Search

Your search keyword '"Kramer H"' showing total 980 results
Start Over Author "Kramer H" Search Limiters Full Text

Refine your results

980 results on '"Kramer H"'

3. On the computational complexity of uncapacitated multi-plant lot-sizing problems

Author

Cunha, J. O., Kramer, H. H., and Melo, R. A.

Subjects
Mathematics - Optimization and Control, Computer Science - Computational Complexity
Abstract

Production and inventory planning have become crucial and challenging in nowadays competitive industrial and commercial sectors, especially when multiple plants or warehouses are involved. In this context, this paper addresses the complexity of uncapacitated multi-plant lot-sizing problems. We consider a multi-item uncapacitated multi-plant lot-sizing problem with fixed transfer costs and show that two of its very restricted special cases are already NP-hard. Namely, we show that the single-item uncapacitated multi-plant lot-sizing problem with a single period and the multi-item uncapacitated two-plant lot-sizing problem with fixed transfer costs are NP-hard. Furthermore, as a direct implication of the proven results, we also show that a two-echelon multi-item lot-sizing with joint setup costs on transportation is NP-hard.

Published
2020
Full Text
View/download PDF

5. Building analytics and monitoring-based commissioning: industry practice, costs, and savings

Author

Kramer, H, Lin, G, Curtin, C, Crowe, E, and Granderson, J

Subjects
Civil Engineering, Electrical and Electronic Engineering, Urban and Regional Planning
Abstract

As building energy and system-level monitoring becomes more common, facility teams are faced with an overwhelming amount of data. This data does not typically lead to insights, corrective actions, and energy savings unless it is stored, organized, analyzed, and prioritized in automated ways. The Smart Energy Analytics Campaign is a public-private sector partnership program focused on supporting commercially available energy management and information systems (EMIS) technology use and monitoring-based commissioning (MBCx) practices. MBCx is an ongoing commissioning process with focus on analyzing large amounts of data on a continuous basis. EMIS tools are used in the MBCx process to organize, present, visualize, and analyze the data. With campaign data from over 400 million square feet (sq. ft.) of installed space, this paper presents the results achieved by owners that are implementing EMIS, along with associated technology costs. The study’s EMIS users that reported savings achieved the median cost savings of $0.19/sq. ft. and 7% annually, with savings shown to increase over time. For 35 portfolio owners, the median base cost to install an EMIS was $0.03/sq. ft., with an annual recurring software cost of $0.02/sq. ft. and an estimated annual labor cost of $0.03/sq. ft. Two types of EMIS systems—energy information systems and fault detection and diagnostic systems—are defined in the body of the paper. Of the two, we find that fault detection and diagnostic systems have both higher savings and higher costs. The paper offers a characterization of EMIS products, MBCx services, and trends in the industry.

Published
2020

6. Building fault detection and diagnostics: Achieved savings, and methods to evaluate algorithm performance

Author

Lin, G, Kramer, H, and Granderson, J

Subjects
Bioengineering, Architecture, Building, Environmental Science and Management, Building & Construction
Abstract

Fault detection and diagnosis (FDD) represents one of the most active areas of research and commercial product development in the buildings industry. This paper addresses two questions concerning FDD implementation and advancement 1) What are today's users of FDD saving and spending on the technology? 2) What methods and datasets can be used to evaluate and benchmark FDD algorithm performance? Relevant to the first question, 26 organizations that use FDD across a total 550 buildings and 97 M sf achieved median savings of 8%. Twenty-seven FDD users reported that the median base cost for FDD software, annual recurring software cost, and annual labor cost were $8, $2.7 and $8 per monitoring point, with a median implementation size of approximately 1300 points. To address the second question, this paper describes a systematic methodology for evaluating the performance of FDD algorithms, curates an initial test dataset of air handling unit (AHU) system faults, and completes a trial to demonstrate the evaluation process on three sample FDD algorithms. The work provided a first step toward a standard evaluation of different FDD technologies. It showed the test methodology is indeed scalable and repeatable, provided an understanding of the types of insights that can be gained from algorithm performance testing, and highlighted the priorities for further expanding the test dataset.

Published
2020

7. A framework for monitoring-based commissioning: Identifying variables that act as barriers and enablers to the process

Author

Harris, N, Shealy, T, Kramer, H, Granderson, J, and Reichard, G

Subjects
Engineering, Built Environment and Design, Building & Construction
Abstract

The practice of monitoring-based commissioning (MBCx) using energy management and information systems (EMIS) has been shown to enable and help sustain up to 20% energy savings in buildings. Despite research that has quantified the costs, benefits, and energy savings of MBCx, the process remains under-utilized. To understand why MBCx is not more frequently adopted and how to encourage its use, this research synthesizes qualitative data from over 40 organizations, currently engaging in MBCx. The outcome of this research is a framework containing variables that emerged from the qualitative data, marked as barriers or enablers, organized by phases of the MBCx process. The framework is comprised of 51 emergent variables that fall within 13 different categories. The variables that most frequently act as barriers are data configuration, measurement & verification (M&V), developing specifications for EMIS, and data architecture. Although some variables that act as barriers for one organization were identified as enablers for another. For example, payback/ROI was considered a barrier 7 times and an enabler 3 times. One organization had difficulty making the business case for the initial investment for MBCx due to lack of cost information, while another was able to justify large investments with documented savings of previously implemented measures identified through MBCx. The framework formally validates barriers found in previous research, and can be used by practitioners to better understand common experiences with MBCx. This research highlights the need for a similar collective data set to validate common enablers to MBCx and also the need for empirical research to determine relationships between variables.

Published
2018

8. Rapid growth of the US wildland-urban interface raises wildfire risk

Author

Radeloff, Volker C, Helmers, David P, Kramer, H Anu, Mockrin, Miranda H, Alexandre, Patricia M, Bar-Massada, Avi, Butsic, Van, Hawbaker, Todd J, Martinuzzi, Sebastián, Syphard, Alexandra D, and Stewart, Susan I

Subjects
Ecological Applications, Environmental Sciences, Life on Land, Conservation of Natural Resources, Ecosystem, Housing, Humans, Risk Factors, United States, Urbanization, Wildfires, development, fragmentation, housing growth, sprawl, wildfires
Abstract

The wildland-urban interface (WUI) is the area where houses and wildland vegetation meet or intermingle, and where wildfire problems are most pronounced. Here we report that the WUI in the United States grew rapidly from 1990 to 2010 in terms of both number of new houses (from 30.8 to 43.4 million; 41% growth) and land area (from 581,000 to 770,000 km2; 33% growth), making it the fastest-growing land use type in the conterminous United States. The vast majority of new WUI areas were the result of new housing (97%), not related to an increase in wildland vegetation. Within the perimeter of recent wildfires (1990-2015), there were 286,000 houses in 2010, compared with 177,000 in 1990. Furthermore, WUI growth often results in more wildfire ignitions, putting more lives and houses at risk. Wildfire problems will not abate if recent housing growth trends continue.

Published
2018

9. Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen

Author

Torres, David E, Kramer, H Martin, Tracanna, Vittorio, Fiorin, Gabriel L, Cook, David E, Seidl, Michael F, Thomma, Bart P H J, Torres, David E, Kramer, H Martin, Tracanna, Vittorio, Fiorin, Gabriel L, Cook, David E, Seidl, Michael F, and Thomma, Bart P H J

Abstract

The spatial organization of eukaryotic genomes is linked to their biological functions, although it is not clear how this impacts the overall evolution of a genome. Here, we uncover the three-dimensional (3D) genome organization of the phytopathogen Verticillium dahliae, known to possess distinct genomic regions, designated adaptive genomic regions (AGRs), enriched in transposable elements and genes that mediate host infection. Short-range DNA interactions form clear topologically associating domains (TADs) with gene-rich boundaries that show reduced levels of gene expression and reduced genomic variation. Intriguingly, TADs are less clearly insulated in AGRs than in the core genome. At a global scale, the genome contains bipartite long-range interactions, particularly enriched for AGRs and more generally containing segmental duplications. Notably, the patterns observed for V. dahliae are also present in other Verticillium species. Thus, our analysis links 3D genome organization to evolutionary features conserved throughout the Verticillium genus.

Published
2024

10. Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen

Author

Theoretical Biology and Bioinformatics, Sub Bioinformatics, Torres, David E, Kramer, H Martin, Tracanna, Vittorio, Fiorin, Gabriel L, Cook, David E, Seidl, Michael F, Thomma, Bart P H J, Theoretical Biology and Bioinformatics, Sub Bioinformatics, Torres, David E, Kramer, H Martin, Tracanna, Vittorio, Fiorin, Gabriel L, Cook, David E, Seidl, Michael F, and Thomma, Bart P H J

Published
2024

11. Greenhouse gas reporting of the LULUCF sector in the Netherlands : Methodological background, update 2024

Author

van Baren, S.A., Arets, E.J.M.M., Hendriks, C.M.J., Kramer, H., Lesschen, J.P., Schelhaas, M.J., van Baren, S.A., Arets, E.J.M.M., Hendriks, C.M.J., Kramer, H., Lesschen, J.P., and Schelhaas, M.J.

Abstract

This report provides a complete methodological description and background information on the Dutch National System for Greenhouse Gas reporting of the LULUCF sector. It provides a detailed description of the methodologies, activity data and emission factors that were used. Each reporting category Forest land, Cropland, Grassland, Wetlands, Settlements, Other Land and Harvested Wood Products, is described in a separate chapter., Dit rapport geeft de methodologische achtergrondinformatie die gebruikt wordt binnen het nationale systeem om de broeikasgasemissies voor de LULUCF (landgebruik en bosbouw) sector te berekenen, zoals die aan de VN Klimaat-conventie (UNFCCC) worden gerapporteerd. Het rapport geeft gedetailleerde beschrijvingen van de gehanteerde methodologie, gebruikte activiteitendata en emissie-factoren. De te rapporteren categorieën Bos (Forest land), Bouwland (Cropland), Grasland (Grassland), Wetlands, Bebouwd gebied (Settlements), Ander land (Other Land), en Geoogste houtproducten (Harvested Wood Products) worden per hoofdstuk beschreven.

Published
2024

14. The f_LT Response Function of D(e,e'p)n at Q^2=0.33(GeV/c)^2

Author

Boeglin, W. U., Arenhövel, H., Blomqvist, K. I., Böhm, R., Distler, M., Edelhoff, R., Ewald, I., Florizone, R., Friedrich, J., Geiges, R., Jourdan, J., Kahrau, M., Korn, M., Kramer, H., Krygier, K. W., Kunde, V., Kuss, M., Liesenfeld, A., Merle, K., Neuhausen, R., Offermann, E. A. J. M., Pospischil, Th., Potokar, M., Richter, A. W., Rokavec, A., Rosner, G., Sauer, P., Sick, I., Schardt, S. Sirca S., Serdarevic, A., Vodenik, B., Wagner, A., Walcher, Th., and Wolf, S.

Subjects
Nuclear Experiment
Abstract

The interference response function f_LT (R_LT) of the D(e,e'p)n reaction has been determined at squared four-momentum transfer Q^2 = 0.33 (GeV/c)^2 and for missing momenta up to p_miss= 0.29 (GeV/c). The results have been compared to calculations that reproduce f_LT quite well but overestimate the cross sections by 10 - 20% for missing momenta between 0.1 (GeV/c) and 0.2 (GeV/c) ., Comment: 12 Pages, 10 figures

Published
2008
Full Text
View/download PDF

15. Blood pressure and chronic kidney disease progression in a multi-racial cohort: the Multi-Ethnic Study of Atherosclerosis

Author

Bloomfield, GS, Yi, SS, Astor, BC, Kramer, H, Shea, S, Shlipak, MG, and Post, WS

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Hypertension, Aging, Cardiovascular, Renal and urogenital, Black or African American, Aged, Aged, 80 and over, Asian, Biomarkers, Blood Pressure, Chi-Square Distribution, Creatinine, Cystatin C, Disease Progression, Female, Glomerular Filtration Rate, Hispanic or Latino, Humans, Kidney, Logistic Models, Male, Middle Aged, Models, Biological, Multivariate Analysis, Odds Ratio, Predictive Value of Tests, Prevalence, Prognosis, Renal Insufficiency, Chronic, Risk Factors, Time Factors, United States, White People, blood pressure, glomerular filtration rate, renal disease, cystatin C, creatinine, ethnicity, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

The relationship between blood pressure (BP) and kidney function among individuals with chronic kidney disease (CKD) remains controversial. This study evaluated the association between BP and estimated glomerular filtration rate (eGFR) decline among adults with nondiabetic stage 3 CKD. The Multi-Ethnic Study of Atherosclerosis participants with an eGFR 30-59  ml min(-1) per 1.73 m2 at baseline without diabetes were included. Participants were followed over a 5-year period. Kidney function change was determined by annualizing the change in eGFR using cystatin C, creatinine and a combined equation. Risk factors for progression of CKD (defined as a decrease in annualized eGFR>2.5 ml min(-1) per 1.73 m2) were identified using univariate analyses and sequential logistic regression models. There were 220 participants with stage 3 CKD at baseline using cystatin C, 483 participants using creatinine and 381 participants using the combined equation. The median (interquartile range) age of the sample was 74 (68-79) years. The incidence of progression of CKD was 16.8% using cystatin C and 8.9% using creatinine (P=0.002). Systolic BP>140 mm Hg or diastolic BP>90 mm Hg was significantly associated with progression using a cystatin C-based (odds ratio (OR), 2.49; 95% confidence interval (CI), 1.12-5.52) or the combined equation (OR, 2.07; 95% CI, 1.16-3.69), but not when using creatinine after adjustment for covariates. In conclusion, with the inclusion of cystatin C in the eGFR assessment hypertension was an important predictor of CKD progression in a multi-ethnic cohort with stage 3 CKD.

Published
2013

16. The focal plane proton-polarimeter for the 3-spectrometer setup at MAMI

Author

Pospischil, T., Bartsch, P., Baumann, D., Boehm, R., Bohinc, K., Clawiter, N., Ding, M., Derber, S., Distler, M., Elsner, D., Ewald, I., Friedrich, J., Friedrich, J. M., Geiges, R., Groezinger, S., Hamdorf, M., Hedicke, S., Jennewein, P., Jourdan, J., Kahrau, M., Klein, F., Koenig, P., Kozlov, A., Kramer, H., Krygier, K. W., Lac, J., Liesenfeld, A., Malov, S., McIntyre, J., Merkel, H., Merle, P., Mueller, U., Neuhausen, R., Offermann, E. A., Potokar, M., Ransome, R., Richter, A., Rosner, G., Sanner, J., Schmieden, H., Seimetz, M., Sick, I., Straehle, O., Suele, A., Wagner, A., Walcher, T., Warren, G. A., Weis, M., and Wu, X. Q.

Subjects
Nuclear Experiment
Abstract

For experiments of the type A(\vec e,e'\vec p) the 3-spectrometer setup of the A1 collaboration at MAMI has been supplemented by a focal plane proton-polarimeter. To this end, a carbon analyzer of variable thickness and two double-planes of horizontal drift chambers have been added to the standard detector system of Spectrometer A. Due to the spin precession in the spectrometer magnets, all three polarization components at the target can be measured simultaneously. The performance of the polarimeter has been studied using elastic p(e,e'p) scattering., Comment: 23 pages LaTeX, 13 ps figures

Published
2000
Full Text
View/download PDF

20. Wirksamkeit stationärer Stimmrehabilitation

Author

Beschorner, V, Damásdi, N, Imre, A, Stangl, P, Hacki, T, Kramer, H, Kummer, P, Beschorner, V, Damásdi, N, Imre, A, Stangl, P, Hacki, T, Kramer, H, and Kummer, P

Abstract

Hintergrund: Eine stationäre Stimmrehabilitation ist bei bestehender oder drohender Minderung der Teilhabe eine Therapiemöglichkeit für Patienten mit Stimmstörungen nach erfolgloser ambulanter logopädischer Behandlung. Die prospektiv zwischen 2015 und 2017 durchgeführte Studie dient der Evaluation dieses stationären Therapieangebots am PASSAUER WOLF Reha-Zentrum Bad Gögging.Material und Methoden: Bei 256 Patienten wurden nach dem ELS Protokoll im Rahmen einer stationären Stimmrehabilitation als Eingangs- und Abschlussdiagnostik neben dem stroboskopischen Befund objektive funktionsdiagnostische Daten der Stimmgebung, sozialmedizinische und Daten zur Grunderkrankung sowie das subjektive Erleben mittels des VHI-12 erhoben, letzteres auch nach 3 und 12 Monaten nach Entlassung.Ergebnisse: Die mittlere Abnahme im VHI-12 betrug 5,2 Punkte. Der Therapieerfolg war langanhaltend und nach 12 Monaten nicht wesentlich gemindert.Der subjektive Therapieerfolg korrelierte mit Messgrößen objektiver Stimmdiagnostik (perzeptive Stimmklangbewertung, objektive Stimmschallanalyse und Stimmleistung in Untersuchungen des Sprech- und Singstimmfeldes).Der Therapieerfolg war von Geschlecht, Alter, Diagnosegruppe, beruflichem Stimmanspruch, Umfang der ambulanten Vortherapie und Chronizität der Stimmstörung unabhängig.Diskussion: Die Daten beschreiben erstmals den kurz-, mittel- und langfristigen Erfolg einer stationären Stimmrehabilitation.Die Verbesserung des stimmlichen Handicaps entspricht mit durchschnittlich 5 Punkten fast einer ganzen Stufe der VHI-12 Skala. Die subjektive Einschätzung korreliert mit den objektiven Messparametern und macht Erfolg und Qualitätsbeurteilung der Maßnahme transparent. Für die Indikationsstellung ist relevant, dass der Erfolg der Maßnahme unabhängig von den untersuchten Einflussgrößen ist; für alle Patientengruppen ist ein vergleichbarer Erfolg zu erwarten, lediglich sinkt die Schwelle, ab der eine stationäre Rehabilitation in Anspruch genommen wird, mit dem M

Published
2023

21. Epigenetic regulation of nuclear processes in fungal plant pathogens

Author

Kramer, H Martin, Cook, David E, Seidl, Michael F, Thomma, Bart P H J, Kramer, H Martin, Cook, David E, Seidl, Michael F, and Thomma, Bart P H J

Abstract

AU Through: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly the association of protein complexes to DNA, the eukaryotic : nuclear genome is broadly organized into open euchromatin that is accessible for enzymes acting on DNA and condensed heterochromatin that is inaccessible. Chemical and physical alterations to chromatin may impact its organization and functionality and are therefore important regulators of nuclear processes. Studies in various fungal plant pathogens have uncovered an association between chromatin organization and expression of in planta-induced genes that are important for pathogenicity. This review discusses chromatin-based regulation mechanisms as determined in the fungal plant pathogen Verticillium dahliae and relates the importance of epigenetic transcriptional regulation and other nuclear processes more broadly in fungal plant pathogens.

Published
2023

22. Epigenetic regulation of nuclear processes in fungal plant pathogens

Author

Sub Bioinformatics, Theoretical Biology and Bioinformatics, Kramer, H Martin, Cook, David E, Seidl, Michael F, Thomma, Bart P H J, Sub Bioinformatics, Theoretical Biology and Bioinformatics, Kramer, H Martin, Cook, David E, Seidl, Michael F, and Thomma, Bart P H J

Published
2023

23. Estimating body dimensions and weight of cattle on pasture with 3D models from UAV imagery

Author

Los, S., Mücher, C.A., Kramer, H., Franke, G.J., Kamphuis, C., Los, S., Mücher, C.A., Kramer, H., Franke, G.J., and Kamphuis, C.

Abstract

Monitoring traits of cattle with an Unmanned Aerial Vehicle (UAV) could assist farmers in monitoring the status and health of their herd without actually visiting them. This feasibility study presents 3D methods to manually estimate body dimensions, such as height and weight, of individual Holstein Friesian cows with stereo RGB imagery, video and LiDAR data from UAVs. In total, 25 different cows over 3 years were monitored and 4,611 images, ∼10 videos, and a LiDAR dataset were analysed. The methods used were estimating weight by analysing 3D models made with RGB imagery and video from UAV, and estimating height and weight from LiDAR data. Software used in this study to process the UAV data and to extract 3D models are Agisoft Metashape Professional, CloudCompare, RiPROCESS 1.8.4 Riegl Software and Potree Desktop. LiDAR showed accurate results for estimating withers height (mean error 6cm) and weight (mean error 38 kg). Estimating weight with 3D models extracted with Structure for Motion (SfM) from overlapping RGB imagery resulted in less accurate results (mean error 62kg). The latter result improved to a mean error of 31 kg when three outliers were removed which exceeded twice the standard deviation. These results suggest that the use of UAVs is promising for estimating body dimensions in extensive beef production systems. The main challenge remains to record individual cows from all sides without too much movement or motion from the cow to enable 3D modelling. Another challenge was to decrease the mean error in weight estimations so that changes in body weight over time can be monitored. Future research should focus on improving the overall mean error of cattle weight estimation, finding solutions for moving cattle and shifting from manual to automated processing of UAV imagery into 3D models.

Published
2023

24. Greenhouse gas reporting of the LULUCF sector in the Netherlands : methodological background, update 2023

Author

Arets, E.J.M.M., van Baren, S.A., Hendriks, C.M.J., Kramer, H., Lesschen, J.P., Schelhaas, M.J., Arets, E.J.M.M., van Baren, S.A., Hendriks, C.M.J., Kramer, H., Lesschen, J.P., and Schelhaas, M.J.

Abstract

This report provides a complete methodological description and background information of the Dutch National System for Greenhouse gas reporting of the LULUCF sector. It provides detailed description of the methodologies, activity data and emission factors that were used. Each of the reporting categories Forest Land, Cropland, Grassland, Wetlands, Settlements, Other Land and Harvested Wood Products are described in a separate chapter., Dit rapport geeft de methodologische achtergrondinformatie die gebruikt wordt binnen het nationale systeem om de broeikasgasemissies voor de LULUCF (landgebruik en bosbouw) sector te berekenen zoals die aan de VN Klimaatconventie (UNFCCC) worden gerapporteerd. Het rapport geeft gedetailleerde beschrijvingen van de gehanteerde methodologie, gebruikte activiteitendata en emissie-factoren. De te rapporteren categorieën Bos (Forest Land), Bouwland (Cropland), Grasland (Grassland), Wetlands, Bebouwd gebied (Settlements), Ander land (Other Land), en Geoogste houtproducten (Harvested Wood Products) worden per hoofdstuk beschreven.

Published
2023

25. Ziritaxestat, a novel autotaxin inhibitor, and lung function in idiopathic pulmonary fibrosis

Author

Maher, TM, Ford, P, Brown, KK, Costabel, U, Cottin, V, Danoff, SK, Groenveld, I, Helmer, E, Jenkins, RG, Milner, J, Molenberghs, G, Penninckx, B, Randall, MJ, Van Den Blink, B, Fieuw, A, Vandenrijn, C, Rocak, S, Seghers, I, Shao, L, Taneja, A, Jentsch, G, Watkins, TR, Wuyts, WA, Kreuter, M, Verbruggen, N, Prasad, N, Wijsenbeek, MS, Chambers, D, Chia, M, Corte, T, Glaspole, I, Goh, N, Holmes, M, Malouf, M, Thien, F, Veitch, E, Bondue, B, Dahlqvist, C, Froidure, A, Slabbynck, H, Wuyts, W, Cartagena Salinas, C, Feijoó Seoane, R, Martínez, V, Maturana, R, Pavie Gallegos, J, Rosenblut, A, Silva, R, Undurraga Pereira, A, Doubkova, M, Pauk, N, Plackova, M, Sterclova, M, Bendstrup, E, Shaker, SB, Titlestad, I, Budweiser, S, Grohé, C, Koschel, D, Prasse, A, Weber, M, Wirtz, H, Antoniou, K, Daniil, Z, Gaga, M, Papakosta, D, Izumi, S, Okamoto, M, Guerreros Benavides, A, Iberico Barrera, C, Peña Villalobos, AM, Campo Ezquibela, A, Cifrian Martinez, JM, Fernandez Fabrellas, E, Leiro, V, Molina-Molina, M, Nieto Barbero, A, Sellares Torres, J, Valenzuela, C, Cheng, S-L, Kuo, P-H, Lee, K-Y, Sheu, C-C, Gunen, H, Mogulkoc Bishop, N, Nayci, S, Adamali, H, Bianchi, S, Chaudhuri, N, Gibbons, M, Hart, S, Molyneaux, P, Parfrey, H, Saini, G, Spencer, LG, Wiscombe, S, Antin-Ozerkis, D, Bascom, R, Belperio, J, Britt, E, Fitzgerald, J, Gomez Manjarres, D, Gotfried, M, Gupta, N, Hotchkin, D, Kaye, M, Kreider, M, Kureishy, S, Lacamera, P, Lancaster, L, Lasky, J, Lorch, D, Mannem, H, Morrow, L, Moua, T, Nambiar, A, Raghu, G, Raj, R, Ramaswamy, M, Reddy, R, Russell, T, Scholand, MB, Shea, B, Suliman, S, Swigris, J, Thavarajah, K, Tolle, L, Tomic, R, Warshoff, N, Wesselius, L, Yung, G, Bergna, M, De Salvo, M, Fernandez Acquier, M, Rodriguez, A, Saez Scherbovsky, P, Assayag, D, Dhar, A, Khalil, N, Morisset, J, Provencher, S, Ryerson, C, Shapera, S, Bourdin, A, Crestani, B, Lebargy, F, Reynaud-Gaubert, M, Bonella, FT, Claussen, M, Hammerl, P, Karagiannidis, C, Keller, C, Randerath, W, Stubbe, B, Csánky, E, Medgyasszay, B, Muller, V, Adir, Y, Bar-Shai, A, Berkman, N, Fink, G, Kramer, M, Shitrit, D, Bargagli, E, Gasparini, S, Harari, S, Ravaglia, C, Richeldi, L, Vancheri, C, Ebina, M, Fujita, M, Ichikado, K, Inoue, Y, Ishikawa, N, Kato, M, Kawamura, T, Kondoh, Y, Nishioka, Y, Ogura, T, Owan, I, Saito, T, Sakamoto, N, Sakamoto, K, Shirai, M, Suda, T, Tomii, K, Chung, MP, Jeong, SH, Park, CS, Park, JS, Song, JW, Uh, S-T, Chavarria Martinez, U, Montano Gonzalez, E, Ramirez, A, Selman Lama, ME, Bresser, P, Kramer, H, Mostard, R, Nossent, E, Veltkamp, M, Wijsenbeek, M, Beckert, L, Chang, CL, Veale, A, Wilsher, M, Bednarek, M, Gasior, G, Jasieniak-Pinis, G, Jassem, E, Mroz, R, Piotrowski, W, Abdullah, I, Ambaram, A, Irusen, E, Van der Linden, M, Van Zyl-Smit, R, Williams, P, Allen, J, Averill, F, Belloli, E, Brown, A, Case, A, Chaudhary, S, Criner, G, DeBoer, K, Dilling, D, Dorf, J, Enelow, R, Ettinger, N, Feldman, J, Gibson, K, Golden, J, Hamblin, M, Hunninghake, G, Karunakara, R, Kim, H, Luckhardt, T, Menon, P, Morrison, L, Oldham, J, Patel, N, Schmidt, S, Strek, M, Summer, R, Sussman, R, Tita, J, Veeraraghavan, S, Whelan, T, and Zibrak, J

Abstract

Importance There is a major need for effective, well-tolerated treatments for idiopathic pulmonary fibrosis (IPF). Objective To assess the efficacy and safety of the autotaxin inhibitor ziritaxestat in patients with IPF. Design, Setting, and Participants The 2 identically designed, phase 3, randomized clinical trials, ISABELA 1 and ISABELA 2, were conducted in Africa, Asia-Pacific region, Europe, Latin America, the Middle East, and North America (26 countries). A total of 1306 patients with IPF were randomized (525 patients at 106 sites in ISABELA 1 and 781 patients at 121 sites in ISABELA 2). Enrollment began in November 2018 in both trials and follow-up was completed early due to study termination on April 12, 2021, for ISABELA 1 and on March 30, 2021, for ISABELA 2. Interventions Patients were randomized 1:1:1 to receive 600 mg of oral ziritaxestat, 200 mg of ziritaxestat, or placebo once daily in addition to local standard of care (pirfenidone, nintedanib, or neither) for at least 52 weeks. Main Outcomes and Measures The primary outcome was the annual rate of decline for forced vital capacity (FVC) at week 52. The key secondary outcomes were disease progression, time to first respiratory-related hospitalization, and change from baseline in St George’s Respiratory Questionnaire total score (range, 0 to 100; higher scores indicate poorer health-related quality of life). Results At the time of study termination, 525 patients were randomized in ISABELA 1 and 781 patients in ISABELA 2 (mean age: 70.0 [SD, 7.2] years in ISABELA 1 and 69.8 [SD, 7.1] years in ISABELA 2; male: 82.4% and 81.2%, respectively). The trials were terminated early after an independent data and safety monitoring committee concluded that the benefit to risk profile of ziritaxestat no longer supported their continuation. Ziritaxestat did not improve the annual rate of FVC decline vs placebo in either study. In ISABELA 1, the least-squares mean annual rate of FVC decline was –124.6 mL (95% CI, −178.0 to −71.2 mL) with 600 mg of ziritaxestat vs –147.3 mL (95% CI, −199.8 to −94.7 mL) with placebo (between-group difference, 22.7 mL [95% CI, −52.3 to 97.6 mL]), and –173.9 mL (95% CI, −225.7 to −122.2 mL) with 200 mg of ziritaxestat (between-group difference vs placebo, −26.7 mL [95% CI, −100.5 to 47.1 mL]). In ISABELA 2, the least-squares mean annual rate of FVC decline was –173.8 mL (95% CI, −209.2 to −138.4 mL) with 600 mg of ziritaxestat vs –176.6 mL (95% CI, −211.4 to −141.8 mL) with placebo (between-group difference, 2.8 mL [95% CI, −46.9 to 52.4 mL]) and –174.9 mL (95% CI, −209.5 to −140.2 mL) with 200 mg of ziritaxestat (between-group difference vs placebo, 1.7 mL [95% CI, −47.4 to 50.8 mL]). There was no benefit with ziritaxestat vs placebo for the key secondary outcomes. In ISABELA 1, all-cause mortality was 8.0% with 600 mg of ziritaxestat, 4.6% with 200 mg of ziritaxestat, and 6.3% with placebo; in ISABELA 2, it was 9.3% with 600 mg of ziritaxestat, 8.5% with 200 mg of ziritaxestat, and 4.7% with placebo. Conclusions and Relevance Ziritaxestat did not improve clinical outcomes compared with placebo in patients with IPF receiving standard of care treatment with pirfenidone or nintedanib or in those not receiving standard of care treatment. Trial Registration ClinicalTrials.gov Identifiers: NCT03711162 and NCT03733444

