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Introduction: Assessing the risk factors for and consequences of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy is essential to guide clinical care. Previous studies on SARS-CoV-2 infection in pregnancy have been among hospitalized patients, which may have exaggerated risk estimates of severe outcomes because all cases of SARS-CoV-2 infection in the pregnant population were not included. The objectives of this study were to identify risk factors for and outcomes after SARS-CoV-2 infection in pregnancy independent of severity of infection in a universally tested population, and to identify risk factors for and outcomes after severe infection requiring hospital admission. Material and methods: This was a prospective population-based cohort study in Denmark using data from the Danish National Patient Register and Danish Microbiology Database and prospectively registered data from medical records. We included all pregnancies between March 1 and October 31, 2020 and compared women with a positive SARS-CoV-2 test during pregnancy to non-infected pregnant women. Cases of SARS-CoV-2 infection in pregnancy were both identified prospectively and through register linkage to ensure that all cases were identified and that cases were pregnant during infection. Main outcome measures were pregnancy, delivery, maternal, and neonatal outcomes. Severe infection was defined as hospital admission due to coronavirus disease 2019 (COVID-19) symptoms. Results: Among 82 682 pregnancies, 418 women had SARS-CoV-2 infection during pregnancy, corresponding to an incidence of 5.1 per 1000 pregnancies, 23 (5.5%) of which required hospital admission due to COVID-19. Risk factors for infection were asthma (odds ratio [OR] 2.19, 95% CI 1.41–3.41) and being foreign born (OR 2.12, 95% CI 1.70–2.64). Risk factors for hospital admission due to COVID-19 included obesity (OR 2.74, 95% CI 1.00–7.51), smoking (OR 4.69, 95% CI 1.58–13.90), infection after gestational age (GA) 22 weeks (GA 22–27 weeks: OR 3.77, 95% CI 1.16–12.29; GA 28–36 weeks: OR 4.76, 95% CI 1.60–14.12), and having asthma (OR 4.53, 95% CI 1.39–14.79). We found no difference in any obstetrical or neonatal outcomes. Conclusions: Only 1 in 20 women with SARS-CoV-2 infection during pregnancy required admission to hospital due to COVID-19. Risk factors for admission comprised obesity, smoking, asthma, and infection after GA 22 weeks. Severe adverse outcomes of SARS-CoV-2 infection in pregnancy were rare.

We examine whether Covid-19, which is widely believed to have originated in China, negatively affected the environment for Chinese people in London leading to an increase in hate crimes toward this group relative to others. With data from the Metropolitan Police for the whole of the Metropolitan area of London, we use a difference-in-differences approach to examine what happened to hate crimes against Chinese people in London in the months before (October to December 2019) and the months after the Covid-19 pandemic (January to March 2020) relative to other ethnic groups, to other crimes, and to other time periods. Our methodology utilizes the fact that Covid-19 came as an unexpected shock, which very quickly changed the environment for crime, and did so differentially across ethnicities. We argue that this shock is likely to negatively affect attitudes and behaviors toward Chinese people, but has no effect on other ethnicities. Our results show that in the months after Covid-19, there was an increase in hate crimes against Chinese people, but this increase was not seen among the other ethnic groups, other non hate crimes, or in any other time period. This leads us to conclude that Covid-19 led to an increase in hate crimes against Chinese people in London. That Covid-19 changed behavior toward Chinese people highlights an intrinsic link between Covid-19 and racism. Unfortunately, the rise in hate crime that we identify adds to a growing list of ways in which ethnic minority groups disproportionately suffered, and continue to do so, during the pandemic.

Policy-makers wanting to support child development can choose to adjust the quantity or quality of publicly funded universal pre-school. To assess the impact of such changes, we estimate the effects of an increase in free pre-school education in England of about 3.5 months at age 3 on children’s school achievement at age 5. We exploit date-of-birth discontinuities that create variation in the length and starting age of free pre-school using administrative school records linked to nursery characteristics. Estimated effects are small overall, but the impact of the additional term is substantially larger in settings with the highest inspection quality rating but not in settings with highly qualified staff. Estimated effects fade out by age 7.

