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2. Adhesion-independent topography-based leukocyte migration.

Author

Friedl, Peter, Konstantopoulos, Konstantinos, Sahai, Erik, and Weiner, Orion

Subjects
Biochemistry and Cell Biology, Engineering, Biological Sciences, Biomedical Engineering, Bioengineering, 1.1 Normal biological development and functioning, Underpinning research, Inflammatory and immune system, Actin, adhesion, cells, leukocyte
Abstract

Cells need to couple intracellular actin flows with the substrate to generate forward movement. This has traditionally been studied in the context of specific transmembrane receptors, particularly integrin adhesion receptors, which link extracellular adhesive molecules to the actin cytoskeleton. However, leukocytes and other cells can also migrate using integrin-independent strategies both in vivo and in vitro, though the cellular and environmental requirements for this mode are not fully understood. In seminal recent work, Reversat et al.1 develop a range of innovative 2D and 3D engineered microdevices and probe the biophysical mechanisms underlying T lymphocytes and dendritic cells in conditions of limited substrate adhesion. They identify a physical principle of mechano-coupling between retrograde actin flow and irregular extracellular confinement, which allows the cell to generate mechanical resistance and move in the absence of receptor-mediated adhesion. Through the combined use of experiments and theoretical modeling, this work resolves a long-standing question in cell biology and establishes mechanical interaction with an irregular-shaped 3D environment which may be relevant to cell migration in a range of tissue contexts.

Published
2022

3. A spatially explicit impact assessment of road characteristics, road-induced fragmentation and noise on bird species in Cyprus

Author

Konstantopoulos, Konstantinos, Moustakas, Aristides, and Vogiatzakis, Ioannis N.

Subjects
Quantitative Biology - Quantitative Methods, Quantitative Biology - Populations and Evolution, Statistics - Applications
Abstract

The rapid increase of transportation infrastructure during the recent decades has caused a number of effects on bird species, including collision mortality, habitat loss, fragmentation and noise. This paper investigates the effects of traffic noise and road-induced fragmentation on breeding bird richness in Cyprus. Cyprus, situated along one of the main migratory routes for birds, has a rich and diverse avifauna threatened by an ever-expanding road network and a road density among the highest in Europe. In this first island-wide study we used data from 102 breeding birds recorded in 10 km x 10 km grid cells. Within every cell we calculated road traffic noise and eight road-related properties. Most of the grid cells are subject to intense fragmentation and traffic noise with combined impact hotspots located even within protected areas (such as Cape Greco, and the Troodos Massif). Results from variance partitioning indicated that road-related properties (total road extent and road length) accounted for a combined 59% of variation in species richness, followed by fragmentation-related properties and noise properties. The study posits the need for further in-depth research on the effects of road networks on birds, and road construction, particularly in protected areas within Mediterranean islands.

Published
2020
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7. Extracellular fluid viscosity enhances cell migration and cancer dissemination

Author

Bera, Kaustav, Kiepas, Alexander, Godet, Inês, Li, Yizeng, Mehta, Pranav, Ifemembi, Brent, Paul, Colin D., Sen, Anindya, Serra, Selma A., Stoletov, Konstantin, Tao, Jiaxiang, Shatkin, Gabriel, Lee, Se Jong, Zhang, Yuqi, Boen, Adrianna, Mistriotis, Panagiotis, Gilkes, Daniele M., Lewis, John D., Fan, Chen-Ming, Feinberg, Andrew P., Valverde, Miguel A., Sun, Sean X., and Konstantopoulos, Konstantinos

Published
2022
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11. Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma

Author

Kenchappa, Rajappa S., Mistriotis, Panagiotis, Wisniewski, Emily, Bhattacharya, Santanu, Kulkarni, Tanmay, West, Rita, Luu, Amanda, Conlon, Meghan, Heimsath, Ernest, Crish, James F., Picariello, Hannah S., Dovas, Athanassios, Zarco, Natanael, Lara-Velazquez, Montserrat, Quiñones-Hinojosa, Alfredo, Hammer, John A., Mukhopadhyay, Debrabrata, Cheney, Richard E., Konstantopoulos, Konstantinos, Canoll, Peter, and Rosenfeld, Steven S.

