional, Feng, Yuanchao, additional, Macdonald, Matthew, additional, King, Melanie, additional, Bristow, Michael, additional, Kolman, Louis, additional, Howarth, Andrew G, additional, Lydell, Carmen P, additional, Miller, Robert J H, additional, Fine, Nowell M, additional, and White, James A, additional

Published
2024
Full Text
View/download PDF

6. Biventricular CMR Strain-based Phenotyping for the Prediction of Cardiovascular Outcomes in Cardiac Amyloidosis

Author

Labib, Dina, primary, White, Brooke V, additional, Multani, Asmi, additional, Sarak, Bradley, additional, Dykstra, Steven, additional, Hasanzadeh, Fereshteh, additional, Feng, Yuanchao, additional, MacDonald, Matthew, additional, King, Melanie, additional, Rivest, Sandra, additional, Flewitt, Jacqueline, additional, Howarth, Andrew G., additional, Lydell, Carmen P., additional, Miller, Robert JH, additional, Fine, Nowell M, additional, and White, James A, additional

Published
2024
Full Text
View/download PDF

7. Comparison of Multi-chamber CMR Phenotype and Clinical Outcomes in ATTR versus AL Cardiac Amyloidosis

Author

Labib, Dina, primary, White, Brooke V, additional, Sarak, Bradley, additional, Multani, Asmi, additional, Dykstra, Steven, additional, Hasanzadeh, Fereshteh, additional, Feng, Yuanchao, additional, MacDonald, Matthew, additional, King, Melanie, additional, Rivest, Sandra, additional, Flewitt, Jacqueline, additional, Howarth, Andrew G., additional, Lydell, Carmen P., additional, Miller, Robert JH, additional, Fine, Nowell M, additional, and White, James, additional

Published
2024
Full Text
View/download PDF

8. The realist evaluation of educational technology

Author

King, Melanie R. N.

Subjects
371.33, Realist evaluation, Educational technology, Complex implementations
Abstract

PURPOSE. This thesis considers the best way to address the challenges faced by educators, institutions and funding bodies trying to not only develop and implement educational technology successfully but tackle the challenge of understanding and evidencing what works (and what does not) and why. The aim of the research was to find and validate an evaluation method that provided usable and useful evidence. APPROACH. A range of evaluations were undertaken to elicit the strengths and weaknesses of different approaches, augmented by drawing upon the experiences and outcomes published by others. An analysis of the issues was made and significance of the problem established. The problem being premature timing, unsuitable models, rapid change, complex implementation chains, inconsistent terminology, ideology and marketisation. A tailored realist evaluation framework was proposed as an alternative method and it was tested to evaluate an institutional lecture capture (LC) initiative. FINDINGS. The theory-driven realist approach provided a level of abstraction that helped gather evidence about wider influences and theories of potential future impact of the LC programme and its linked policy. It proved valuable in generating real and practical recommendations for the institution, including what more could be done to improve uptake and support embedding in teaching and learning, from practice, policy and technological points of view. It identified some unanticipated disadvantages of LC as well determining how and when it was most effective. PRACTICAL IMPLICATIONS. A Realist Evaluation of Technology Initiative (RETI) framework has been produced as tool to aid the rapid adoption of the approach. Recommendations for future research and seven guiding principles have been proposed to encourage the formation of a community of realist evaluative researchers in educational technology. ORIGINALITY/VALUE. The rigorous application of a tailored realist evaluation framework (RETI) for educational technology (including the development of two Domain Reference Models) is the primary contribution to new knowledge. This research is significance because it has potential to enable the synthesis of evaluation findings within the sector. This will enable an evidence-base of what works, for whom, in which contexts and why, ultimately benefiting policy-makers and practitioners to support better informed decision making and investment in education.

