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4. Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group

Author

Baker, Turner S., primary, Kellner, Christopher P., additional, Colbourne, Frederick, additional, Rincon, Fred, additional, Kollmar, Rainer, additional, Badjatia, Neeraj, additional, Dangayach, Neha, additional, Mocco, J., additional, Selim, Magdy H., additional, Lyden, Patrick, additional, Polderman, Kees, additional, and Mayer, Stephan, additional

Published
2022
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5. Erratum zu: Das ist neu in der Neurointensiv- und Notfallmedizin: die wichtigsten Studien des Jahres im Rück- und Überblick

Author

Alonso, Angelika, Kollmar, Rainer, and Dimitriadis, Konstantin

Subjects
Psychiatry and Mental health, Critical Care, Neurology, Emergency Medicine, Humans, COVID-19, Anticonvulsants, Neurology (clinical), General Medicine, Erratum, Subarachnoid Hemorrhage
Abstract

This review article summarizes the major clinical studies in neurological emergency and intensive care medicine from the end of 2020 to 2021 on the topics: recanalizing treatment in ischemic stroke, usefulness and effect of brain tissue oxygen monitoring in subarachnoid hemorrhage, efficacy of induced hypothermia in patients with cardiac arrest (CA), value of early cranial imaging after CA, relevance of rapid management and effects of different anticonvulsants in status epilepticus and incidence of critical illness polyneuropathy myopathy in intensive care unit patients with COVID-19 infections.Die vorliegende Übersichtsarbeit fasst wichtige klinische Studien der neurologischen Notfall- und Intensivmedizin zwischen 2020 und 2021 zusammen zu den Themen: rekanalisierende Therapie beim ischämischen Schlaganfall, Anwendbarkeit und Auswirkung eines zerebralen Sauerstoffgewebemonitorings bei Subarachnoidalblutung, Wirksamkeit induzierter Hypothermie bei Patienten mit „cardiac arrest“ (CA), Wertigkeit früher kranialer Bildgebung nach CA, Relevanz eines schnellen Managements und medikamentöser Therapie beim Status epilepticus sowie Inzidenz von Critical-illness-Polyneuropathie-Myopathie bei intensivpflichtigen COVID-Patienten.

Published
2022

8. Granulocyte Colony–Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial

Author

Ringelstein, E. Bernd, Thijs, Vincent, Norrving, Bo, Chamorro, Angel, Aichner, Franz, Grond, Martin, Saver, Jeff, Laage, Rico, Schneider, Armin, Rathgeb, Frank, Vogt, Gerhard, Charissé, Gabriele, Fiebach, Jochen B., Schwab, Stefan, Schäbitz, Wolf R., Kollmar, Rainer, Fisher, Marc, Brozman, Miroslav, Skoloudik, David, Gruber, Franz, Leal, Joaquin Serena, Veltkamp, Roland, Köhrmann, Martin, Berrouschot, Jörg, Egerer, Gerlinde, Mikus, Gerd, Limmroth, Volker, Kieser, Meinhard, Bracoud, Luc, Fiebach, Jochen B., Hermier, Marc, Bouffard, Juliette, and Weber, Rüdiger

Published
2013
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16. Palliative Care for Stroke Patients and Their Families: Barriers for Implementation

Author

Steigleder, Tobias, Kollmar, Rainer, and Ostgathe, Christoph

Subjects
early integration, caregiver burden, palliative care, family, Neurology, Medizinische Fakultät, Mini Review, palliative care needs, ddc:610, stroke, next-of-kin, palliative care indication
Abstract