Published
2020
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14. A physical sciences network characterization of non-tumorigenic and metastatic cells

Author

Agus, David B, Alexander, Jenolyn F, Arap, Wadih, Ashili, Shashanka, Aslan, Joseph E, Austin, Robert H, Backman, Vadim, Bethel, Kelly J, Bonneau, Richard, Chen, Wei-Chiang, Chen-Tanyolac, Chira, Choi, Nathan C, Curley, Steven A, Dallas, Matthew, Damania, Dhwanil, Davies, Paul CW, Decuzzi, Paolo, Dickinson, Laura, Estevez-Salmeron, Luis, Estrella, Veronica, Ferrari, Mauro, Fischbach, Claudia, Foo, Jasmine, Fraley, Stephanie I, Frantz, Christian, Fuhrmann, Alexander, Gascard, Philippe, Gatenby, Robert A, Geng, Yue, Gerecht, Sharon, Gillies, Robert J, Godin, Biana, Grady, William M, Greenfield, Alex, Hemphill, Courtney, Hempstead, Barbara L, Hielscher, Abigail, Hillis, W Daniel, Holland, Eric C, Ibrahim-Hashim, Arig, Jacks, Tyler, Johnson, Roger H, Joo, Ahyoung, Katz, Jonathan E, Kelbauskas, Laimonas, Kesselman, Carl, King, Michael R, Konstantopoulos, Konstantinos, Kraning-Rush, Casey M, Kuhn, Peter, Kung, Kevin, Kwee, Brian, Lakins, Johnathon N, Lambert, Guillaume, Liao, David, Licht, Jonathan D, Liphardt, Jan T, Liu, Liyu, Lloyd, Mark C, Lyubimova, Anna, Mallick, Parag, Marko, John, McCarty, Owen JT, Meldrum, Deirdre R, Michor, Franziska, Mumenthaler, Shannon M, Nandakumar, Vivek, O’Halloran, Thomas V, Oh, Steve, Pasqualini, Renata, Paszek, Matthew J, Philips, Kevin G, Poultney, Christopher S, Rana, Kuldeepsinh, Reinhart-King, Cynthia A, Ros, Robert, Semenza, Gregg L, Senechal, Patti, Shuler, Michael L, Srinivasan, Srimeenakshi, Staunton, Jack R, Stypula, Yolanda, Subramanian, Hariharan, Tlsty, Thea D, Tormoen, Garth W, Tseng, Yiider, van Oudenaarden, Alexander, Verbridge, Scott S, Wan, Jenny C, Weaver, Valerie M, Widom, Jonathan, Will, Christine, Wirtz, Denis, Wojtkowiak, Jonathan, and Wu, Pei-Hsun

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Breast Cancer, Women's Health, 2.1 Biological and endogenous factors, Biomarkers, Tumor, Cell Line, Tumor, Cell Movement, Cell Size, Cell Survival, Computer Simulation, Gene Expression Regulation, Neoplastic, Humans, Models, Biological, Neoplasm Metastasis, Neoplasm Proteins, Physical Sciences - Oncology Centers Network
Abstract

To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences-Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis. Experiments were performed in 20 laboratories from 12 PS-OCs. Each laboratory was supplied with identical aliquots and common reagents and culture protocols. Analyses of these measurements revealed dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles. Model-based multi-omics approaches identified key differences between these cells' regulatory networks involved in morphology and survival. These results provide a multifaceted description of cellular parameters of two widely used cell lines and demonstrate the value of the PS-OC Network approach for integration of diverse experimental observations to elucidate the phenotypes associated with cancer metastasis.