IntroductionAssessing the risk factors for and consequences of infection with SARS-CoV-2 during pregnancy is essential to guide clinical guidelines and care. Previous studies on the influence of SARS-CoV-2 infection in pregnancy have been among hospitalised patients, which may have exaggerated risk estimates of severe outcomes because all cases of SARS-CoV-2 infection in the pregnant population were not included. The objectives of this study were to identify risk factors for and outcomes after SARS-CoV-2 infection in pregnancy independent of severity of infection in a universally tested population, and to identify risk factors for and outcomes after severe infection requiring hospital admission.Material and MethodsThis was a prospective population-based cohort study in Denmark using data from the Danish National Patient Register and Danish Microbiology Database and prospectively registered data from medical records. We included all pregnancies between March 1 and October 31, 2020 and compared women with a positive SARS-CoV-2 test during pregnancy to non-infected pregnant women. Cases of SARS-CoV-2 infection in pregnancy were both identified prospectively and through register linkage to secure that all cases were identified and that cases were pregnant during infection. Main outcome measures were pregnancy, delivery, maternal, and neonatal outcomes. Severe infection was defined as hospital admission due to COVID-19.ResultsAmong 82 682 pregnancies, 418 women had SARS-CoV-2 infection during pregnancy, corresponding to an incidence of 5.1 per 1000 pregnancies, 23 (5.5%) of which required hospital admission due to COVID-19. Risk factors for infection were asthma (OR 2.19 [1.41–3.41]) and being foreign born (OR 2.12 [1.70–2.64]). Risk factors for hospital admission due to COVID-19 included obesity (OR 2.74 [1.00–7.51]), smoking (OR 4.69 [1.58–13.90]), infection after gestational age (GA) 22 weeks (GA 22–27 weeks: OR 3.77 [1.16–12.29]; GA 28–36 weeks: OR 4.76 [1.60–14.12]) and having asthma (OR 4.53 [1.39–14.79]). We found no difference in any obstetric or neonatal outcomes.ConclusionsOnly 1 in 20 women with SARS-CoV-2 infection during pregnancy require admission to hospital due to COVID-19. And severe outcomes of SARS-CoV-2 infection in pregnancy are rare.Key MessagePopulation based cohort study about SARS-CoV-2 infection during pregnancy. Asthma and foreign ethnicity were identified as risk factors for infection while obstetric outcomes did not change. Obesity, smoking, infection after GA 22, and asthma increased the risk of hospital admission.

Gaps in GCSE attainment have long been the concern of policy makers, academics, and social commentators, largely due to the importance of these exams for setting children on their future academic a...

AIMS: The aim of the study was to evaluate the incidence and causes of rehospitalisation within one year after percutaneous coronary intervention (PCI) in a country where the National Health Service provides universal tax-supported healthcare, guaranteeing residents free hospital access.METHODS AND RESULTS: Between January 2010 and September 2014, 17,111 patients were treated with PCI in two University Hospitals in Western Denmark. Patients who were readmitted within one year after PCI were identified. The overall one-year readmission rate was 50.4%. The cause was angina/myocardial infarction (MI) in 4,282 patients (49.7%), and other reasons in 4,334 (50.3%). Predictors of angina/MI-related readmissions were female gender (odds ratio [OR] 1.15, 95% confidence interval [CI]: 1.07-1.25), diabetes (OR 1.14, 95% CI: 1.04-1.26), age (per 10-year increase) (OR 0.86, 95% CI: 0.83-0.88), and indication for index PCI (stable angina pectoris as reference): ST-segment elevation myocardial infarction (OR 1.34, 95% CI: 1.23-1.47) and non-ST-segment elevation myocardial infarction (OR 1.18, 95% CI: 1.08-1.29). Predictors for other readmissions were female gender (OR 1.09, 95% CI: 1.01-1.18), diabetes (OR 1.29, 95% CI: 1.18-1.42), age (OR 1.30, 95% CI: 1.26-1.34) and Charlson comorbidity index ≥3 (OR 3.03, 95% CI: 2.71-3.27).CONCLUSIONS: In an unselected patient cohort treated with PCI, half of the patients were rehospitalised within one year, highlighting the impact of comorbidity in patients with ischaemic heart disease.