Published
2017

9. Caracteristiques des hospitalisations au Canada d'enfants ayant contracte une infection aigue par le SRAS-CoV-2 en 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Infection, Health
Abstract

Contexte : Les facteurs de risque de complications graves de l'infection par le SRAS-CoV-2 n'ont pas ete bien etablis chez les enfants. Nous avons voulu decrire les hospitalisations pediatriques associees au SRAS-CoV-2 au Canada et identifier les facteurs de risque de maladie grave. Methodes : Nous avons procede a une etude prospective nationale en utilisant l'infrastructure du Programme canadien de surveillance pediatrique (PCSP). Les hospitalisations d'enfants ayant contracte une infection par le SRAS-CoV-2 confirmee en laboratoire de microbiologie ont ete rapportees du 8 avril au 31 decembre 2020 au moyen de questionnaires hebdomadaires en ligne distribues au reseau du PCSP, qui compte plus de 2800 pediatres. Nous avons categorise les hospitalisations comme suit : liees a la COVID-19, infections decouvertes fortuitement, ou hospitalisations pour des raisons sociales ou de controle des infections, et degage les facteurs de risque associes a la gravite de la maladie chez les patients hospitalises. Resultats : Sur les 264 hospitalisations d'enfants ayant contracte le SRAS-CoV-2 au cours de la periode de l'etude de 9 mois, 150 (56,8 %) ont ete associees a la COVID-19 et 100 (37,9 %o) etaient des cas decouverts fortuitement (admission pour d'autres raisons et decouverte fortuite du SRAS-CoV-2 par depistage positif). Les nourrissons (37,3 %) et les adolescents (29,6 %) representaient la majorite des cas. Parmi les hospitalisations liees a la COVID-19, 52 patients (34,7 %) etaient atteints d'une forme grave de la mala die, dont 42 (28,0 % des cas lies a la COVID-19) ont eu besoin d'une forme d'assistance respiratoire ou hemodynamique, et 59 (39,3 %o) presentaient au moins 1 comorbidite sous-jacente. Les enfants atteints d'obesite, de maladies neurologiques chroniques ou de maladies pulmonaires chroniques, a l'exclusion de l'asthme, etaient plus susceptibles de presenter une forme grave ou critique de la COVID-19. Interpretation : Parmi les enfants hospitalises au Canada chez lesquels on a diagnostique une infection par le SRAS-CoV-2 au debut de la pandemie de COVID-19, la decouverte fortuite du SRAS-CoV-2 a ete frequente. Chez les enfants hospitalises pour une COVID-19 aigue, l'obesite et les comorbidites neurologiques et respiratoires ont ete associees a une gravite accrue., En date du 31 decembre 2020, le Canada comptait 581 427 cas confirmes d'infection par le SRAS-CoV-2 (1). Comme dans d'autres pays, la plupart des infections confirmees ont ete diagnostiquees [...]

Published
2021
Full Text
View/download PDF

10. Bases and Structure Constants of Generalized Splines with Integer Coefficients on Cycles

Author

Bowden, Nealy, Hagen, Sarah, King, Melanie, and Reinders, Stephanie

Subjects
Mathematics - Rings and Algebras, 05E15 (Primary)
Abstract

An integer generalized spline is a set of vertex labels on an edge-labeled graph that satisfy the condition that if two vertices are joined by an edge, the vertex labels are congruent modulo the edge label. Foundational work on these objects comes from Gilbert, Polster, and Tymoczko, who generalize ideas from geometry/topology (equivariant cohomology rings) and algebra (algebraic splines) to develop the notion of generalized splines. Gilbert, Polster, and Tymoczko prove that the ring of splines on a graph can be decomposed in terms of splines on its subgraphs (in particular, on trees and cycles), and then fully analyze splines on trees. Following Handschy-Melnick-Reinders and Rose, we analyze splines on cycles, in our case integer generalized splines. The primary goal of this paper is to establish two new bases for the module of integer generalized splines on cycles: the triangulation basis and the King basis. Unlike bases in previous work, we are able to characterize each basis element completely in terms of the edge labels of the underlying cycle. As an application we explicitly construct the multiplication table for the ring of integer generalized splines in terms of the King basis., Comment: 18 pages