Published
2013

15. A physical sciences network characterization of non-tumorigenic and metastatic cells.

Author

Physical Sciences - Oncology Centers Network, Agus, David B, Alexander, Jenolyn F, Arap, Wadih, Ashili, Shashanka, Aslan, Joseph E, Austin, Robert H, Backman, Vadim, Bethel, Kelly J, Bonneau, Richard, Chen, Wei-Chiang, Chen-Tanyolac, Chira, Choi, Nathan C, Curley, Steven A, Dallas, Matthew, Damania, Dhwanil, Davies, Paul CW, Decuzzi, Paolo, Dickinson, Laura, Estevez-Salmeron, Luis, Estrella, Veronica, Ferrari, Mauro, Fischbach, Claudia, Foo, Jasmine, Fraley, Stephanie I, Frantz, Christian, Fuhrmann, Alexander, Gascard, Philippe, Gatenby, Robert A, Geng, Yue, Gerecht, Sharon, Gillies, Robert J, Godin, Biana, Grady, William M, Greenfield, Alex, Hemphill, Courtney, Hempstead, Barbara L, Hielscher, Abigail, Hillis, W Daniel, Holland, Eric C, Ibrahim-Hashim, Arig, Jacks, Tyler, Johnson, Roger H, Joo, Ahyoung, Katz, Jonathan E, Kelbauskas, Laimonas, Kesselman, Carl, King, Michael R, Konstantopoulos, Konstantinos, Kraning-Rush, Casey M, Kuhn, Peter, Kung, Kevin, Kwee, Brian, Lakins, Johnathon N, Lambert, Guillaume, Liao, David, Licht, Jonathan D, Liphardt, Jan T, Liu, Liyu, Lloyd, Mark C, Lyubimova, Anna, Mallick, Parag, Marko, John, McCarty, Owen JT, Meldrum, Deirdre R, Michor, Franziska, Mumenthaler, Shannon M, Nandakumar, Vivek, O'Halloran, Thomas V, Oh, Steve, Pasqualini, Renata, Paszek, Matthew J, Philips, Kevin G, Poultney, Christopher S, Rana, Kuldeepsinh, Reinhart-King, Cynthia A, Ros, Robert, Semenza, Gregg L, Senechal, Patti, Shuler, Michael L, Srinivasan, Srimeenakshi, Staunton, Jack R, Stypula, Yolanda, Subramanian, Hariharan, Tlsty, Thea D, Tormoen, Garth W, Tseng, Yiider, van Oudenaarden, Alexander, Verbridge, Scott S, Wan, Jenny C, Weaver, Valerie M, Widom, Jonathan, Will, Christine, Wirtz, Denis, Wojtkowiak, Jonathan, and Wu, Pei-Hsun

Subjects
Physical Sciences - Oncology Centers Network, Cell Line, Tumor, Humans, Neoplasm Metastasis, Neoplasm Proteins, Cell Movement, Cell Size, Cell Survival, Gene Expression Regulation, Neoplastic, Models, Biological, Computer Simulation, Biomarkers, Tumor, Cancer, Breast Cancer, Biotechnology, 2.1 Biological and endogenous factors
Abstract

To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences-Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis. Experiments were performed in 20 laboratories from 12 PS-OCs. Each laboratory was supplied with identical aliquots and common reagents and culture protocols. Analyses of these measurements revealed dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles. Model-based multi-omics approaches identified key differences between these cells' regulatory networks involved in morphology and survival. These results provide a multifaceted description of cellular parameters of two widely used cell lines and demonstrate the value of the PS-OC Network approach for integration of diverse experimental observations to elucidate the phenotypes associated with cancer metastasis.