There is an established literature that suggests teacher perceptions of pupils affect how they interact with them, how they teach them and how they rate their ability and behaviour. Evidence also indicates that a teacher’s perception of a child is often based on ascriptive characteristics such as gender, ethnicity and socio-economic background independent of a child’s ability. This paper builds on the literature by examining the relationship between teacher perceptions of a child’s ability and behaviour and their perceptions of a particular ascriptive characteristic of those children - their attractiveness. Using data from the National Child Development Study (NCDS) results show that not only do teachers rate the academic ability of pupils they perceive to be attractive more highly than less attractive students both in terms of their performance across different areas of learning (general knowledge, numbers, books and oral ability) and whether they show any outstanding potential but they are also more likely to over rate and less likely to under rate their ability than other students. This is true even after controlling for a wide range of other factors related to the child, their family, their teacher and their school that could influence the relationship, many of which are shown to be independently related to teacher’s ratings.

INTRODUCTION: The viscoelastic properties of the cervical mucus plug are considered essential for the occlusion of the cervical canal and thereby for protection against ascending infections during pregnancy. Factors controlling this property are virtually unknown. This study explores a possible role of trefoil factor peptides 1, 2 and 3 (TFF1-3); peptides believed to influence mucus viscosity.MATERIALS AND METHODS: The study is based on spontaneously shed cervical mucus plugs from 14 women in active labor. The viscoelastic properties; the elastic modulus (G') and the viscous modulus (G'') were determined by an oscillatory rheometer. The concentrations of TFF1-3 were measured by an in-house ELISA. Associations were analyzed by random-effects generalized least squares regression analyses.RESULTS: Median (range) concentrations of TFF1, (TFF2) and [TFF3] were 3.1 (1.2-8.6), (1.1 (CONCLUSION: We suggest that TFF3 plays a role for the viscoelastic properties of cervical mucus plug. This article is protected by copyright. All rights reserved.

Income is regarded as one of the clearest indicators of socioeconomic status and wellbeing in the developed world and is highly correlated with a wide range of outcomes. Despite its importance, there remains an issue as to the best way to collect income as part of surveys. This paper examines differences in how income is collected in a nationally representative UK birth cohort, the Millennium Cohort Study, looking at variations by questions asked and by respondent characteristics before then examining the implications different methods of collecting and reporting income may have for measuring poverty. Results show that less than a third of respondents give consistent information on income between measurement tools. Using multiple questions is associated with a substantially lower response rate but this method generally results in a higher estimate of family income than using a single question. This is particularly true for certain groups of the population—those on means tested benefits, in self-employment and in part-time employment. Not surprisingly then in our analysis of poverty, using a single question produces an inflated proportion of families who could be classified as living in poverty and is less associated with other measures of financial deprivation than the more conservative poverty measure based on multiple questions.

The cervical mucus plug (CMP) differs from the cervical secretions of non-pregnant women, and is the ultimate sealant of the uterine cavity during pregnancy. Although several studies have analyzed biochemical properties of large glycoproteins in the CMP, comprehensive information about its protein composition is yet unavailable. We hypothesized that protein profiling of the CMP could provide key clues to its physiological functions in pregnancy. For this purpose, five CMPs obtained from women in labor at term were analyzed by LC–MS/MS. Out of 291 total proteins identified, 137 were detected in two or more samples, which included S100A8, S100A9, and complement proteins (C3, C4a, C4b, C6, and C8g). Several proteins, which have not been described in the cervical mucus of non-pregnant women or in cervicovaginal fluids, such as CD81 antigen and pregnancy zone protein, were also identified. Gene ontology analysis of identified proteins showed significant enrichment of 28 biological processes such as ‘activation of plasma proteins involved in acute inflammatory response’ and ‘positive regulation of cholesterol esterification’. We report the proteome of CMPs from pregnant women at term for the first time, and the overall findings strongly suggest an important role for the CMP in the maintenance of pregnancy and parturition.