Published
2015

11. Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Children -- Diseases, Pediatric research -- 2020 AD, Hospital patients -- Statistics -- Demographic aspects -- 2020 AD, Health
Abstract

Background: Risk factors for severe outcomes of SARS-CoV-2 infection are not well established in children. We sought to describe pediatric hospital admissions associated with SARS-CoV-2 infection in Canada and identify risk factors for more severe disease. Methods: We conducted a national prospective study using the infrastructure of the Canadian Paediatric Surveillance Program (CPSP). Cases involving children who were admitted to hospital with microbiologically confirmed SARS-CoV-2 infection were reported from Apr. 8 to Dec. 31 2020, through weekly online questionnaires distributed to the CPSP network of more than 2800 pediatricians. We categorized hospital admissions as related to COVID-19, incidental, or for social or infection control reasons and determined risk factors for disease severity in hospital. Results: Among 264 hospital admissions involving children with SARS-CoV-2 infection during the 9-month study period, 150 (56.8%) admissions were related to COVID-19 and 100 (37.9%) were incidental infections (admissions for other reasons and found to be positive for SARS-CoV-2 on screening). Infants (37.3%) and adolescents (29.6%) represented most cases. Among hospital admissions related to COVID-19, 52 (34.7%) had critical disease, 42 (28.0%) of whom required any form of respiratory or hemodynamic support, and 59 (39.3%) had at least 1 underlying comorbidity. Children with obesity, chronic neurologic conditions or chronic lung disease other than asthma were more likely to have severe or critical COVID-19. Interpretation: Among children who were admitted to hospital with SARS-CoV-2 infection in Canada during the early COVID-19 pandemic period, incidental SARS-CoV-2 infection was common. In children admitted with acute COVID-19, obesity and neurologic and respiratory comorbidities were associated with more severe disease., As of Dec. 31, 2020, Canada had 581427 confirmed cases of SARS-CoV-2 infection. (1) Similar to other countries, most confirmed infections were in adults, in part because of initial testing [...]

Published
2021
Full Text
View/download PDF

13. Direct Instruction in Phonological Awareness

Author

King, Melanie P.

Abstract

The purpose of this study was to determine the significance of teaching phonological awareness directly in the classroom. Student samples were conducted of both special education and general education students. Teacher interviews and observations were also used in this process. This research was conducted in an elementary school with approximately 500 students, 10% of the population being special education students. The results showed that students can benefit and improve their reading with the direct instruction of phonological awareness. Teachers need to understand the importance of this piece and be sure to integrate it into their curriculum. Without this instruction, some students do not make the connection to the letter-sound correspondence, therefore, leading to difficulty in the areas of reading and writing. It is recommended that teachers in grades kindergarten through second grade spend about 20 minutes per day teaching this concept. The following are appended: (1) Data Collection Plan; (2) Interview; (3) Observation Checklist; (4) Interview #2; and (5) Teacher Survey. (Contains 1 table and 4 figures.)

Published
2005

15. Kiosk 7R-FC-03 - Prevalence, Associations, and Prognostic Relevance of Right Ventricular Dysfunction in Patients with Chronic Ischemic Cardiomyopathy Undergoing Cardiovascular Magnetic Resonance Imaging

Author

Aguilar-Iglesias, Lara, Labib, Dina, Santos, Miguel, Dykstra, Steven, Liang, Zhiying, Tao, Eric, MacDonald, Matthew, Feng, Yuanchao, Flewitt, Jacqueline, King, Melanie, Sajjad, Sahar, Dharia, Amee, Rivest, Sandra, Manoushagian, Shant, Nabet, Edward, Patel, Neil, Marzo, Kevin, Miller, Robert, White, James, and Gaztanaga, Juan