Published
2023

26. Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

Author

Bian, Zehua, Wang, Qiang, Zhou, Xinyu, Tan, Tao, Park, Ki Ho, Kramer, H. Fritz, McDougal, Alan, Laping, Nicholas J., Kumar, Sanjay, Adesanya, T. M. Ayodele, Sermersheim, Matthew, Yi, Frank, Wang, Xinxin, Wu, Junwei, Gumpper, Kristyn, Jiang, Qiwei, He, Duofen, Lin, Pei-Hui, Li, Haichang, Guan, Fangxia, Zhou, Jingsong, Kohr, Mark J., Zeng, Chunyu, Zhu, Hua, and Ma, Jianjie

Published
2019
Full Text
View/download PDF

28. Local Rather than Global H3K27me3 Dynamics Are Associated with Differential Gene Expression in Verticillium dahliae

Author

Kramer, H Martin, Seidl, Michael F, Thomma, Bart P H J, Cook, David E, Kramer, H Martin, Seidl, Michael F, Thomma, Bart P H J, and Cook, David E

Abstract

Differential growth conditions typically trigger global transcriptional responses in filamentous fungi. Such fungal responses to environmental cues involve epigenetic regulation, including chemical histone modifications. It has been proposed that conditionally expressed genes, such as those that encode secondary metabolites but also effectors in pathogenic species, are often associated with a specific histone modification, lysine27 methylation of H3 (H3K27me3). However, thus far, no analyses on the global H3K27me3 profiles have been reported under differential growth conditions in order to assess if H3K27me3 dynamics govern differential transcription. Using chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing data from the plant-pathogenic fungus Verticillium dahliae grown in three in vitro cultivation media, we now show that a substantial number of the identified H3K27me3 domains globally display stable profiles among these growth conditions. However, we observe local quantitative differences in H3K27me3 ChIP-seq signals that are associated with a subset of differentially transcribed genes between media. Comparing the in vitro results to expression during plant infection suggests that in planta-induced genes may require chromatin remodeling to achieve expression. Overall, our results demonstrate that some loci display H3K27me3 dynamics associated with concomitant transcriptional variation, but many differentially expressed genes are associated with stable H3K27me3 domains. Thus, we conclude that while H3K27me3 is required for transcriptional repression, it does not appear that transcriptional activation requires the global erasure of H3K27me3. We propose that the H3K27me3 domains that do not undergo dynamic methylation may contribute to transcription through other mechanisms or may serve additional genomic regulatory functions. IMPORTANCE In many organisms, including filamentous fungi, epigenetic mechanisms that involve chemical and physical mo

Published
2022

30. Building Analytics Tool Deployment at Scale: Benefits, Costs, and Deployment Practices

Author

Lin, G, Lin, G, Kramer, H, Nibler, V, Crowe, E, Granderson, J, Lin, G, Lin, G, Kramer, H, Nibler, V, Crowe, E, and Granderson, J

Abstract

Buildings are becoming more data-rich. Building analytics tools, including energy information systems (EIS) and fault detection and diagnostic (FDD) tools, have emerged to enable building operators to translate large amounts of time-series data into actionable findings to achieve energy and non-energy benefits. To expedite data analytics adoption and facilitate technology innovation, building owners, technology developers, and researchers need reliable cost–benefit data and evidence-based guidance on deployment practices. This paper fulfills these needs with the energy use and survey data from a wide-ranging research and industry partnership program that covers thousands of buildings installed with analytics tools. The paper indicates that after two years of implementation, organizations using FDD tools and EIS tools achieved 9% and 3% median annual energy savings, respectively. The median base cost and annual recurring cost for FDD are USD 0.65 per square meter (m2) (USD 0.06 per square foot [ft2]) and USD 0.22 per m2 (USD 0.02 per ft2), and are USD 0.11 per m2 (USD 0.01 per ft2) and USD 0.11 per m2 (USD 0.01 per ft2) for EIS. The common metrics and analyses that are used in the tools to support the discovery of energy efficiency measures are summarized in detail. Two best practice examples identified to maximize the benefits of tool implementation are also presented. Opportunities to advance the state of technology include simplified data integration and management, and more efficient processes for acting on analytics outputs. Compared with previous efforts in the literature, the findings presented in this paper demonstrate the effectiveness of building analytics tools with the largest known dataset.

Published
2022

31. Basiskaart Natuur 2017 : een landsdekkend basisbestand voor de terrestrische natuur in Nederland

Author

Kramer, H., Clement, J., Kramer, H., and Clement, J.

Abstract

De Basiskaart Natuur 2017 (BKN2017) is een GIS-bestand waarin het areaal natuurgebied in Nederland opgenomen is. BKN2021 is een rasterbestand met een celgrootte van 25 bij 25 meter. In het bestand zijn dertien klassen opgenomen met een code en naam voor het betreffende grondgebruik. Het belangrijkste onderdeel van het bestand is het areaal natuur. Volgens de gebruikte definitie van natuur in BKN2017 is dit 656.010 ha. Dit omvat de klassen natuurgraslanden (11), heide (30), bos (40), rietmoeras (80), stuifzanden (90) en duinen, strand en zandplaten (91). BKN2017 is voor het gebruik bij monitoring nog niet gevalideerd.---The Nature Base Map 2017 (Basiskaart Natuur 2017, or BKN2017) is a geodatabase of nature in the Netherlands. It is a raster database with a cell size of 25 x 25 metres. The database includes 13 land use classes, each with its own code and descriptor. The most important part of the database is the area of nature (natural and semi-natural ecosystems); according to the definition of nature used in BKN2017, the total area is t 656,010 ha. This area includes the following land use classes: natural grassland (code 11), heath (30), forest (40), reed marsh (80), drift sand (90) and dune, beach and sand banks (91). BKN2017 has not yet been validated for use in monitoring.

Published
2022

32. Greenhouse gas reporting for the LULUCF sector in the Netherlands : Methodological background, update 2022

Author

Arets, E.J.M.M., van Baren, S.A., Kramer, H., Lesschen, J.P., Schelhaas, M.J., Arets, E.J.M.M., van Baren, S.A., Kramer, H., Lesschen, J.P., and Schelhaas, M.J.

Abstract

This report provides a complete methodological description and background information of the Dutch National System for Greenhouse gas reporting of the LULUCF sector. It provides detailed description of the methodologies, activity data and emission factors that were used. Each of the reporting categories Forest Land, Cropland, Grassland, Wetlands, Settlements, Other land and Harvested Wood Products are described in a separate chapter. Additionally, it gives a table-by-table elaboration of the choices and motivations for filling the CRF tables for KP-LULUCF., Dit rapport geeft de methodologische achtergrondinformatie die gebruikt wordt binnen het nationale systeem om de broeikasgasemissies voor de LULUCF (landgebruik en bosbouw) sector te berekenen zoals die aan de VN Klimaatconventie (UNFCCC) en het Kyoto Protocol (KP) worden gerapporteerd. Het rapport geeft gedetailleerde beschrijvingen van de gehanteerde methodologie, gebruikte activiteitendata en emissie-factoren. De te rapporteren categorieën Bos (Forest land), Bouwland (Cropland), Grasland (Grassland), Wetlands, Bebouwd gebied (Settlements), Ander land, en geoogste houtproducten worden per hoofdstuk beschreven. Daarnaast worden in een apart hoofdstuk de gebruikte aggregatiestappen gegeven om tot de berekeningen voor het Kyoto Protocol te komen en worden voor iedere KP-LULUCF-CRF-tabel de gemaakte keuzes om de tabel te vullen, beschreven en gemotiveerd.

Published
2022

36. Tall, heterogeneous forests improve prey capture, delivery to nestlings, and reproductive success for Spotted Owls in southern California.

Author

Wilkinson, Zachary A., Kramer, H. Anu, Jones, Gavin M., Zulla, Ceeanna J., McGinn, Kate, Barry, Josh M., Sawyer, Sarah C., Tanner, Richard, Gutiérrez, R. J., Keane, John J., and Peery, M. Zachariah

Subjects
*BABY birds, *BIRD reproduction, *SPOTTED owl, *BIRD habitats
Abstract

Predator–prey interactions can be profoundly influenced by vegetation conditions, particularly when predator and prey prefer different habitats. Although such interactions have proven challenging to study for small and cryptic predators, recent methodological advances substantially improve opportunities for understanding how vegetation influences prey acquisition and strengthen conservation planning for this group. The California Spotted Owl (Strix occidentalis occidentalis) is well known as an old-forest species of conservation concern, but whose primary prey in many regions—woodrats (Neotoma spp.)—occurs in a broad range of vegetation conditions. Here, we used high-resolution GPS tracking coupled with nest video monitoring to test the hypothesis that prey capture rates vary as a function of vegetation structure and heterogeneity, with emergent, reproductive consequences for Spotted Owls in Southern California. Foraging owls were more successful capturing prey, including woodrats, in taller multilayered forests, in areas with higher heterogeneity in vegetation types, and near forest-chapparal edges. Consistent with these findings, Spotted Owls delivered prey items more frequently to nests in territories with greater heterogeneity in vegetation types and delivered prey biomass at a higher rate in territories with more forest-chaparral edge. Spotted Owls had higher reproductive success in territories with higher mean canopy cover, taller trees, and more shrubby vegetation. Collectively, our results provide additional and compelling evidence that a mosaic of large tree forest with complex canopy and shrubby vegetation increases access to prey with potential reproductive benefits to Spotted Owls in landscapes where woodrats are a primary prey item. We suggest that forest management activities that enhance forest structure and vegetation heterogeneity could help curb declining Spotted Owl populations while promoting resilient ecosystems in some regions. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

40. Noisy neighbors and reticent residents: Distinguishing resident from non-resident individuals to improve passive acoustic monitoring

Author

Reid, Dana S., primary, Wood, Connor M., additional, Whitmore, Sheila A., additional, Berigan, William J., additional, Keane, John J., additional, Sawyer, Sarah C., additional, Shaklee, Paula A., additional, Kramer, H. Anu, additional, Kelly, Kevin G., additional, Reiss, Aimee, additional, Kryshak, Nick, additional, Gutiérrez, R.J., additional, Klinck, Holger, additional, and Peery, M. Zachariah, additional

Published
2021
Full Text
View/download PDF

41. Greenhouse gas reporting for the LULUCF sector in the Netherlands : Methodological background, update 2021

Author

Arets, E.J.M.M., van der Kolk, J.W.H., Hengeveld, G.M., Lesschen, J.P., Kramer, H., Kuikman, P.J., and Schelhaas, N.J.

Subjects
Sustainable Soil Use, Earth Observation and Environmental Informatics, WIMEK, Vegetation, Bos- en Landschapsecologie, PE&RC, Biometris, Aardobservatie en omgevingsinformatica, Life Science, Vegetatie, Bos- en Landschapsecologie, Forest and Landscape Ecology, Vegetation, Forest and Landscape Ecology, Duurzaam Bodemgebruik, Vegetatie
Abstract

This report provides a complete methodological description and background information of the Dutch National System for Greenhouse gas reporting of the LULUCF sector. It provides detailed description of the methodologies, activity data and emission factors that were used. Each of the reporting categories Forest Land, Cropland, Grassland, Wetlands, Settlements, Other land and Harvested Wood Products are described in a separate chapter. Additionally it gives a table-by-table elaboration of the choices and motivations for filling the CRF tables for KP-LULUCF. Dit rapport geeft de methodologische achtergrondinformatie die gebruikt wordt binnen het nationale systeem om de broeikasgasemissies voor de LULUCF (landgebruik en bosbouw) sector te berekenen zoals die aan de VN Klimaatconventie (UNFCCC) en het Kyoto Protocol (KP) worden gerapporteerd. Het rapport geeft gedetailleerde beschrijvingen van de gehanteerde methodologie, gebruikte activiteitendata en emissiefactoren. De te rapporteren categorieën Bos (Forest land), Bouwland (Cropland), Grasland (Grassland), Wetlands, Bebouwd gebied (Settlements), Ander land, en geoogste houtproducten worden per hoofdstuk beschreven. Daarnaast worden in een apart hoofdstuk de gebruikte aggregatiestappen gegeven om tot de berekeningen voor het Kyoto Protocol te komen en worden voor iedere KP-LULUCF-CRF-tabel de gemaakte keuzes om de tabel te vullen, beschreven en gemotiveerd.

