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4. Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.

Author

Thavendiranathan, Paaladinesh, Zhang, Lili, Zafar, Amna, Drobni, Zsofia D, Mahmood, Syed S, Cabral, Marcella, Awadalla, Magid, Nohria, Anju, Zlotoff, Daniel A, Thuny, Franck, Heinzerling, Lucie M, Barac, Ana, Sullivan, Ryan J, Chen, Carol L, Gupta, Dipti, Kirchberger, Michael C, Hartmann, Sarah E, Weinsaft, Jonathan W, Gilman, Hannah K, Rizvi, Muhammad A, Kovacina, Bojan, Michel, Caroline, Sahni, Gagan, González-Mansilla, Ana, Calles, Antonio, Fernández-Avilés, Francisco, Mahmoudi, Michael, Reynolds, Kerry L, Ganatra, Sarju, Gavira, Juan José, González, Nahikari Salterain, García de Yébenes Castro, Manuel, Kwong, Raymond Y, Jerosch-Herold, Michael, Coelho-Filho, Otavio R, Afilalo, Jonathan, Zataraín-Nicolás, Eduardo, Baksi, A John, Wintersperger, Bernd J, Calvillo-Arguelles, Oscar, Ederhy, Stephane, Yang, Eric H, Lyon, Alexander R, Fradley, Michael G, and Neilan, Tomas G

Abstract

Myocarditis is a potentially fatal complication of immune checkpoint inhibitor (ICI) therapy. Data on the utility of cardiovascular magnetic resonance (CMR) T1 and T2 mapping in ICI myocarditis are limited.This study sought to assess the value of CMR T1 and T2 mapping in patients with ICI myocarditis.In this retrospective study from an international registry of patients with ICI myocarditis, clinical and CMR findings (including T1 and T2 maps) were collected. Abnormal T1 and T2 were defined as 2 SD above site (vendor/field strength specific) reference values and a z-score was calculated for each patient. Major adverse cardiovascular events (MACE) were a composite of cardiovascular death, cardiogenic shock, cardiac arrest, and complete heart block.Of 136 patients with ICI myocarditis with a CMR, 86 (63%) had T1 maps and 79 (58%) also had T2 maps. Among the 86 patients (66.3 ± 13.1 years of age), 36 (41.9%) had a left ventricular ejection fraction

Published
2021

8. Sex-Specific Stress Perfusion Cardiac Magnetic Resonance Imaging in Suspected Ischemic Heart Disease: Insights From SPINS Retrospective Registry

Author

Heydari, Bobak, Ge, Yin, Antiochos, Panagiotis, Islam, Sabeeh, Steel, Kevin, Bingham, Scott, Abdullah, Shuaib, Mikolich, J. Ronald, Arai, Andrew E., Bandettini, W. Patricia, Patel, Amit R., Shanbhag, Sujata M., Farzaneh-Far, Afshin, Heitner, John F., Shenoy, Chetan, Leung, Steve W., Gonzalez, Jorge A., Raman, Subha V., Ferrari, Victor A., Shah, Dipan J., Schulz-Menger, Jeanette, Stuber, Matthias, Simonetti, Orlando P., and Kwong, Raymond Y.

Published
2023
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9. 3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy: Insights From the NHLBI International HCM Registry

Author

Heydari, Bobak, Satriano, Alessandro, Jerosch-Herold, Michael, Kolm, Paul, Kim, Dong-Yun, Cheng, Kathleen, Choi, Yuna L., Antiochos, Panagiotis, White, James A., Mahmod, Masliza, Chan, Kenneth, Raman, Betty, Desai, Milind Y., Ho, Carolyn Y., Dolman, Sarahfaye F., Desvigne-Nickens, Patrice, Maron, Martin S., Friedrich, Matthias G., Schulz-Menger, Jeanette, Piechnik, Stefan K., Appelbaum, Evan, Weintraub, William S., Neubauer, Stefan, Kramer, Christopher M., and Kwong, Raymond Y.

Published
2023
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11. Ischemia With Nonobstructive Coronary Arteries: Insights From the ISCHEMIA Trial

Author

Reynolds, Harmony R., Diaz, Ariel, Cyr, Derek D., Shaw, Leslee J., Mancini, G.B. John, Leipsic, Jonathon, Budoff, Matthew J., Min, James K., Hague, Cameron J., Berman, Daniel S., Chaitman, Bernard R., Picard, Michael H., Hayes, Sean W., Scherrer-Crosbie, Marielle, Kwong, Raymond Y., Lopes, Renato D., Senior, Roxy, Dwivedi, Sudhanshu K., Miller, Todd D., Chow, Benjamin J.W., de Silva, Ramesh, Stone, Gregg W., Boden, William E., Bangalore, Sripal, O’Brien, Sean M., Hochman, Judith S., and Maron, David J.