Stroke is a leading cause of death, disability and is a symptom burden worldwide. It impacts patients and their families in various ways, including physical, emotional, social, and spiritual aspects. As stroke is potentially lethal and causes severe symptom burden, a palliative care (PC) approach is indicated in accordance with the definition of PC published by the WHO in 2002. Stroke patients can benefit from a structured approach to palliative care needs (PCN) and the amelioration of symptom burden. Stroke outcome is uncertain and outlook may change rapidly. Regarding these challenges, core competencies of PC include the critical appraisal of various treatment options, and openly and respectfully discussing therapeutic goals with patients, families, and caregivers. Nevertheless, PC in stroke has to date mainly been restricted to short care periods for dying patients after life-limiting complications. There is currently no integrated concept for PC in stroke care addressing the appropriate moment to initiate PC for stroke patients, and the question of how to screen for symptoms remains unanswered. Therefore, PC for stroke patients is often perceived as a stopgap in cases of unfavorable prognosis and very short survival times. In contrast, PC can provide much more for stroke patients and support a holistic approach, improve quality of life and ensure treatment according to the patient's wishes and values. In this short review we identify key aspects of PC in stroke care and current barriers to implementation. Additionally, we provide insights into our approach to PC in stroke care.

Published
2019

24. Sphenopalatine Ganglion Stimulation to Augment Cerebral Blood Flow

Author

Bornstein, Natan M., primary, Saver, Jeffrey L., additional, Diener, Hans-Christoph, additional, Gorelick, Philip B., additional, Shuaib, Ashfaq, additional, Solberg, Yoram, additional, Devlin, Thomas, additional, Leung, Thomas, additional, Molina, Carlos A., additional, Skoloudik, David, additional, Fiksa, Jan, additional, Krieger, Derk, additional, Andersen, Grethe, additional, Berrouschot, Joerg, additional, Hobohm, Carsten, additional, Schneider, Dietmar, additional, Griewing, Bernd, additional, Endres, Matthias, additional, Hausler, Karl-Georg, additional, Kimmig, Hubert, additional, Ringleb, Peter, additional, Weimar, Christian, additional, Schilling, Matthias, additional, Kohrmann, Martin, additional, Hetzel, Andreas, additional, Kaps, Manfred, additional, Cheung, Raymond, additional, Sobolewski, Piotr, additional, Nyke, Walenty, additional, Czlonkowska, Anna, additional, Stepien, Adam, additional, Waldemar, Brola, additional, Słowik, Agnieszka, additional, Zbigniewem, Stelmasiakiem, additional, Lubiński, Ignacy, additional, Portela, Pedro, additional, Segure, Tomas, additional, Marti-Fabregas, Joan, additional, Alonso, Maria, additional, Nunez, Antonio, additional, Miguel, Miguel Blanco, additional, Campello, Anna, additional, Arenillas, Joaquin, additional, Marshall, Nash, additional, Chiu, David, additional, Shownkeen, Harish, additional, Rymer, Marilyn, additional, Sen, Souvik, additional, Roubec, Martin, additional, Kuliha, Martin, additional, Lakomý, Ctirad, additional, Tyl, David, additional, Kemlink, David, additional, Doležal, Ondřej, additional, Rekova, Petra, additional, Krejčí, Veronika, additional, Christensen, Anders, additional, Belhage, Bo, additional, Maschmann, Christian, additional, Kruse Larsen, Christian, additional, Pott, Frank, additional, Christensen, Hanne, additional, Marstrand, Jakob, additional, Nielsen, Jens Kjellberg, additional, Meden, Per, additional, Prytz, Svend, additional, Rosenbaum, Sverre, additional, Hedemann Sorensen, Jens Christian, additional, Stenhoj Meier, Kaare, additional, Schmift Ettrup, Kare, additional, Dupont Hougaard, Kristina, additional, Von