Published
2021

42. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Author

Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, MH, Abudu, YP, Acevedo-Arozena, A, Adamopoulos, IE, Adeli, K, Adolph, TE, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, BB, Agnello, M, Agostinis, P, Agrewala, JN, Agrotis, A, Aguilar, PV, Ahmad, ST, Ahmed, ZM, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, HA, Al-Abd, AM, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, MA, Alberti, S, Alcocer-Gomez, E, Alessandri, C, Ali, M, Al-Bari, MAA, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Alonso, GD, Altan-Bonnet, N, Altieri, DC, Alves, S, da Costa, CA, Alzaharna, MM, Amadio, M, Amantini, C, Amaral, C, Ambrosio, S, Amer, AO, Ammanathan, V, An, ZY, Andersen, SU, Andrabi, SA, Andrade-Silva, M, Andres, AM, Angelini, S, Ann, D, Anozie, UC, Ansari, MY, Antas, P, Antebi, A, Anton, Z, Anwar, T, Apetoh, L, Apostolova, N, Araki, T, Araki, Y, Arasaki, K, Araujo, WL, Araya, J, Arden, C, Arevalo, MA, Arguelles, S, Arias, E, Arikkath, J, Arimoto, H, Ariosa, AR, Armstrong-James, D, Arnaune-Pelloquin, L, Aroca, A, Arroyo, DS, Arsov, I, Artero, R, Asaro, DML, Aschner, M, Ashrafizadeh, M, Ashur-Fabian, O, Atanasov, AG, Au, AK, Auberger, P, Auner, HW, Aurelian, L, Autelli, R, Avagliano, L, Avalos, Y, Aveic, S, Aveleira, CA, AvinWittenberg, T, Aydin, Y, Ayton, S, Ayyadevara, S, Azzopardi, M, Baba, M, Backer, JM, Backues, SK, Bae, DH, Bae, ON, Bae, SH, Baehrecke, EH, Baek, A, Baek, SH, Bagetta, G, Bagniewska-Zadworna, A, Bai, H, Bai, J, Bai, XY, Bai, YD, Bairagi, N, Baksi, S, Balbi, T, Baldari, CT, Balduini, W, Ballabio, A, Ballester, M, Balazadeh, S, Balzan, R, Bandopadhyay, R, Banerjee, S, Bao, Y, Baptista, MS, Baracca, A, Barbati, C, Bargiela, A, Barila, D, Barlow, PG, Barmada, SJ, Barreiro, E, Barreto, GE, Bartek, J, Bartel, B, Bartolome, A, Barve, GR, Basagoudanavar, SH, Bassham, DC, Jr, RCB, Basu, A, Batoko, H, Batten, I, Baulieu, EE, Baumgarner, BL, Bayry, J, Beale, R, Beau, I, Beaumatin, F, Bechara, LRG, Beck, GR, Beers, MF, Begun, J, Behrends, C, Behrens, GMN, Bei, R, Bejarano, E, Bel, S, Behl, C, Belaid, A, Belgareh-Touze, N, Bellarosa, C, Belleudi, F, Perez, MB, Bello-Morales, R, Beltran, JSD, Beltran, S, Benbrook, DM, Bendorius, M, Benitez, BA, Benito-Cuesta, I, Bensalem, J, Berchtold, MW, Berezowska, S, Bergamaschi, D, Bergami, M, Bergmann, A, Berliocchi, L, Berlioz-Torrent, C, Bernard, A, Berthoux, L, Besirli, CG, Besteiro, S, Betin, VM, Beyaert, R, Bezbradica, JS, Bhaskar, K, Bhatia-Kissova, I, Bhattacharya, R, Bhattacharya, S, Bhattacharyya, S, Bhuiyan, MS, Bhutia, SK, Bi, LR, Bi, XL, Biden, TJ, Bijian, K, Billes, VA, Binart, N, Bincoletto, C, Birgisdottir, AB, Bjorkoy, G, Blanco, G, Blas-Garcia, A, Blasiak, J, Blomgran, R, Blomgren, K, Blum, JS, Boada-Romero, E, Boban, M, BoeszeBattaglia, K, Boeuf, P, Boland, B, Bomont, P, Bonaldo, P, Bonam, SR, Bonfili, L, Bonifacino, JS, Boone, BA, Bootman, MD, Bordi, M, Borner, C, Bornhauser, BC, Borthakur, G, Bosch, J, Bose, S, Botana, LM, Botas, J, Boulanger, CM, Boulton, ME, Bourdenx, M, Bourgeois, B, Bourke, NM, Bousquet, G, Boya, P, Bozhkov, PV, Bozi, LHM, Bozkurt, TO, Brackney, DE, Brandts, CH, Braun, RJ, Braus, GH, Bravo-Sagua, R, Bravo-San Pedro, JM, Brest, P, Bringer, MA, Briones-Herrera, A, Broaddus, VC, Brodersen, P, Alvarez, EMC, Brodsky, JL, Brody, SL, Bronson, PG, Bronstein, JM, Brown, CN, Brown, RE, Brum, PC, Brumell, JH, Brunetti-Pierri, N, Bruno, D, Bryson-Richardson, RJ, Bucci, C, Buchrieser, C, Bueno, M, Buitrago-Molina, LE, Buraschi, S, Buch, S, Buchan, JR, Buckingham, EM, Budak, H, Budini, M, Bultynck, G, Burada, F, Burgoyne, JR, Buron, MI, Bustos, V, Buttner, S, Butturini, E, Byrd, A, Cabas, I, Cabrera-Benitez, S, Cadwell, K, Cai, JJ, Cai, L, Cai, Q, Cairo, M, Calbet, JA, Caldwell, GA, Caldwell, KA, Call, JA, Calvani, R, Calvo, AC, Barrera, MCR, Camara, NO, Camonis, JH, Camougrand, N, Campanella, M, Campbell, EM, Campbell-Valois, FX, Campello, S, Campesi, I, Campos, JC, Camuzard, O, Cancino, J, de Almeida, DC, Canesi, L, Caniggia, I, Canonico, B, Canti, C, Cao, B, Caraglia, M, Carames, B, Carchman, EH, Cardenal-Munoz, E, Cardenas, C, Cardenas, L, Cardoso, SM, Carew, JS, Carle, GF, Carleton, G, Carloni, S, Carmona-Gutierrez, D, Carneiro, LA, Carnevali, O, Carosi, JM, Carra, S, Carrier, A, Carrier, L, Carroll, B, Carter, AB, Carvalho, AN, Casanova, M, Casas, C, Casas, J, Cassioli, C, Castillo, EF, Castillo, K, Castillo-Lluva, S, Castoldi, F, Castori, M, Castro, AF, Castro-Caldas, M, Castro-Hernandez, J, Castro-Obregon, S, Catz, SD, Cavadas, C, Cavaliere, F, Cavallini, G, Cavinato, M, Cayuela, ML, Rica, PC, Cecarini, V, Cecconi, F, Cechowska-Pasko, M, Cenci, S, Ceperuelo-Mallafre, V, Cerqueira, JJ, Cerutti, JM, Cervia, D, Cetintas, VB, Cetrullo, S, Chae, HJ, Chagin, AS, Chai, CY, Chakrabarti, G, Chakrabarti, O, Chakraborty, T, Chami, M, Chamilos, G, Chan, DW, Chan, EYW, Chan, ED, Chan, HYE, Chan, HH, Chan, H, Chan, MTV, Chan, YS, Chandra, PK, Chang, CP, Chang, CM, Chang, HC, Chang, K, Chao, J, Chapman, T, Charlet-Berguerand, N, Chatterjee, S, Chaube, SK, Chaudhary, A, Chauhan, S, Chaum, E, Checler, F, Cheetham, ME, Chen, CS, Chen, GC, Chen, JF, Chen, LL, Chen, L, Chen, ML, Chen, MK, Chen, N, Chen, Q, Chen, RH, Chen, S, Chen, W, Chen, WQ, Chen, XM, Chen, XW, Chen, X, Chen, Y, Chen, YG, Chen, YY, Chen, YQ, Chen, YJ, Chen, ZS, Chen, Z, Chen, ZH, Chen, ZJ, Chen, ZX, Cheng, HH, Cheng, J, Cheng, SY, Cheng, W, Cheng, XD, Cheng, XT, Cheng, YY, Cheng, ZY, Cheong, H, Cheong, JK, Chernyak, BV, Cherry, S, Cheung, CFR, Cheung, CHA, Cheung, KH, Chevet, E, Chi, RJ, Chiang, AKS, Chiaradonna, F, Chiarelli, R, Chiariello, M, Chica, N, Chiocca, S, Chiong, M, Chiou, SH, Chiramel, AI, Chiurchiu, V, Cho, DH, Choe, SK, Choi, AMK, Choi, ME, Choudhury, KR, Chow, NS, Chu, CT, Chua, JP, Chua, JJE, Chung, H, Chung, KP, Chung, S, Chung, SH, Chung, YL, Cianfanelli, V, Ciechomska, IA, Cifuentes, M, Cinque, L, Cirak, S, Cirone, M, Clague, MJ, Clarke, R, Clementi, E, Coccia, EM, Codogno, P, Cohen, E, Cohen, MM, Colasanti, T, Colasuonno, F, Colbert, RA, Colell, A, Coll, NS, Collins, MO, Colombo, MI, Colon-Ramos, DA, Combaret, L, Comincini, S, Cominetti, MR, Consiglio, A, Conte, A, Conti, F, Contu, VR, Cookson, MR, Coombs, KM, Coppens, I, Corasaniti, MT, Corkery, DP, Cordes, N, Cortese, K, Costa, MD, Costantino, S, Costelli, P, Coto-Montes, A, Crack, PJ, Crespo, JL, Criollo, A, Crippa, V, Cristofani, R, Csizmadia, T, Cuadrado, A, Cui, B, Cui, J, Cui, YX, Cui, Y, Culetto, E, Cumino, AC, Cybulsky, AV, Czaja, MJ, Czuczwar, SJ, D'Adamo, S, D'Amelio, M, D'Arcangelo, D, D'Lugos, AC, D'Orazi, G, da Silva, JA, Dafsari, HS, Dagda, RK, Dagdas, Y, Daglia, M, Dai, X, Dai, Y, Dai, YY, Dal Col, J, Dalhaimer, P, Dalla Valle, L, Dallenga, T, Dalmasso, G, Damme, M, Dando, I, Dantuma, NP, Darling, AL, Das, H, Dasarathy, S, Dasari, SK, Dash, S, Daumke, O, Dauphinee, AN, Davies, JS, Davila, VA, Davis, RJ, Davis, T, Naidu, SD, De Amicis, F, De Bosscher, K, De Felice, F, De Franceschi, L, De Leonibus, C, Barbosa, MGD, De Meyer, GRY, De Milito, A, De Nunzio, C, De Palma, C, De Santi, M, De Virgilio, C, De Zio, D, Debnath, J, DeBosch, BJ, Decuypere, J, Deehan, MA, Deflorian, G, DeGregori, J, Dehay, B, Del Rio, G, Delaney, JR, Delbridge, LMD, Delorme-Axford, E, Delpino, MV, Demarchi, F, Dembitz, V, Demers, ND, Deng, HB, Deng, ZQ, Dengjel, J, Dent, P, Denton, D, DePamphilis, ML, Der, CJ, Deretic, V, Descoteaux, A, Devis, L, Devkota, S, Devuyst, O, Dewson, G, Dharmasivam, M, Dhiman, R, di Bernardo, D, Di Cristina, M, Di Domenico, F, Di Fazio, P, Di Fonzo, A, Di Guardo, G, Di Guglielmo, GM, Di Leo, L, Di Malta, C, Di Nardo, A, Di Rienzo, M, Di Sano, F, Diallinas, G, Diao, JJ, Diaz-Araya, G, Diaz-Laviada, I, Dickinson, JM, Diederich, M, Dieude, M, Dikic, I, Ding, SP, Ding, WX, Dini, L, Dinic, M, Dinkova-Kostova, AT, Dionne, MS, Distler, JHW, Diwan, A, Dixon, IMC, Djavaheri-Mergny, M, Dobrinski, I, Dobrovinskaya, O, Dobrowolski, R, Dobson, RCJ, Emre, SD, Donadelli, M, Dong, B, Dong, XN, Dong, ZW, Ii, GWD, Dotsch, V, Dou, H, Dou, J, Dowaidar, M, Dridi, S, Drucker, L, Du, AL, Du, CG, Du, GW, Du, HN, Du, LL, du Toit, A, Duan, SB, Duan, XQ, Duarte, SP, Dubrovska, A, Dunlop, EA, Dupont, N, Duran, RV, Dwarakanath, BS, Dyshlovoy, SA, Ebrahimi-Fakhari, D, Eckhart, L, Edelstein, CL, Efferth, T, Eftekharpour, E, Eichinger, L, Eid, N, Eisenberg, T, Eissa, NT, Eissa, S, Ejarque, M, El Andaloussi, A, El-Hage, N, El-Naggar, S, Eleuteri, AM, El-Shafey, ES, Elgendy, M, Eliopoulos, AG, Elizalde, MM, Elks, PM, Elsasser, HP, Elsherbiny, ES, Emerling, BM, Emre, NCT, Eng, CH, Engedal, N, Engelbrecht, AM, Engelsen, AST, Enserink, JM, Escalante, R, Esclatine, A, Escobar-Henriques, M, Eskelinen, EL, Espert, L, Eusebio, MO, Fabrias, G, Fabrizi, C, Facchiano, A, Facchiano, F, Fadeel, B, Fader, C, Faesen, AC, Fairlie, WD, Falco, A, Falkenburger, BH, Fan, DP, Fan, J, Fan, YB, Fang, EF, Fang, YS, Fang, YQ, Fanto, M, Farfel-Becker, T, Faure, M, Fazeli, G, Fedele, AO, Feldman, AM, Feng, D, Feng, JC, Feng, LF, Feng, YB, Feng, YC, Feng, W, Araujo, TF, Ferguson, TA, Fernandez-Checa, JC, FernandezVeledo, S, Fernie, AR, Ferrante, AW, Ferraresi, A, Ferrari, MF, Ferreira, JCB, Ferro-Novick, S, Figueras, A, Filadi, R, Filigheddu, N, FilippiChiela, E, Filomeni, G, Fimia, GM, Fineschi, V, Finetti, F, Finkbeiner, S, Fisher, EA, Fisher, PB, Flamigni, F, Fliesler, SJ, Flo, TH, Florance, I, Florey, O, Florio, T, Fodor, E, Follo, C, Fon, EA, Forlino, A, Fornai, F, Fortini, P, Fracassi, A, Fraldi, A, Franco, B, Franco, R, Franconi, F, Frankel, LB, Friedman, SL, Frohlich, LF, Fruhbeck, G, Fuentes, JM, Fujiki, Y, Fujita, N, Fujiwara, Y, Fukuda, M, Fulda, S, Furic, L, Furuya, N, Fusco, C, Gack, MU, Gaffke, L, Galadari, S, Galasso, A, Galindo, MF, Kankanamalage, SG, Galluzzi, L, Galy, V, Gammoh, N, Gan, BY, Ganley, IG, Gao, F, Gao, H, Gao, MH, Gao, P, Gao, SJ, Gao, WT, Gao, XB, Garcera, A, Garcia, MN, Garcia, VE, Garcia-Del Portillo, F, Garcia-Escudero, V, GarciaGarcia, A, Garcia-Macia, M, Garcia-Moreno, D, Garcia-Ruiz, C, Garcia-Sanz, P, Garg, AD, Gargini, R, Garofalo, T, Garry, RF, Gassen, NC, Gatica, D, Ge, L, Ge, WZ, Geiss-Friedlander, R, Gelfi, C, Genschik, P, Gentle, IE, Gerbino, V, Gerhardt, C, Germain, K, Germain, M, Gewirtz, DA, Afshar, EG, Ghavami, S, Ghigo, A, Ghosh, M, Giamas, G, Giampietri, C, Giatromanolaki, A, Gibson, GE, Gibson, SB, Ginet, V, Giniger, E, Giorgi, C, Girao, H, Girardin, SE, Giridharan, M, Giuliano, S, Giulivi, C, Giuriato, S, Giustiniani, J, Gluschko, A, Goder, V, Goginashvili, A, Golab, J, Goldstone, DC, Golebiewska, A, Gomes, LR, Gomez, R, Gomez-Sanchez, R, Gomez-Puerto, MC, Gomez-Sintes, R, Gong, Q, Goni, FM, Gonzalez-Gallego, J, Gonzalez-Hernandez, T, Gonzalez-Polo, RA, Gonzalez-Reyes, JA, Gonzalez-Rodriguez, P, Goping, IS, Gorbatyuk, MS, Gorbunov, NV, Gorojod, RM, Gorski, SM, Goruppi, S, Gotor, C, Gottlieb, RA, Gozes, I, Gozuacik, D, Graef, M, Graler, MH, Granatiero, V, Grasso, D, Gray, JP, Green, DR, Greenhough, A, Gregory, SL, Griffin, EF, Grinstaff, MW, Gros, F, Grose, C, Gross, AS, Gruber, F, Grumati, P, Grune, T, Gu, XY, Guan, JL, Guardia, CM, Guda, K, Guerra, F, Guerri, C, Guha, P, Guillen, C, Gujar, S, Gukovskaya, A, Gukovsky, I, Gunst, J, Gunther, A, Guntur, AR, Guo, CY, Guo, C, Guo, HQ, Guo, LW, Guo, M, Gupta, P, Fernandez, AF, Gupta, SK, Gupta, S, Gupta, VB, Gupta, V, Gustafsson, AB, Gutterman, DD, Ranjitha, HB, Haapasalo, A, Haber, JE, Hadano, S, Hafren, AJ, Haidar, M, Hall, BS, Hallden, G, Hamacher-Brady, A, Hamann, A, Hamasaki, M, Han, WD, Hansen, M, Hanson, PI, Hao, ZJ, Harada, M, Harhaji-Trajkovic, L, Hariharan, N, Haroon, N, Harris, J, Hasegawa, T, Nagoor, NH, Haspel, JA, Haucke, V, Hawkins, WD, Hay, BA, Haynes, CM, Hayrabedyan, SB, Hays, TS, He, CC, He, Q, He, RR, He, YW, He, YY, Heakal, Y, Heberle, AM, Hejtmancik, JF, Helgason, GV, Henkel, V, Herb, M, Hergovich, A, Herman-Antosiewicz, A, Hernandez, A, Hernandez, C, Hernandez-Diaz, S, Hernandez-Gea, V, Herpin, A, Herreros, J, Hervas, JH, Hesselson, D, Hetz, C, Heussler, VT, Higuchi, Y, Hilfiker, S, Hill, JA, Hlavacek, WS, Ho, EA, Ho, IHT, Ho, PWL, Ho, S, Ho, WY, Hobbs, GA, Hochstrasser, M, Hoet, PHM, Hofius, D, Hofman, P, Hohn, A, Holmberg, CI, Hombrebueno, JR, Hong, CW, Hong, YR, Hooper, LV, Hoppe, T, Horos, R, Hoshida, Y, Hsin, IL, Hsu, HY, Hu, B, Hu, D, Hu, LF, Hu, MC, Hu, RG, Hu, W, Hu, YC, Hu, ZW, Hua, F, Hua, JL, Hua, YQ, Huan, CM, Huang, CH, Huang, CS, Huang, CX, Huang, CL, Huang, HS, Huang, K, Huang, MLH, Huang, R, Huang, S, Huang, TZ, Huang, X, Huang, YJ, Huber, TB, Hubert, V, Hubner, CA, Hughes, SM, Hughes, WE, Humbert, M, Hummer, G, Hurley, JH, Hussain, S, Hussey, PJ, Hutabarat, M, Hwang, HY, Hwang, S, Ieni, A, Ikeda, F, Imagawa, Y, Imai, Y, Imbriano, C, Imoto, M, Inman, DM, Inoki, K, Iovanna, J, Iozzo, RV, Ippolito, G, Irazoqui, JE, Iribarren, P, Ishaq, M, Ishikawa, M, Ishimwe, N, Isidoro, C, Ismail, N, Issazadeh-Navikas, S, Itakura, E, Ito, D, Ivankovic, D, Ivanova, S, Iyer, AKV, Izquierdo, JM, Izumi, M, Jaattela, M, Jabir, MS, Jackson, WT, Jacobo-Herrera, N, Jacomin, AC, Jacquin, E, Jadiya, P, Jaeschke, H, Jagannath, C, Jakobi, AJ, Jakobsson, J, Janji, B, JansenDurr, P, Jansson, PJ, Jantsch, J, Januszewski, S, Jassey, A, Jean, S, JeltschDavid, H, Jendelova, P, Jenny, A, Jensen, TE, Jessen, N, Jewell, JL, Ji, J, Jia, LJ, Jia, R, Jiang, LW, Jiang, Q, Jiang, RC, Jiang, T, Jiang, XJ, Jiang, Y, Jimenez-Sanchez, M, Jin, EJ, Jin, FY, Jin, HC, Jin, L, Jin, LQ, Jin, MY, Jin, S, Jo, EK, Joffre, C, Johansen, T, Johnson, GVW, Johnston, SA, Jokitalo, E, Jolly, MK, Joosten, LAB, Jordan, J, Joseph, B, Ju, DW, Ju, JS, Ju, JF, Juarez, E, Judith, D, Juhasz, G, Jun, Y, Jung, CH, Jung, S, Jung, YK, Jungbluth, H, Jungverdorben, J, Just, S, Kaarniranta, K, Kaasik, A, Kabuta, T, Kaganovich, D, Kahana, A, Kain, R, Kajimura, S, Kalamvoki, M, Kalia, M, Kalinowski, DS, Kaludercic, N, Kalvari, I, Kaminska, J, Kaminskyy, VO, Kanamori, H, Kanasaki, K, Kang, C, Kang, R, Kang, SS, Kaniyappan, S, Kanki, T, Kanneganti, TD, Kanthasamy, AG, Kanthasamy, A, Kantorow, M, Kapuy, O, Karamouzis, MV, Karim, MR, Karmakar, P, Katare, RG, Kato, M, Kaufmann, SHE, Kauppinen, A, Kaushal, GP, Kaushik, S, Kawasaki, K, Kazan, K, Ke, PY, Keating, DJ, Keber, U, Kehrl, JH, Keller, KE, Keller, CW, Kemper, JK, Kenific, CM, Kepp, O, Kermorgant, S, Kern, A, Ketteler, R, Keulers, TG, Khalfin, B, Khalil, H, Khambu, B, Khan, SY, Khandelwal, VKM, Khandia, R, Kho, W, Khobrekar, NV, Khuansuwan, S, Khundadze, M, Killackey, SA, Kim, D, Kim, DR, Kim, DH, Kim, DE, Kim, EY, Kim, EK, Kim, H, Kim, HS, Kim, HR, Kim, JH, Kim, JK, Kim, J, Kim, KI, Kim, PK, Kim, SJ, Kimball, SR, Kimchi, A, Kimmelman, AC, Kimura, T, King, MA, Kinghorn, KJ, Kinsey, CG, Kirkin, V, Kirshenbaum, LA, Kiselev, SL, Kishi, S, Kitamoto, K, Kitaoka, Y, Kitazato, K, Kitsis, RN, Kittler, JT, Kjaerulff, O, Klein, PS, Klopstock, T, Klucken, J, Knovelsrud, H, Knorr, RL, Ko, BB, Ko, F, Ko, JL, Kobayashi, H, Kobayashi, S, Koch, I, Koch, JC, Koenig, U, Kogel, D, Koh, YH, Koike, M, Kohlwein, SD, Kocaturk, NM, Komatsu, M, Konig, J, Kono, T, Kopp, BT, Korcsmaros, T, Korkmaz, G, Korolchuk, VI, Korsnes, MS, Koskela, A, Kota, J, Kotake, Y, Kotler, ML, Kou, YJ, Koukourakis, MI, Koustas, E, Kovacs, AL, Kovacs, T, Koya, D, Kozako, T, Kraft, C, Krainc, D, Kramer, H, Krasnodembskaya, AD, Kretz-Remy, C, Kroemer, G, Ktistakis, NT, Kuchitsu, K, Kuenen, S, Kuerschner, L, Kukar, T, Kumar, A, Kumar, D, Kumar, S, Kume, S, Kumsta, C, Kundu, CN, Kundu, M, Kunnumakkara, AB, Kurgan, L, Kutateladze, TG, Kutlu, O, Kwak, S, Kwon, HJ, Kwon, TK, Kwon, YT, Kyrmizi, I, La Spada, A, Labonte, P, Ladoire, S, Laface, I, Lafont, F, Lagace, DC, Lahiri, V, Lai, ZB, Laird, AS, Lakkaraju, A, Lamark, T, Lan, SH, Landajuela, A, Lane, DJR, Lane, JD, Lang, CH, Lange, C, Langer, R, Lapaquette, P, Laporte, J, LaRusso, NF, Lastres-Becker, I, Lau, WCY, Laurie, GW, Lavandero, S, Law, BYK, Law, HKW, Layfield, R, Le, WD, Le Stunff, H, Leary, AY, Lebrun, JJ, Leck, LYW, Leduc-Gaudet, JP, Lee, C, Lee, CP, Lee, DH, Lee, EB, Lee, EF, Lee, GM, Lee, HJ, Lee, HK, Lee, JM, Lee, JS, Lee, JA, Lee, JY, Lee, JH, Lee, M, Lee, MG, Lee, MJ, Lee, MS, Lee, SY, Lee, SJ, Lee, SB, Lee, WH, Lee, YR, Lee, YH, Lee, Y, Lefebvre, C, Legouis, R, Lei, YL, Lei, YC, Leikin, S, Leitinger, G, Lemus, L, Leng, SL, Lenoir, O, Lenz, G, Lenz, HJ, Lenzi, P, Leon, Y, Leopoldino, AM, Leschczyk, C, Leskela, S, Letellier, E, Leung, CT, Leung, PS, Leventhal, JS, Levine, B, Lewis, PA, Ley, K, Li, B, Li, DQ, Li, JM, Li, J, Li, K, Li, LW, Li, M, Li, MC, Li, PL, Li, MQ, Li, Q, Li, S, Li, TG, Li, W, Li, WM, Li, X, Li, YP, Li, Y, Li, ZQ, Li, ZY, Lian, JQ, Liang, CY, Liang, QR, Liang, WC, Liang, YH, Liang, YT, Liao, GH, Liao, LJ, Liao, MZ, Liao, YF, Librizzi, M, Lie, PPY, Lilly, MA, Lim, HJ, Lima, TRR, Limana, F, Lin, C, Lin, CW, Lin, DS, Lin, FC, Lin, JDD, Lin, KM, Lin, KH, Lin, LT, Lin, PH, Lin, Q, Lin, SF, Lin, SJ, Lin, WY, Lin, XY, Lin, YX, Lin, YS, Linden, R, Lindner, P, Ling, SC, Lingor, P, Linnemann, AK, Liou, Y, Lipinski, MM, Lipovsek, S, Lira, VA, Lisiak, N, Liton, PB, Liu, C, Liu, CH, Liu, CF, Liu, F, Liu, H, Liu, HS, Liu, HF, Liu, J, Liu, JL, Liu, LY, Liu, LH, Liu, ML, Liu, Q, Liu, W, Liu, WD, Liu, XH, Liu, XD, Liu, XG, Liu, X, Liu, YF, Liu, Y, Liu, YY, Liu, YL, Livingston, JA, Lizard, G, Lizcano, JM, Ljubojevic-Holzer, S, LLeonart, ME, Llobet-Navas, D, Llorente, A, Lo, CH, Lobato-Marquez, D, Long, Q, Long, YC, Loos, B, Loos, JA, Lopez, MG, Lopez-Domenech, G, Lopez-Guerrero, JA, Lopez-Jimenez, AT, Lopez-Valero, I, Lorenowicz, MJ, Lorente, M, Lorincz, P, Lossi, L, Lotersztajn, S, Lovat, PE, Lovell, JF, Lovy, A, Lu, G, Lu, HC, Lu, JH, Lu, JJ, Lu, MJ, Lu, SY, Luciani, A, Lucocq, JM, Ludovico, P, Luftig, MA, Luhr, M, Luis-Ravelo, D, Lum, JJ, Luna-Dulcey, L, Lund, AH, Lund, VK, Lunemann, JD, Luningschror, P, Luo, HL, Luo, RC, Luo, SQ, Luo, Z, Luparello, C, Luscher, B, Luu, L, Lyakhovich, A, Lyamzaev, KG, Lystad, AH, Lytvynchuk, L, Ma, AC, Ma, CL, Ma, MX, Ma, NF, Ma, QH, Ma, XL, Ma, YY, Ma, ZY, MacDougald, OA, Macian, F, MacIntosh, GC, MacKeigan, JP, Macleod, KF, Maday, S, Madeo, F, Madesh, M, Madl, T, Madrigal-Matute, J, Maeda, A, Maejima, Y, Magarinos, M, Mahavadi, P, Maiani, E, Maiese, K, Maiti, P, Maiuri, MC, Majello, B, Major, MB, Makareeva, E, Malik, F, Mallilankaraman, K, Malorni, W, Maloyan, A, Mammadova, N, Man, GCW, Manai, F, Mancias, JD, Mandelkow, EM, Mandell, MA, Manfredi, AA, Manjili, MH, Manjithaya, R, Manque, P, Manshian, BB, Manzano, R, Manzoni, C, Mao, K, Marchese, C, Marchetti, S, Marconi, AM, Marcucci, F, Mardente, S, Mareninova, OA, Margeta, M, Mari, M, Marinelli, S, Marinelli, O, Marino, G, Mariotto, S, Marshall, RS, Marten, MR, Martens, S, Martin, APJ, Martin, KR, Martin, S, Martin-Segura, A, Martin-Acebes, MA, Martin-Burriel, I, Martin-Rincon, M, Martin-Sanz, P, Martina, JA, Martinet, W, Martinez, A, Martinez, J, Velazquez, MM, Martinez-Lopez, N, Martinez-Vicente, M, Martins, DO, Lange, U, Lopez-Perez, O, Martins, JO, Martins, WK, Martins-Marques, T, Marzetti, E, Masaldan, S, Masclaux-Daubresse, C, Mashek, DG, Massa, V, Massieu, L, Masson, GR, Masuelli, L, Masyuk, AI, Masyuk, TV, Matarrese, P, Matheu, A, Matoba, S, Matsuzaki, S, Mattar, P, Matte, A, Mattoscio, D, Mauriz, JL, Mauthe, M, Mauvezin, C, Maverakis, E, Maycotte, P, Mayer, J, Mazzoccoli, G, Mazzoni, C, Mazzulli, JR, McCarty, N, McDonald, C, McGill, MR, McKenna, SL, McLaughlin, B, McLoughlin, F, McNiven, MA, McWilliams, TG, Mechta-Grigoriou, F, Medeiros, TC, Medina, DL, Megeney, LA, Megyeri, K, Mehrpour, M, Mehta, JL, Meijer, AJ, Meijer, AH, Mejlvang, J, Melendez, A, Melk, A, Memisoglu, G, Mendes, AF, Meng, D, Meng, F, Meng, T, Menna-Barreto, R, Menon, MB, Mercer, C, Mercier, AE, Mergny, JL, Merighi, A, Merkley, SD, Merla, G, Meske, V, Mestre, AC, Metur, SP, Meyer, C, Meyer, H, Mi, WY, Mialet-Perez, J, Miao, JY, Micale, L, Miki, Y, Milan, E, Miller, DL, Miller, SI, Miller, S, Millward, SW, Milosevic, I, Minina, EA, Mirzaei, H, Mirzaei, HR, Mirzaei, M, Mishra, A, Mishra, N, Mishra, PK, Marjanovic, MM, Misasi, R, Misra, A, Misso, G, Mitchell, C, Mitou, G, Miura, T, Miyamoto, S, Miyazaki, M, Miyazaki, T, Miyazawa, K, Mizushima, N, Mogensen, TH, Mograbi, B, Mohammadinejad, R, Mohamud, Y, Mohanty, A, Mohapatra, S, Mohlmann, T, Mohmmed, A, Moles, A, Moley, KH, Molinari, M, Mollace, V, Muller, AB, Mollereau, B, Mollinedo, F, Montagna, C, Monteiro, MJ, Montella, A, Montes, LR, Montico, B, Mony, VK, Compagnoni, GM, Moore, MN, Moosavi, MA, Mora, AL, Mora, M, Morales-Alamo, D, Moratalla, R, Moreira, PI, Morelli, E, Moreno, S, Moreno-Blas, D, Moresi, V, Morga, B, Morgan, AH, Morin, F, Morishita, H, Moritz, OL, Moriyama, M, Moriyasu, Y, Morleo, M, Morselli, E, Moruno-Manchon, JF, Moscat, J, Mostowy, S, Motori, E, Moura, AF, Moustaid-Moussa, N, Mrakovcic, M, MucinoHernandez, G, Mukherjee, A, Mukhopadhyay, S, Levy, JMM, Mulero, V, Muller, S, Munch, C, Munjal, A, Munoz-Canoves, P, Munoz-Galdeano, T, Munz, C, Murakawa, T, Muratori, C, Murphy, BM, Murphy, JP, Murthy, A, Myohanen, TT, Mysorekar, IU, Mytych, J, Nabavi, SM, Nabissi, M, Nagy, P, Nah, J, Nahimana, A, Nakagawa, I, Nakamura, K, Nakatogawa, H, Nandi, SS, Nanjundan, M, Nanni, M, Napolitano, G, Nardacci, R, Narita, M, Nassif, M, Nathan, I, Natsumeda, M, Naude, RJ, Naumann, C, Naveiras, O, Navid, F, Nawrocki, ST, Nazarko, TY, Nazio, F, Negoita, F, Neill, T, Neisch, AL, Neri, LM, Netea, MG, Neubert, P, Neufeld, TP, Neumann, D, Neutzner, A, Newton, PT, Ney, PA, Nezis, IP, Ng, CCW, Ng, TB, Nguyen, HTT, Nguyen, LT, Ni, HM, Cheallaigh, CN, Ni, Z, Nicolao, MC, Nicoli, F, Nieto-Diaz, M, Nilsson, P, Ning, S, Niranjan, R, Nishimune, H, Niso-Santano, M, Nixon, RA, Nobili, A, Nobrega, C, Noda, T, Nogueira-Recalde, U, Nolan, TM, Nombela, I, Novak, I, Novoa, B, Nozawa, T, Nukina, N, Nussbaum-Krammer, C, Nylandsted, J, O'Donovan, TR, O'Leary, SM, O'Rourke, EJ, O'Sullivan, MP, O'Sullivan, TE, Oddo, S, Oehme, I, Ogawa, M, Ogier-Denis, E, Ogmundsdottir, MH, Ogretmen, B, Oh, GT, Oh, SH, Oh, YJ, Ohama, T, Ohashi, Y, Ohmuraya, M, Oikonomou, V, Ojha, R, Okamoto, K, Okazawa, H, Oku, M, Olivan, S, Oliveira, JMA, Ollmann, M, Olzmann, JA, Omari, S, Omary, MB, Onal, G, Ondrej, M, Ong, SB, Ong, SG, Onnis, A, Orellana, JA, Orellana-Munoz, S, Ortega-Villaizan, MD, Ortiz-Gonzalez, XR, Ortona, E, Osiewacz, HD, Osman, AHK, Osta, R, Otegui, MS, Otsu, K, Ott, C, Ottobrini, L, Ou, JHJ, Outeiro, TF, Oynebraten, I, Ozturk, M, Pages, G, Pahari, S, Pajares, M, Pajvani, UB, Pal, R, Paladino, S, Pallet, N, Palmieri, M, Palmisano, G, Palumbo, C, Pampaloni, F, Pan, LF, Pan, QJ, Pan, WL, Pan, X, Panasyuk, G, Pandey, R, Pandey, UB, Pandya, V, Paneni, F, Pang, SY, Panzarini, E, Papademetrio, DL, Papaleo, E, Papinski, D, Papp, D, Park, EC, Park, HT, Park, JM, Park, J, Park, JT, Park, SC, Park, SY, Parola, AH, Parys, JB, Pasquier, A, Pasquier, B, Passos, JF, Pastore, N, Patel, HH, Patschan, D, Pattingre, S, Pedraza-Alva, G, Pedraza-Chaverri, J, Pedrozo, Z, Pei, G, Pei, JM, Peled-Zehavi, H, Pellegrini, JM, Pelletier, J, Penalva, MA, Peng, D, Peng, Y, Penna, F, Pennuto, M, Pentimalli, F, Pereira, CM, Pereira, GJS, Pereira, LC, de Almeida, LP, Perera, ND, PerezOliva, AB, Perez-Perez, ME, Periyasamy, P, Perl, A, Perrotta, C, Perrotta, I, Pestell, RG, Petersen, M, Petrache, I, Petrovski, G, Pfirrmann, T, Pfister, AS, Philips, JA, Pi, HF, Picca, A, Pickrell, AM, Picot, S, Pierantoni, GM, Pierdominici, M, Pierre, P, Pierrefite-Carle, V, Pierzynowska, K, Pietrocola, F, Pietruczuk, M, Pignata, C, PimentelMuinos, FX, Pinar, M, Pinheiro, RO, Pinkas-Kramarski, R, Pinton, P, Pircs, K, Piya, S, Pizzo, P, Plantinga, TS, Platta, HW, Plaza-Zabala, A, Plomann, M, Plotnikov, EY, Plun-Favreau, H, Pluta, R, Pocock, R, Poggeler, S, Pohl, C, Poirot, M, Poletti, A, Ponpuak, M, Popelka, H, Popova, B, Porta, H, Alcon, SP, Portilla-Fernandez, E, Post, M, Potts, MB, Poulton, J, Powers, T, Prahlad, V, Prajsnar, TK, Pratico, D, Prencipe, R, Priault, M, ProikasCezanne, T, Promponas, VJ, Proud, CG, Puertollano, R, Puglielli, L, Pulinilkunnil, T, Puri, D, Puri, R, Puyal, J, Qi, XP, Qi, YM, Qian, WB, Qiang, L, Qiu, Y, Quadrilatero, J, Quarleri, J, Raben, N, Rabinowich, H, Ragona, D, Ragusa, MJ, Rahimi, N, Rahmati, M, Raia, V, Raimundo, N, Rajasekaran, NS, Rao, SR, Rami, A, Ramirez-Pardo, I, Ramsden, DB, Randow, F, Rangarajan, PN, Ranieri, D, Rao, H, Rao, L, Rao, R, Rathore, S, Ratnayaka, JA, Ratovitski, EA, Ravanan, P, Ravegnini, G, Ray, SK, Razani, B, Rebecca, V, Reggiori, F, Regnier-Vigouroux, A, Reichert, AS, Reigada, D, Reiling, JH, Rein, T, Reipert, S, Rekha, RS, Ren, HM, Ren, J, Ren, WC, Renault, T, Renga, G, Reue, K, Rewitz, K, Ramos, BRD, Riazuddin, SA, Ribeiro-Rodrigues, TM, Ricci, JE, Ricci, R, Riccio, V, Richardson, D, Rikihisa, Y, Risbud, MV, Risueno, RM, Ritis, K, Rizza, S, Rizzuto, R, Roberts, HC, Roberts, LD, Robinson, KJ, Roccheri, MC, Rocchi, S, Rodney, GG, Rodrigues, T, Silva, VRR, Rodriguez, A, Rodriguez-Barrueco, R, Rodriguez-Henche, N, Rodriguez-Rocha, H, Roelofs, J, Rogers, RS, Rogov, VV, Rojo, AI, Rolka, K, Romanello, V, Romani, L, Romano, A, Romano, PS, Romeo-Guitart, D, Romero, LC, Romero, M, Roney, JC, Rongo, C, Roperto, S, Rosenfeldt, MT, Rosenstiel, P, Rosenwald, AG, Roth, KA, Roth, L, Roth, S, Rouschop, KMA, Roussel, BD, Roux, S, Rovere-Querini, P, Roy, A, Rozieres, A, Ruano, D, Rubinsztein, DC, Rubtsova, MP, Ruckdeschel, K, Ruckenstuhl, C, Rudolf, E, Rudolf, R, Ruggieri, A, Ruparelia, AA, Rusmini, P, Russell, RR, Russo, GL, Russo, M, Russo, R, Ryabaya, OO, Ryan, KM, Ryu, KY, Sabater-Arcis, M, Sachdev, U, Sacher, M, Sachse, C, Sadhu, A, Sadoshima, J, Safren, N, Saftig, P, Sagona, AP, Sahay, G, Sahebkar, A, Sahin, M, Sahin, O, Sahni, S, Saito, N, Saito, S, Saito, T, Sakai, R, Sakai, Y, Sakamaki, JI, Saksela, K, Salazar, G, Salazar-Degracia, A, Salekdeh, GH, Saluja, AK, Sampaio-Marques, B, Sanchez, MC, Sanchez-Alcazar, JA, Sanchez-Vera, V, Sancho-Shimizu, V, Sanderson, JT, Sandri, M, Santaguida, S, Santambrogio, L, Santana, MM, Santoni, G, Sanz, A, Sanz, P, Saran, S, Sardiello, M, Sargeant, TJ, Sarin, A, Sarkar, C, Sarkar, S, Sarrias, MR, Sarmah, DT, Sarparanta, J, Sathyanarayan, A, Sathyanarayanan, R, Scaglione, KM, Scatozza, F, Schaefer, L, Schafer, ZT, Schaible, UE, Schapira, AHV, Scharl, M, Schatzl, HM, Schein, CH, Scheper, W, Scheuring, D, Schiaffino, MV, Schiappacassi, M, Schindl, R, Schlattner, U, Schmidt, O, Schmitt, R, Schmidt, SD, Schmitz, I, Schmukler, E, Schneider, A, Schneider, BE, Schober, R, Schoijet, AC, Schott, MB, Schramm, M, Schroder, B, Schuh, K, Schuller, C, Schulze, RJ, Schurmanns, L, Schwamborn, JC, Schwarten, M, Scialo, F, Sciarretta, S, Scott, MJ, Scotto, KW, Scovassi, AI, Scrima, A, Scrivo, A, Sebastian, D, Sebti, S, Sedej, S, Segatori, L, Segev, N, Seglen, PO, Seiliez, I, Seki, E, Selleck, SB, Sellke, FW, Perez-Lara, A, Selsby, JT, Sendtner, M, Senturk, S, Seranova, E, Sergi, C, Serra-Moreno, R, Sesaki, H, Settembre, C, Setty, SRG, Sgarbi, G, Sha, O, Shacka, JJ, Shah, JA, Shang, DT, Shao, CS, Shao, F, Sharbati, S, Sharkey, LM, Sharma, D, Sharma, G, Sharma, K, Sharma, P, Sharma, S, Shen, HM, Shen, HT, Shen, JG, Shen, M, Shen, WL, Shen, ZN, Sheng, R, Sheng, Z, Sheng, ZH, Shi, JJ, Shi, XB, Shi, YH, Shiba-Fukushima, K, Shieh, J, Shimada, Y, Shimizu, S, Shimozawa, M, Shintani, T, Shoemaker, CJ, Shojaei, S, Shoji, I, Shravage, BV, Shridhar, V, Shu, CW, Shu, HB, Shui, K, Shukla, AK, Shutt, TE, Sica, V, Siddiqui, A, Sierra, A, Sierra-Torre, V, Signorelli, S, Sil, P, Silva, BJD, Silva, JD, Silva-Pavez, E, Silvente-Poirot, S, Simmonds, RE, Simon, AK, Simon, HU, Simons, M, Singh, A, Singh, LP, Singh, R, Singh, SV, Singh, SK, Singh, SB, Singh, S, Singh, SP, Sinha, D, Sinha, RA, Sinha, S, Sirko, A, Sirohi, K, Sivridis, EL, Skendros, P, Skirycz, A, Slaninova, I, Smaili, SS, Smertenko, A, Smith, MD, Soenen, SJ, Sohn, EJ, Sok, SPM, Solaini, G, Soldati, T, Soleimanpour, SA, Soler, RM, Solovchenko, A, Somarelli, JA, Sonawane, A, Song, FY, Song, HK, Song, JX, Song, KH, Song, ZY, Soria, LR, Sorice, M, Soukas, AA, Soukup, SF, Sousa, D, Sousa, N, Spagnuolo, PA, Spector, SA, Bharath, MMS, St Clair, D, Stagni, V, Staiano, L, Stalnecker, CA, Stankov, MV, Stathopulos, PB, Stefan, K, Stefan, SM, Stefanis, L, Steffan, JS, Steinkasserer, A, Stenmark, H, Sterneckert, J, Stevens, C, Stoka, V, Storch, S, Stork, B, Strappazzon, F, Strohecker, AM, Stupack, DG, Su, HX, Su, LY, Su, LX, SuarezFontes, AM, Subauste, CS, Subbian, S, Subirada, PV, Sudhandiran, G, Sue, CM, Sui, XB, Summers, C, Sun, GC, Sun, J, Sun, K, Sun, MX, Sun, QM, Sun, Y, Sun, ZJ, Sunahara, KKS, Sundberg, E, Susztak, K, Sutovsky, P, Suzuki, H, Sweeney, G, Symons, JD, Sze, SCW, Szewczyk, NJ, Tabolacci, C, Tacke, F, Taegtmeyer, H, Tafani, M, Tagaya, M, Tai, HR, Tait, SWG, Takahashi, Y, Takats, S, Talwar, P, Tam, C, Tam, SY, Tampellini, D, Tamura, A, Tan, CT, Tan, EK, Tan, YQ, Tanaka, M, Tang, D, Tang, JF, Tang, TS, Tanida, I, Tao, ZP, Taouis, M, Tatenhorst, L, Tavernarakis, N, Taylor, A, Taylor, GA, Taylor, JM, Tchetina, E, Tee, AR, Tegeder, I, Teis, D, Teixeira, N, Teixeira-Clerc, F, Tekirdag, KA, Tencomnao, T, Tenreiro, S, Tepikin, AV, Testillano, PS, Tettamanti, G, Tharaux, P, Thedieck, K, Thekkinghat, AA, Thellung, S, Thinwa, JW, Thirumalaikumar, VP, Thomas, SM, Thomes, PG, Thorburn, A, Thukral, L, Thum, T, Thumm, M, Tian, L, Tichy, A, Till, A, Timmerman, V, Titorenko, VI, Todi, SV, Todorova, K, Toivonen, JM, Tomaipitinca, L, Tomar, D, Tomas-Zapico, C, Tong, BCK, Tong, C, Tong, X, Tooze, SA, Torgersen, ML, Torii, S, Torres-Lopez, L, Torriglia, A, Towers, CG, Towns, R, Toyokuni, S, Trajkovic, V, Tramontano, D, Tran, Q, Travassos, LH, Trelford, CB, Tremel, S, Trougakos, IP, Tsao, BP, Tschan, MP, Tse, HF, Tse, TF, Tsugawa, H, Tsvetkov, AS, Tumbarello, DA, Tumtas, Y, Tunon, MJ, Turcotte, S, Turk, B, Turk, V, Turner, BJ, Tuxworth, RI, Tyler, JK, Tyutereva, EV, Uchiyama, Y, UgunKlusek, A, Uhlig, HH, Ulasov, IV, Umekawa, M, Ungermann, C, Unno, R, Urbe, S, Uribe-Carretero, E, Ustun, S, Uversky, VN, Vaccari, T, Vaccaro, MI, Vahsen, BF, Vakifahmetoglu-Norberg, H, Valdor, R, Valente, MJ, Valko, A, Vallee, RB, Valverde, AM, Van den Berghe, G, van Der Veen, S, Van Kaer, L, van Loosdregt, J, van Wijk, SJL, Vandenberghe, W, Vanhorebeek, I, Vannier-Santos, MA, Vannini, N, Vanrell, MC, Vantaggiato, C, Varano, G, Varela-Nieto, I, Varga, M, Vasconcelos, MH, Vats, S, Vavvas, DG, VegaNaredo, I, Vega-Rubin-de-Celis, S, Velasco, G, Velazquez, AP, Vellai, T, Vellenga, E, Velotti, F, Verdier, M, Verginis, P, Vergne, I, Verkade, P, Verma, M, Verstreken, P, Vervliet, T, Vervoorts, J, Vessoni, AT, Victor, VM, Vidal, M, Vidoni, C, Vieira, OV, Vierstra, RD, Vigano, S, Vihinen, H, Vijayan, V, Vila, M, Vilar, M, Villalba, JM, Villalobo, A, Villarejo-Zori, B, Villarroya, F, Villarroya, J, Vincent, O, Vindis, C, Viret, C, Viscomi, MT, Visnjic, D, Vitale, I, Vocadlo, DJ, Voitsekhovskaja, OV, Volonte, C, Volta, M, Vomero, M, Von Haefen, C, Vooijs, MA, Voos, W, Vucicevic, L, Wade-Martins, R, Waguri, S, Waite, KA, Wakatsuki, S, Walker, DW, Walker, MJ, Walker, SA, Walter, J, Wandosell, FG, Wang, B, Wang, CY, Wang, C, Wang, CR, Wang, CW, Wang, D, Wang, FY, Wang, F, Wang, FM, Wang, GS, Wang, H, Wang, HX, Wang, HG, Wang, JR, Wang, JG, Wang, J, Wang, JD, Wang, K, Wang, LR, Wang, LM, Wang, MH, Wang, MQ, Wang, NB, Wang, PW, Wang, PP, Wang, P, Wang, QJ, Wang, Q, Wang, QK, Wang, QA, Wang, WT, Wang, WY, Wang, XN, Wang, XJ, Wang, Y, Wang, YC, Wang, YZ, Wang, YY, Wang, YH, Wang, YP, Wang, YQ, Wang, Z, Wang, ZY, Wang, ZG, Warnes, G, Warnsmann, V, Watada, H, Watanabe, E, Watchon, M, Weaver, TE, Wegrzyn, G, Wehman, AM, Wei, HF, Wei, L, Wei, TT, Wei, YJ, Weiergraber, OH, Weihl, CC, Weindl, G, Weiskirchen, R, Wells, A, Wen, RXH, Wen, X, Werner, A, Weykopf, B, Wheatley, SP, Whitton, JL, Whitworth, AJ, Wiktorska, K, Wildenberg, ME, Wileman, T, Wilkinson, S, Willbold, D, Williams, B, Williams, RSB, Williams, RL, Williamson, PR, Wilson, RA, Winner, B, Winsor, NJ, Witkin, SS, Wodrich, H, Woehlbier, U, Wollert, T, Wong, E, Wong, JH, Wong, RW, Wong, VKW, Wong, WWL, Wu, AG, Wu, CB, Wu, J, Wu, JF, Wu, KK, Wu, M, Wu, SY, Wu, SZ, Wu, SF, Wu, WKK, Wu, XH, Wu, XQ, Wu, YW, Wu, YH, Xavier, RJ, Xia, HG, Xia, LX, Xia, ZY, Xiang, G, Xiang, J, Xiang, ML, Xiang, W, Xiao, B, Xiao, GZ, Xiao, HY, Xiao, HT, Xiao, J, Xiao, L, Xiao, S, Xiao, Y, Xie, BM, Xie, CM, Xie, M, Xie, YX, Xie, ZP, Xie, ZL, Xilouri, M, Xu, CF, Xu, E, Xu, HX, Xu, J, Xu, JR, Xu, L, Xu, WW, Xu, XL, Xue, Y, Yakhine-Diop, SMS, Yamaguchi, M, Yamaguchi, O, Yamamoto, A, Yamashina, S, Yan, SM, Yan, SJ, Yan, Z, Yanagi, Y, Yang, CB, Yang, DS, Yang, H, Yang, HT, Yang, JM, Yang, J, Yang, JY, Yang, L, Yang, M, Yang, PM, Yang, Q, Yang, S, Yang, SF, Yang, WN, Yang, WY, Yang, XY, Yang, XS, Yang, Y, Yao, HH, Yao, SG, Yao, XQ, Yao, YG, Yao, YM, Yasui, T, Yazdankhah, M, Yen, PM, Yi, C, Yin, XM, Yin, YH, Yin, ZY, Ying, MD, Ying, Z, Yip, CK, Yiu, SPT, Yoo, YH, Yoshida, K, Yoshii, SR, Yoshimori, T, Yousefi, B, Yu, BX, Yu, HY, Yu, J, Yu, L, Yu, ML, Yu, SW, Yu, VC, Yu, WH, Yu, ZP, Yu, Z, Yuan, JY, Yuan, LQ, Yuan, SL, Yuan, SSF, Yuan, YG, Yuan, ZQ, Yue, JB, Yue, ZY, Yun, J, Yung, RL, Zacks, DN, Zaffagnini, G, Zambelli, VO, Zanella, I, Zang, QS, Zanivan, S, Zappavigna, S, Zaragoza, P, Zarbalis, KS, Zarebkohan, A, Zarrouk, A, Zeitlin, SO, Zeng, JL, Zeng, JD, Zerovnik, E, Zhan, LX, Zhang, B, Zhang, DD, Zhang, HL, Zhang, H, Zhang, HH, Zhang, HF, Zhang, HY, Zhang, JB, Zhang, JH, Zhang, JP, Zhang, KLYB, Zhang, LSW, Zhang, L, Zhang, LS, Zhang, LY, Zhang, MH, Zhang, P, Zhang, S, Zhang, W, Zhang, XN, Zhang, XW, Zhang, XL, Zhang, XY, Zhang, X, Zhang, XX, Zhang, XD, Zhang, Y, Zhang, YJ, Zhang, YD, Zhang, YM, Zhang, YY, Zhang, YC, Zhang, Z, Zhang, ZG, Zhang, ZB, Zhang, ZH, Zhang, ZY, Zhang, ZL, Zhao, HB, Zhao, L, Zhao, S, Zhao, TB, Zhao, XF, Zhao, Y, Zhao, YC, Zhao, YL, Zhao, YT, Zheng, GP, Zheng, K, Zheng, L, Zheng, SZ, Zheng, XL, Zheng, Y, Zheng, ZG, Zhivotovsky, B, Zhong, Q, Zhou, A, Zhou, B, Zhou, CF, Zhou, G, Zhou, H, Zhou, HB, Zhou, J, Zhou, JY, Zhou, KL, Zhou, RJ, Zhou, XJ, Zhou, YS, Zhou, YH, Zhou, YB, Zhou, ZY, Zhou, Z, Zhu, BL, Zhu, CL, Zhu, GQ, Zhu, HN, Zhu, HX, Zhu, H, Zhu, WG, Zhu, YP, Zhu, YS, Zhuang, HX, Zhuang, XH, Zientara-Rytter, K, Zimmermann, CM, Ziviani, E, Zoladek, T, Zong, WX, Zorov, DB, Zorzano, A, Zou, WP, Zou, Z, Zou, ZZ, Zuryn, S, Zwerschke, W, Brand-Saberi, B, Dong, XC, Kenchappa, CS, Li, ZG, Lin, Y, Oshima, S, Rong, YG, Sluimer, JC, Stallings, CL, and Tong, CK