Published
2023
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12. Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis.

Author

Zhang, Lili, Awadalla, Magid, Mahmood, Syed S, Nohria, Anju, Hassan, Malek Z O, Thuny, Franck, Zlotoff, Daniel A, Murphy, Sean P, Stone, James R, Golden, Doll Lauren Alexandra, Alvi, Raza M, Rokicki, Adam, Jones-O'Connor, Maeve, Cohen, Justine V, Heinzerling, Lucie M, Mulligan, Connor, Armanious, Merna, Barac, Ana, Forrestal, Brian J, Sullivan, Ryan J, Kwong, Raymond Y, Yang, Eric H, Damrongwatanasuk, Rongras, Chen, Carol L, Gupta, Dipti, Kirchberger, Michael C, Moslehi, Javid J, Coelho-Filho, Otavio R, Ganatra, Sarju, Rizvi, Muhammad A, Sahni, Gagan, Tocchetti, Carlo G, Mercurio, Valentina, Mahmoudi, Michael, Lawrence, Donald P, Reynolds, Kerry L, Weinsaft, Jonathan W, Baksi, A John, Ederhy, Stephane, Groarke, John D, Lyon, Alexander R, Fradley, Michael G, Thavendiranathan, Paaladinesh, and Neilan, Tomas G

Abstract

Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with ICI-associated myocarditis are presented.From an international registry of patients with ICI-associated myocarditis, clinical, CMR, and histopathological findings were collected. Major adverse cardiovascular events (MACE) were a composite of cardiovascular death, cardiogenic shock, cardiac arrest, and complete heart block. In 103 patients diagnosed with ICI-associated myocarditis who had a CMR, the mean left ventricular ejection fraction (LVEF) was 50%, and 61% of patients had an LVEF ≥50%. Late gadolinium enhancement (LGE) was present in 48% overall, 55% of the reduced EF, and 43% of the preserved EF cohort. Elevated T2-weighted short tau inversion recovery (STIR) was present in 28% overall, 30% of the reduced EF, and 26% of the preserved EF cohort. The presence of LGE increased from 21.6%, when CMR was performed within 4 days of admission to 72.0% when CMR was performed on Day 4 of admission or later. Fifty-six patients had cardiac pathology. Late gadolinium enhancement was present in 35% of patients with pathological fibrosis and elevated T2-weighted STIR signal was present in 26% with a lymphocytic infiltration. Forty-one patients (40%) had MACE over a follow-up time of 5 months. The presence of LGE, LGE pattern, or elevated T2-weighted STIR were not associated with MACE.These data suggest caution in reliance on LGE or a qualitative T2-STIR-only approach for the exclusion of ICI-associated myocarditis.

Published
2020

13. Predicting the effects of supplemental EPA and DHA on the omega-3 index

Author

Walker, Rachel E, Jackson, Kristina Harris, Tintle, Nathan L, Shearer, Gregory C, Bernasconi, Aldo, Masson, Serge, Latini, Roberto, Heydari, Bobak, Kwong, Raymond Y, Flock, Michael, Kris-Etherton, Penny M, Hedengran, Anne, Carney, Robert M, Skulas-Ray, Ann, Gidding, Samuel S, Dewell, Antonella, Gardner, Christopher D, Grenon, S Marlene, Sarter, Barbara, Newman, John W, Pedersen, Theresa L, Larson, Mark K, and Harris, William S

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Dietary Supplements, Nutrition, Prevention, Complementary and Integrative Health, Women's Health, 3.3 Nutrition and chemoprevention, Bayes Theorem, Docosahexaenoic Acids, Eicosapentaenoic Acid, Erythrocytes, Female, Humans, Male, Middle Aged, Models, Biological, n-3 fatty acids, omega-3 index, dietary supplements, EPA, DHA, statistical models, n–3 fatty acids, Engineering, Medical and Health Sciences, Nutrition & Dietetics, Clinical sciences, Nutrition and dietetics
Abstract

