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3. Synthesis of imidazo[1,2- a ]pyridine-containing peptidomimetics by tandem of Groebke-Blackburn-Bienaymé and Ugi reactions.

Author

Kolomiiets OV, Tsygankov AV, Kornet MN, Brazhko AA, Musatov VI, and Chebanov VA

Abstract

Peptidomimetics with a substituted imidazo[1,2- a ]pyridine fragment were synthesized by a tandem of Groebke-Blackburn-Bienaymé and Ugi reactions. The target products contain substituted imidazo[1,2- a ]pyridine and peptidomimetic moieties as pharmacophores with four diversity points introduced from readily available starting materials, including scaffold diversity. A small focused compound library of 20 Ugi products was prepared and screened for antibacterial activity., (Copyright © 2023, Kolomiiets et al.)

Published
2023
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