Published
2013

17. Dysarthria in early Parkinson's disease

Author

Konstantopoulos, Konstantinos

Subjects
616.833
Abstract

The aim of the present study was threefold. First, to examine the incidence of dysarthria in patients in the beginning of Parkinson's disease by using a standardised test (Frenchay Dysarthria Assessment/FDA) and an intelligibility assessment tool. Second, to identify differences in speech and in measures of phonation between the Parkinsonian group and a matched control geriatric group using the FDA and electrolaryngography. Finally, to identify the effect of medication on speech and phonation in the dysarthric Parkinsonian group. The results showed that 8 out of 12 (66%) Parkinsonian subjects exhibited lower scores in the FDA compared to controls. Qualitative differences between the two groups were found in the isolated movements of the articulators but not in running speech and speech intelligibility. An improvement in the FDA scoring was found 3-3.5 months after medication. This improvement focused on the areas of tongue and lips and was accompanied with significant increases in intelligibility. No differences in measures of phonation were found either between the two groups or in the same group after medication. The above results suggest that in the beginning of Parkinson's disease, dysarthria is expressed as slowness and may be related to the primary diagnostic symptom of bradykinesia. Due to the small sample and the lack of dosage control, the significance of these findings appears to be inconclusive and warrants further investigation. Future research should employ instrumental quantitative measures on isolated movements of the articulators that may correlate with running speech and will aim to find clinical markers of speech in the diagnosis of Parkinson's disease.

Published
2004

20. Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement

Author

Law, Robert A., Kiepas, Alexander, Desta, Habben E., Ipina, Emiliano Perez, Parlani, M., Lee, Se Jong, Friedl, P.H.A., Camley, Brian A., Konstantopoulos, Konstantinos, Law, Robert A., Kiepas, Alexander, Desta, Habben E., Ipina, Emiliano Perez, Parlani, M., Lee, Se Jong, Friedl, P.H.A., Camley, Brian A., and Konstantopoulos, Konstantinos

Abstract

Item does not contain fulltext

Published
2023

22. Targeting hypersialylation in pancreatic ductal adenocarcinoma to reverts their malignant phenotype

Author

Guerrero, Pedro E., Miró, Laura, López, Júlia, Hernández-Hatibi, Soraya, Wong, Bin S., Massaguer, Anna, Konstantopoulos, Konstantinos, Martínez-Bosch, Neus, Manero-Rupérez, Noemí, Moreno-Estellés, Mireia, Ortiz, Rosa M., Llop, Esther, Navarro Medrano, Pilar, Peracaula, Rosa, García-Aznar, José M., Guerrero, Pedro E., Miró, Laura, López, Júlia, Hernández-Hatibi, Soraya, Wong, Bin S., Massaguer, Anna, Konstantopoulos, Konstantinos, Martínez-Bosch, Neus, Manero-Rupérez, Noemí, Moreno-Estellés, Mireia, Ortiz, Rosa M., Llop, Esther, Navarro Medrano, Pilar, Peracaula, Rosa, and García-Aznar, José M.

Published
2023

24. HER2 missense mutations have distinct effects on oncogenic signaling and migration

Author

Zabransky, Daniel J., Yankaskas, Christopher L., Cochran, Rory L., Wong, Hong Yuen, Croessmann, Sarah, Chu, David, Kavuri, Shyam M., Brewer, Monica Red, Rosen, D. Marc, Dalton, W. Brian, Cimino-Mathews, Ashley, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Cidado, Justin, Erlanger, Bracha, Parsons, Heather A., Manto, Kristen M., Bose, Ron, Lauring, Josh, Arteaga, Carlos L., Konstantopoulos, Konstantinos, and Park, Ben Ho

Published
2015

26. Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement

Author

Law, Robert A., primary, Kiepas, Alexander, additional, Desta, Habben E., additional, Perez Ipiña, Emiliano, additional, Parlani, Maria, additional, Lee, Se Jong, additional, Yankaskas, Christopher L., additional, Zhao, Runchen, additional, Mistriotis, Panagiotis, additional, Wang, Nianchao, additional, Gu, Zhizhan, additional, Kalab, Petr, additional, Friedl, Peter, additional, Camley, Brian A., additional, and Konstantopoulos, Konstantinos, additional

Published
2023
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32. Pharmaceutical Prevention and Management of Cardiotoxicity in Hematological Malignancies