Children’s development in the early years has been shown to be related to their success in later life in a range of areas including education, employment and crime. Determining why some children do better than others in the early years is a key issue for policy and is crucial in attempts to reduce inequalities. This research examines differences in early child development by examining the factors associated with the cognitive ability of children up to age 5 using cognitive assessments administered as part of the Millennium Cohort Study (MCS) and teacher reports of child ability. The results show that younger children, those with low birth weight, lower parental education, lower income and living in social housing are more likely to have lower achievement, on average, and a higher probability of being at the bottom of the distribution of cognitive scores at age 5.

Childcare provision in the UK has evolved alongside the expansion of mothers' employment, transforming the experiences of successive generations. This paper reviews some mixed evidence on child outcomes of maternal employment and offers a detailed examination of the working mothers' use of childcare. In particular, it looks at the differential use of formal and informal childcare provision using the first survey of the Millennium Cohort Study, which is compared, as far as possible, with evidence from the earlier birth cohort studies in 1970 and 1958. The affordability and trustworthiness of formal childcare remains a constraint on its use and indirectly on labour supply for some mothers.

That crime tends to rise and peak in the mid to late teens and early twenties then declines with age has, by now, become an accepted fact. Despite this, over the last twenty years there have been numerous debates over the true nature of the relationship between crime and age. This paper uses self-report data collected from young males aged 16-25 in England and Wales to examine the crime-age profiles of two groups: those who leave school at 16 and those who stay on past the compulsory school leaving age. Findings show that for three categories of crime (property, handling and violent offences1) the two groups have significantly different crime-age profiles but that the gap between the two profiles can be accounted for by differences across the two groups in a number of observable variables related to the labour market, education, family, individual and the neighbourhood/area in which people live. The most important factors underpinning differences in the crime-age profiles by education group are whether an individual lives with their parents, family contact with the police and school truancy.

Objective To evaluate the microbial load and the inflammatory response in the distal and proximal parts of the cervical mucus plug. Design Experimental research. Population Twenty women with a normal, singleton pregnancy. Sample Vaginal swabs and specimens from the distal and proximal parts of the cervical mucus plug. Methods Immunohistochemistry, enzyme-linked immunosorbent assay, quantitative polymerase chain reaction and histology. Results The total bacterial load (16S rDNA) was significantly lower in the cervical mucus plug compared with the vagina (p = 0.001). Among women harboring Ureaplasma parvum, the median genome equivalents/g were 1574 (interquartile range 2526) in the proximal part, 657 (interquartile range 1620) in the distal part and 60 240 (interquartile range 96 386) in the vagina. Histological examinations and quantitative polymerase chain reaction revealed considerable amounts of lactobacilli and inflammatory cells in both parts of the cervical mucus plug. The matrix metalloproteinase-8 concentration was decreased in the proximal part of the plug compared with the distal part (p = 0.08). Conclusion The cervical mucus plug inhibits, but does not block, the passage of Ureaplasma parvum during its ascending route from the vagina through the cervical canal.