Subjects
flux, macroautophagy, phagophore, stress, vacuole, Autophagosome, LC3, lysosome, neurodegeneration, cancer
Abstract

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

Published
2021

43. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Author

Natarajan, P. (Pradeep), Pampana, A. (Akhil), Graham, S. E. (Sarah E.), Ruotsalainen, S. E. (Sanni E.), Perry, J. A. (James A.), de Vries, P. S. (Paul S.), Broome, J. G. (Jai G.), Pirruccello, J. P. (James P.), Honigbere, M. C. (Michael C.), Aragam, K. (Krishna), Wolford, B. (Brooke), Brody, J. A. (Jennifer A.), Antonacci-Fulton, L. (Lucinda), Arden, M. (Moscati), Aslibekyan, S. (Stella), Assimes, T. L. (Themistocles L.), Ballantyne, C. M. (Christie M.), Bielak, L. F. (Lawrence F.), Bisl, J. C. (Joshua C.), Cade, B. E. (Brian E.), Do, R. (Ron), Doddapaneni, H. (Harsha), Emery, L. S. (Leslie S.), Hung, Y.-J. (Yi-Jen), Irvin, M. R. (Marguerite R.), Khan, A. T. (Alyna T.), Lange, L. (Leslie), Lee, J. (Jiwon), Lemaitre, R. N. (Rozenn N.), Martin, L. W. (Lisa W.), Metcalf, G. (Ginger), Montasser, M. E. (May E.), Moon, J.-Y. (Jee-Young), Muzny, D. (Donna), Connell, J. R. (Jeffrey R. O.), Palmer, N. D. (Nicholette D.), Peralta, J. M. (Juan M.), Peyser, P. A. (Patricia A.), Stilp, A. M. (Adrienne M.), Tsai, M. (Michael), Wang, F. F. (Fei Fei), Weeks, D. E. (Daniel E.), Yanek, L. R. (Lisa R.), Wilson, J. G. (James G.), Abecasis, G. (Goncalo), Arnett, D. K. (Donna K.), Becker, L. C. (Lewis C.), Blangercy, J. (John), Boerwinkle, E. (Eric), Bowden, D. W. (Donald W.), Chang, Y.-C. (Yi-Cheng), Chen, Y. I. (Yii-Der, I), Choi, W. J. (Won Jung), Correa, A. (Adolfo), Curran, J. E. (Joanne E.), Daly, M. J. (Mark J.), DutcherE, S. K. (Susan K.), Ellinor, P. T. (Patrick T.), Fornage, M. (Myriam), Freedman, B. I. (Barry, I), Gabriel, S. (Stacey), Germer, S. (Soren), Gibbs, R. A. (Richard A.), He, J. (Jiang), Hveem, K. (Kristian), Jarvik, G. P. (Gail P.), Kaplan, R. C. (Robert C.), Kardia, S. L. (Sharon L. R.), Kennyn, E. (Eimear), Kim, R. W. (Ryan W.), Kooperberg, C. (Charles), Laurie, C. C. (Cathy C.), Lee, S. (Seonwook), Lloyd-Jones, D. M. (Don M.), Loos, R. J. (Ruth J. F.), Lubitz, S. A. (Steven A.), Mathias, R. A. (Rasika A.), Martinez, K. A. (Karine A. Viaud), McGarvey, S. T. (Stephen T.), Mitche, B. D. (Braxton D.), Nickerson, D. A. (Deborah A.), North, K. E. (Kari E.), Palotie, A. (Aarno), Park, C. J. (Cheol Joo), Psat, B. M. (Bruce M. Y.), Rao, D. C. (D. C.), Redline, S. (Susan), Reiner, A. P. (Alexander P.), Seo, D. (Daekwan), Seo, J.-S. (Jeong-Sun), Smith, A. V. (Albert, V), Tracy, R. P. (Russell P.), Kathiresan, S. (Sekar), Cupples, L. A. (L. Adrienne), Rotten, J. I. (Jerome, I), Morrison, A. C. (Alanna C.), Rich, S. S. (Stephen S.), Ripatti, S. (Samuli), Wilier, C. (Cristen), Peloso, G. M. (Gina M.), Vasan, R. S. (Ramachandran S.), Abe, N. (Namiko), Albert, C. (Christine), Almasy, L. (Laura), Alonso, A. (Alvaro), Ament, S. (Seth), Anderson, P. (Peter), Applebaum-Bowden, D. (Deborah), Arking, D. (Dan), Ashley-Koch, A. (Allison), Auer, P. (Paul), Avramopoulos, D. (Dimitrios), Barnard, J. (John), Barnes, K. (Kathleen), Barr, R. G. (R. Graham), Barron-Casella, E. (Emily), Beaty, T. (Terri), Becker, D. (Diane), Beer, R. (Rebecca), Begum, F. (Ferdouse), Beitelshees, A. (Amber), Benjamin, E. (Emelia), Bezerra, M. (Marcos), Bielak, L. (Larry), Blackwel, T. (Thomas), Bowler, R. (Russell), Broecke, U. (Ulrich), Bunting, K. (Karen), Burchard, E. (Esteban), Buth, E. (Erin), Cardwel, J. (Jonathan), Carty, C. (Cara), Casaburi, R. (Richard), Casella, J. (James), Chaffin, M. (Mark), Chang, C. (Christy), Chasman, D. (Daniel), Chavan, S. (Sameer), Chen, B.-J. (Bo-Juen), Chen, W.-M. (Wei-Min), Chol, M. (Michael), Choi, S. H. (Seung Hoan), Chuang, L.-M. (Lee-Ming), Chung, M. (Mina), Conomos, M. P. (Matthew P.), Cornell, E. (Elaine), Crapo, J. (James), Curtis, J. (Jeffrey), Custer, B. (Brian), Damcott, C. (Coleen), Darbar, D. (Dawood), Das, S. (Sayantan), David, S. (Sean), Davis, C. (Colleen), Daya, M. (Michelle), de Andrade, M. (Mariza), DeBaunuo, M. (Michael), Duan, Q. (Qing), Devine, R. D. (Ranjan Deka Dawn DeMeo Scott), Duggirala, Q. R. (Qing Ravi), Durda, J. P. (Jon Peter), Dutcher, S. (Susan), Eaton, C. (Charles), Ekunwe, L. (Lynette), Farber, C. (Charles), Farnaml, L. (Leanna), Fingerlin, T. (Tasha), Flickinger, M. (Matthew), Franceschini, N. (Nora), Fu, M. (Mao), Fullerton, S. M. (Stephanie M.), Fulton, L. (Lucinda), Gan, W. (Weiniu), Gao, Y. (Yan), Gass, M. (Margery), Ge, B. (Bruce), Geng, X. P. (Xiaoqi Priscilla), Gignoux, C. (Chris), Gladwin, M. (Mark), Glahn, D. (David), Gogarten, S. (Stephanie), Gong, D.-W. (Da-Wei), Goring, H. (Harald), Gu, C. C. (C. Charles), Guan, Y. (Yue), Guo, X. (Xiuqing), Haessler, J. (Jeff), Hall, M. (Michael), Harris, D. (Daniel), Hawle, N. Y. (Nicola Y.), Heavner, B. (Ben), Heckbert, S. (Susan), Hernandez, R. (Ryan), Herrington, D. (David), Hersh, C. (Craig), Hidalgo, B. (Bertha), Hixson, J. (James), Hokanson, J. (John), Hong, E. (Elliott), Hoth, K. (Karin), Hsiung, C. A. (Chao Agnes), Huston, H. (Haley), Hwu, C. M. (Chii Min), Jackson, R. (Rebecca), Jain, D. (Deepti), Jaquish, C. (Cashell), Jhun, M. A. (Min A.), Johnsen, J. (Jill), Johnson, A. (Andrew), Johnson, C. (Craig), Johnston, R. (Rich), Jones, K. (Kimberly), Kang, H. M. (Hyun Min), Kaufman, L. (Laura), Kell, S. Y. (Shannon Y.), Kessler, M. (Michael), Kinney, G. (Greg), Konkle, B. (Barbara), Kramer, H. (Holly), Krauter, S. (Stephanie), Lange, C. (Christoph), Lange, E. (Ethan), Laurie, C. (Cecelia), LeBoff, M. (Meryl), Lee, S. S. (Seunggeun Shawn), Lee, W.-J. (Wen-Jane), LeFaive, J. (Jonathon), Levine, D. (David), Levy, D. (Dan), Lewis, J. (Joshua), Li, Y. (Yun), Lin, H. (Honghuang), Lin, K. H. (Keng Han), Lin, X. (Xihong), Liu, S. (Simin), Liu, Y. (Yongmei), Lunetta, K. (Kathryn), Luo, J. (James), Mahaney, M. (Michael), Make, B. (Barry), Manichaikul, A. (Ani), Mansonl, J. (JoAnn), Margolin, L. (Lauren), Mathai, S. (Susan), McArdle, P. (Patrick), Mcdonald, M.-L. (Merry-Lynn), McFarland, S. (Sean), McHugh, C. (Caitlin), Mei, H. (Hao), Meyers, D. A. (Deborah A.), Mikulla, J. (Julie), Min, N. (Nancy), Minear, M. (Mollie), Minster, R. L. (Ryan L.), Musani, S. (Solomon), Mwasongwe, S. (Stanford), Mychaleckyj, J. C. (Josyf C.), Nadkarni, G. (Girish), Naik, R. (Rakhi), Naseri, T. (Take), Nekhai, S. (Sergei), Nelson, S. C. (Sarah C.), Nickerson, D. (Deborah), Connell, J. O. (Jeff O.), Connor, T. O. (Tim O.), Ochs-Balcom, H. (Heather), Pankow, J. (James), Papanicolaou, G. (George), Parkerl, M. (Margaret), Parsa, A. (Afshin), Penchey, S. (Sara), Perez, M. (Marco), Peters, U. (Ulrike), Phillips, L. S. (Lawrence S.), Phillips, S. (Sam), Pollin, T. (Toni), Post, W. (Wendy), Becker, J. P. (Julia Powers), Boorgula, M. P. (Meher Preethi), Preuss, M. (Michael), Prokopenko, D. (Dmitry), Qasba, P. (Pankaj), Qiao, D. (Dandi), Rafaels, N. (Nicholas), Raffield, L. (Laura), Rasmussen-Torvik, L. (Laura), Ratan, A. (Aakrosh), Reed, R. (Robert), Reganl, E. (Elizabeth), Reupena, M. S. (Muagututi Sefuiva), Rice, K. (Ken), Roden, D. (Dan), Roselli, C. (Carolina), Ruczinski, I. (Ingo), Russel, P. (Pamela), Ruuska, S. (Sarah), Ryan, K. (Kathleen), Sabino, E. C. (Ester Cerdeira), Sakornsakolpatl, P. (Phuwanat), Salzberg, S. (Steven), Sandow, K. (Kevin), Sankaran, V. G. (Vijay G.), Scheller, C. (Christopher), Schmidt, E. (Ellen), Schwander, K. (Karen), Schwartz, D. (David), Sciurba, F. (Frank), Seidman, C. (Christine), Seidman, J. (Jonathan), Sheehan, V. (Vivien), Shetty, A. (Amol), Shetty, A. (Aniket), Sheu, W. H. (Wayne Hui-Heng), Shoemaker, M. B. (M. Benjamin), Silver, B. (Brian), Silvermanl, E. (Edwin), Smith, J. (Jennifer), Smith, J. (Josh), Smith, N. (Nicholas), Smith, T. (Tanja), Smoller, S. (Sylvia), Snively, B. (Beverly), Soferlm, T. (Tamar), Streeten, E. (Elizabeth), Su, J. L. (Jessica Lasky), Sung, Y. J. (Yun Ju), Sylvia, J. (Jody), Sztalryd, C. (Carole), Taliun, D. (Daniel), Tang, H. (Hua), Taub, M. (Margaret), Taylor, K. D. (Kent D.), Taylor, S. (Simeon), Telen, M. (Marilyn), Thornton, T. A. (Timothy A.), Tinker, L. (Lesley), Tirschwel, D. (David), Tiwari, H. (Hemant), Vaidya, D. (Dhananjay), VandeHaar, P. (Peter), Vrieze, S. (Scott), Walker, T. (Tarik), Wallace, R. (Robert), Waits, A. (Avram), Wan, E. (Emily), Wang, H. (Heming), Watson, K. (Karol), Weir, B. (Bruce), Weiss, S. (Scott), Weng, L.-C. (Lu-Chen), Williams, K. (Kayleen), Williams, L. K. (L. Keoki), Wilson, C. (Carla), Wong, Q. (Quenna), Xu, H. (Huichun), Yang, I. (Ivana), Yang, R. (Rongze), Zaghlou, N. (Norann), Zekavat, M. (Maryam), Zhang, Y. (Yingze), Zhao, S. X. (Snow Xueyan), Zhao, W. (Wei), Zni, D. (Degui), Zhou, X. (Xiang), Zhu, X. (Xiaofeng), Zody, M. (Michael), Zoellner, S. (Sebastian), Daly, M. (Mark), Jacob, H. (Howard), Matakidou, A. (Athena), Runz, H. (Heiko), John, S. (Sally), Plenge, R. (Robert), McCarthy, M. (Mark), Hunkapiller, J. (Julie), Ehm, M. (Meg), Waterworth, D. (Dawn), Fox, C. (Caroline), Malarstig, A. (Anders), Klinger, K. (Kathy), Call, K. (Kathy), Mkel, T. (Tomi), Kaprio, J. (Jaakko), Virolainen, P. (Petri), Pulkki, K. (Kari), Kilpi, T. (Terhi), Perola, M. (Markus), Partanen, J. (Jukka), Pitkranta, A. (Anne), Kaarteenaho, R. (Riitta), Vainio, S. (Seppo), Savinainen, K. (Kimmo), Kosma, V.-M. (Veli-Matti), Kujala, U. (Urho), Tuovila, O. (Outi), Hendolin, M. (Minna), Pakkanen, R. (Raimo), Waring, J. (Jeff), Riley-Gillis, B. (Bridget), Liu, J. (Jimmy), Biswas, S. (Shameek), Diogo, D. (Dorothee), Marshall, C. (Catherine), Hu, X. (Xinli), Gossel, M. (Matthias), Schleutker, J. (Johanna), Arvas, M. (Mikko), Hinttala, R. (Reetta), Kettunen, J. (Johannes), Laaksonen, R. (Reijo), Mannermaa, A. (Arto), Paloneva, J. (Juha), Soininen, H. (Hilkka), Julkunen, V. (Valtteri), Remes, A. (Anne), Klviinen, R. (Reetta), Hiltunen, M. (Mikko), Peltola, J. (Jukka), Tienari, P. (Pentti), Rinne, J. (Juha), Ziemann, A. (Adam), Waring, J. (Jeffrey), Esmaeeli, S. (Sahar), Smaoui, N. (Nizar), Lehtonen, A. (Anne), Eaton, S. (Susan), Landenper, S. (Sanni), Michon, J. (John), Kerchner, G. (Geoff), Bowers, N. (Natalie), Teng, E. (Edmond), Eicher, J. (John), Mehta, V. (Vinay), Gormle, P. Y. (Padhraig Y.), Linden, K. (Kari), Whelan, C. (Christopher), Xu, F. (Fanli), Pulford, D. (David), Frkkil, M. (Martti), Pikkarainen, S. (Sampsa), Jussila, A. (Airi), Blomster, T. (Timo), Kiviniemi, M. (Mikko), Voutilainen, M. (Markku), Georgantas, B. (Bob), Heap, G. (Graham), Rahimov, F. (Fedik), Usiskin, K. (Keith), Maranville, J. (Joseph), Lu, T. (Tim), Oh, D. (Danny), Kalpala, K. (Kirsi), Miller, M. (Melissa), McCarthy, L. (Linda), Eklund, K. (Kari), Palomki, A. (Antti), Isomki, P. (Pia), Piri, L. (Laura), Kaipiainen-Seppnen, O. (Oili), Lertratanaku, A. (Apinya), Bing, D. C. (David Close Marla Hochfeld Nan), Gordillo, J. E. (Jorge Esparza), Mars, N. (Nina), Laitinen, T. (Tarja), Pelkonen, M. (Margit), Kauppi, P. (Paula), Kankaanranta, H. (Hannu), Harju, T. (Terttu), Greenberg, S. (Steven), Chen, H. (Hubert), Betts, J. (Jo), Ghosh, S. (Soumitra), Salomaa, V. (Veikko), Niiranen, T. (Teemu), Juonala, M. (Markus), Metsrinne, K. (Kaj), Khnen, M. (Mika), Junttila, J. (Juhani), Laakso, M. (Markku), Pihlajamki, J. (Jussi), Sinisalo, J. (Juha), Taskinen, M.-R. (Marja-Riitta), Tuomi, T. (Tiinamaija), Laukkanen, J. (Jari), Challis, B. (Ben), Peterson, A. (Andrew), Chu, A. (Audrey), Parkkinen, J. (Jaakko), Muslin, A. (Anthony), Joensuu, H. (Heikki), Meretoja, T. (Tuomo), Aaltonen, L. (Lauri), Auranen, A. (Annika), Karihtala, P. (Peeter), Kauppila, S. (Saila), Auvinen, P. (Pivi), Elenius, K. (Klaus), Popovic, R. (Relja), Schutzman, J. (Jennifer), Loboda, A. (Andrey), Chhibber, A. (Aparna), Lehtonen, H. (Heli), McDonough, S. (Stefan), Crohns, M. (Marika), Kulkarni, D. (Diptee), Kaarniranta, K. (Kai), Turunen, J. (Joni), Ollila, T. (Terhi), Seitsonen, S. (Sanna), Uusitalo, H. (Hannu), Aaltonen, V. (Vesa), Uusitalo-Jrvinen, H. (Hannele), Luodonp, M. (Marja), Hautala, N. (Nina), Strauss, E. (Erich), Chen, H. (Hao), Podgornaia, A. (Anna), Hoffman, J. (Joshua), Tasanen, K. (Kaisa), Huilaja, L. (Laura), Hannula-Jouppi, K. (Katariina), Salmi, T. (Teea), Peltonen, S. (Sirkku), Koulu, L. (Leena), Harvima, I. (Ilkka), Wu, Y. (Ying), Choy, D. (David), Jalanko, A. (Anu), Kajanne, R. (Risto), Lyhs, U. (Ulrike), Kaunisto, M. (Mari), Davis, J. W. (Justin Wade), Quarless, D. (Danjuma), Petrovski, S. (Slav), Chen, C.-Y. (Chia-Yen), Bronson, P. (Paola), Yang, R. (Robert), Chang, D. (Diana), Bhangale, T. (Tushar), Holzinger, E. (Emily), Wang, X. (Xulong), Chen, X. (Xing), Auro, K. (Kirsi), Wang, C. (Clarence), Xu, E. (Ethan), Auge, F. (Franck), Chatelain, C. (Clement), Kurki, M. (Mitja), Karjalainen, J. (Juha), Havulinna, A. (Aki), Palin, K. (Kimmo), Palta, P. (Priit), Parolo, P. D. (Pietro Della Briotta), Zhou, W. (Wei), Lemmel, S. (Susanna), Rivas, M. (Manuel), Harju, J. (Jarmo), Lehisto, A. (Arto), Ganna, A. (Andrea), Llorens, V. (Vincent), Karlsson, A. (Antti), Kristiansson, K. (Kati), Hyvrinen, K. (Kati), Ritari, J. (Jarmo), Wahlfors, T. (Tiina), Koskinen, M. (Miika), Pylkäs, K. (Katri), Kalaoja, M. (Marita), Karjalainen, M. (Minna), Mantere, T. (Tuomo), Kangasniemi, E. (Eeva), Heikkinen, S. (Sami), Laakkonen, E. (Eija), Kononen, J. (Juha), Loukola, A. (Anu), Laiho, P. (Pivi), Sistonen, T. (Tuuli), Kaiharju, E. (Essi), Laukkanen, M. (Markku), Jrvensivu, E. (Elina), Lhteenmki, S. (Sini), Mnnikk, L. (Lotta), Wong, R. (Regis), Mattsson, H. (Hannele), Hiekkalinna, T. (Tero), Jimnez, M. G. (Manuel Gonzlez), Donner, K. (Kati), Prn, K. (KaIle), Nunez-Fontarnau, J. (Javier), Kilpelinen, E. (Elina), Sipi, T. P. (Timo P.), Brein, G. (Georg), Dada, A. (Alexander), Awaisa, G. (Ghazal), Shcherban, A. (Anastasia), Sipil, T. (Tuomas), Laivuori, H. (Hannele), Kiiskinen, T. (Tuomo), Siirtola, H. (Harri), Tabuenca, J. G. (Javier Gracia), Kallio, L. (Lila), Soini, S. (Sirpa), Pitknen, K. (Kimmo), and Kuopio, T. (Teijo)

Subjects
Cardiovascular genetics, Genome-wide association studies
Abstract

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10−72), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls (P = 1.7 × 10−4), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls (P = 1.4 × 10−5). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.