Published
2024
Full Text
View/download PDF

18. Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage

Author

El Tal, Tala, primary, Morin, Marie-Paule, additional, Morris, Shaun K., additional, Farrar, Daniel S., additional, Berard, Roberta A., additional, Kakkar, Fatima, additional, Moore Hepburn, Charlotte, additional, Baerg, Krista, additional, Beaufils, Camille, additional, Bennett, Terri-Lyn, additional, Benseler, Susanne M., additional, Beaudoin-Bussières, Guillaume, additional, Chan, Kevin, additional, Cyr, Claude, additional, Dahdah, Nagib, additional, Donner, Elizabeth J., additional, Drouin, Olivier, additional, Edjoc, Rojiemiahd, additional, Eljaouhari, Maryem, additional, Embree, Joanne E., additional, Farrell, Catherine, additional, Finzi, Andrés, additional, Forgie, Sarah, additional, Giroux, Ryan, additional, Kang, Kristopher T., additional, King, Melanie, additional, Laffin Thibodeau, Melanie, additional, Lang, Bianca, additional, Laxer, Ronald M., additional, Luu, Thuy Mai, additional, McCrindle, Brian W., additional, Orkin, Julia, additional, Papenburg, Jesse, additional, Pound, Catherine M., additional, Price, Victoria E., additional, Proulx-Gauthier, Jean-Philippe, additional, Purewal, Rupeena, additional, Sadarangani, Manish, additional, Salvadori, Marina I., additional, Thibeault, Roseline, additional, Top, Karina A., additional, Viel-Thériault, Isabelle, additional, Haddad, Elie, additional, Scuccimarri, Rosie, additional, and Yeung, Rae S. M., additional

Published
2023
Full Text
View/download PDF

20. 50 Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author

Farrar, Daniel, primary, Drouin, Olivier, additional, Hepburn, Charlotte Moore, additional, Baerg, Krista, additional, Chan, Kevin, additional, Cyr, Claude, additional, Donner, Elizabeth, additional, Embree, Joanne, additional, Farrell, Catherine, additional, Forgie, Sarah, additional, Giroux, Ryan, additional, Kang, Kristopher, additional, King, Melanie, additional, Laffin-Thibodeau, Melanie, additional, Luu, Thuy-Mai, additional, Orkin, Julia, additional, Ouldali, Naïm, additional, Papenburg, Jesse, additional, Pound, Catherine, additional, Price, Victoria E, additional, Proulx-Gauthier, Jean-Phillippe, additional, Purewal, Rupeena, additional, Sadarangani, Manish, additional, Salvadori, Marina, additional, Thibeault, Roseline, additional, Top, Karina, additional, Viel-Thériault, Isabelle, additional, Kakkar, Fatima, additional, and Morris, Shaun, additional

Published
2022
Full Text
View/download PDF

21. Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada.

Author

Farrar, Daniel, Hepburn, Charlotte Moore, Drouin, Olivier, Tal, Tala El, Morin, Marie-Paule, Berard, Roberta, King, Melanie, Thibodeau, Melanie Laffin, Baerg, Krista, Beaudoin-Bussières, Guillaume, Beaufils, Camille, Bennett, Terri-Lyn, Benseler, Susanne, Chan, Kevin, Cyr, Claude, Dahdah, Nagib, Donner, Elizabeth, Embree, Joanne, Farrell, Catherine, and Finzi, Andrés

Subjects
MULTISYSTEM inflammatory syndrome in children, SARS-CoV-2, HOSPITAL care of children, JUVENILE diseases, CORONAVIRUS diseases, COVID-19
Abstract