Wietzel, Paul, additional, Stoll, Anett, additional, Schwetlick, Hans, additional, Pradel, Hendirk, additional, Hemprich, Alexander, additional, Schulz, Andreas, additional, Frerich, Bernhard, additional, Weise, Christopher, additional, Michalski, Dominik, additional, Schaller, Felix, additional, Schiefke, Franziska, additional, Helmrich, Jens, additional, Pelz, Johann, additional, Schnieder, Martin, additional, Schneider, Martin, additional, Matzen, Peter, additional, Langos, Rudiger, additional, Müller-Duerwald, Stephan, additional, Lukhaup, Sven, additional, Bauer, Ute, additional, Kloppig, Wolfgang, additional, Hiermann, Erich, additional, Mucha, Gregor, additional, Soda, Hassan, additional, Weinhardt, Renate, additional, Mucha, Teresa, additional, Ziegler, Volker, additional, Abbushi, Alexander, additional, Hotter, Benjamin, additional, Winter, Benjamin, additional, Anthofer, Birgit, additional, Noack, Cornelia, additional, Laubisch, Dinah, additional, Heldge Schneider, Gerd, additional, Jan Jungehulsing, Gerhard, additional, Mueller, Heiko, additional, Dreier, Jens, additional, Fiebach, Jochen, additional, Flechsenhar, Julia, additional, Villringer, Kersten, additional, Ebinger, Martin, additional, Rozanski, Michael, additional, Vajkoczy, Peter, additional, Klingebiel, Randolf, additional, Steinicke, Robert, additional, Pittl, Sandra, additional, Hoffmann, Sarah, additional, Maul, Stephan, additional, Krause, Thomas, additional, Liman, Thomas, additional, Plath, Thomas, additional, Nowe, Tim, additional, Schmidt, Wolf, additional, Fritzsch, Carsten, additional, Haas, Christopher, additional, Will, Hans-Gerd, additional, Haußmann-Betz, Katja, additional, Bayat, Mohsen, additional, Pordzik, Tomazs, additional, Hug, Andreas, additional, Staff, Christian Jürgen, additional, Lichy, Christoph, additional, Eggers, Georg, additional, Kloss, Manja, additional, Bendszus, Martin, additional, Herrmann, Oliver, additional, Seeberger, Robin, additional, Schwarting, Soenke, additional, Rhode, Stefan, additional, Rizos, Timolaos, additional, Hacke, Werner, additional, Frank, Benedikt, additional, Bozkurt, Bessi, additional, Holle, Dagny, additional, Mueller, Daniel, additional, Koch, Dirk, additional, Shanib, Hind, additional, Sudendey, Joachim, additional, Brenck, Johannes, additional, Busch, Kolja, additional, Gartzen, Kristina, additional, Gasser, Thomas, additional, Hagenacker, Tim, additional, Buerke, Boris, additional, Prigge, Gudrun, additional, Minnerup, Jens, additional, Albers, Johannes, additional, Wermker, Kai, additional, Schwindt, Wolfram, additional, Kallmünzer, Ringlestein, Bernd, additional, Hauer, Eva, additional, Breuer, Lorenz, additional, Schellinger, Peter, additional, Kollmar, Rainer, additional, Sauer, Roland, additional, Schwab, Stefan, additional, Struffert, Tobias, additional, Funfack, Anette, additional, Stechmann, Anne, additional, Schlaeger, Axel, additional, Laeppchen, Claus, additional, Schuchardt, Florian, additional, Klingler, Jan-Helge, additional, Reis, Janine, additional, Lambeck, Johann, additional, Friedrich, Mirko, additional, Laible, Mona, additional, Wellermeyer, Philip, additional, Beck, Sandra, additional, Rutsch, Sebastian, additional, Niesen, Wolf-Dirk, additional, Tanislav, Christian, additional, Schaaf, Heidrun, additional, Kerkmann, Heiko, additional, Schirotzek, Ingo, additional, Allendörfer, Jens, additional, Wolff, Stephanie, additional, Yuk-Lun Lau, Alexander, additional, Yin Yan Chan, Anne, additional, Siu, Deyond, additional, Wong, Edward HC, additional, Chu Wong, George Kwok, additional, Leung, Howan, additional, Wong, Lawrence K.S., additional, Zhu, Xian Lun, additional, Yan Soo, Yannie Oi, additional, Ting Tse, Alan Choi, additional, Kit Leung, Gilberto Ka, additional, Leung, Kar Ming, additional, Ngai Hung, Kwan, additional, Wai Mei Kwan, May, additional, Man Yu Tse, Mona, additional, Tse, Philip, additional, Hon Chan, Ping, additional, Lee, Raymand, additional, Shek Kwan Chang, Richard, additional, Yin Yu Pang, Shirley, additional, Fong Kwong Hon, Sonny, additional, Cheng, Tat Sun, additional, Lui, Wai Man, additional, Wo Mak, Windsor