Published
2021

44. Het Nederlandse bos op de kaart

Author

Schelhaas, M., Arets, E.J.M.M., van Baren, S.A., Lerink, B.J.W., Filipek, S.P., Kramer, H., and Los, S.

Subjects
Life Science
Abstract

Mede naar aanleiding van eerdere commotie over de afname van het bosare-aal in Nederland heeft het ministerie van LNV de bossenstrategie opgesteld, waarin gestreefd wordt naar 10% meer bos in 2030. Is daar al iets van te zien in de cijfers? In dit artikel bespreken we de stand van het bosareaal vanuit de nationale klimaatmonitoring van de sector landgebruik en bosbouw. Dit kan ook dienst doen als een ijkpunt voor de monitoring van de doelstelling voor de bossenstrategie.

Published
2021

45. Ruimte voor het ooiboslandschap

Author

Maas, G.J., Bijlsma, R.J., Ottburg, F.G.W.A., and Kramer, H.

Subjects
Earth Observation and Environmental Informatics, Soil, Water and Land Use, Aardobservatie en omgevingsinformatica, Dierecologie, Vegetatie, Bos- en Landschapsecologie, Animal Ecology, Vegetation, Forest and Landscape Ecology, Bodem, Water en Landgebruik
Abstract

Het winterbed van de grote rivieren in Nederland is een kansrijk milieu voor ontwikkeling van ooibos en struweel. Maar de ruimte die ooibos in het winterbed krijgt om tot ontwikkeling te komen, is door waterveiligheid sterk ingeperkt. Het Afwegingskader ooibossen is een online-instrument voor natuurplanners, natuurontwikkelaars en terreinbeheerders om de kansen voor ooibosontwikkeling in beeld te brengen. Het instrument laat zien waar potentiële ruimte is voor duurzame ooibosontwikkeling en welke ooibosgemeenschappen zijn te verwachten.

Published
2021

46. The interspecific fungal hybrid Verticillium longisporum displays subgenome-specific gene expression

Author

Depotter, Jasper R L, van Beveren, Fabian, Rodriguez-Moreno, Luis, Kramer, H Martin, Chavarro Carrero, Edgar A, Fiorin, Gabriel L, van den Berg, Grardy C M, Wood, Thomas A, Thomma, Bart P H J, Seidl, Michael F, Depotter, Jasper R L, van Beveren, Fabian, Rodriguez-Moreno, Luis, Kramer, H Martin, Chavarro Carrero, Edgar A, Fiorin, Gabriel L, van den Berg, Grardy C M, Wood, Thomas A, Thomma, Bart P H J, and Seidl, Michael F

Abstract

Hybridization is an important evolutionary mechanism that can enable organisms to adapt to environmental challenges. It has previously been shown that the fungal allodiploid species Verticillium longisporum, the causal agent of verticillium stem striping in rapeseed, originated from at least three independent hybridization events between two haploid Verticillium species. To reveal the impact of genome duplication as a consequence of hybridization, we studied the genome and transcriptome dynamics upon two independent V. longisporum hybridization events, represented by the hybrid lineages "A1/D1" and "A1/D3." We show that V. longisporum genomes are characterized by extensive chromosomal rearrangements, including between parental chromosomal sets. V. longisporum hybrids display signs of evolutionary dynamics that are typically associated with the aftermath of allodiploidization, such as haploidization and more relaxed gene evolution. The expression patterns of the two subgenomes within the two hybrid lineages are more similar than those of the shared A1 parent between the two lineages, showing that the expression patterns of the parental genomes homogenized within a lineage. However, as genes that display differential parental expression in planta do not typically display the same pattern in vitro, we conclude that subgenome-specific responses occur in both lineages. Overall, our study uncovers genomic and transcriptomic plasticity during the evolution of the filamentous fungal hybrid V. longisporum and illustrates its adaptive potential. IMPORTANCE Verticillium is a genus of plant-associated fungi that includes a few plant pathogens that collectively affect a wide range of hosts. On several occasions, haploid Verticillium species hybridized into the stable allodiploid species Verticillium longisporum, which is, in contrast to haploid Verticillium species, a Brassicaceae specialist. Here, we studied the evolutionary genome and transcriptome dynamics of V. longisporu

Published
2021

47. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

Author

Gorski, M. (Mathias), Jung, B. (Bettina), Li, Y. (Yong), Matias-Garcia, P.R. (Pamela R.), Wuttke, M. (Matthias), Coassin, S. (Stefan), Thio, C.H.L. (Chris H.L.), Kleber, M.E. (Marcus E.), Winkler, T.W. (Thomas W.), Wanner, V. (Veronika), Chai, J.-F. (Jin-Fang), Chu, A.Y. (Audrey Y), Cocca, M. (Massimiliano), Feitosa, M.F. (Mary Furlan), Ghasemi, S. (Sahar), Hoppmann, A. (Anselm), Horn, K. (Katrin), Li, M. (Man), Nutile, T. (Teresa), Scholz, M. (Markus), Sieber, K.B. (Karsten B.), Teumer, A. (Alexander), Tin, A. (Adrienne), Wang, J. (Judy), Tayo, B. (Bamidele), Ahluwalia, T.S. (Tarunveer Singh), Almgren, P. (Peter), Bakker, S.J.L. (Stephan), Banas, B. (Bernhard), Bansal, N. (Nisha), Biggs, M.L. (M.), Boerwinkle, E.A. (Eric), Bottinger, E.P. (Erwin), Brenner, H. (Hermann), Carroll, R.J. (Robert J.), Chalmers, J. (John), Chee, M.-L. (Miao-Li), Chee, M.-L. (Miao-Ling), Cheng, C.-Y. (Ching-Yu), Coresh, J. (Josef), de Borst, M.H. (Martin H.), Degenhardt, F. (Frauke), Eckardt, K.-U. (Kai-Uwe), Endlich, K. (Karlhans), Franke, A. (Andre), Freitag-Wolf, S. (Sandra), Gampawar, P. (Piyush), Gansevoort, R.T. (Ron), Ghanbari, M. (Mohsen), Gieger, C. (Christian), Hamet, P. (Pavel), Ho, K. (Kevin), Hofer, E. (Edith), Holleczek, B. (B.), Xian Foo, V.H. (Valencia Hui), Hutri-Kähönen, N. (Nina), Hwang, S.-J. (Shih-Jen), Ikram, M.A. (Arfan), Josyula, N.S. (Navya Shilpa), Kähönen, M. (Mika), Khor, C.C., Koenig, W. (Wolfgang), Kramer, H. (Holly), Krämer, B.K. (Bernhard), Kuhnel, B. (Brigitte), Lange, L.A. (Leslie A.), Lehtimäki, T. (Terho), Lieb, W. (Wolfgang), Alizadeh, B.Z. (Behrooz), Boezen, H.M. (H. Marike), Franke, L. (Lude), van der Harst, P. (Pim), Matullo, G., Rots, M.G. (M.), Snieder, H. (Harold), Swertz, M. (Morris), Wolffenbuttel, B.H.R. (Bruce), Wijmenga, C. (Cisca), Abecasis, G.R. (Gonçalo), Baras, A. (Aris), Cantor, M. (Michael), Coppola, G. (Giovanni), Economides, A. (Aris), Lotta, L.A. (Luca A.), Overton, J.D. (John D.), Reid, J.G. (Jeffrey G.), Shuldiner, A. (Alan), Beechert, C. (Christina), Forsythe, C. (Caitlin), Fuller, E.D. (Erin D.), Gu, Z. (Zhenhua), Lattari, M. (Michael), Lopez, A. (Alexander), Schleicher, T.D. (Thomas D.), Padilla, M.S. (Maria Sotiropoulos), Toledo, K. (Karina), Widom, L. (Louis), Wolf, S.E. (Sarah E.), Pradhan, M. (Manasi), Manoochehri, K. (Kia), Ulloa, R.H. (Ricardo H.), Bai, X. (Xiaodong), Balasubramanian, S. (Suganthi), Barnard, L. (Leland), Blumenfeld, A. (Andrew), Eom, G. (Gisu), Habegger, L. (Lukas), Hawes, A. (Alicia), Khalid, S. (Shareef), Maxwell, E.K. (Evan K.), Salerno, W. (William), Staples, J.C. (Jeffrey C.), Jones, M.B. (Marcus B.), Mitnaul, L.J. (Lyndon), Loos, R.J.F. (Ruth J.F.), Lukas, M.A. (Mary Ann), Lyytikäinen, L.-P. (Leo-Pekka), Meisinger, C. (Christa), Meitinger, T. (Thomas), Melander, O. (Olle), Milaneschi, Y. (Yuri), Mishra, P.P. (Pashupati P.), Mononen, N. (Nina), Mychaleckyj, J.C. (Josyf), Nadkarni, G. (Girish), Nauck, M. (Matthias), Nikus, K. (Kjell), Ning, B. (Boting), Nolte, I.M. (Ilja), O'Donoghue, M.L. (Michelle L.), Orho-Melander, M. (Marju), Pendergrass, S.A. (Sarah), Penninx, B.W.J.H. (Brenda), Preuss, M. (Michael), Psaty, B.M. (Bruce M.), Raffield, L.M. (Laura M.), Raitakari, O. (Olli), Rettig, R. (Rainer), Rheinberger, M. (Myriam), Rice, K.M. (Kenneth M.), Rosenkranz, A.R. (Alexander R.), Rossing, K., Rotter, J.I. (Jerome I.), Sabanayagam, C. (Charumathi), Schmidt, H. (Helena), Schmidt, R. (Reinhold), Schöttker, B. (Ben), Schulz, C.A. (Christina Alexandra), Sedaghat, S. (Sanaz), Shaffer, C.M. (Christian M.), Strauch, K. (Konstantin), Szymczak, S. (Silke), Taylor, K.D. (Kent D.), Tremblay, J. (Johanne), Chaker, L. (Layal), Most, P.J. (Peter) van der, Verweij, N. (Niek), Völker, U. (Uwe), Waldenberger, M. (Melanie), Wallentin, L.C. (Lars), Waterworth, D.M. (Dawn M.), White, H.D. (Harvey), Wilson, J.G. (James G.), Wong, T.-Y. (Tien-Yin), Woodward, M. (Mark), Yang, Q. (Qiong), Yasuda, M. (Masayuki), Yerges-Armstrong, L.M. (Laura), Zhang, Y. (Yan), Wanner, C. (Christoph), Böger, C.A. (Carsten), Köttgen, A. (Anna), Kronenberg, F. (Florian), Penninx, B.W.J.H., Heid, I.M. (Iris), Gorski, M. (Mathias), Jung, B. (Bettina), Li, Y. (Yong), Matias-Garcia, P.R. (Pamela R.), Wuttke, M. (Matthias), Coassin, S. (Stefan), Thio, C.H.L. (Chris H.L.), Kleber, M.E. (Marcus E.), Winkler, T.W. (Thomas W.), Wanner, V. (Veronika), Chai, J.-F. (Jin-Fang), Chu, A.Y. (Audrey Y), Cocca, M. (Massimiliano), Feitosa, M.F. (Mary Furlan), Ghasemi, S. (Sahar), Hoppmann, A. (Anselm), Horn, K. (Katrin), Li, M. (Man), Nutile, T. (Teresa), Scholz, M. (Markus), Sieber, K.B. (Karsten B.), Teumer, A. (Alexander), Tin, A. (Adrienne), Wang, J. (Judy), Tayo, B. (Bamidele), Ahluwalia, T.S. (Tarunveer Singh), Almgren, P. (Peter), Bakker, S.J.L. (Stephan), Banas, B. (Bernhard), Bansal, N. (Nisha), Biggs, M.L. (M.), Boerwinkle, E.A. (Eric), Bottinger, E.P. (Erwin), Brenner, H. (Hermann), Carroll, R.J. (Robert J.), Chalmers, J. (John), Chee, M.-L. (Miao-Li), Chee, M.-L. (Miao-Ling), Cheng, C.-Y. (Ching-Yu), Coresh, J. (Josef), de Borst, M.H. (Martin H.), Degenhardt, F. (Frauke), Eckardt, K.-U. (Kai-Uwe), Endlich, K. (Karlhans), Franke, A. (Andre), Freitag-Wolf, S. (Sandra), Gampawar, P. (Piyush), Gansevoort, R.T. (Ron), Ghanbari, M. (Mohsen), Gieger, C. (Christian), Hamet, P. (Pavel), Ho, K. (Kevin), Hofer, E. (Edith), Holleczek, B. (B.), Xian Foo, V.H. (Valencia Hui), Hutri-Kähönen, N. (Nina), Hwang, S.-J. (Shih-Jen), Ikram, M.A. (Arfan), Josyula, N.S. (Navya Shilpa), Kähönen, M. (Mika), Khor, C.C., Koenig, W. (Wolfgang), Kramer, H. (Holly), Krämer, B.K. (Bernhard), Kuhnel, B. (Brigitte), Lange, L.A. (Leslie A.), Lehtimäki, T. (Terho), Lieb, W. (Wolfgang), Alizadeh, B.Z. (Behrooz), Boezen, H.M. (H. Marike), Franke, L. (Lude), van der Harst, P. (Pim), Matullo, G., Rots, M.G. (M.), Snieder, H. (Harold), Swertz, M. (Morris), Wolffenbuttel, B.H.R. (Bruce), Wijmenga, C. (Cisca), Abecasis, G.R. (Gonçalo), Baras, A. (Aris), Cantor, M. (Michael), Coppola, G. (Giovanni), Economides, A. (Aris), Lotta, L.A. (Luca A.), Overton, J.D. (John D.), Reid, J.G. (Jeffrey G.), Shuldiner, A. (Alan), Beechert, C. (Christina), Forsythe, C. (Caitlin), Fuller, E.D. (Erin D.), Gu, Z. (Zhenhua), Lattari, M. (Michael), Lopez, A. (Alexander), Schleicher, T.D. (Thomas D.), Padilla, M.S. (Maria Sotiropoulos), Toledo, K. (Karina), Widom, L. (Louis), Wolf, S.E. (Sarah E.), Pradhan, M. (Manasi), Manoochehri, K. (Kia), Ulloa, R.H. (Ricardo H.), Bai, X. (Xiaodong), Balasubramanian, S. (Suganthi), Barnard, L. (Leland), Blumenfeld, A. (Andrew), Eom, G. (Gisu), Habegger, L. (Lukas), Hawes, A. (Alicia), Khalid, S. (Shareef), Maxwell, E.K. (Evan K.), Salerno, W. (William), Staples, J.C. (Jeffrey C.), Jones, M.B. (Marcus B.), Mitnaul, L.J. (Lyndon), Loos, R.J.F. (Ruth J.F.), Lukas, M.A. (Mary Ann), Lyytikäinen, L.-P. (Leo-Pekka), Meisinger, C. (Christa), Meitinger, T. (Thomas), Melander, O. (Olle), Milaneschi, Y. (Yuri), Mishra, P.P. (Pashupati P.), Mononen, N. (Nina), Mychaleckyj, J.C. (Josyf), Nadkarni, G. (Girish), Nauck, M. (Matthias), Nikus, K. (Kjell), Ning, B. (Boting), Nolte, I.M. (Ilja), O'Donoghue, M.L. (Michelle L.), Orho-Melander, M. (Marju), Pendergrass, S.A. (Sarah), Penninx, B.W.J.H. (Brenda), Preuss, M. (Michael), Psaty, B.M. (Bruce M.), Raffield, L.M. (Laura M.), Raitakari, O. (Olli), Rettig, R. (Rainer), Rheinberger, M. (Myriam), Rice, K.M. (Kenneth M.), Rosenkranz, A.R. (Alexander R.), Rossing, K., Rotter, J.I. (Jerome I.), Sabanayagam, C. (Charumathi), Schmidt, H. (Helena), Schmidt, R. (Reinhold), Schöttker, B. (Ben), Schulz, C.A. (Christina Alexandra), Sedaghat, S. (Sanaz), Shaffer, C.M. (Christian M.), Strauch, K. (Konstantin), Szymczak, S. (Silke), Taylor, K.D. (Kent D.), Tremblay, J. (Johanne), Chaker, L. (Layal), Most, P.J. (Peter) van der, Verweij, N. (Niek), Völker, U. (Uwe), Waldenberger, M. (Melanie), Wallentin, L.C. (Lars), Waterworth, D.M. (Dawn M.), White, H.D. (Harvey), Wilson, J.G. (James G.), Wong, T.-Y. (Tien-Yin), Woodward, M. (Mark), Yang, Q. (Qiong), Yasuda, M. (Masayuki), Yerges-Armstrong, L.M. (Laura), Zhang, Y. (Yan), Wanner, C. (Christoph), Böger, C.A. (Carsten), Köttgen, A. (Anna), Kronenberg, F. (Florian), Penninx, B.W.J.H., and Heid, I.M. (Iris)

Abstract

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more (“Rapid3”; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline (“CKDi25”; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized varia

Published
2021
Full Text
View/download PDF

48. Registration of magnetic resonance and computed tomography images in patients with oral squamous cell carcinoma for three-dimensional vir

Author

Polfliet, M., Hendriks, M.S. (M. S.), Guyader, J.-M. (Jean-Marie), Ten Hove, I. (Ivo), Mast-Kramer, H. (Hetty), Vandemeulebroucke, J. (Jef), Lugt, A. (Aad) van der, Wolvius, E.B. (Eppo), Klein, S. (Stefan), Polfliet, M., Hendriks, M.S. (M. S.), Guyader, J.-M. (Jean-Marie), Ten Hove, I. (Ivo), Mast-Kramer, H. (Hetty), Vandemeulebroucke, J. (Jef), Lugt, A. (Aad) van der, Wolvius, E.B. (Eppo), and Klein, S. (Stefan)

Abstract

The aim of this study was to evaluate and present an automated method for registration of magnetic resonance imaging (MRI) and computed tomography (CT) or cone beam CT (CBCT) images of the mandibular region for patients with oral squamous cell carcinoma (OSCC). Registered MRI and (CB)CT could facilitate the three-dimensional virtual planning of surgical guides employed for resection and reconstruction in patients with OSCC with mandibular invasion. MRI and (CB)CT images were collected retrospectively from 19 patients. MRI images were aligned with (CB)CT images employing a rigid registration approach (stage 1), a rigid registration approach using a mandibular mask (stage 2), and two non-rigid registration approaches (stage 3). Registration accuracy was quantified by the mean target registration error (mTRE), calculated over a set of landmarks annotated by two observers. Stage 2 achieved the best registration result, with an mTRE of 2.5 ± 0.7 mm, which was comparable to the inter- and intra-observer variabilities of landmark placement in MRI. Stage 2 was significantly better aligned compared to all approaches in stage 3. In conclusion, this study demonstrated that rigid registration with the use of a mask is an appropriate image registration method for aligning MRI and (CB)CT images of the mandibular region in patients with OSCC.

Published
2021
Full Text
View/download PDF

49. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

Author

Gorski, M, Jung, B, Li, Y, Matias-Garcia, PR, Wuttke, M, Coassin, S, Thio, CHL, Kleber, ME, Winkler, TW, Wanner, V, Chai, JF, Chu, AY, Cocca, M, Feitosa, MF, Ghasemi, S, Hoppmann, A, Horn, K, Li, M, Nutile, T, Scholz, M, Sieber, KB, Teumer, A, Tin, A, Wang, J, Tayo, BO, Ahluwalia, TS, Almgren, P, Bakker, SJL, Banas, B, Bansal, N, Biggs, ML, Boerwinkle, E, Bottinger, EP, Brenner, H, Carroll, RJ, Chalmers, J, Chee, ML, Cheng, CY, Coresh, J, de Borst, MH, Degenhardt, F, Eckardt, KU, Endlich, K, Franke, A, Freitag-Wolf, S, Gampawar, P, Gansevoort, RT, Ghanbari, M, Gieger, C, Hamet, P, Ho, K, Hofer, E, Holleczek, B, Xian Foo, VH, Hutri-Kähönen, N, Hwang, SJ, Ikram, MA, Josyula, NS, Kähönen, M, Khor, CC, Koenig, W, Kramer, H, Krämer, BK, Kühnel, B, Lange, LA, Lehtimäki, T, Lieb, W, Alizadeh, BZ, Boezen, HM, Franke, L, van der Harst, P, Navis, G, Rots, M, Snieder, H, Swertz, M, Wolffenbuttel, BHR, Wijmenga, C, Abecasis, G, Baras, A, Cantor, M, Coppola, G, Economides, A, Lotta, LA, Overton, JD, Reid, JG, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, ED, Gu, Z, Lattari, M, Lopez, A, Schleicher, TD, Padilla, MS, Toledo, K, Widom, L, Wolf, SE, Pradhan, M, Manoochehri, K, Gorski, M, Jung, B, Li, Y, Matias-Garcia, PR, Wuttke, M, Coassin, S, Thio, CHL, Kleber, ME, Winkler, TW, Wanner, V, Chai, JF, Chu, AY, Cocca, M, Feitosa, MF, Ghasemi, S, Hoppmann, A, Horn, K, Li, M, Nutile, T, Scholz, M, Sieber, KB, Teumer, A, Tin, A, Wang, J, Tayo, BO, Ahluwalia, TS, Almgren, P, Bakker, SJL, Banas, B, Bansal, N, Biggs, ML, Boerwinkle, E, Bottinger, EP, Brenner, H, Carroll, RJ, Chalmers, J, Chee, ML, Cheng, CY, Coresh, J, de Borst, MH, Degenhardt, F, Eckardt, KU, Endlich, K, Franke, A, Freitag-Wolf, S, Gampawar, P, Gansevoort, RT, Ghanbari, M, Gieger, C, Hamet, P, Ho, K, Hofer, E, Holleczek, B, Xian Foo, VH, Hutri-Kähönen, N, Hwang, SJ, Ikram, MA, Josyula, NS, Kähönen, M, Khor, CC, Koenig, W, Kramer, H, Krämer, BK, Kühnel, B, Lange, LA, Lehtimäki, T, Lieb, W, Alizadeh, BZ, Boezen, HM, Franke, L, van der Harst, P, Navis, G, Rots, M, Snieder, H, Swertz, M, Wolffenbuttel, BHR, Wijmenga, C, Abecasis, G, Baras, A, Cantor, M, Coppola, G, Economides, A, Lotta, LA, Overton, JD, Reid, JG, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, ED, Gu, Z, Lattari, M, Lopez, A, Schleicher, TD, Padilla, MS, Toledo, K, Widom, L, Wolf, SE, Pradhan, M, and Manoochehri, K

Abstract

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more (“Rapid3”; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline (“CKDi25”; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.