BackgroundSupplemental long-chain omega-3 (n-3) fatty acids (EPA and DHA) raise erythrocyte EPA + DHA [omega-3 index (O3I)] concentrations, but the magnitude or variability of this effect is unclear.ObjectiveThe purpose of this study was to model the effects of supplemental EPA + DHA on the O3I.MethodsDeidentified data from 1422 individuals from 14 published n-3 intervention trials were included. Variables considered included dose, baseline O3I, sex, age, weight, height, chemical form [ethyl ester (EE) compared with triglyceride (TG)], and duration of treatment. The O3I was measured by the same method in all included studies. Variables were selected by stepwise regression using the Bayesian information criterion.ResultsIndividuals supplemented with EPA + DHA (n = 846) took a mean ± SD of 1983 ± 1297 mg/d, and the placebo controls (n = 576) took none. The mean duration of supplementation was 13.6 ± 6.0 wk. The O3I increased from 4.9% ± 1.7% to 8.1% ± 2.7% in the supplemented individuals ( P

Published
2019

14. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

Author

Das, Saumya, Consortium, The Extracellular RNA Communication, Abdel-Mageed, Asim B, Adamidi, Catherine, Adelson, P David, Akat, Kemal M, Alsop, Eric, Ansel, K Mark, Arango, Jorge, Aronin, Neil, Avsaroglu, Seda Kilinc, Azizian, Azadeh, Balaj, Leonora, Ben-Dov, Iddo Z, Bertram, Karl, Bitzer, Markus, Blelloch, Robert, Bogardus, Kimberly A, Breakefield, Xandra Owens, Calin, George A, Carter, Bob S, Charest, Al, Chen, Clark C, Chitnis, Tanuja, Coffey, Robert J, Courtright-Lim, Amanda, Datta, Amrita, DeHoff, Peter, Diacovo, Thomas G, Erle, David J, Etheridge, Alton, Ferrer, Marc, Franklin, Jeffrey L, Freedman, Jane E, Galas, David J, Galeev, Timur, Gandhi, Roopali, Garcia, Aitor, Gerstein, Mark Bender, Ghai, Vikas, Ghiran, Ionita Calin, Giraldez, Maria D, Goga, Andrei, Gogakos, Tasos, Goilav, Beatrice, Gould, Stephen J, Guo, Peixuan, Gupta, Mihir, Hochberg, Fred, Huang, Bo, Huentelman, Matt, Hunter, Craig, Hutchins, Elizabeth, Jackson, Andrew R, Kalani, M Yashar S, Kanlikilicer, Pinar, Karaszti, Reka Agnes, Van Keuren-Jensen, Kendall, Khvorova, Anastasia, Kim, Yong, Kim, Hogyoung, Kim, Taek Kyun, Kitchen, Robert, Kraig, Richard P, Krichevsky, Anna M, Kwong, Raymond Y, Laurent, Louise C, Lee, Minyoung, L’Etoile, Noelle, Levy, Shawn E, Li, Feng, Li, Jenny, Li, Xin, Lopez-Berestein, Gabriel, Lucero, Rocco, Mateescu, Bogdan, Matin, AC, Max, Klaas EA, McManus, Michael T, Mempel, Thorsten R, Meyer, Cindy, Milosavljevic, Aleksandar, Mondal, Debasis, Mukamal, Kenneth Jay, Murillo, Oscar D, Muthukumar, Thangamani, Nickerson, Deborah A, O’Donnell, Christopher J, Patel, Dinshaw J, Patel, Tushar, Patton, James G, Paul, Anu, Peskind, Elaine R, Phelps, Mitch A, Putterman, Chaim, Quesenberry, Peter J, Quinn, Joseph F, Raffai, Robert L, and Ranabothu, Saritha

Subjects
Biological Sciences, Genetics, Biomarkers, Cell-Free Nucleic Acids, Extracellular Vesicles, Humans, Knowledge Bases, MicroRNAs, RNA, Extracellular RNA Communication Consortium, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data.

Published
2019

20. Cost-Minimization Analysis for Cardiac Revascularization in 12 Health Care Systems Based on the EuroCMR/SPINS Registries

Author

Moschetti, Karine, Kwong, Raymond Y., Petersen, Steffen E., Lombardi, Massimo, Garot, Jerome, Atar, Dan, Rademakers, Frank E., Sierra-Galan, Lilia M., Mavrogeni, Sophie, Li, Kuncheng, Fernandes, Juliano Lara, Schneider, Steffen, Pinget, Christophe, Ge, Yin, Antiochos, Panagiotis, Deluigi, Christina, Bruder, Oliver, Mahrholdt, Heiko, and Schwitter, Juerg

Published
2022
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21. Prognostic Value of Stress Cardiac Magnetic Resonance in Patients With Known Coronary Artery Disease

Author

Antiochos, Panagiotis, Ge, Yin, Heydari, Bobak, Steel, Kevin, Bingham, Scott, Abdullah, Shuaib M., Mikolich, J. Ronald, Arai, Andrew E., Bandettini, W. Patricia, Patel, Amit R., Farzaneh-Far, Afshin, Heitner, John F., Shenoy, Chetan, Leung, Steve W., Gonzalez, Jorge A., Shah, Dipan J., Raman, Subha V., Ferrari, Victor A., Schulz-Menger, Jeanette, Stuber, Matthias, Simonetti, Orlando P., and Kwong, Raymond Y.