Wai, additional, Sobota, Anna, additional, Wiater, Baeta, additional, Loch, Barbara, additional, Wolak, Genowefa, additional, Łabudzka, Irena, additional, Dabal, Jan, additional, Grzesik, Marcin, additional, Sledzinska, Monika, additional, Hatalska-Żerebiec, Renata, additional, Szczuchniak, Wiktor, additional, Gójska, Anna, additional, Nałęcz, Dariusz, additional, Gasecki, Dariusz, additional, Kozera, Grzegorz, additional, Dylewicz, Łukasz, additional, Niekra, Marcin, additional, Kwarciany, Mariusz, additional, Chomik, Piotr, additional, Skowron, Piotr, additional, Kobayashi, Adam, additional, Chabik, Grzegorz, additional, Makowicz, Grzegorz, additional, Bembenek, Jan, additional, Jędrzejewska, Julia, additional, Karlinski, Michal, additional, Czepiel, Wojciech, additional, Brodacki, Bogdan, additional, Staszewski, Jacek, additional, Kosek, Jarosław, additional, Jadczak, Marcin, additional, Durka-Kęsy, Marta, additional, Kaluzny, Krzysztof, additional, Ziomek, Małgorzata, additional, Fudala, Małgorzata, additional, Sosnowski, Zbigniew, additional, Ferens, Antoni, additional, Szczygieł, Elżbieta, additional, Banaszkiewicz, Krzysztof, additional, Ziomek, Maciej, additional, Wnuk, Marcin, additional, Szczepańska-Szerej, Anna, additional, Jach, Ewa, additional, Maslanko, Grazyna Elzbieta, additional, Wojczal, Joanna, additional, Luchowski, Piotr, additional, Kowalczyk, Andrzej, additional, Jakubiak, Jerzy, additional, Kopcewicz, Joanna, additional, Gajda, Maciej, additional, Wichlinska-Lubinska, Malgorzata, additional, Rodriguez, David, additional, Santamarin, Estevo, additional, Pagola, Jorge, additional, Lorente Guerrero, Juan, additional, Ribo, Marc, additional, Rubiera, Marta, additional, Maisterra, Olga, additional, Pinero, Soccoro, additional, Catalina Iglesias, Valera, additional, Plans, Gerard, additional, Quesada, Helena, additional, Aparicio Caballero, Marco Alberto, additional, Portela, Pedro Cardona, additional, De Diego, Antonio Belinchon, additional, Garay, David Sopelana, additional, García Rodriguez, Máximo Rafael, additional, Martin, Oscar Ayo, additional, Braña, Silvia Crusat, additional, Garcia, Jorge, additional, Hernandez, Fernando Munoz, additional, Catala, Ignasi, additional, Marti-Vilalta, Josep Lluis, additional, Delgado Mederos, Rachel, additional, de Quintana, Schmid Cristian, additional, Martinez-Ramirez, Sergi, additional, Valcarcel Gonzalez, Jaime, additional, Masjuan Vallejo, Jaime, additional, Diamantopoulus, Jorge, additional, Del Alamo, Marta, additional, Poveda, Pedro Domingo, additional, Pastor, Andres Garcia, additional, Carballal, Calros Fernandez, additional, Diaz, Fernando, additional, Garcia Leal, Roberto, additional, Juretschke, Ruiz, additional, Echabe, Eduardo Arán, additional, Sanchez, Jose Castillo, additional, Yanez, Manuel Rodriguez, additional, Garcia, Ramon Serramito, additional, Muino, Rogelio Leira, additional, Rivas, Susana Arias, additional, Lopez Gonzalez, Demian Manzano, additional, Cuadrado, Elisa, additional, Giralt, Eva, additional, Villalba, Gloria, additional, Roquer, Jaime, additional, Angel, Ois, additional, Jimenez, Maria, additional, Cedeño, René Robles, additional, Salinas, Ruy, additional, Lejarreta, Saioa, additional, Silva, Yolanda, additional, Fraile, Adela, additional, Calleja, Ana, additional, Cepeda Landínez, Guillermo Arturo, additional, Tellez, Nieves, additional, Garcia Bermejo, Pablo, additional, Santos, Pérez Jaime, additional, Herranz, Rosa Fernandez, additional, Hunt, Peter, additional, Browning, Donald, additional, Violette, Michael, additional, Hoddeson, Robert, additional, Rose, James, additional, Zhang, Jonathan, additional, Mazumdar, Avi, additional, Echiverri, Henri, additional, Chow, James, additional, Lovick, Darren, additional, Coleman, Martin, additional, Akhtar, Naveed, additional, Sugg, Rebecca, additional, Zanation, Adam, additional, Germanwala, Anand, additional, Senior, Brent, additional, Huang, David, additional, Aucutt-Walter, Natalie, additional, Kasner, Scott, additional, LeRoux, Peter, additional, von Kummer, Rüdiger, additional, and Palesch, Yuko, additional