Published
2021

50. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Author

Quadrilatero J., Walker D.W., Walker M.J., Walker S.A., Walter J., Wandosell F.G., Wang B., Wang C., Wang C.-Y., Wang D., Wang F., Wang G., Wang H., Wang H.-G., Wang J., Wang K., Wang L., Wang M.H., Wang M., Wang N., Wang P., Wang Q.J., Wang Q., Wang Q.K., Wang Q.A., Wang W.-T., Wang W., Wang X., Wang Y.-Y., Wang Y., Wang Z., Warnes G., Warnsmann V., Watada H., Watanabe E., Watchon M., Wawrzynska A., Weaver T.E., Wegrzyn G., Wehman A.M., Wei H., Wei L., Wei T., Wei Y., Weiergraber O.H., Weihl C.C., Weindl G., Weiskirchen R., Wells A., Wen R.H., Wen X., Werner A., Weykopf B., Wheatley S.P., W... [Ovid has truncated this field to avoid Excel character limitations], Klionsky D.J., Abdel-Aziz A.K., Abdelfatah S., Abdellatif M., Abdoli A., Abel S., Abeliovich H., Abildgaard M.H., Abudu Y.P., Acevedo-Arozena A., Adamopoulos I.E., Adeli K., Adolph T.E., Adornetto A., Aflaki E., Agam G., Agarwal A., Aggarwal B.B., Agnello M., Agostinis P., Agrewala J.N., Agrotis A., Aguilar P.V., Ahmad S.T., Ahmed Z.M., Ahumada-Castro U., Aits S., Aizawa S., Akkoc Y., Akoumianaki T., Akpinar H.A., Al-Abd A.M., Al-Akra L., Al-Gharaibeh A., Alaoui-Jamali M.A., Alberti S., Alcocer-Gomez E., Alessandri C., Ali M., Alim Al-Bari M.A., Aliwaini S., Alizadeh J., Almacellas E., Almasan A., Alonso A., Alonso G.D., Altan-Bonnet N., Altieri D.C., Alvarez E.M.C., Alves S., Alves da Costa C., Alzaharna M.M., Amadio M., Amantini C., Amaral C., Ambrosio S., Amer A.O., Ammanathan V., An Z., Andersen S.U., Andrabi S.A., Andrade-Silva M., Andres A.M., Angelini S., Ann D., Anozie U.C., Ansari M.Y., Antas P., Antebi A., Anton Z., Anwar T., Apetoh L., Apostolova N., Araki T., Araki Y., Arasaki K., Araujo W.L., Araya J., Arden C., Arevalo M.-A., Arguelles S., Arias E., Arikkath J., Arimoto H., Ariosa A.R., Armstrong-James D., Arnaune-Pelloquin L., Aroca A., Arroyo D.S., Arsov I., Artero R., Asaro D.M.L., Aschner M., Ashrafizadeh M., Ashur-Fabian O., Atanasov A.G., Au A.K., Auberger P., Auner H.W., Aurelian L., Autelli R., Avagliano L., Avalos Y., Aveic S., Aveleira C.A., Avin-Wittenberg T., Aydin Y., Ayton S., Ayyadevara S., Azzopardi M., Baba M., Backer J.M., Backues S.K., Bae D.-H., Bae O.-N., Bae S.H., Baehrecke E.H., Baek A., Baek S.-H., Baek S.H., Bagetta G., Bagniewska-Zadworna A., Bai H., Bai J., Bai X., Bai Y., Bairagi N., Baksi S., Balbi T., Baldari C.T., Balduini W., Ballabio A., Ballester M., Balazadeh S., Balzan R., Bandopadhyay R., Banerjee S., Banreti A., Bao Y., Baptista M.S., Baracca A., Barbati C., Bargiela A., Barila D., Barlow P.G., Barmada S.J., Barreiro E., Barreto G.E., Bartek J., Bartel B., Bartolome A., Barve G.R., Basagoudanavar S.H., Bassham D.C., Bast R.C., Basu A., Batoko H., Batten I., Baulieu E.E., Baumgarner B.L., Bayry J., Beale R., Beau I., Beaumatin F., Bechara L.R.G., Beck G.R., Beers M.F., Begun J., Behrends C., Behrens G.M.N., Bei R., Bejarano E., Bel S., Behl C., Belaid A., Belgareh-Touze N., Bellarosa C., Belleudi F., Bello Perez M., Bello-Morales R., Beltran J.S.D.O., Beltran S., Benbrook D.M., Bendorius M., Benitez B.A., Benito-Cuesta I., Bensalem J., Berchtold M.W., Berezowska S., Bergamaschi D., Bergami M., Bergmann A., Berliocchi L., Berlioz-Torrent C., Bernard A., Berthoux L., Besirli C.G., Besteiro S., Betin V.M., Beyaert R., Bezbradica J.S., Bhaskar K., Bhatia-Kissova I., Bhattacharya R., Bhattacharya S., Bhattacharyya S., Bhuiyan M.S., Bhutia S.K., Bi L., Bi X., Biden T.J., Bijian K., Billes V.A., Binart N., Bincoletto C., Birgisdottir A.B., Bjorkoy G., Blanco G., Blas-Garcia A., Blasiak J., Blomgran R., Blomgren K., Blum J.S., Boada-Romero E., Boban M., Boesze-Battaglia K., Boeuf P., Boland B., Bomont P., Bonaldo P., Bonam S.R., Bonfili L., Bonifacino J.S., Boone B.A., Bootman M.D., Bordi M., Borner C., Bornhauser B.C., Borthakur G., Bosch J., Bose S., Botana L.M., Botas J., Boulanger C.M., Boulton M.E., Bourdenx M., Bourgeois B., Bourke N.M., Bousquet G., Boya P., Bozhkov P.V., Bozi L.H.M., Bozkurt T.O., Brackney D.E., Brandts C.H., Braun R.J., Braus G.H., Bravo-Sagua R., Bravo-San Pedro J.M., Brest P., Bringer M.-A., Briones-Herrera A., Broaddus V.C., Brodersen P., Brodsky J.L., Brody S.L., Bronson P.G., Bronstein J.M., Brown C.N., Brown R.E., Brum P.C., Brumell J.H., Brunetti-Pierri N., Bruno D., Bryson-Richardson R.J., Bucci C., Buchrieser C., Bueno M., Buitrago-Molina L.E., Buraschi S., Buch S., Buchan J.R., Buckingham E.M., Budak H., Budini M., Bultynck G., Burada F., Burgoyne J.R., Buron M.I., Bustos V., Buttner S., Butturini E., Byrd A., Cabas I., Cabrera-Benitez S., Cadwell K., Cai J., Cai L., Cai Q., Cairo M., Calbet J.A., Caldwell G.A., Caldwell K.A., Call J.A., Calvani R., Calvo A.C., Calvo-Rubio Barrera M., Camara N.O.S., Camonis J.H., Camougrand N., Campanella M., Campbell E.M., Campbell-Valois F.-X., Campello S., Campesi I., Campos J.C., Camuzard O., Cancino J., Candido de Almeida D., Canesi L., Caniggia I., Canonico B., Canti C., Cao B., Caraglia M., Carames B., Carchman E.H., Cardenal-Munoz E., Cardenas C., Cardenas L., Cardoso S.M., Carew J.S., Carle G.F., Carleton G., Carloni S., Carmona-Gutierrez D., Carneiro L.A., Carnevali O., Carosi J.M., Carra S., Carrier A., Carrier L., Carroll B., Carter A.B., Carvalho A.N., Casanova M., Casas C., Casas J., Cassioli C., Castillo E.F., Castillo K., Castillo-Lluva S., Castoldi F., Castori M., Castro A.F., Castro-Caldas M., Castro-Hernandez J., Castro-Obregon S., Catz S.D., Cavadas C., Cavaliere F., Cavallini G., Cavinato M., Cayuela M.L., Cebollada Rica P., Cecarini V., Cecconi F., Cechowska-Pasko M., Cenci S., Ceperuelo-Mallafre V., Cerqueira J.J., Cerutti J.M., Cervia D., Cetintas V.B., Cetrullo S., Chae H.-J., Chagin A.S., Chai C.-Y., Chakrabarti G., Chakrabarti O., Chakraborty T., Chami M., Chamilos G., Chan D.W., Chan E.Y.W., Chan E.D., Chan H.Y.E., Chan H.H., Chan H., Chan M.T.V., Chan Y.S., Chandra P.K., Chang C.-P., Chang C., Chang H.-C., Chang K., Chao J., Chapman T., Charlet-Berguerand N., Chatterjee S., Chaube S.K., Chaudhary A., Chauhan S., Chaum E., Checler F., Cheetham M.E., Chen C.-S., Chen G.-C., Chen J.-F., Chen L.L., Chen L., Chen M., Chen M.-K., Chen N., Chen Q., Chen R.-H., Chen S., Chen W., Chen X.-M., Chen X.-W., Chen X., Chen Y.-G., Chen Y., Chen Y.-J., Chen Y.-Q., Chen Z.S., Chen Z.-H., Chen Z.J., Cheng H., Cheng J., Cheng S.-Y., Cheng W., Cheng X., Cheng X.-T., Cheng Y., Cheng Z., Chen Z., Cheong H., Cheong J.K., Chernyak B.V., Cherry S., Cheung C.F.R., Cheung C.H.A., Cheung K.-H., Chevet E., Chi R.J., Chiang A.K.S., Chiaradonna F., Chiarelli R., Chiariello M., Chica N., Chiocca S., Chiong M., Chiou S.-H., Chiramel A.I., Chiurchiu V., Cho D.-H., Choe S.-K., Choi A.M.K., Choi M.E., Choudhury K.R., Chow N.S., Chu C.T., Chua J.P., Chua J.J.E., Chung H., Chung K.P., Chung S., Chung S.-H., Chung Y.-L., Cianfanelli V., Ciechomska I.A., Cifuentes M., Cinque L., Cirak S., Cirone M., Clague M.J., Clarke R., Clementi E., Coccia E.M., Codogno P., Cohen E., Cohen M.M., Colasanti T., Colasuonno F., Colbert R.A., Colell A., Colic M., Coll N.S., Collins M.O., Colombo M.I., Colon-Ramos D.A., Combaret L., Comincini S., Cominetti M.R., Consiglio A., Conte A., Conti F., Contu V.R., Cookson M.R., Coombs K.M., Coppens I., Corasaniti M.T., Corkery D.P., Cordes N., Cortese K., Costa M.D.C., Costantino S., Costelli P., Coto-Montes A., Crack P.J., Crespo J.L., Criollo A., Crippa V., Cristofani R., Csizmadia T., Cuadrado A., Cui B., Cui J., Cui Y., Culetto E., Cumino A.C., Cybulsky A.V., Czaja M.J., Czuczwar S.J., D'Adamo S., D'Amelio M., D'Arcangelo D., D'Lugos A.C., D'Orazi G., da Silva J.A., Dafsari H.S., Dagda R.K., Dagdas Y., Daglia M., Dai X., Dai Y., Dal Col J., Dalhaimer P., Dalla Valle L., Dallenga T., Dalmasso G., Damme M., Dando I., Dantuma N.P., Darling A.L., Das H., Dasarathy S., Dasari S.K., Dash S., Daumke O., Dauphinee A.N., Davies J.S., Davila V.A., Davis R.J., Davis T., Dayalan Naidu S., De Amicis F., De Bosscher K., De Felice F., De Franceschi L., De Leonibus C., de Mattos Barbosa M.G., De Meyer G.R.Y., De Milito A., De Nunzio C., De Palma C., De Santi M., De Virgilio C., De Zio D., Debnath J., DeBosch B.J., Decuypere J.-P., Deehan M.A., Deflorian G., DeGregori J., Dehay B., Del Rio G., Delaney J.R., Delbridge L.M.D., Delorme-Axford E., Delpino M.V., Demarchi F., Dembitz V., Demers N.D., Deng H., Deng Z., Dengjel J., Dent P., Denton D., DePamphilis M.L., Der C.J., Deretic V., Descoteaux A., Devis L., Devkota S., Devuyst O., Dewson G., Dharmasivam M., Dhiman R., di Bernardo D., Di Cristina M., Di Domenico F., Di Fazio P., Di Fonzo A., Di Guardo G., Di Guglielmo G.M., Di Leo L., Di Malta C., Di Nardo A., Di Rienzo M., Di Sano F., Diallinas G., Diao J., Diaz-Araya G., Diaz-Laviada I., Dickinson J.M., Diederich M., Dieude M., Dikic I., Ding S., Ding W.-X., Dini L., Dinic J., Dinic M., Dinkova-Kostova A.T., Dionne M.S., Distler J.H.W., Diwan A., Dixon I.M.C., Djavaheri-Mergny M., Dobrinski I., Dobrovinskaya O., Dobrowolski R., Dobson R.C.J., Dokic J., Dokmeci Emre S., Donadelli M., Dong B., Dong X., Dong Z., Dorn II G.W., Dotsch V., Dou H., Dou J., Dowaidar M., Dridi S., Drucker L., Du A., Du C., Du G., Du H.-N., Du L.-L., du Toit A., Duan S.-B., Duan X., Duarte S.P., Dubrovska A., Dunlop E.A., Dupont N., Duran R.V., Dwarakanath B.S., Dyshlovoy S.A., Ebrahimi-Fakhari D., Eckhart L., Edelstein C.L., Efferth T., Eftekharpour E., Eichinger L., Eid N., Eisenberg T., Eissa N.T., Eissa S., Ejarque M., El Andaloussi A., El-Hage N., El-Naggar S., Eleuteri A.M., El-Shafey E.S., Elgendy M., Eliopoulos A.G., Elizalde M.M., Elks P.M., Elsasser H.-P., Elsherbiny E.S., Emerling B.M., Emre N.C.T., Eng C.H., Engedal N., Engelbrecht A.-M., Engelsen A.S.T., Enserink J.M., Escalante R., Esclatine A., Escobar-Henriques M., Eskelinen E.-L., Espert L., Eusebio M.-O., Fabrias G., Fabrizi C., Facchiano A., Facchiano F., Fadeel B., Fader C., Faesen A.C., Fairlie W.D., Falco A., Falkenburger B.H., Fan D., Fan J., Fan Y., Fang E.F., Fang Y., Fanto M., Farfel-Becker T., Faure M., Fazeli G., Fedele A.O., Feldman A.M., Feng D., Feng J., Feng L., Feng Y., Feng W., Fenz Araujo T., Ferguson T.A., Fernandez A.F., Fernandez-Checa J.C., Fernandez-Veledo S., Fernie A.R., Ferrante A.W., Ferraresi A., Ferrari M.F., Ferreira J.C.B., Ferro-Novick S., Figueras A., Filadi R., Filigheddu N., Filippi-Chiela E., Filomeni G., Fimia G.M., Fineschi V., Finetti F., Finkbeiner S., Fisher E.A., Fisher P.B., Flamigni F., Fliesler S.J., Flo T.H., Florance I., Florey O., Florio T., Fodor E., Follo C., Fon E.A., Forlino A., Fornai F., Fortini P., Fracassi A., Fraldi A., Franco B., Franco R., Franconi F., Frankel L.B., Friedman S.L., Frohlich L.F., Fruhbeck G., Fuentes J.M., Fujiki Y., Fujita N., Fujiwara Y., Fukuda M., Fulda S., Furic L., Furuya N., Fusco C., Gack M.U., Gaffke L., Galadari S., Galasso A., Galindo M.F., Gallolu Kankanamalage S., Galluzzi L., Galy V., Gammoh N., Gan B., Ganley I.G., Gao F., Gao H., Gao M., Gao P., Gao S.-J., Gao W., Gao X., Garcera A., Garcia M.N., Garcia V.E., Garcia-Del Portillo F., Garcia-Escudero V., Garcia-Garcia A., Garcia-Macia M., Garcia-Moreno D., Garcia-Ruiz C., Garcia-Sanz P., Garg A.D., Gargini R., Garofalo T., Garry R.F., Gassen N.C., Gatica D., Ge L., Ge W., Geiss-Friedlander R., Gelfi C., Genschik P., Gentle I.E., Gerbino V., Gerhardt C., Germain K., Germain M., Gewirtz D.A., Ghasemipour Afshar E., Ghavami S., Ghigo A., Ghosh M., Giamas G., Giampietri C., Giatromanolaki A., Gibson G.E., Gibson S.B., Ginet V., Giniger E., Giorgi C., Girao H., Girardin S.E., Giridharan M., Giuliano S., Giulivi C., Giuriato S., Giustiniani J., Gluschko A., Goder V., Goginashvili A., Golab J., Goldstone D.C., Golebiewska A., Gomes L.R., Gomez R., Gomez-Sanchez R., Gomez-Puerto M.C., Gomez-Sintes R., Gong Q., Goni F.M., Gonzalez-Gallego J., Gonzalez-Hernandez T., Gonzalez-Polo R.A., Gonzalez-Reyes J.A., Gonzalez-Rodriguez P., Goping I.S., Gorbatyuk M.S., Gorbunov N.V., Gorgulu K., Gorojod R.M., Gorski S.M., Goruppi S., Gotor C., Gottlieb R.A., Gozes I., Gozuacik D., Graef M., Graler M.H., Granatiero V., Grasso D., Gray J.P., Green D.R., Greenhough A., Gregory S.L., Griffin E.F., Grinstaff M.W., Gros F., Grose C., Gross A.S., Gruber F., Grumati P., Grune T., Gu X., Guan J.-L., Guardia C.M., Guda K., Guerra F., Guerri C., Guha P., Guillen C., Gujar S., Gukovskaya A., Gukovsky I., Gunst J., Gunther A., Guntur A.R., Guo C., Guo H., Guo L.-W., Guo M., Gupta P., Gupta S.K., Gupta S., Gupta V.B., Gupta V., Gustafsson A.B., Gutterman D.D., H.B R., Haapasalo A., Haber J.E., Hac A., Hadano S., Hafren A.J., Haidar M., Hall B.S., Hallden G., Hamacher-Brady A., Hamann A., Hamasaki M., Han W., Hansen M., Hanson P.I., Hao Z., Harada M., Harhaji-Trajkovic L., Hariharan N., Haroon N., Harris J., Hasegawa T., Hasima Nagoor N., Haspel J.A., Haucke V., Hawkins W.D., Hay B.A., Haynes C.M., Hayrabedyan S.B., Hays T.S., He C., He Q., He R.-R., He Y.-W., He Y.-Y., Heakal Y., Heberle A.M., Hejtmancik J.F., Helgason G.V., Henkel V., Herb M., Hergovich A., Herman-Antosiewicz A., Hernandez A., Hernandez C., Hernandez-Diaz S., Hernandez-Gea V., Herpin A., Herreros J., Hervas J.H., Hesselson D., Hetz C., Heussler V.T., Higuchi Y., Hilfiker S., Hill J.A., Hlavacek W.S., Ho E.A., Ho I.H.T., Ho P.W.-L., Ho S.-L., Ho W.Y., Hobbs G.A., Hochstrasser M., Hoet P.H.M., Hofius D., Hofman P., Hohn A., Holmberg C.I., Hombrebueno J.R., Yi-Ren Hong C.-W.H., Hooper L.V., Hoppe T., Horos R., Hoshida Y., Hsin I.-L., Hsu H.-Y., Hu B., Hu D., Hu L.-F., Hu M.C., Hu R., Hu W., Hu Y.-C., Hu Z.-W., Hua F., Hua J., Hua Y., Huan C., Huang C., Huang H., Huang K., Huang M.L.H., Huang R., Huang S., Huang T., Huang X., Huang Y.J., Huber T.B., Hubert V., Hubner C.A., Hughes S.M., Hughes W.E., Humbert M., Hummer G., Hurley J.H., Hussain S., Hussey P.J., Hutabarat M., Hwang H.-Y., Hwang S., Ieni A., Ikeda F., Imagawa Y., Imai Y., Imbriano C., Imoto M., Inman D.M., Inoki K., Iovanna J., Iozzo R.V., Ippolito G., Irazoqui J.E., Iribarren P., Ishaq M., Ishikawa M., Ishimwe N., Isidoro C., Ismail N., Issazadeh-Navikas S., Itakura E., Ito D., Ivankovic D., Ivanova S., Iyer A.K.V., Izquierdo J.M., Izumi M., Jaattela M., Jabir M.S., Jackson W.T., Jacobo-Herrera N., Jacomin A.-C., Jacquin E., Jadiya P., Jaeschke H., Jagannath C., Jakobi A.J., Jakobsson J., Janji B., Jansen-Durr P., Jansson P.J., Jantsch J., Januszewski S., Jassey A., Jean S., Jeltsch-David H., Jendelova P., Jenny A., Jensen T.E., Jessen N., Jewell J.L., Ji J., Jia L., Jia R., Jiang L., Jiang Q., Jiang R., Jiang T., Jiang X., Jiang Y., Jimenez-Sanchez M., Jin E.-J., Jin F., Jin H., Jin L., Jin M., Jin S., Jo E.-K., Joffre C., Johansen T., Johnson G.V.W., Johnston S.A., Jokitalo E., Jolly M.K., Joosten L.A.B., Jordan J., Joseph B., Ju D., Ju J.-S., Ju J., Juarez E., Judith D., Juhasz G., Jun Y., Jung C.H., Jung S.-C., Jung Y.K., Jungbluth H., Jungverdorben J., Just S., Kaarniranta K., Kaasik A., Kabuta T., Kaganovich D., Kahana A., Kain R., Kajimura S., Kalamvoki M., Kalia M., Kalinowski D.S., Kaludercic N., Kalvari I., Kaminska J., Kaminskyy V.O., Kanamori H., Kanasaki K., Kang C., Kang R., Kang S.S., Kaniyappan S., Kanki T., Kanneganti T.-D., Kanthasamy A.G., Kanthasamy A., Kantorow M., Kapuy O., Karamouzis M.V., Karim M.R., Karmakar P., Katare R.G., Kato M., Kaufmann S.H.E., Kauppinen A., Kaushal G.P., Kaushik S., Kawasaki K., Kazan K., Ke P.-Y., Keating D.J., Keber U., Kehrl J.H., Keller K.E., Keller C.W., Kemper J.K., Kenific C.M., Kepp O., Kermorgant S., Kern A., Ketteler R., Keulers T.G., Khalfin B., Khalil H., Khambu B., Khan S.Y., Khandelwal V.K.M., Khandia R., Kho W., Khobrekar N.V., Khuansuwan S., Khundadze M., Killackey S.A., Kim D., Kim D.R., Kim D.-H., Kim D.-E., Kim E.Y., Kim E.-K., Kim H.-R., Kim H.-S., Hyung-Ryong Kim, Kim J.K., Kim J.-H., Kim J., Kim J.H., Kim K.I., Kim P.K., Kim S.-J., Kimball S.R., Kimchi A., Kimmelman A.C., Kimura T., King M.A., Kinghorn K.J., Kinsey C.G., Kirkin V., Kirshenbaum L.A., Kiselev S.L., Kishi S., Kitamoto K., Kitaoka Y., Kitazato K., Kitsis R.N., Kittler J.T., Kjaerulff O., Klein P.S., Klopstock T., Klucken J., Knaevelsrud H., Knorr R.L., Ko B.C.B., Ko F., Ko J.-L., Kobayashi H., Kobayashi S., Koch I., Koch J.C., Koenig U., Kogel D., Koh Y.H., Koike M., Kohlwein S.D., Kocaturk N.M., Komatsu M., Konig J., Kono T., Kopp B.T., Korcsmaros T., Korkmaz G., Korolchuk V.I., Korsnes M.S., Koskela A., Kota J., Kotake Y., Kotler M.L., Kou Y., Koukourakis M.I., Koustas E., Kovacs A.L., Kovacs T., Koya D., Kozako T., Kraft C., Krainc D., Kramer H., Krasnodembskaya A.D., Kretz-Remy C., Kroemer G., Ktistakis N.T., Kuchitsu K., Kuenen S., Kuerschner L., Kukar T., Kumar A., Kumar D., Kumar S., Kume S., Kumsta C., Kundu C.N., Kundu M., Kunnumakkara A.B., Kurgan L., Kutateladze T.G., Kutlu O., Kwak S., Kwon H.J., Kwon T.K., Kwon Y.T., Kyrmizi I., La Spada A., Labonte P., Ladoire S., Laface I., Lafont F., Lagace D.C., Lahiri V., Lai Z., Laird A.S., Lakkaraju A., Lamark T., Lan S.-H., Landajuela A., Lane D.J.R., Lane J.D., Lang C.H., Lange C., Langel U., Langer R., Lapaquette P., Laporte J., LaRusso N.F., Lastres-Becker I., Lau W.C.Y., Laurie G.W., Lavandero S., Law B.Y.K., Law H.K.-W., Layfield R., Le W., Le Stunff H., Leary A.Y., Lebrun J.-J., Leck L.Y.W., Leduc-Gaudet J.-P., Lee C., Lee C.-P., Lee D.-H., Lee E.B., Lee E.F., Lee G.M., Lee H.-J., Lee H.K., Lee J.M., Lee J.S., Lee J.-A., Lee J.-Y., Lee J.H., Lee M., Lee M.G., Lee M.J., Lee M.-S., Lee S.-J., Lee S.Y., Lee S.B., Lee W.H., Lee Y.-R., Lee Y.-H., Lee Y., Lefebvre C., Legouis R., Lei Y.L., Lei Y., Leikin S., Leitinger G., Lemus L., Leng S., Lenoir O., Lenz G., Lenz H.J., Lenzi P., Leon Y., Leopoldino A.M., Leschczyk C., Leskela S., Letellier E., Leung C.-T., Leung P.S., Leventhal J.S., Levine B., Lewis P.A., Ley K., Li B., Li D.-Q., Li J., Li K., Li L., Li M., Li P.-L., Li M.-Q., Li Q., Li S., Li T., Li W., Li X., Li Y.-P., Li Y., Lian J., Liang C., Liang Q., Liang W., Liang Y., Liao G., Liao L., Liao M., Liao Y.-F., Librizzi M., Lie P.P.Y., Lilly M.A., Lim H.J., Lima T.R.R., Limana F., Lin C., Lin C.-W., Lin D.-S., Lin F.-C., Lin J.D., Lin K.M., Lin K.-H., Lin L.-T., Lin P.-H., Lin Q., Lin S., Lin S.-J., Lin W., Lin X., Lin Y.-X., Lin Y.-S., Linden R., Lindner P., Ling S.-C., Lingor P., Linnemann A.K., Liou Y.-C., Lipinski M.M., Lipovsek S., Lira V.A., Lisiak N., Liton P.B., Liu C., Liu C.-H., Liu C.-F., Liu C.H., Liu F., Liu H.-S., Liu H.-F., Liu H., Liu J., Liu L., Liu M., Liu Q., Liu W., Liu X.-H., Liu X., Liu Y., Livingston J.A., Lizard G., Lizcano J.M., Ljubojevic-Holzer S., LLeonart M.E., Llobet-Navas D., Llorente A., Lo C.H., Lobato-Marquez D., Long Q., Long Y.C., Loos B., Loos J.A., Lopez M.G., Lopez-Domenech G., Lopez-Guerrero J.A., Lopez-Jimenez A.T., Lopez-Perez O., Lopez-Valero I., Lorenowicz M.J., Lorente M., Lorincz P., Lossi L., Lotersztajn S., Lovat P.E., Lovell J.F., Lovy A., Low P., Lu G., Lu H., Lu J.-H., Lu J.-J., Lu M., Lu S., Luciani A., Lucocq J.M., Ludovico P., Luftig M.A., Luhr M., Luis-Ravelo D., Lum J.J., Luna-Dulcey L., Lund A.H., Lund V.K., Lunemann J.D., Luningschror P., Luo H., Luo R., Luo S., Luo Z., Luparello C., Luscher B., Luu L., Lyakhovich A., Lyamzaev K.G., Lystad A.H., Lytvynchuk L., Ma A.C., Ma C., Ma M., Ma N.-F., Ma Q.-H., Ma X., Ma Y., Ma Z., MacDougald O.A., Macian F., MacIntosh G.C., MacKeigan J.P., Macleod K.F., Maday S., Madeo F., Madesh M., Madl T., Madrigal-Matute J., Maeda A., Maejima Y., Magarinos M., Mahavadi P., Maiani E., Maiese K., Maiti P., Maiuri M.C., Majello B., Major M.B., Makareeva E., Malik F., Mallilankaraman K., Malorni W., Maloyan A., Mammadova N., Man G.C.W., Manai F., Mancias J.D., Mandelkow E.-M., Mandell M.A., Manfredi A.A., Manjili M.H., Manjithaya R., Manque P., Manshian B.B., Manzano R., Manzoni C., Mao K., Marchese C., Marchetti S., Marconi A.M., Marcucci F., Mardente S., Mareninova O.A., Margeta M., Mari M., Marinelli S., Marinelli O., Marino G., Mariotto S., Marshall R.S., Marten M.R., Martens S., Martin A.P.J., Martin K.R., Martin S., Martin-Segura A., Martin-Acebes M.A., Martin-Burriel I., Martin-Rincon M., Martin-Sanz P., Martina J.A., Martinet W., Martinez A., Martinez J., Martinez Velazquez M., Martinez-Lopez N., Martinez-Vicente M., Martins D.O., Martins J.O., Martins W.K., Martins-Marques T., Marzetti E., Masaldan S., Masclaux-Daubresse C., Mashek D.G., Massa V., Massieu L., Masson G.R., Masuelli L., Masyuk A.I., Masyuk T.V., Matarrese P., Matheu A., Matoba S., Matsuzaki S., Mattar P., Matte A., Mattoscio D., Mauriz J.L., Mauthe M., Mauvezin C., Maverakis E., Maycotte P., Mayer J., Mazzoccoli G., Mazzoni C., Mazzulli J.R., McCarty N., McDonald C., McGill M.R., McKenna S.L., McLaughlin B., McLoughlin F., McNiven M.A., McWilliams T.G., Mechta-Grigoriou F., Medeiros T.C., Medina D.L., Megeney L.A., Megyeri K., Mehrpour M., Mehta J.L., Meijer A.J., Meijer A.H., Mejlvang J., Melendez A., Melk A., Memisoglu G., Mendes A.F., Meng D., Meng F., Meng T., Menna-Barreto R., Menon M.B., Mercer C., Mercier A.E., Mergny J.