Author

Perpinia, Anastasia Stella, primary, Kadoglou, Nikolaos, additional, Vardaka, Maria, additional, Gkortzolidis, Georgios, additional, Karavidas, Apostolos, additional, Marinakis, Theodoros, additional, Papachrysostomou, Chrysostomi, additional, Makaronis, Panagiotis, additional, Vlachou, Charikleia, additional, Mantzourani, Marina, additional, Farmakis, Dimitrios, additional, and Konstantopoulos, Konstantinos, additional

Published
2022
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43. Sarcomeric deficits underlie MYBPC1-associated myopathy with myogenic tremor

Author

Geist Hauserman, Janelle, primary, Stavusis, Janis, additional, Joca, Humberto C., additional, Robinett, Joel C., additional, Hanft, Laurin, additional, Vandermeulen, Jack, additional, Zhao, Runchen, additional, Stains, Joseph P., additional, Konstantopoulos, Konstantinos, additional, McDonald, Kerry S., additional, Ward, Christopher, additional, and Kontrogianni-Konstantopoulos, Aikaterini, additional

Published
2021
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44. E-selectin receptors on human leukocytes

Author

Nimrichter, Leonardo, Burdick, Monica M., Aoki, Kazuhiro, Laroy, Wouter, Fierro, Mark A., Hudson, Sherry A., Von Seggern, Christopher E., Cotter, Robert J., Bochner, Bruce S., Tiemeyer, Michael, Konstantopoulos, Konstantinos, and Schnaar, Ronald L.

Published
2008
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46. The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Author

Yankaskas, Christopher L., primary, Bera, Kaustav, additional, Stoletov, Konstantin, additional, Serra, Selma A., additional, Carrillo-Garcia, Julia, additional, Tuntithavornwat, Soontorn, additional, Mistriotis, Panagiotis, additional, Lewis, John D., additional, Valverde, Miguel A., additional, and Konstantopoulos, Konstantinos, additional

Published
2021
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48. Defective blood vessel development and pericyte/pvSMC distribution in [alpha]4 integrin-deficient mouse embryos

Author

Grazioli, Alison, Alves, Christina S., Konstantopoulos, Konstantinos, and Yang, Joy T.

Subjects
Fibronectins, Embryonic development, Integrins, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ydbio.2006.01.026 Byline: Alison Grazioli (a), Christina S. Alves (b), Konstantinos Konstantopoulos (b), Joy T. Yang (a) Keywords: Blood vessel development; Cell motility; [alpha]4[beta]1 integrin; Fibronectin; Pericyte; Presumptive vascular smooth muscle cell Abstract: Blood vessel development is in part regulated by pericytes/presumptive vascular smooth muscle cells (PC/pvSMCs). Here, we demonstrate that interactions between PC/pvSMCs and extracellular matrix play a critical role in this event. We show that the cranial vessels in [alpha]4 integrin-deficient mouse embryos at the stage of vessel remodeling are increased in diameter. This defect is accompanied by a failure of PC/pvSMCs, which normally express [alpha]4[beta]1 integrin, to spread uniformly along the vessels. We also find that fibronectin but not VCAM-1 is localized in the cranial vessels at this stage. Furthermore, cultured [alpha]4 integrin-null PC/pvSMCs plated on fibronectin display a delay in initiating migration, a reduction in migration speed, and a decrease in directional persistence in response to a polarized force of shear flow. These results suggest that specific motile activities of PC/pvSMCs regulated by mechanical signals imposed by the interstitial extracellular matrix may also be required in vivo for the distribution and function of the PC/pvSMCs during blood vessel development. Author Affiliation: (a) Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (b) Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21205, USA Article History: Received 19 September 2005; Revised 20 January 2006; Accepted 27 January 2006

Published
2006

49. Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos

Author

Grazioli, Alison, Alves, Christina S., Konstantopoulos, Konstantinos, and Yang, Joy T.

Subjects
Blood vessels -- Research, Integrins -- Research, Mice, mutant strains -- Research, Smooth muscle -- Research, Biological sciences
Abstract

The role of pericytes/presumptive vascular smooth muscle cells in blood vessel development, using alpha 4 integrin-deficient mouse embryo studies, is presented.

Published
2006

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