Published
2019
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27. Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.

Author

van der Worp, H Bart, Macleod, Malcolm R, Bath, Philip MW, Bathula, Raj, Christensen, Hanne, Colam, Bridget, Cordonnier, Charlotte, Demotes-Mainard, Jacques, Durand-Zaleski, Isabelle, Gluud, Christian, Jakobsen, Janus Christian, Kallmünzer, Bernd, Kollmar, Rainer, Krieger, Derk W, Lees, Kennedy R, Michalski, Dominik, Molina, Carlos, Montaner, Joan, Roine, Risto O, and Petersson, Jesper

Published
2019
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28. Granulocyte colony-stimulating factor in patients with acute ischemic stroke : results of the AX200 for Ischemic Stroke trial

Author

Ringelstein, E Bernd, Thijs, Vincent, Norrving, Bo, Chamorro, Angel, Aichner, Franz, Grond, Martin, Saver, Jeff, Laage, Rico, Schneider, Armin, Rathgeb, Frank, Vogt, Gerhard, Charissé, Gabriele, Fiebach, Jochen B, Schwab, Stefan, Schäbitz, Wolf R, Kollmar, Rainer, Fisher, Marc, Brozman, Miroslav, Skoloudik, David, Gruber, Franz, Serena Leal, Joaquin, Veltkamp, Roland, Köhrmann, Martin, Berrouschot, Jörg, AXIS 2 Investigators, and Diener, Hans Christoph (Beitragende*r)

Subjects
Advanced and Specialized Nursing, medicine.medical_specialty, Neurology, business.industry, Medizin, Filgrastim, Placebo, medicine.disease, Surgery, Granulocyte colony-stimulating factor, Clinical trial, Modified Rankin Scale, medicine.artery, Internal medicine, Middle cerebral artery, medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Stroke, medicine.drug
Abstract

Background and Purpose— Granulocyte colony–stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose–escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients. Methods— G-CSF (135 µg/kg body weight intravenous over 72 hours) was tested against placebo in 328 patients in a multinational, multicenter, randomized, and placebo-controlled trial (NCT00927836; www.clinicaltrial.gov ). Main inclusion criteria were ≤9-hour time window after stroke onset, infarct localization in the middle cerebral artery territory, baseline National Institutes of Health Stroke Scale score range of 6 to 22, and baseline diffusion-weighted imaging lesion size ≥15 mL. Primary and secondary end points were the modified Rankin scale score and the National Institutes of Health Stroke Scale score at day 90, respectively. Data were analyzed using a prespecified model that adjusted for age, National Institutes of Health Stroke Scale score at baseline, and initial infarct volume (diffusion-weighted imaging). Results— G-CSF treatment failed to meet the primary and secondary end points of the trial. For additional end points such as mortality, Barthel index, or infarct size at day 30, G-CSF did not show efficacy either. There was, however, a trend for reduced infarct growth in the G-CSF group. G-CSF showed the expected peripheral pharmacokinetic and pharmacodynamic profiles, with a strong increase in leukocytes and monocytes. In parallel, the cytokine profile showed a significant decrease of interleukin-1. Conclusions— G-CSF, a novel and promising drug candidate with a comprehensive preclinical and clinical package, did not provide any significant benefit with respect to either clinical outcome or imaging biomarkers. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00927836.