-L., Merighi A., Merkley S.D., Merla G., Meske V., Mestre A.C., Metur S.P., Meyer C., Meyer H., Mi W., Mialet-Perez J., Miao J., Micale L., Miki Y., Milan E., Milczarek M., Miller D.L., Miller S.I., Miller S., Millward S.W., Milosevic I., Minina E.A., Mirzaei H., Mirzaei H.R., Mirzaei M., Mishra A., Mishra N., Mishra P.K., Misirkic Marjanovic M., Misasi R., Misra A., Misso G., Mitchell C., Mitou G., Miura T., Miyamoto S., Miyazaki M., Miyazaki T., Miyazawa K., Mizushima N., Mogensen T.H., Mograbi B., Mohammadinejad R., Mohamud Y., Mohanty A., Mohapatra S., Mohlmann T., Mohmmed A., Moles A., Moley K.H., Molinari M., Mollace V., Moller A.B., Mollereau B., Mollinedo F., Montagna C., Monteiro M.J., Montella A., Montes L.R., Montico B., Mony V.K., Monzio Compagnoni G., Moore M.N., Moosavi M.A., Mora A.L., Mora M., Morales-Alamo D., Moratalla R., Moreira P.I., Morelli E., Moreno S., Moreno-Blas D., Moresi V., Morga B., Morgan A.H., Morin F., Morishita H., Moritz O.L., Moriyama M., Moriyasu Y., Morleo M., Morselli E., Moruno-Manchon J.F., Moscat J., Mostowy S., Motori E., Moura A.F., Moustaid-Moussa N., Mrakovcic M., Mucino-Hernandez G., Mukherjee A., Mukhopadhyay S., Mulcahy Levy J.M., Mulero V., Muller S., Munch C., Munjal A., Munoz-Canoves P., Munoz-Galdeano T., Munz C., Murakawa T., Muratori C., Murphy B.M., Murphy J.P., Murthy A., Myohanen T.T., Mysorekar I.U., Mytych J., Nabavi S.M., Nabissi M., Nagy P., Nah J., Nahimana A., Nakagawa I., Nakamura K., Nakatogawa H., Nandi S.S., Nanjundan M., Nanni M., Napolitano G., Nardacci R., Narita M., Nassif M., Nathan I., Natsumeda M., Naude R.J., Naumann C., Naveiras O., Navid F., Nawrocki S.T., Nazarko T.Y., Nazio F., Negoita F., Neill T., Neisch A.L., Neri L.M., Netea M.G., Neubert P., Neufeld T.P., Neumann D., Neutzner A., Newton P.T., Ney P.A., Nezis I.P., Ng C.C.W., Ng T.B., Nguyen H.T.T., Nguyen L.T., Ni H.-M., Ni Cheallaigh C., Ni Z., Nicolao M.C., Nicoli F., Nieto-Diaz M., Nilsson P., Ning S., Niranjan R., Nishimune H., Niso-Santano M., Nixon R.A., Nobili A., Nobrega C., Noda T., Nogueira-Recalde U., Nolan T.M., Nombela I., Novak I., Novoa B., Nozawa T., Nukina N., Nussbaum-Krammer C., Nylandsted J., O'Donovan T.R., O'Leary S.M., O'Rourke E.J., O'Sullivan M.P., O'Sullivan T.E., Oddo S., Oehme I., Ogawa M., Ogier-Denis E., Ogmundsdottir M.H., Ogretmen B., Oh G.T., Oh S.-H., Oh Y.J., Ohama T., Ohashi Y., Ohmuraya M., Oikonomou V., Ojha R., Okamoto K., Okazawa H., Oku M., Olivan S., Oliveira J.M.A., Ollmann M., Olzmann J.A., Omari S., Omary M.B., Onal G., Ondrej M., Ong S.-B., Ong S.-G., Onnis A., Orellana J.A., Orellana-Munoz S., Ortega-Villaizan M.D.M., Ortiz-Gonzalez X.R., Ortona E., Osiewacz H.D., Osman A.-H.K., Osta R., Otegui M.S., Otsu K., Ott C., Ottobrini L., Ou J.-H.J., Outeiro T.F., Oynebraten I., Ozturk M., Pages G., Pahari S., Pajares M., Pajvani U.B., Pal R., Paladino S., Pallet N., Palmieri M., Palmisano G., Palumbo C., Pampaloni F., Pan L., Pan Q., Pan W., Pan X., Panasyuk G., Pandey R., Pandey U.B., Pandya V., Paneni F., Pang S.Y., Panzarini E., Papademetrio D.L., Papaleo E., Papinski D., Papp D., Park E.C., Park H.T., Park J.-M., Park J.-I., Park J.T., Park J., Park S.C., Park S.-Y., Parola A.H., Parys J.B., Pasquier A., Pasquier B., Passos J.F., Pastore N., Patel H.H., Patschan D., Pattingre S., Pedraza-Alva G., Pedraza-Chaverri J., Pedrozo Z., Pei G., Pei J., Peled-Zehavi H., Pellegrini J.M., Pelletier J., Penalva M.A., Peng D., Peng Y., Penna F., Pennuto M., Pentimalli F., Pereira C.M.F., Pereira G.J.S., Pereira L.C., Pereira de Almeida L., Perera N.D., Perez-Lara A., Perez-Oliva A.B., Perez-Perez M.E., Periyasamy P., Perl A., Perrotta C., Perrotta I., Pestell R.G., Petersen M., Petrache I., Petrovski G., Pfirrmann T., Pfister A.S., Philips J.A., Pi H., Picca A., Pickrell A.M., Picot S., Pierantoni G.M., Pierdominici M., Pierre P., Pierrefite-Carle V., Pierzynowska K., Pietrocola F., Pietruczuk M., Pignata C., Pimentel-Muinos F.X., Pinar M., Pinheiro R.O., Pinkas-Kramarski R., Pinton P., Pircs K., Piya S., Pizzo P., Plantinga T.S., Platta H.W., Plaza-Zabala A., Plomann M., Plotnikov E.Y., Plun-Favreau H., Pluta R., Pocock R., Poggeler S., Pohl C., Poirot M., Poletti A., Ponpuak M., Popelka H., Popova B., Porta H., Porte Alcon S., Portilla-Fernandez E., Post M., Potts M.B., Poulton J., Powers T., Prahlad V., Prajsnar T.K., Pratico D., Prencipe R., Priault M., Proikas-Cezanne T., Promponas V.J., Proud C.G., Puertollano R., Puglielli L., Pulinilkunnil T., Puri D., Puri R., Puyal J., Qi X., Qi Y., Qian W., Qiang L., Qiu Y., Quarleri J., Raben N., Rabinowich H., Ragona D., Ragusa M.J., Rahimi N., Rahmati M., Raia V., Raimundo N., Rajasekaran N.-S., Ramachandra Rao S., Rami A., Ramirez-Pardo I., Ramsden D.B., Randow F., Rangarajan P.N., Ranieri D., Rao H., Rao L., Rao R., Rathore S., Ratnayaka J.A., Ratovitski E.A., Ravanan P., Ravegnini G., Ray S.K., Razani B., Rebecca V., Reggiori F., Regnier-Vigouroux A., Reichert A.S., Reigada D., Reiling J.H., Rein T., Reipert S., Rekha R.S., Ren H., Ren J., Ren W., Renault T., Renga G., Reue K., Rewitz K., Ribeiro de Andrade Ramos B., Riazuddin S.A., Ribeiro-Rodrigues T.M., Ricci J.-E., Ricci R., Riccio V., Richardson D.R., Rikihisa Y., Risbud M.V., Risueno R.M., Ritis K., Rizza S., Rizzuto R., Roberts H.C., Roberts L.D., Robinson K.J., Roccheri M.C., Rocchi S., Rodney G.G., Rodrigues T., Rodrigues Silva V.R., Rodriguez A., Rodriguez-Barrueco R., Rodriguez-Henche N., Rodriguez-Rocha H., Roelofs J., Rogers R.S., Rogov V.V., Rojo A.I., Rolka K., Romanello V., Romani L., Romano A., Romano P.S., Romeo-Guitart D., Romero L.C., Romero M., Roney J.C., Rongo C., Roperto S., Rosenfeldt M.T., Rosenstiel P., Rosenwald A.G., Roth K.A., Roth L., Roth S., Rouschop K.M.A., Roussel B.D., Roux S., Rovere-Querini P., Roy A., Rozieres A., Ruano D., Rubinsztein D.C., Rubtsova M.P., Ruckdeschel K., Ruckenstuhl C., Rudolf E., Rudolf R., Ruggieri A., Ruparelia A.A., Rusmini P., Russell R.R., Russo G.L., Russo M., Russo R., Ryabaya O.O., Ryan K.M., Ryu K.-Y., Sabater-Arcis M., Sachdev U., Sacher M., Sachse C., Sadhu A., Sadoshima J., Safren N., Saftig P., Sagona A.P., Sahay G., Sahebkar A., Sahin M., Sahin O., Sahni S., Saito N., Saito S., Saito T., Sakai R., Sakai Y., Sakamaki J.-I., Saksela K., Salazar G., Salazar-Degracia A., Salekdeh G.H., Saluja A.K., Sampaio-Marques B., Sanchez M.C., Sanchez-Alcazar J.A., Sanchez-Vera V., Sancho-Shimizu V., Sanderson J.T., Sandri M., Santaguida S., Santambrogio L., Santana M.M., Santoni G., Sanz A., Sanz P., Saran S., Sardiello M., Sargeant T.J., Sarin A., Sarkar C., Sarrias M.-R., Sarkar S., Sarmah D.T., Sarparanta J., Sathyanarayan A., Sathyanarayanan R., Scaglione K.M., Scatozza F., Schaefer L., Schafer Z.T., Schaible U.E., Schapira A.H.V., Scharl M., Schatzl H.M., Schein C.H., Scheper W., Scheuring D., Schiaffino M.V., Schiappacassi M., Schindl R., Schlattner U., Schmidt O., Schmitt R., Schmidt S.D., Schmitz I., Schmukler E., Schneider A., Schneider B.E., Schober R., Schoijet A.C., Schott M.B., Schramm M., Schroder B., Schuh K., Schuller C., Schulze R.J., Schurmanns L., Schwamborn J.C., Schwarten M., Scialo F., Sciarretta S., Scott M.J., Scotto K.W., Scovassi A.I., Scrima A., Scrivo A., Sebastian D., Sebti S., Sedej S., Segatori L., Segev N., Seglen P.O., Seiliez I., Seki E., Selleck S.B., Sellke F.W., Selsby J.T., Sendtner M., Senturk S., Seranova E., Sergi C., Serra-Moreno R., Sesaki H., Settembre C., Setty S.R.G., Sgarbi G., Sha O., Shacka J.J., Shah J.A., Shang D., Shao C., Shao F., Sharbati S., Sharkey L.M., Sharma D., Sharma G., Sharma K., Sharma P., Sharma S., Shen H.-M., Shen H., Shen J., Shen M., Shen W., Shen Z., Sheng R., Sheng Z., Sheng Z.-H., Shi J., Shi X., Shi Y.-H., Shiba-Fukushima K., Shieh J.-J., Shimada Y., Shimizu S., Shimozawa M., Shintani T., Shoemaker C.J., Shojaei S., Shoji I., Shravage B.V., Shridhar V., Shu C.-W., Shu H.-B., Shui K., Shukla A.K., Shutt T.E., Sica V., Siddiqui A., Sierra A., Sierra-Torre V., Signorelli S., Sil P., Silva B.J.D.A., Silva J.D., Silva-Pavez E., Silvente-Poirot S., Simmonds R.E., Simon A.K., Simon H.-U., Simons M., Singh A., Singh L.P., Singh R., Singh S.V., Singh S.K., Singh S.B., Singh S., Singh S.P., Sinha D., Sinha R.A., Sinha S., Sirko A., Sirohi K., Sivridis E.L., Skendros P., Skirycz A., Slaninova I., Smaili S.S., Smertenko A., Smith M.D., Soenen S.J., Sohn E.J., Sok S.P.M., Solaini G., Soldati T., Soleimanpour S.A., Soler R.M., Solovchenko A., Somarelli J.A., Sonawane A., Song F., Song H.K., Song J.-X., Song K., Song Z., Soria L.R., Sorice M., Soukas A.A., Soukup S.-F., Sousa D., Sousa N., Spagnuolo P.A., Spector S.A., Srinivas Bharath M.M., St. Clair D., Stagni V., Staiano L., Stalnecker C.A., Stankov M.V., Stathopulos P.B., Stefan K., Stefan S.M., Stefanis L., Steffan J.S., Steinkasserer A., Stenmark H., Sterneckert J., Stevens C., Stoka V., Storch S., Stork B., Strappazzon F., Strohecker A.M., Stupack D.G., Su H., Su L.-Y., Su L., Suarez-Fontes A.M., Subauste C.S., Subbian S., Subirada P.V., Sudhandiran G., Sue C.M., Sui X., Summers C., Sun G., Sun J., Sun K., Sun M.-X., Sun Q., Sun Y., Sun Z., Sunahara K.K.S., Sundberg E., Susztak K., Sutovsky P., Suzuki H., Sweeney G., Symons J.D., Sze S.C.W., Szewczyk N.J., Tabecka-Lonczynska A., Tabolacci C., Tacke F., Taegtmeyer H., Tafani M., Tagaya M., Tai H., Tait S.W.G., Takahashi Y., Takats S., Talwar P., Tam C., Tam S.Y., Tampellini D., Tamura A., Tan C.T., Tan E.-K., Tan Y.-Q., Tanaka M., Tang D., Tang J., Tang T.-S., Tanida I., Tao Z., Taouis M., Tatenhorst L., Tavernarakis N., Taylor A., Taylor G.A., Taylor J.M., Tchetina E., Tee A.R., Tegeder I., Teis D., Teixeira N., Teixeira-Clerc F., Tekirdag K.A., Tencomnao T., Tenreiro S., Tepikin A.V., Testillano P.S., Tettamanti G., Tharaux P.-L., Thedieck K., Thekkinghat A.A., Thellung S., Thinwa J.W., Thirumalaikumar V.P., Thomas S.M., Thomes P.G., Thorburn A., Thukral L., Thum T., Thumm M., Tian L., Tichy A., Till A., Timmerman V., Titorenko V.I., Todi S.V., Todorova K., Toivonen J.M., Tomaipitinca L., Tomar D., Tomas-Zapico C., Tomic S., Tong B.C.-K., Tong C., Tong X., Tooze S.A., Torgersen M.L., Torii S., Torres-Lopez L., Torriglia A., Towers C.G., Towns R., Toyokuni S., Trajkovic V., Tramontano D., Tran Q.-G., Travassos L.H., Trelford C.B., Tremel S., Trougakos I.P., Tsao B.P., Tschan M.P., Tse H.-F., Tse T.F., Tsugawa H., Tsvetkov A.S., Tumbarello D.A., Tumtas Y., Tunon M.J., Turcotte S., Turk B., Turk V., Turner B.J., Tuxworth R.I., Tyler J.K., Tyutereva E.V., Uchiyama Y., Ugun-Klusek A., Uhlig H.H., Ulamek-Koziol M., Ulasov I.V., Umekawa M., Ungermann C., Unno R., Urbe S., Uribe-Carretero E., Ustun S., Uversky V.N., Vaccari T., Vaccaro M.I., Vahsen B.F., Vakifahmetoglu-Norberg H., Valdor R., Valente M.J., Valko A., Vallee R.B., Valverde A.M., Van den Berghe G., van der Veen S., Van Kaer L., van Loosdregt J., van Wijk S.J.L., Vandenberghe W., Vanhorebeek I., Vannier-Santos M.A., Vannini N., Vanrell M.C., Vantaggiato C., Varano G., Varela-Nieto I., Varga M., Vasconcelos M.H., Vats S., Vavvas D.G., Vega-Naredo I., Vega-Rubin-de-Celis S., Velasco G., Velazquez A.P., Vellai T., Vellenga E., Velotti F., Verdier M., Verginis P., Vergne I., Verkade P., Verma M., Verstreken P., Vervliet T., Vervoorts J., Vessoni A.T., Victor V.M., Vidal M., Vidoni C., Vieira O.V., Vierstra R.D., Vigano S., Vihinen H., Vijayan V., Vila M., Vilar M., Villalba J.M., Villalobo A., Villarejo-Zori B., Villarroya F., Villarroya J., Vincent O., Vindis C., Viret C., Viscomi M.T., Visnjic D., Vitale I., Vocadlo D.J., Voitsekhovskaja O.V., Volonte C., Volta M., Vomero M., Von Haefen C., Vooijs M.A., Voos W., Vucicevic L., Wade-Martins R., Waguri S., Waite K.A., Wakatsuki S., Quadrilatero J., Walker D.W., Walker M.J., Walker S.A., Walter J., Wandosell F.G., Wang B., Wang C., Wang C.-Y., Wang D., Wang F., Wang G., Wang H., Wang H.-G., Wang J., Wang K., Wang L., Wang M.H., Wang M., Wang N., Wang P., Wang Q.J., Wang Q., Wang Q.K., Wang Q.A., Wang W.-T., Wang W., Wang X., Wang Y.-Y., Wang Y., Wang Z., Warnes G., Warnsmann V., Watada H., Watanabe E., Watchon M., Wawrzynska A., Weaver T.E., Wegrzyn G., Wehman A.M., Wei H., Wei L., Wei T., Wei Y., Weiergraber O.H., Weihl C.C., Weindl G., Weiskirchen R., Wells A., Wen R.H., Wen X., Werner A., Weykopf B., Wheatley S.P., W... [Ovid has truncated this field to avoid Excel character limitations], Klionsky D.J., Abdel-Aziz A.K., Abdelfatah S., Abdellatif M., Abdoli A., Abel S., Abeliovich H., Abildgaard M.H., Abudu Y.P., Acevedo-Arozena A., Adamopoulos I.E., Adeli K., Adolph T.E., Adornetto A., Aflaki E., Agam G., Agarwal A., Aggarwal B.B., Agnello M., Agostinis P., Agrewala J.N., Agrotis A., Aguilar P.V., Ahmad S.T., Ahmed Z.M., Ahumada-Castro U., Aits S., Aizawa S., Akkoc Y., Akoumianaki T., Akpinar H.A., Al-Abd A.M., Al-Akra L., Al-Gharaibeh A., Alaoui-Jamali M.A., Alberti S., Alcocer-Gomez E., Alessandri C., Ali M., Alim Al-Bari M.A., Aliwaini S., Alizadeh J., Almacellas E., Almasan A., Alonso A., Alonso G.D., Altan-Bonnet N., Altieri D.C., Alvarez E.M.C., Alves S., Alves da Costa C., Alzaharna M.M., Amadio M., Amantini C., Amaral C., Ambrosio S., Amer A.O., Ammanathan V., An Z., Andersen S.U., Andrabi S.A., Andrade-Silva M., Andres A.M., Angelini S., Ann D., Anozie U.C., Ansari M.Y., Antas P., Antebi A., Anton Z., Anwar T., Apetoh L., Apostolova N., Araki T., Araki Y., Arasaki K., Araujo W.L., Araya J., Arden C., Arevalo M.-A., Arguelles S., Arias E., Arikkath J., Arimoto H., Ariosa A.R., Armstrong-James D., Arnaune-Pelloquin L., Aroca A., Arroyo D.S., Arsov I., Artero R., Asaro D.M.L., Aschner M., Ashrafizadeh M., Ashur-Fabian O., Atanasov A.G., Au A.K., Auberger P., Auner H.W., Aurelian L., Autelli R., Avagliano L., Avalos Y., Aveic S., Aveleira C.A., Avin-Wittenberg T., Aydin Y., Ayton S., Ayyadevara S., Azzopardi M., Baba M., Backer J.M., Backues S.K., Bae D.-H., Bae O.-N., Bae S.H., Baehrecke E.H., Baek A., Baek S.-H., Baek S.H., Bagetta G., Bagniewska-Zadworna A., Bai H., Bai J., Bai X., Bai Y., Bairagi N., Baksi S., Balbi T., Baldari C.T., Balduini W., Ballabio A., Ballester M., Balazadeh S., Balzan R., Bandopadhyay R., Banerjee S., Banreti A., Bao Y., Baptista M.S., Baracca A., Barbati C., Bargiela A., Barila D., Barlow P.G., Barmada S.J., Barreiro E., Barreto G.E., Bartek J., Bartel B., Bartolome A., Barve G.R., Basagoudanavar S.H., Bassham D.C., Bast R.C., Basu A., Batoko H., Batten I., Baulieu E.E., Baumgarner B.L., Bayry J., Beale R., Beau I., Beaumatin F., Bechara L.R.G., Beck G.R., Beers M.F., Begun J., Behrends C., Behrens G.M.N., Bei R., Bejarano E., Bel S., Behl C., Belaid A., Belgareh-Touze N., Bellarosa C., Belleudi F., Bello Perez M., Bello-Morales R., Beltran J.S.D.O., Beltran S., Benbrook D.M., Bendorius M., Benitez B.A., Benito-Cuesta I., Bensalem J., Berchtold M.W., Berezowska S., Bergamaschi D., Bergami M., Bergmann A., Berliocchi L., Berlioz-Torrent C., Bernard A., Berthoux L., Besirli C.G., Besteiro S., Betin V.M., Beyaert R., Bezbradica J.S., Bhaskar K., Bhatia-Kissova I., Bhattacharya R., Bhattacharya S., Bhattacharyya S., Bhuiyan M.S., Bhutia S.K., Bi L., Bi X., Biden T.J., Bijian K., Billes V.A., Binart N., Bincoletto C., Birgisdottir A.B., Bjorkoy G., Blanco G., Blas-Garcia A., Blasiak J., Blomgran R., Blomgren K., Blum J.S., Boada-Romero E., Boban M., Boesze-Battaglia K., Boeuf P., Boland B., Bomont P., Bonaldo P., Bonam S.R., Bonfili L., Bonifacino J.S., Boone B.A., Bootman M.D., Bordi M., Borner C., Bornhauser B.C., Borthakur G., Bosch J., Bose S., Botana L.M., Botas J., Boulanger C.M., Boulton M.E., Bourdenx M., Bourgeois B., Bourke N.M., Bousquet G., Boya P., Bozhkov P.V., Bozi L.H.M., Bozkurt T.O., Brackney D.E., Brandts C.H., Braun R.J., Braus G.H., Bravo-Sagua R., Bravo-San Pedro J.M., Brest P., Bringer M.-A., Briones-Herrera A., Broaddus V.C., Brodersen P., Brodsky J.L., Brody S.L., Bronson P.G., Bronstein J.M., Brown C.N., Brown R.E., Brum P.C., Brumell J.H., Brunetti-Pierri N., Bruno D., Bryson-Richardson R.J., Bucci C., Buchrieser C., Bueno M., Buitrago-Molina L.E., Buraschi S., Buch S., Buchan J.R., Buckingham E.M., Budak H., Budini M., Bultynck G., Burada F., Burgoyne J.R., Buron M.I., Bustos V., Buttner S., Butturini E., Byrd A., Cabas I., Cabrera-Benitez S., Cadwell K., Cai J., Cai L., Cai Q., Cairo M., Calbet J.A., Caldwell G.A., Caldwell K.A., Call J.A., Calvani R., Calvo A.C., Calvo-Rubio Barrera M., Camara N.O.S., Camonis J.H., Camougrand N., Campanella M., Campbell E.M., Campbell-Valois F.-X., Campello S., Campesi I., Campos J.C., Camuzard O., Cancino J., Candido de Almeida D., Canesi L., Caniggia I., Canonico B., Canti C., Cao B., Caraglia M., Carames B., Carchman E.H., Cardenal-Munoz E., Cardenas C., Cardenas L., Cardoso S.M., Carew J.S., Carle G.F., Carleton G., Carloni S., Carmona-Gutierrez D., Carneiro L.A., Carnevali O., Carosi J.M., Carra S., Carrier A., Carrier L., Carroll B., Carter A.B., Carvalho A.N., Casanova M., Casas C., Casas J., Cassioli C., Castillo E.F., Castillo K., Castillo-Lluva S., Castoldi F., Castori M., Castro A.F., Castro-Caldas M., Castro-Hernandez J., Castro-Obregon S., Catz S.D., Cavadas C., Cavaliere F., Cavallini G., Cavinato M., Cayuela M.L., Cebollada Rica P., Cecarini V., Cecconi F., Cechowska-Pasko M., Cenci S., Ceperuelo-Mallafre V., Cerqueira J.J., Cerutti J.M., Cervia D., Cetintas V.B., Cetrullo S., Chae H.-J., Chagin A.S., Chai C.-Y., Chakrabarti G., Chakrabarti O., Chakraborty T., Chami M., Chamilos G., Chan D.W., Chan E.Y.W., Chan E.D., Chan H.Y.E., Chan H.H., Chan H., Chan M.T.V., Chan Y.S., Chandra P.K., Chang C.-P., Chang C., Chang H.-C., Chang K., Chao J., Chapman T., Charlet-Berguerand N., Chatterjee S., Chaube S.K., Chaudhary A., Chauhan S., Chaum E., Checler F., Cheetham M.E., Chen C.-S., Chen G.-C., Chen J.-F., Chen L.L., Chen L., Chen M., Chen M.-K., Chen N., Chen Q., Chen R.-H., Chen S., Chen W., Chen X.-M., Chen X.-W., Chen X., Chen Y.-G., Chen Y., Chen Y.-J., Chen Y.-Q., Chen Z.S., Chen Z.-H., Chen Z.J., Cheng H., Cheng J., Cheng S.-Y., Cheng W., Cheng X., Cheng X.-T., Cheng Y., Cheng Z., Chen Z., Cheong H., Cheong J.K., Chernyak B.V., Cherry S., Cheung C.F.R., Cheung C.H.A., Cheung K.-H., Chevet E., Chi R.J., Chiang A.K.S., Chiaradonna F., Chiarelli R., Chiariello M., Chica N., Chiocca S., Chiong M., Chiou S.-H., Chiramel A.I., Chiurchiu V., Cho D.-H., Choe S.-K., Choi A.M.K., Choi M.E., Choudhury K.R., Chow N.S., Chu C.T., Chua J.P., Chua J.J.E., Chung H., Chung K.P., Chung S., Chung S.-H., Chung Y.-L., Cianfanelli V., Ciechomska I.A., Cifuentes M., Cinque L., Cirak S., Cirone M., Clague M.J., Clarke R., Clementi E., Coccia E.M., Codogno P., Cohen E., Cohen M.M., Colasanti T., Colasuonno F., Colbert R.A., Colell A., Colic M., Coll N.S., Collins M.O., Colombo M.I., Colon-Ramos D.A., Combaret L., Comincini S., Cominetti M.R., Consiglio A., Conte A., Conti F., Contu V.R., Cookson M.R., Coombs K.M., Coppens I., Corasaniti M.T., Corkery D.P., Cordes N., Cortese K., Costa M.D.C., Costantino S., Costelli P., Coto-Montes A., Crack P.J., Crespo J.L., Criollo A., Crippa V., Cristofani R., Csizmadia T., Cuadrado A., Cui B., Cui J., Cui Y., Culetto E., Cumino A.C., Cybulsky A.V., Czaja M.J., Czuczwar S.J., D'Adamo S., D'Amelio M., D'Arcangelo D., D'Lugos A.C., D'Orazi G., da Silva J.A., Dafsari H.S., Dagda R.K., Dagdas Y., Daglia M., Dai X., Dai Y., Dal Col J., Dalhaimer P., Dalla Valle L., Dallenga T., Dalmasso G., Damme M., Dando I., Dantuma N.P., Darling A.L., Das H., Dasarathy S., Dasari S.K., Dash S., Daumke O., Dauphinee A.N., Davies J.S., Davila V.A., Davis R.J., Davis T., Dayalan Naidu S., De Amicis F., De Bosscher K., De Felice F., De Franceschi L., De Leonibus C., de Mattos Barbosa M.G., De Meyer G.R.Y., De Milito A., De Nunzio C., De Palma C., De Santi M., De Virgilio C., De Zio D., Debnath J., DeBosch B.J., Decuypere J.-P., Deehan M.A., Deflorian G., DeGregori J., Dehay B., Del Rio G., Delaney J.R., Delbridge L.M.D., Delorme-Axford E., Delpino M.V., Demarchi F., Dembitz V., Demers N.D., Deng H., Deng Z., Dengjel J., Dent P., Denton D., DePamphilis M.L., Der C.J., Deretic V., Descoteaux A., Devis L., Devkota S., Devuyst O., Dewson G., Dharmasivam M., Dhiman R., di Bernardo D., Di Cristina M., Di Domenico F., Di Fazio P., Di Fonzo A., Di Guardo G., Di Guglielmo G.M., Di Leo L., Di Malta C., Di Nardo A., Di Rienzo M., Di Sano F., Diallinas G., Diao J., Diaz-Araya G., Diaz-Laviada I., Dickinson J.M., Diederich M., Dieude M., Dikic I., Ding S., Ding W.-X., Dini L., Dinic J., Dinic M., Dinkova-Kostova A.T., Dionne M.S., Distler J.H.W., Diwan A., Dixon I.M.C., Djavaheri-Mergny M., Dobrinski I., Dobrovinskaya O., Dobrowolski R., Dobson R.C.J., Dokic J., Dokmeci Emre S., Donadelli M., Dong B., Dong X., Dong Z., Dorn II G.W., Dotsch V., Dou H., Dou J., Dowaidar M., Dridi S., Drucker L., Du A., Du C., Du G., Du H.-N., Du L.-L., du Toit A., Duan S.-B., Duan X., Duarte S.P., Dubrovska A., Dunlop E.A., Dupont N., Duran R.V., Dwarakanath B.S., Dyshlovoy S.A., Ebrahimi-Fakhari D., Eckhart L., Edelstein C.L., Efferth T., Eftekharpour E., Eichinger L., Eid N., Eisenberg T., Eissa N.T., Eissa S., Ejarque M., El Andaloussi A., El-Hage N., El-Naggar S., Eleuteri A.M., El-Shafey E.S., Elgendy M., Eliopoulos A.G., Elizalde M.M., Elks P.M., Elsasser H.-P., Elsherbiny E.S., Emerling B.M., Emre N.C.T., Eng C.H., Engedal N., Engelbrecht A.-M., Engelsen A.S.T., Enserink J.M., Escalante R., Esclatine A., Escobar-Henriques M., Eskelinen E.-L., Espert L., Eusebio M.-O., Fabrias G., Fabrizi C., Facchiano A., Facchiano F., Fadeel B., Fader C., Faesen A.C., Fairlie W.D., Falco A., Falkenburger B.H., Fan D., Fan J., Fan Y., Fang E.F., Fang Y., Fanto M., Farfel-Becker T., Faure M., Fazeli G., Fedele A.O., Feldman A.M., Feng D., Feng J., Feng L., Feng Y., Feng W., Fenz Araujo T., Ferguson T.A., Fernandez A.F., Fernandez-Checa J.C., Fernandez-Veledo S., Fernie A.R., Ferrante A.W., Ferraresi A., Ferrari M.F., Ferreira J.C.B., Ferro-Novick S., Figueras A., Filadi R., Filigheddu N., Filippi-Chiela E., Filomeni G., Fimia G.M., Fineschi V., Finetti F., Finkbeiner S., Fisher E.A., Fisher P.B., Flamigni F., Fliesler S.J., Flo T.H., Florance I., Florey O., Florio T., Fodor E., Follo C., Fon E.A., Forlino A., Fornai F., Fortini P., Fracassi A., Fraldi A., Franco B., Franco R., Franconi F., Frankel L.B., Friedman S.L., Frohlich L.F., Fruhbeck G., Fuentes J.M., Fujiki Y., Fujita N., Fujiwara Y., Fukuda M., Fulda S., Furic L., Furuya N., Fusco C., Gack M.U., Gaffke L., Galadari S., Galasso A., Galindo M.F., Gallolu Kankanamalage S., Galluzzi L., Galy V., Gammoh N., Gan B., Ganley I.G., Gao F., Gao H., Gao M., Gao P., Gao S.