The paper presents evidence of serious skill shortages in the information technology (IT) sector and in IT-related occupations in France, Germany, Singapore the UK and the US. The extent to which higher education (HE) has responded to the increased demand for skills by providing an increasing number of study places in computer science courses, is examined. In Europe and Singapore the proportion of the age group entering IT courses has increased since 1990. Germany shows a rapid increase since 1995. The US shows a downward trend after an increase in the early 1980s. In Europe, expansion of entrants to IT took place when participation rates were flattening out after growth in the 80s and early 90s. Expansion indicates that entrants were switching to IT from other subject areas. The quality of entrants to IT HE was measured by performance on pre-requisites. In 1998, in all countries except France and Singapore, the quality of entrants to computer science courses was below the average for all HE entrants. Ein klarer Fachkräftemangel behindert das Wachstum der Informationstechnik (IT)-Branche nicht nur in Deutschland, sondern auch in anderen Ländern. In dieser Studie wird untersucht, in welchem Ausmaß Schulabgänger mit einem Studium der Informatik in fünf industrialisierten Ländern, den USA, Großbritannien, Frankreich, Singapur und Deutschland, auf die steigende Nachfrage reagiert haben. Seit 1985 stieg in Europa und Singapur der Anteil der Altersgruppe, die sich für ein Studium in Informatik entschieden haben, beträchtlich an, obwohl in Deutschland die gesamten Studienanfängerzahlen zurückgingen. In Deutschland war ein starker Anstieg an Studienanfängern seit 1995 in diesem Fach zu verzeichnen. In den USA zeigt sich dagegen ein Abwärtstrend, nachdem die Zahlen in den 80erJahren beachtlich zugenommen hatten. Die Qualität der Studienanfänger wurden an ihren Schulabgangsqualifikationen bzw. -tests gemessen. Außer in Frankreich und Singapur lag das Qualitätsniveau der Studienanfänger für Informatik im Jahr 1998 unterhalb des durchschnittlichen Niveaus aller Studienanfänger.

Analysis of labour market performance using individual level data can reach radically different conclusions to those provided by a household-based analysis, using the same source of information. In Britain and other OECD countries the number of households without access to earned income has grown despite rising employment rates. Built around a comparison of the actual jobless rate in households with that which would occur if work were randomly distributed, the authors show that work is becoming increasingly polarised in many countries. Changing household structure can only account for a minority of the rise in workless households, so that labour market failure is the dominant explanation. Polarisation of work will have important welfare and budgetary consequences for any country.

Dispersion in pay is lower among union members than among non-unionists. This reflects two factors. First, union members and jobs are more homogeneous than their non-union counterparts. Second, union wage policies within and across firms lower pay dispersion. Unions' minimum wage targets also truncate the lower tail of the union distribution. There are two major consequences of these egalitarian union wage policies. First, the return to human capital is lower in firms which recognise unions than in the unorganised sector. Second, unions compress the wage structure by gender, race and occupation.

Ouabain, a specific inhibitor of the Na + /K + -pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells is regulated through an interaction between the Na + /K + -pump and the Na + /Ca 2+ -exchanger leading to an increase in the intracellular calcium concentration ([Ca 2+ ] i ) in discrete areas near the plasma membrane. [Ca 2+ ] i in smooth muscle cells was imaged in cultured rat aortic smooth muscle cell pairs (A7r5) and in rat mesenteric small artery segments simultaneously with force. In A7r5 coupling between cells was estimated by measuring membrane capacitance. Smooth muscle cells were uncoupled when the Na + /K + -pump was inhibited either by a low concentration of ouabain, which also caused a localized increase of [Ca 2+ ] i near the membrane, or by ATP depletion. Reduction of Na + /K + -pump activity by removal of extracellular potassium ([K + ] o ) also uncoupled cells, but only after inhibition of K ATP channels. Inhibition of the Na + /Ca 2+ -exchange activity by SEA0400 or by a reduction of the equilibrium potential (making it more negative) also uncoupled the cells. Depletion of intracellular Na + and clamping of [Ca 2+ ] i at low concentrations prevented the uncoupling. The experiments suggest that the Na + /K + -pump may affect gap junction conductivity via localized changes in [Ca 2+ ] i through modulation of Na + /Ca 2+ -exchanger activity.