Published
2013

32. AXIS

Author

Schäbitz, Wolf R., primary, Laage, Rico, additional, Vogt, Gerhard, additional, Koch, Winfried, additional, Kollmar, Rainer, additional, Schwab, Stefan, additional, Schneider, Dietmar, additional, Hamann, Gerhard F., additional, Rosenkranz, Michael, additional, Veltkamp, Roland, additional, Fiebach, Jochen B., additional, Hacke, Werner, additional, Grotta, James C., additional, Fisher, Marc, additional, and Schneider, Armin, additional

Published
2010
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34. Abstract 5504: Transient Decrease in Circulating Dendritic Cell Precursors After Acute Stroke - Potential Recruitment Into the Brain

Author

Yilmaz, Atilla, primary, Fuchs, Tanja, additional, Dietel, Barbara, additional, Altendorf, Regina, additional, Cicha, Iwona, additional, Stumpf, Christian, additional, Schellinger, Peter, additional, Blümcke, Ingmar, additional, Schwab, Stefan, additional, Daniel, Werner G., additional, Garlichs, Christoph D., additional, and Kollmar, Rainer, additional

Published
2009
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39. Abstract 2653.

Author

Staykov, Dimitre, Wagner, Ingrid, Doerfler, Arnd, Schwab, Stefan, and Kollmar, Rainer

Published
2012

40. COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS): a pilot study.

Author

Bardutzky J, Kollmar R, Al-Rawi F, Lambeck J, Fazel M, Taschner C, and Niesen WD

Subjects
Humans, Aged, Pilot Projects, Male, Female, Treatment Outcome, Time Factors, Aged, 80 and over, Middle Aged, Combined Modality Therapy, Recovery of Function, Time-to-Treatment, Prospective Studies, Thrombectomy adverse effects, Feasibility Studies, Hypothermia, Induced adverse effects, Endovascular Procedures adverse effects, Endovascular Procedures instrumentation, Ischemic Stroke therapy, Ischemic Stroke physiopathology, Ischemic Stroke diagnosis, Ischemic Stroke diagnostic imaging
Abstract

Background: To evaluate the feasibility and safety of a fast initiation of cooling to a target temperature of 35°C by means of transnasal cooling in patients with anterior circulation large vessel occlusion (LVO) undergoing endovascular thrombectomy (EVT)., Methods: Patients with an LVO onset of <24 hour who had an indication for EVT were included in the study. Transnasal cooling (RhinoChill) was initiated immediately after the patient was intubated for EVT and continued until an oesophageal target temperature of 35°C was reached. Hypothermia was maintained with surface cooling for 6-hour postrecanalisation, followed by active rewarming (+0.2°C/hour). The primary outcome was defined as the time required to reach 35°C, while secondary outcomes comprised clinical, radiological and safety parameters., Results: Twenty-two patients (median age, 77 years) were included in the study (14 received additional thrombolysis, 4 additional stenting of the proximal internal carotid artery). The median time intervals were 309 min for last-seen-normal-to-groin, 58 min for door-to-cooling-initiation, 65 min for door-to-groin and 123 min for door-to-recanalisation. The target temperature of 35°C was reached within 30 min (range 13-78 min), corresponding to a cooling rate of 2.6 °C/hour. On recanalisation, 86% of the patients had a body temperature of ≤35°C. The median National Institutes of Health Stroke Scale at admission was 15 and improved to 2 by day 7, and 68% of patients had a good outcome (modified Rankin Scale 0-2) at 3 months. Postprocedure complications included asymptomatic bradycardia (32%), pneumonia (18%) and asymptomatic haemorrhagic transformation (18%)., Conclusion: The combined application of hypothermia and thrombectomy was found to be feasible in sedated and ventilated patents. Adverse events were comparable to those previously described for EVT in the absence of hypothermia. The effect of this procedure will next be evaluated in the randomised COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke-2 trial., Competing Interests: Competing interests: MF is an employee of the company BrainCool., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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