-J., Gao W., Gao X., Garcera A., Garcia M.N., Garcia V.E., Garcia-Del Portillo F., Garcia-Escudero V., Garcia-Garcia A., Garcia-Macia M., Garcia-Moreno D., Garcia-Ruiz C., Garcia-Sanz P., Garg A.D., Gargini R., Garofalo T., Garry R.F., Gassen N.C., Gatica D., Ge L., Ge W., Geiss-Friedlander R., Gelfi C., Genschik P., Gentle I.E., Gerbino V., Gerhardt C., Germain K., Germain M., Gewirtz D.A., Ghasemipour Afshar E., Ghavami S., Ghigo A., Ghosh M., Giamas G., Giampietri C., Giatromanolaki A., Gibson G.E., Gibson S.B., Ginet V., Giniger E., Giorgi C., Girao H., Girardin S.E., Giridharan M., Giuliano S., Giulivi C., Giuriato S., Giustiniani J., Gluschko A., Goder V., Goginashvili A., Golab J., Goldstone D.C., Golebiewska A., Gomes L.R., Gomez R., Gomez-Sanchez R., Gomez-Puerto M.C., Gomez-Sintes R., Gong Q., Goni F.M., Gonzalez-Gallego J., Gonzalez-Hernandez T., Gonzalez-Polo R.A., Gonzalez-Reyes J.A., Gonzalez-Rodriguez P., Goping I.S., Gorbatyuk M.S., Gorbunov N.V., Gorgulu K., Gorojod R.M., Gorski S.M., Goruppi S., Gotor C., Gottlieb R.A., Gozes I., Gozuacik D., Graef M., Graler M.H., Granatiero V., Grasso D., Gray J.P., Green D.R., Greenhough A., Gregory S.L., Griffin E.F., Grinstaff M.W., Gros F., Grose C., Gross A.S., Gruber F., Grumati P., Grune T., Gu X., Guan J.-L., Guardia C.M., Guda K., Guerra F., Guerri C., Guha P., Guillen C., Gujar S., Gukovskaya A., Gukovsky I., Gunst J., Gunther A., Guntur A.R., Guo C., Guo H., Guo L.-W., Guo M., Gupta P., Gupta S.K., Gupta S., Gupta V.B., Gupta V., Gustafsson A.B., Gutterman D.D., H.B R., Haapasalo A., Haber J.E., Hac A., Hadano S., Hafren A.J., Haidar M., Hall B.S., Hallden G., Hamacher-Brady A., Hamann A., Hamasaki M., Han W., Hansen M., Hanson P.I., Hao Z., Harada M., Harhaji-Trajkovic L., Hariharan N., Haroon N., Harris J., Hasegawa T., Hasima Nagoor N., Haspel J.A., Haucke V., Hawkins W.D., Hay B.A., Haynes C.M., Hayrabedyan S.B., Hays T.S., He C., He Q., He R.-R., He Y.-W., He Y.-Y., Heakal Y., Heberle A.M., Hejtmancik J.F., Helgason G.V., Henkel V., Herb M., Hergovich A., Herman-Antosiewicz A., Hernandez A., Hernandez C., Hernandez-Diaz S., Hernandez-Gea V., Herpin A., Herreros J., Hervas J.H., Hesselson D., Hetz C., Heussler V.T., Higuchi Y., Hilfiker S., Hill J.A., Hlavacek W.S., Ho E.A., Ho I.H.T., Ho P.W.-L., Ho S.-L., Ho W.Y., Hobbs G.A., Hochstrasser M., Hoet P.H.M., Hofius D., Hofman P., Hohn A., Holmberg C.I., Hombrebueno J.R., Yi-Ren Hong C.-W.H., Hooper L.V., Hoppe T., Horos R., Hoshida Y., Hsin I.-L., Hsu H.-Y., Hu B., Hu D., Hu L.-F., Hu M.C., Hu R., Hu W., Hu Y.-C., Hu Z.-W., Hua F., Hua J., Hua Y., Huan C., Huang C., Huang H., Huang K., Huang M.L.H., Huang R., Huang S., Huang T., Huang X., Huang Y.J., Huber T.B., Hubert V., Hubner C.A., Hughes S.M., Hughes W.E., Humbert M., Hummer G., Hurley J.H., Hussain S., Hussey P.J., Hutabarat M., Hwang H.-Y., Hwang S., Ieni A., Ikeda F., Imagawa Y., Imai Y., Imbriano C., Imoto M., Inman D.M., Inoki K., Iovanna J., Iozzo R.V., Ippolito G., Irazoqui J.E., Iribarren P., Ishaq M., Ishikawa M., Ishimwe N., Isidoro C., Ismail N., Issazadeh-Navikas S., Itakura E., Ito D., Ivankovic D., Ivanova S., Iyer A.K.V., Izquierdo J.M., Izumi M., Jaattela M., Jabir M.S., Jackson W.T., Jacobo-Herrera N., Jacomin A.-C., Jacquin E., Jadiya P., Jaeschke H., Jagannath C., Jakobi A.J., Jakobsson J., Janji B., Jansen-Durr P., Jansson P.J., Jantsch J., Januszewski S., Jassey A., Jean S., Jeltsch-David H., Jendelova P., Jenny A., Jensen T.E., Jessen N., Jewell J.L., Ji J., Jia L., Jia R., Jiang L., Jiang Q., Jiang R., Jiang T., Jiang X., Jiang Y., Jimenez-Sanchez M., Jin E.-J., Jin F., Jin H., Jin L., Jin M., Jin S., Jo E.-K., Joffre C., Johansen T., Johnson G.V.W., Johnston S.A., Jokitalo E., Jolly M.K., Joosten L.A.B., Jordan J., Joseph B., Ju D., Ju J.-S., Ju J., Juarez E., Judith D., Juhasz G., Jun Y., Jung C.H., Jung S.-C., Jung Y.K., Jungbluth H., Jungverdorben J., Just S., Kaarniranta K., Kaasik A., Kabuta T., Kaganovich D., Kahana A., Kain R., Kajimura S., Kalamvoki M., Kalia M., Kalinowski D.S., Kaludercic N., Kalvari I., Kaminska J., Kaminskyy V.O., Kanamori H., Kanasaki K., Kang C., Kang R., Kang S.S., Kaniyappan S., Kanki T., Kanneganti T.-D., Kanthasamy A.G., Kanthasamy A., Kantorow M., Kapuy O., Karamouzis M.V., Karim M.R., Karmakar P., Katare R.G., Kato M., Kaufmann S.H.E., Kauppinen A., Kaushal G.P., Kaushik S., Kawasaki K., Kazan K., Ke P.-Y., Keating D.J., Keber U., Kehrl J.H., Keller K.E., Keller C.W., Kemper J.K., Kenific C.M., Kepp O., Kermorgant S., Kern A., Ketteler R., Keulers T.G., Khalfin B., Khalil H., Khambu B., Khan S.Y., Khandelwal V.K.M., Khandia R., Kho W., Khobrekar N.V., Khuansuwan S., Khundadze M., Killackey S.A., Kim D., Kim D.R., Kim D.-H., Kim D.-E., Kim E.Y., Kim E.-K., Kim H.-R., Kim H.-S., Hyung-Ryong Kim, Kim J.K., Kim J.-H., Kim J., Kim J.H., Kim K.I., Kim P.K., Kim S.-J., Kimball S.R., Kimchi A., Kimmelman A.C., Kimura T., King M.A., Kinghorn K.J., Kinsey C.G., Kirkin V., Kirshenbaum L.A., Kiselev S.L., Kishi S., Kitamoto K., Kitaoka Y., Kitazato K., Kitsis R.N., Kittler J.T., Kjaerulff O., Klein P.S., Klopstock T., Klucken J., Knaevelsrud H., Knorr R.L., Ko B.C.B., Ko F., Ko J.-L., Kobayashi H., Kobayashi S., Koch I., Koch J.C., Koenig U., Kogel D., Koh Y.H., Koike M., Kohlwein S.D., Kocaturk N.M., Komatsu M., Konig J., Kono T., Kopp B.T., Korcsmaros T., Korkmaz G., Korolchuk V.I., Korsnes M.S., Koskela A., Kota J., Kotake Y., Kotler M.L., Kou Y., Koukourakis M.I., Koustas E., Kovacs A.L., Kovacs T., Koya D., Kozako T., Kraft C., Krainc D., Kramer H., Krasnodembskaya A.D., Kretz-Remy C., Kroemer G., Ktistakis N.T., Kuchitsu K., Kuenen S., Kuerschner L., Kukar T., Kumar A., Kumar D., Kumar S., Kume S., Kumsta C., Kundu C.N., Kundu M., Kunnumakkara A.B., Kurgan L., Kutateladze T.G., Kutlu O., Kwak S., Kwon H.J., Kwon T.K., Kwon Y.T., Kyrmizi I., La Spada A., Labonte P., Ladoire S., Laface I., Lafont F., Lagace D.C., Lahiri V., Lai Z., Laird A.S., Lakkaraju A., Lamark T., Lan S.-H., Landajuela A., Lane D.J.R., Lane J.D., Lang C.H., Lange C., Langel U., Langer R., Lapaquette P., Laporte J., LaRusso N.F., Lastres-Becker I., Lau W.C.Y., Laurie G.W., Lavandero S., Law B.Y.K., Law H.K.-W., Layfield R., Le W., Le Stunff H., Leary A.Y., Lebrun J.-J., Leck L.Y.W., Leduc-Gaudet J.-P., Lee C., Lee C.-P., Lee D.-H., Lee E.B., Lee E.F., Lee G.M., Lee H.-J., Lee H.K., Lee J.M., Lee J.S., Lee J.-A., Lee J.-Y., Lee J.H., Lee M., Lee M.G., Lee M.J., Lee M.-S., Lee S.-J., Lee S.Y., Lee S.B., Lee W.H., Lee Y.-R., Lee Y.-H., Lee Y., Lefebvre C., Legouis R., Lei Y.L., Lei Y., Leikin S., Leitinger G., Lemus L., Leng S., Lenoir O., Lenz G., Lenz H.J., Lenzi P., Leon Y., Leopoldino A.M., Leschczyk C., Leskela S., Letellier E., Leung C.-T., Leung P.S., Leventhal J.S., Levine B., Lewis P.A., Ley K., Li B., Li D.-Q., Li J., Li K., Li L., Li M., Li P.-L., Li M.-Q., Li Q., Li S., Li T., Li W., Li X., Li Y.-P., Li Y., Lian J., Liang C., Liang Q., Liang W., Liang Y., Liao G., Liao L., Liao M., Liao Y.-F., Librizzi M., Lie P.P.Y., Lilly M.A., Lim H.J., Lima T.R.R., Limana F., Lin C., Lin C.-W., Lin D.-S., Lin F.-C., Lin J.D., Lin K.M., Lin K.-H., Lin L.-T., Lin P.-H., Lin Q., Lin S., Lin S.-J., Lin W., Lin X., Lin Y.-X., Lin Y.-S., Linden R., Lindner P., Ling S.-C., Lingor P., Linnemann A.K., Liou Y.-C., Lipinski M.M., Lipovsek S., Lira V.A., Lisiak N., Liton P.B., Liu C., Liu C.-H., Liu C.-F., Liu C.H., Liu F., Liu H.-S., Liu H.-F., Liu H., Liu J., Liu L., Liu M., Liu Q., Liu W., Liu X.-H., Liu X., Liu Y., Livingston J.A., Lizard G., Lizcano J.M., Ljubojevic-Holzer S., LLeonart M.E., Llobet-Navas D., Llorente A., Lo C.H., Lobato-Marquez D., Long Q., Long Y.C., Loos B., Loos J.A., Lopez M.G., Lopez-Domenech G., Lopez-Guerrero J.A., Lopez-Jimenez A.T., Lopez-Perez O., Lopez-Valero I., Lorenowicz M.J., Lorente M., Lorincz P., Lossi L., Lotersztajn S., Lovat P.E., Lovell J.F., Lovy A., Low P., Lu G., Lu H., Lu J.-H., Lu J.-J., Lu M., Lu S., Luciani A., Lucocq J.M., Ludovico P., Luftig M.A., Luhr M., Luis-Ravelo D., Lum J.J., Luna-Dulcey L., Lund A.H., Lund V.K., Lunemann J.D., Luningschror P., Luo H., Luo R., Luo S., Luo Z., Luparello C., Luscher B., Luu L., Lyakhovich A., Lyamzaev K.G., Lystad A.H., Lytvynchuk L., Ma A.C., Ma C., Ma M., Ma N.-F., Ma Q.-H., Ma X., Ma Y., Ma Z., MacDougald O.A., Macian F., MacIntosh G.C., MacKeigan J.P., Macleod K.F., Maday S., Madeo F., Madesh M., Madl T., Madrigal-Matute J., Maeda A., Maejima Y., Magarinos M., Mahavadi P., Maiani E., Maiese K., Maiti P., Maiuri M.C., Majello B., Major M.B., Makareeva E., Malik F., Mallilankaraman K., Malorni W., Maloyan A., Mammadova N., Man G.C.W., Manai F., Mancias J.D., Mandelkow E.-M., Mandell M.A., Manfredi A.A., Manjili M.H., Manjithaya R., Manque P., Manshian B.B., Manzano R., Manzoni C., Mao K., Marchese C., Marchetti S., Marconi A.M., Marcucci F., Mardente S., Mareninova O.A., Margeta M., Mari M., Marinelli S., Marinelli O., Marino G., Mariotto S., Marshall R.S., Marten M.R., Martens S., Martin A.P.J., Martin K.R., Martin S., Martin-Segura A., Martin-Acebes M.A., Martin-Burriel I., Martin-Rincon M., Martin-Sanz P., Martina J.A., Martinet W., Martinez A., Martinez J., Martinez Velazquez M., Martinez-Lopez N., Martinez-Vicente M., Martins D.O., Martins J.O., Martins W.K., Martins-Marques T., Marzetti E., Masaldan S., Masclaux-Daubresse C., Mashek D.G., Massa V., Massieu L., Masson G.R., Masuelli L., Masyuk A.I., Masyuk T.V., Matarrese P., Matheu A., Matoba S., Matsuzaki S., Mattar P., Matte A., Mattoscio D., Mauriz J.L., Mauthe M., Mauvezin C., Maverakis E., Maycotte P., Mayer J., Mazzoccoli G., Mazzoni C., Mazzulli J.R., McCarty N., McDonald C., McGill M.R., McKenna S.L., McLaughlin B., McLoughlin F., McNiven M.A., McWilliams T.G., Mechta-Grigoriou F., Medeiros T.C., Medina D.L., Megeney L.A., Megyeri K., Mehrpour M., Mehta J.L., Meijer A.J., Meijer A.H., Mejlvang J., Melendez A., Melk A., Memisoglu G., Mendes A.F., Meng D., Meng F., Meng T., Menna-Barreto R., Menon M.B., Mercer C., Mercier A.E., Mergny J.-L., Merighi A., Merkley S.D., Merla G., Meske V., Mestre A.C., Metur S.P., Meyer C., Meyer H., Mi W., Mialet-Perez J., Miao J., Micale L., Miki Y., Milan E., Milczarek M., Miller D.L., Miller S.I., Miller S., Millward S.W., Milosevic I., Minina E.A., Mirzaei H., Mirzaei H.R., Mirzaei M., Mishra A., Mishra N., Mishra P.K., Misirkic Marjanovic M., Misasi R., Misra A., Misso G., Mitchell C., Mitou G., Miura T., Miyamoto S., Miyazaki M., Miyazaki T., Miyazawa K., Mizushima N., Mogensen T.H., Mograbi B., Mohammadinejad R., Mohamud Y., Mohanty A., Mohapatra S., Mohlmann T., Mohmmed A., Moles A., Moley K.H., Molinari M., Mollace V., Moller A.B., Mollereau B., Mollinedo F., Montagna C., Monteiro M.J., Montella A., Montes L.R., Montico B., Mony V.K., Monzio Compagnoni G., Moore M.N., Moosavi M.A., Mora A.L., Mora M., Morales-Alamo D., Moratalla R., Moreira P.I., Morelli E., Moreno S., Moreno-Blas D., Moresi V., Morga B., Morgan A.H., Morin F., Morishita H., Moritz O.L., Moriyama M., Moriyasu Y., Morleo M., Morselli E., Moruno-Manchon J.F., Moscat J., Mostowy S., Motori E., Moura A.F., Moustaid-Moussa N., Mrakovcic M., Mucino-Hernandez G., Mukherjee A., Mukhopadhyay S., Mulcahy Levy J.M., Mulero V., Muller S., Munch C., Munjal A., Munoz-Canoves P., Munoz-Galdeano T., Munz C., Murakawa T., Muratori C., Murphy B.M., Murphy J.P., Murthy A., Myohanen T.T., Mysorekar I.U., Mytych J., Nabavi S.M., Nabissi M., Nagy P., Nah J., Nahimana A., Nakagawa I., Nakamura K., Nakatogawa H., Nandi S.S., Nanjundan M., Nanni M., Napolitano G., Nardacci R., Narita M., Nassif M., Nathan I., Natsumeda M., Naude R.J., Naumann C., Naveiras O., Navid F., Nawrocki S.T., Nazarko T.Y., Nazio F., Negoita F., Neill T., Neisch A.L., Neri L.M., Netea M.G., Neubert P., Neufeld T.P., Neumann D., Neutzner A., Newton P.T., Ney P.A., Nezis I.P., Ng C.C.W., Ng T.B., Nguyen H.T.T., Nguyen L.T., Ni H.-M., Ni Cheallaigh C., Ni Z., Nicolao M.C., Nicoli F., Nieto-Diaz M., Nilsson P., Ning S., Niranjan R., Nishimune H., Niso-Santano M., Nixon R.A., Nobili A., Nobrega C., Noda T., Nogueira-Recalde U., Nolan T.M., Nombela I., Novak I., Novoa B., Nozawa T., Nukina N., Nussbaum-Krammer C., Nylandsted J., O'Donovan T.R., O'Leary S.M., O'Rourke E.J., O'Sullivan M.P., O'Sullivan T.E., Oddo S., Oehme I., Ogawa M., Ogier-Denis E., Ogmundsdottir M.H., Ogretmen B., Oh G.T., Oh S.-H., Oh Y.J., Ohama T., Ohashi Y., Ohmuraya M., Oikonomou V., Ojha R., Okamoto K., Okazawa H., Oku M., Olivan S., Oliveira J.M.A., Ollmann M., Olzmann J.A., Omari S., Omary M.B., Onal G., Ondrej M., Ong S.-B., Ong S.-G., Onnis A., Orellana J.A., Orellana-Munoz S., Ortega-Villaizan M.D.M., Ortiz-Gonzalez X.R., Ortona E., Osiewacz H.D., Osman A.-H.K., Osta R., Otegui M.S., Otsu K., Ott C., Ottobrini L., Ou J.-H.J., Outeiro T.F., Oynebraten I., Ozturk M., Pages G., Pahari S., Pajares M., Pajvani U.B., Pal R., Paladino S., Pallet N., Palmieri M., Palmisano G., Palumbo C., Pampaloni F., Pan L., Pan Q., Pan W., Pan X., Panasyuk G., Pandey R., Pandey U.B., Pandya V., Paneni F., Pang S.Y., Panzarini E., Papademetrio D.L., Papaleo E., Papinski D., Papp D., Park E.C., Park H.T., Park J.-M., Park J.-I., Park J.T., Park J., Park S.C., Park S.-Y., Parola A.H., Parys J.B., Pasquier A., Pasquier B., Passos J.F., Pastore N., Patel H.H., Patschan D., Pattingre S., Pedraza-Alva G., Pedraza-Chaverri J., Pedrozo Z., Pei G., Pei J., Peled-Zehavi H., Pellegrini J.M., Pelletier J., Penalva M.A., Peng D., Peng Y., Penna F., Pennuto M., Pentimalli F., Pereira C.M.F., Pereira G.J.S., Pereira L.C., Pereira de Almeida L., Perera N.D., Perez-Lara A., Perez-Oliva A.B., Perez-Perez M.E., Periyasamy P., Perl A., Perrotta C., Perrotta I., Pestell R.G., Petersen M., Petrache I., Petrovski G., Pfirrmann T., Pfister A.S., Philips J.A., Pi H., Picca A., Pickrell A.M., Picot S., Pierantoni G.M., Pierdominici M., Pierre P., Pierrefite-Carle V., Pierzynowska K., Pietrocola F., Pietruczuk M., Pignata C., Pimentel-Muinos F.X., Pinar M., Pinheiro R.O., Pinkas-Kramarski R., Pinton P., Pircs K., Piya S., Pizzo P., Plantinga T.S., Platta H.W., Plaza-Zabala A., Plomann M., Plotnikov E.Y., Plun-Favreau H., Pluta R., Pocock R., Poggeler S., Pohl C., Poirot M., Poletti A., Ponpuak M., Popelka H., Popova B., Porta H., Porte Alcon S., Portilla-Fernandez E., Post M., Potts M.B., Poulton J., Powers T., Prahlad V., Prajsnar T.K., Pratico D., Prencipe R., Priault M., Proikas-Cezanne T., Promponas V.J., Proud C.G., Puertollano R., Puglielli L., Pulinilkunnil T., Puri D., Puri R., Puyal J., Qi X., Qi Y., Qian W., Qiang L., Qiu Y., Quarleri J., Raben N., Rabinowich H., Ragona D., Ragusa M.J., Rahimi N., Rahmati M., Raia V., Raimundo N., Rajasekaran N.-S., Ramachandra Rao S., Rami A., Ramirez-Pardo I., Ramsden D.B., Randow F., Rangarajan P.N., Ranieri D., Rao H., Rao L., Rao R., Rathore S., Ratnayaka J.A., Ratovitski E.A., Ravanan P., Ravegnini G., Ray S.K., Razani B., Rebecca V., Reggiori F., Regnier-Vigouroux A., Reichert A.S., Reigada D., Reiling J.H., Rein T., Reipert S., Rekha R.S., Ren H., Ren J., Ren W., Renault T., Renga G., Reue K., Rewitz K., Ribeiro de Andrade Ramos B., Riazuddin S.A., Ribeiro-Rodrigues T.M., Ricci J.-E., Ricci R., Riccio V., Richardson D.R., Rikihisa Y., Risbud M.V., Risueno R.M., Ritis K., Rizza S., Rizzuto R., Roberts H.C., Roberts L.D., Robinson K.J., Roccheri M.C., Rocchi S., Rodney G.G., Rodrigues T., Rodrigues Silva V.R., Rodriguez A., Rodriguez-Barrueco R., Rodriguez-Henche N., Rodriguez-Rocha H., Roelofs J., Rogers R.S., Rogov V.V., Rojo A.I., Rolka K., Romanello V., Romani L., Romano A., Romano P.S., Romeo-Guitart D., Romero L.C., Romero M., Roney J.C., Rongo C., Roperto S., Rosenfeldt M.T., Rosenstiel P., Rosenwald A.G., Roth K.A., Roth L., Roth S., Rouschop K.M.A., Roussel B.D., Roux S., Rovere-Querini P., Roy A., Rozieres A., Ruano D., Rubinsztein D.C., Rubtsova M.P., Ruckdeschel K., Ruckenstuhl C., Rudolf E., Rudolf R., Ruggieri A., Ruparelia A.A., Rusmini P., Russell R.R., Russo G.L., Russo M., Russo R., Ryabaya O.O., Ryan K.M., Ryu K.-Y., Sabater-Arcis M., Sachdev U., Sacher M., Sachse C., Sadhu A., Sadoshima J., Safren N., Saftig P., Sagona A.P., Sahay G., Sahebkar A., Sahin M., Sahin O., Sahni S., Saito N., Saito S., Saito T., Sakai R., Sakai Y., Sakamaki J.-I., Saksela K., Salazar G., Salazar-Degracia A., Salekdeh G.H., Saluja A.K., Sampaio-Marques B., Sanchez M.C., Sanchez-Alcazar J.A., Sanchez-Vera V., Sancho-Shimizu V., Sanderson J.T., Sandri M., Santaguida S., Santambrogio L., Santana M.M., Santoni G., Sanz A., Sanz P., Saran S., Sardiello M., Sargeant T.J., Sarin A., Sarkar C., Sarrias M.-R., Sarkar S., Sarmah D.T., Sarparanta J., Sathyanarayan A., Sathyanarayanan R., Scaglione K.M., Scatozza F., Schaefer L., Schafer Z.T., Schaible U.E., Schapira A.H.V., Scharl M., Schatzl H.M., Schein C.H., Scheper W., Scheuring D., Schiaffino M.V., Schiappacassi M., Schindl R., Schlattner U., Schmidt O., Schmitt R., Schmidt S.D., Schmitz I., Schmukler E., Schneider A., Schneider B.E., Schober R., Schoijet A.C., Schott M.B., Schramm M., Schroder B., Schuh K., Schuller C., Schulze R.J., Schurmanns L., Schwamborn J.C., Schwarten M., Scialo F., Sciarretta S., Scott M.J., Scotto K.W., Scovassi A.I., Scrima A., Scrivo A., Sebastian D., Sebti S., Sedej S., Segatori L., Segev N., Seglen P.O., Seiliez I., Seki E., Selleck S.B., Sellke F.W., Selsby J.T., Sendtner M., Senturk S., Seranova E., Sergi C., Serra-Moreno R., Sesaki H., Settembre C., Setty S.R.G., Sgarbi G., Sha O., Shacka J.J., Shah J.A., Shang D., Shao C., Shao F., Sharbati S., Sharkey L.M., Sharma D., Sharma G., Sharma K., Sharma P., Sharma S., Shen H.-M., Shen H., Shen J., Shen M., Shen W., Shen Z., Sheng R., Sheng Z., Sheng Z.-H., Shi J., Shi X., Shi Y.-H., Shiba-Fukushima K., Shieh J.-J., Shimada Y., Shimizu S., Shimozawa M., Shintani T., Shoemaker C.J., Shojaei S., Shoji I., Shravage B.V., Shridhar V., Shu C.-W., Shu H.-B., Shui K., Shukla A.K., Shutt T.E., Sica V., Siddiqui A., Sierra A., Sierra-Torre V., Signorelli S., Sil P., Silva B.J.D.A., Silva J.D., Silva-Pavez E., Silvente-Poirot S., Simmonds R.E., Simon A.K., Simon H.-U., Simons M., Singh A., Singh L.P., Singh R., Singh S.V., Singh S.K., Singh S.B., Singh S., Singh S.P., Sinha D., Sinha R.A., Sinha S., Sirko A., Sirohi K., Sivridis E.L., Skendros P., Skirycz A., Slaninova I., Smaili S.S., Smertenko A., Smith M.D., Soenen S.J., Sohn E.J., Sok S.P.M., Solaini G., Soldati T., Soleimanpour S.A., Soler R.M., Solovchenko A., Somarelli J.A., Sonawane A., Song F., Song H.K., Song J.-X., Song K., Song Z., Soria L.R., Sorice M., Soukas A.A., Soukup S.-F., Sousa D., Sousa N., Spagnuolo P.A., Spector S.A., Srinivas Bharath M.M., St. Clair D., Stagni V., Staiano L., Stalnecker C.A., Stankov M.V., Stathopulos P.B., Stefan K., Stefan S.M., Stefanis L., Steffan J.S., Steinkasserer A., Stenmark H., Sterneckert J., Stevens C., Stoka V., Storch S., Stork B., Strappazzon F., Strohecker A.M., Stupack D.G., Su H., Su L.-Y., Su L., Suarez-Fontes A.M., Subauste C.S., Subbian S., Subirada P.V., Sudhandiran G., Sue C.M., Sui X., Summers C., Sun G., Sun J., Sun K., Sun M.-X., Sun Q., Sun Y., Sun Z., Sunahara K.K.S., Sundberg E., Susztak K., Sutovsky P., Suzuki H., Sweeney G., Symons J.D., Sze S.C.W., Szewczyk N.J., Tabecka-Lonczynska A., Tabolacci C., Tacke F., Taegtmeyer H., Tafani M., Tagaya M., Tai H., Tait S.W.G., Takahashi Y., Takats S., Talwar P., Tam C., Tam S.Y., Tampellini D., Tamura A., Tan C.T., Tan E.-K., Tan Y.-Q., Tanaka M., Tang D., Tang J., Tang T.-S., Tanida I., Tao Z., Taouis M., Tatenhorst L., Tavernarakis N., Taylor A., Taylor G.A., Taylor J.M., Tchetina E., Tee A.R., Tegeder I., Teis D., Teixeira N., Teixeira-Clerc F., Tekirdag K.A., Tencomnao T., Tenreiro S., Tepikin A.V., Testillano P.S., Tettamanti G., Tharaux P.-L., Thedieck K., Thekkinghat A.A., Thellung S., Thinwa J.W., Thirumalaikumar V.P., Thomas S.M., Thomes P.G., Thorburn A., Thukral L., Thum T., Thumm M., Tian L., Tichy A., Till A., Timmerman V., Titorenko V.I., Todi S.V., Todorova K., Toivonen J.M., Tomaipitinca L., Tomar D., Tomas-Zapico C., Tomic S., Tong B.C.-K., Tong C., Tong X., Tooze S.A., Torgersen M.L., Torii S., Torres-Lopez L., Torriglia A., Towers C.G., Towns R., Toyokuni S., Trajkovic V., Tramontano D., Tran Q.-G., Travassos L.H., Trelford C.B., Tremel S., Trougakos I.P., Tsao B.P., Tschan M.P., Tse H.-F., Tse T.F., Tsugawa H., Tsvetkov A.S., Tumbarello D.A., Tumtas Y., Tunon M.J., Turcotte S., Turk B., Turk V., Turner B.J., Tuxworth R.I., Tyler J.K., Tyutereva E.V., Uchiyama Y., Ugun-Klusek A., Uhlig H.H., Ulamek-Koziol M., Ulasov I.V., Umekawa M., Ungermann C., Unno R., Urbe S., Uribe-Carretero E., Ustun S., Uversky V.N., Vaccari T., Vaccaro M.I., Vahsen B.F., Vakifahmetoglu-Norberg H., Valdor R., Valente M.J., Valko A., Vallee R.B., Valverde A.M., Van den Berghe G., van der Veen S., Van Kaer L., van Loosdregt J., van Wijk S.J.L., Vandenberghe W., Vanhorebeek I., Vannier-Santos M.A., Vannini N., Vanrell M.C., Vantaggiato C., Varano G., Varela-Nieto I., Varga M., Vasconcelos M.H., Vats S., Vavvas D.G., Vega-Naredo I., Vega-Rubin-de-Celis S., Velasco G., Velazquez A.P., Vellai T., Vellenga E., Velotti F., Verdier M., Verginis P., Vergne I., Verkade P., Verma M., Verstreken P., Vervliet T., Vervoorts J., Vessoni A.T., Victor V.M., Vidal M., Vidoni C., Vieira O.V., Vierstra R.D., Vigano S., Vihinen H., Vijayan V., Vila M., Vilar M., Villalba J.M., Villalobo A., Villarejo-Zori B., Villarroya F., Villarroya J., Vincent O., Vindis C., Viret C., Viscomi M.T., Visnjic D., Vitale I., Vocadlo D.J., Voitsekhovskaja O.V., Volonte C., Volta M., Vomero M., Von Haefen C., Vooijs M.A., Voos W., Vucicevic L., Wade-Martins R., Waguri S., Waite K.A., and Wakatsuki S.

Abstract

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.Copyright © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results