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Your search keyword '"Kjær, Kathrine"' showing total 6 results
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6 results on '"Kjær, Kathrine"'

3. TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes

Author

Schleimann, Mariane H., primary, Kobberø, Maria-Louise, additional, Vibholm, Line K., additional, Kjær, Kathrine, additional, Giron, Leila B., additional, Busman-Sahay, Kathleen, additional, Chan, Chi Ngai, additional, Nekorchuk, Michael, additional, Schmidt, Manuel, additional, Wittig, Burghardt, additional, Damsgaard, Tine E., additional, Ahlburg, Peter, additional, Hellfritzsch, Michel B., additional, Zuwala, Kaja, additional, Rothemejer, Frederik H., additional, Olesen, Rikke, additional, Schommers, Phillipp, additional, Klein, Florian, additional, Dweep, Harsh, additional, Kossenkov, Andrew, additional, Nyengaard, Jens R., additional, Estes, Jacob D., additional, Abdel-Mohsen, Mohamed, additional, Østergaard, Lars, additional, Tolstrup, Martin, additional, Søgaard, Ole S., additional, and Denton, Paul W., additional

Published
2019
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5. Histone Deacetylase Inhibitor Romidepsin Inhibits De Novo HIV-1 Infections

Author

Jønsson, Kasper L., primary, Tolstrup, Martin, additional, Vad-Nielsen, Johan, additional, Kjær, Kathrine, additional, Laustsen, Anders, additional, Andersen, Morten N., additional, Rasmussen, Thomas A., additional, Søgaard, Ole S., additional, Østergaard, Lars, additional, Denton, Paul W., additional, and Jakobsen, Martin R., additional

Published
2015
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6. Histone Deacetylase Inhibitor Romidepsin Inhibits De NovoHIV-1 Infections

Author

Jønsson, Kasper L., Tolstrup, Martin, Vad-Nielsen, Johan, Kjær, Kathrine, Laustsen, Anders, Andersen, Morten N., Rasmussen, Thomas A., Søgaard, Ole S., Østergaard, Lars, Denton, Paul W., and Jakobsen, Martin R.

Abstract

ABSTRACTAdjunct therapy with the histone deacetylase inhibitor (HDACi) romidepsin increases plasma viremia in HIV patients on combination antiretroviral therapy (cART). However, a potential concern is that reversing HIV latency with an HDACi may reactivate the virus in anatomical compartments with suboptimal cART concentrations, leading to de novoinfection of susceptible cells in these sites. We tested physiologically relevant romidepsin concentrations known to reactivate latent HIV in order to definitively address this concern. We found that romidepsin significantly inhibited HIV infection in peripheral blood mononuclear cells and CD4+T cells but not in monocyte-derived macrophages. In addition, romidepsin impaired HIV spreading in CD4+T cell cultures. When we evaluated the impact of romidepsin on quantitative viral outgrowth assays with primary resting CD4+T cells, we found that resting CD4+T cells exposed to romidepsin exhibited reduced proliferation and viability. This significantly lowered assay sensitivity when measuring the efficacy of romidepsin as an HIV latency reversal agent. Altogether, our data indicate that romidepsin-based HIV eradication strategies are unlikely to reseed a latent T cell reservoir, even under suboptimal cART conditions, because romidepsin profoundly restricts de novoHIV infections.

Published
2015
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