Published
2022
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23. Predictors of Major Atrial Fibrillation Endpoints in the National Heart, Lung, and Blood Institute HCMR

Author

Kramer, Christopher M., DiMarco, John P., Kolm, Paul, Ho, Carolyn Y., Desai, Milind Y., Kwong, Raymond Y., Dolman, Sarahfaye F., Desvigne-Nickens, Patrice, Geller, Nancy, Kim, Dong-Yun, Maron, Martin S., Appelbaum, Evan, Jerosch-Herold, Michael, Friedrich, Matthias G., Schulz-Menger, Jeanette, Piechnik, Stefan K., Mahmod, Masliza, Jacoby, Daniel, White, James, Chiribiri, Amedeo, Helms, Adam, Choudhury, Lubna, Michels, Michelle, Bradlow, William, Salerno, Michael, Dawson, Dana K., Weinsaft, Jonathan W., Berry, Colin, Nagueh, Sherif F., Buccarelli-Ducci, Chiara, Owens, Anjali, Casadei, Barbara, Watkins, Hugh, Weintraub, William S., and Neubauer, Stefan

Published
2021
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24. Maximal Wall Thickness Measurement in Hypertrophic Cardiomyopathy: Biomarker Variability and its Impact on Clinical Care

Author

Captur, Gabriella, Manisty, Charlotte H., Raman, Betty, Marchi, Alberto, Wong, Timothy C., Ariga, Rina, Bhuva, Anish, Ormondroyd, Elizabeth, Lobascio, Ilaria, Camaioni, Claudia, Loizos, Savvas, Bonsu-Ofori, Jenade, Turer, Aslan, Zaha, Vlad G., Augutsto, João B., Davies, Rhodri H., Taylor, Andrew J., Nasis, Arthur, Al-Mallah, Mouaz H., Valentin, Sinitsyn, Perez de Arenaza, Diego, Patel, Vimal, Westwood, Mark, Petersen, Steffen E., Li, Chunming, Tang, Lijun, Nakamori, Shiro, Nezafat, Reza, Kwong, Raymond Y., Ho, Carolyn Y., Fraser, Alan G., Watkins, Hugh, Elliott, Perry M., Neubauer, Stefan, Lloyd, Guy, Olivotto, Iacopo, Nihoyannopoulos, Petros, and Moon, James C.

Published
2021
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25. Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study

Author

Wechalekar, Ashutosh, Antoni, Gunnar, Al Azzam, Wasfi, Bergström, Mats, Biswas, Swethajit, Chen, Chao, Cheriyan, Joseph, Cleveland, Matthew, Cookson, Louise, Galette, Paul, Janiczek, Robert L., Kwong, Raymond Y., Lukas, Mary Ann, Millns, Helen, Richards, Duncan, Schneider, Ian, Solomon, Scott D., Sörensen, Jens, Storey, James, Thompson, Douglas, van Dongen, Guus, Vugts, Danielle J., Wall, Anders, Wikström, Gerhard, and Falk, Rodney H.

Published
2022
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27. Society for Cardiovascular Magnetic Resonance (SCMR) guidelines for reporting cardiovascular magnetic resonance examinations

Author

Hundley, W. Gregory, Bluemke, David A., Bogaert, Jan, Flamm, Scott D., Fontana, Marianna, Friedrich, Matthias G., Grosse-Wortmann, Lars, Karamitsos, Theodoros D., Kramer, Christopher M., Kwong, Raymond Y., McConnell, Michael, Nagel, Eike, Neubauer, Stefan, Nijveldt, Robin, Pennell, Dudley J., Petersen, Steffen E., Raman, Subha V., and van Rossum, Albert

Published
2022
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28. Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease

Author

Pandya, Ankur, Yu, Yuan-Jui, Ge, Yin, Nagel, Eike, Kwong, Raymond Y., Bakar, Rafidah Abu, Grizzard, John D., Merkler, Alexander E., Ntusi, Ntobeko, Petersen, Steffen E., Rashedi, Nina, Schwitter, Juerg, Selvanayagam, Joseph B., White, James A., Carr, James, Raman, Subha V., Simonetti, Orlando P., Bucciarelli-Ducci, Chiara, Sierra-Galan, Lilia M., Ferrari, Victor A., Bhatia, Mona, and Kelle, Sebastian