Background: Direct comparisons of paediatric hospitalizations for acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning. We describe the absolute and relative hospital burden of acute paediatric COVID-19 and MIS-C in Canada. Methods: This national prospective study was conducted via the Canadian Paediatric Surveillance Program from March 2020-May 2021. Children younger than 18 years old and hospitalized for acute COVID-19 or MIS-C were included in the analysis. Outcomes included supplemental oxygen (low-flow oxygen or high-flow nasal cannula), ventilation (non-invasive or conventional mechanical), vasopressors, paediatric intensive care unit (PICU) admission, or death. Adjusted risk differences (aRD) and 95% confidence intervals (CI) were calculated to identify factors associated with each diagnosis. Results: Overall, we identified 330 children hospitalized for acute COVID-19 (including five deaths) and 208 hospitalized for MIS-C (including zero deaths); PICU admission was required for 49.5% of MIS-C hospitalizations versus 18.2% of acute COVID-19 hospitalizations (aRD 20.3; 95% CI, 9.9-30.8). Resource use differed by age, with children younger than one year hospitalized more often for acute COVID-19 (aRD 43.4% versus MIS-C; 95% CI, 37.7-49.1) and more children 5-11 years hospitalized for MIS-C (aRD 38.9% vs. acute COVID-19; 95% CI, 31.0-46.9). Conclusion: While there were more hospitalizations and deaths from acute paediatric COVID-19, MIS-C cases were more severe, requiring more intensive care and vasopressor support. Our findings suggest that both acute COVID-19 and MIS-C should be considered when assessing the overall burden of severe acute respiratory syndrome coronavirus 2 in hospitalized children. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

29. Prevalence, Associations, and Prognostic Relevance of Right Ventricular Dysfunction in Patients with Chronic Ischemic Cardiomyopathy Undergoing Cardiovascular Magnetic Resonance Imaging

Author

Aguilar-Iglesias, Lara, Labib, Dina, Santos, Miguel, Dykstra, Steven, Liang, Zhiying, Tao, Eric, MacDonald, Matthew, Feng, Yuanchao, Flewitt, Jacqueline, King, Melanie, Sajjad, Sahar, Dharia, Amee, Rivest, Sandra, Manoushagian, Shant, Nabet, Edward, Patel, Neil, Marzo, Kevin, Miller, Robert, White, James, and Gaztanaga, Juan

Published
2024
Full Text
View/download PDF

30. Surveillance Training for Ebola Preparedness in Côte d'Ivoire, Guinea-Bissau, Senegal, and Mali.

Author

Cáceres, Victor M., Sidibe, Sekou, Andre, McKenzie, Traicoff, Denise, Lambert, Stephanie, King, Melanie E., Kazambu, Ditu, Lopez, Augusto, Pedalino, Biagio, Guibert, Dionisio J. Herrera, Wassawa, Peter, Cardoso, Placido, Assi, Bernard, Ly, Alioune, Traore, Bouyagui, Angulo, Frederick J., and Quick, Linda

Subjects
EBOLA virus disease, EPIDEMIOLOGISTS, PREPAREDNESS, PUBLIC health surveillance, EMERGENCY management, TRAINING
Abstract

The 2014-2015 epidemic of Ebola virus disease in West Africa primarily affected Guinea, Liberia, and Sierra Leone. Several countries, including Mali, Nigeria, and Senegal, experienced Ebola importations. Realizing the importance of a trained field epidemiology workforce in neighboring countries to respond to Ebola importations, the Centers for Disease Control and Prevention Field Epidemiology Training Program unit implemented the Surveillance Training for Ebola Preparedness (STEP) initiative. STEP was a mentored, competency-based initiative to rapidly build up surveillance capacity along the borders of the at-risk neighboring countries Côte d'Ivoire, Mali, Senegal, and Guinea-Bissau. The target audience was district surveillance officers. STEP was delivered to 185 participants from 72 health units (districts or regions). Timeliness of reporting and the quality of surveillance analyses improved 3 months after training. STEP demonstrated that mentored, competency-based training, where learners attain competencies while delivering essential public health services, can be successfully implemented in an emergency response setting. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

31. Regulatory T Cells Expanded from HIV-1-Infected Individuals Maintain Phenotype, TCR Repertoire and Suppressive Capacity

Author

Angin, Mathieu, primary, Klarenbeek, Paul L., additional, King, Melanie, additional, Sharma, Siddhartha M., additional, Moodley, Eshia S., additional, Rezai, Ashley, additional, Piechocka-Trocha, Alicja, additional, Toth, Ildiko, additional, Chan, Andrew T., additional, Goulder, Philip J., additional, Ndung'u, Thumbi, additional, Kwon, Douglas S., additional, and Addo, Marylyn M., additional

Published
2014
Full Text
View/download PDF

34. Correspondence and reply. New therapeutic products and difficult decisions.

Author

Schweiger, Martin, Green, Colin, Akehurst, Ron, Hodgson, Amanda, Griffiths, C. Sarah, King, Melanie J., Roberts, Julian, Hill, Tony, Dimitrov, Borislav D., Hughes, Gwenda, Catchpole, Mike, Swan, A. V., Sloan, David, O'Reilly, Dermot, Stevenson, Mike, Bush, Michael F. H., and Millership, Sally

Subjects
LETTERS to the editor, HEMOPHILIA
Abstract

A letter to the editor and a reply are presented in response to the article "New therapeutic products and difficult decisions: The case of recombinant factor VIII in the management of haemophilia A" in the 1998 issue.

Published
1999

37. Sex-based differences in the phenotypic expression and prognosis of idiopathic non-ischaemic cardiomyopathy: a cardiovascular magnetic resonance study.

Author

Mallabone M, Labib D, Abdelhaleem A, Dykstra S, Thompson RB, Paterson DI, Thompson SK, Hasanzadeh F, Mikami Y, Rivest S, Flewitt J, Feng Y, Macdonald M, King M, Bristow M, Kolman L, Howarth AG, Lydell CP, Miller RJH, Fine NM, and White JA

Subjects
Humans, Male, Female, Middle Aged, Prognosis, Sex Factors, Aged, Stroke Volume physiology, Registries, Retrospective Studies, Cardiomyopathies diagnostic imaging, Cardiomyopathies physiopathology, Magnetic Resonance Imaging, Cine methods, Phenotype
Abstract

Aims: We sought to characterize sex-related differences in cardiovascular magnetic resonance-based cardiovascular phenotypes and prognosis in patients with idiopathic non-ischaemic cardiomyopathy (NICM)., Methods and Results: Patients with NICM enrolled in the Cardiovascular Imaging Registry of Calgary (CIROC) between 2015 and 2021 were identified. Z-score values for chamber volumes and function were calculated as standard deviation from mean values of 157 sex-matched healthy volunteers, ensuring reported differences were independent of known sex-dependencies. Patients were followed for the composite outcome of all-cause mortality, heart failure admission, or ventricular arrhythmia. A total of 747 patients were studied, 531 (71%) males. By Z-score values, females showed significantly higher left ventricular (LV) ejection fraction (EF; median difference 1 SD) and right ventricular (RV) EF (difference 0.6 SD) with greater LV mass (difference 2.1 SD; P < 0.01 for all) vs. males despite similar chamber volumes. Females had a significantly lower prevalence of mid-wall striae (MWS) fibrosis (22% vs. 34%; P < 0.001). Over a median follow-up of 4.7 years, 173 patients (23%) developed the composite outcome, with equal distribution in males and females. LV EF and MWS were significant independent predictors of the outcome (respective HR [95% CI] 0.97 [0.95-0.99] and 1.6 [1.2-2.3]; P = 0.003 and 0.005). There was no association of sex with the outcome., Conclusion: In a large contemporary cohort, NICM was uniquely expressed in females vs. males. Despite similar chamber dilation, females demonstrated greater concentric remodelling, lower reductions in bi-ventricular function, and a lower burden of replacement fibrosis. Overall, their prognosis remained similar to male patients with NICM., Competing Interests: Conflict of interest: J.A.W. receives funding from the Canadian Institute of Health Research (CIHR), receives research support from Siemens Healthineers, and is a shareholder of Cohesic Inc. A.G.H. receives consulting fees from Amgen and is a shareholder of Cohesic Inc. J.F. is a shareholder of Cohesic Inc. R.J.H.M. has received research support and consulting fees from Pfizer., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results