Published
2022
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31. Prognostic Value of Stress CMR Perfusion Imaging in Patients With Reduced Left Ventricular Function

Author

Ge, Yin, Antiochos, Panagiotis, Steel, Kevin, Bingham, Scott, Abdullah, Shuaib, Chen, Yi-Yun, Mikolich, J Ronald, Arai, Andrew E., Bandettini, W. Patricia, Shanbhag, Sujata M., Patel, Amit R., Farzaneh-Far, Afshin, Heitner, John F., Shenoy, Chetan, Leung, Steve W., Gonzalez, Jorge A., Shah, Dipan J., Raman, Subha V., Ferrari, Victor A., Schulz-Menger, Jeanette, Stuber, Matthias, Simonetti, Orlando P., and Kwong, Raymond Y.

Published
2020
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34. Cost-Effectiveness Analysis of Stress Cardiovascular Magnetic Resonance Imaging for Stable Chest Pain Syndromes

Author

Ge, Yin, Pandya, Ankur, Steel, Kevin, Bingham, Scott, Jerosch-Herold, Michael, Chen, Yi-Yun, Mikolich, J. Ronald, Arai, Andrew E., Bandettini, W. Patricia, Patel, Amit R., Farzaneh-Far, Afshin, Heitner, John F., Shenoy, Chetan, Leung, Steve W., Gonzalez, Jorge A., Shah, Dipan J., Raman, Subha V., Ferrari, Victor A., Schulz-Menger, Jeanette, Hachamovitch, Rory, Stuber, Matthias, Simonetti, Orlando P., and Kwong, Raymond Y.

Published
2020
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39. Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy:SEQUOIA-HCM CMR Substudy

Author

Masri, Ahmad, Cardoso, Rhanderson N., Abraham, Theodore P., Claggett, Brian L., Coats, Caroline J., Hegde, Sheila M., Kulac, Ian J., Lee, Matthew M.Y., Maron, Martin S., Merkely, Bela, Michels, Michelle, Olivotto, Iacopo, Oreziak, Artur, Jacoby, Daniel L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Solomon, Scott D., Wohltman, Amy, Kwong, Raymond Y., Kramer, Christopher M., Masri, Ahmad, Cardoso, Rhanderson N., Abraham, Theodore P., Claggett, Brian L., Coats, Caroline J., Hegde, Sheila M., Kulac, Ian J., Lee, Matthew M.Y., Maron, Martin S., Merkely, Bela, Michels, Michelle, Olivotto, Iacopo, Oreziak, Artur, Jacoby, Daniel L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Solomon, Scott D., Wohltman, Amy, Kwong, Raymond Y., and Kramer, Christopher M.

Published
2024

40. Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease : Insights From the ISCHEMIA Trial

Author

Reynolds, Harmony R., Cyr, Derek D., Bairey Merz, C. Noel, Shaw, Leslee J., Chaitman, Bernard R., Boden, William E., Alexander, Karen P., Rosenberg, Yves D., Bangalore, Sripal, Stone, Gregg W., Held, Claes, Spertus, John, Goetschalckx, Kaatje, Bockeria, Olga, Newman, Jonathan D., Berger, Jeffrey S., Elghamaz, Ahmed, Lopes, Renato D., Min, James K., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Harrington, Robert A., Thomas, Boban, O'Brien, Sean M., Maron, David J., Hochman, Judith S., Reynolds, Harmony R., Cyr, Derek D., Bairey Merz, C. Noel, Shaw, Leslee J., Chaitman, Bernard R., Boden, William E., Alexander, Karen P., Rosenberg, Yves D., Bangalore, Sripal, Stone, Gregg W., Held, Claes, Spertus, John, Goetschalckx, Kaatje, Bockeria, Olga, Newman, Jonathan D., Berger, Jeffrey S., Elghamaz, Ahmed, Lopes, Renato D., Min, James K., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Harrington, Robert A., Thomas, Boban, O'Brien, Sean M., Maron, David J., and Hochman, Judith S.

Abstract

Background Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline‐directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on stress testing, with and without invasive management. Methods and Results The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial randomized patients with moderate or severe ischemia to invasive management with angiography, revascularization, and guideline‐directed medical therapy, or initial conservative management with guideline‐directed medical therapy alone. We evaluated the primary outcome (cardiovascular death, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest) and other end points, by sex, in 1168 (22.6%) women and 4011 (77.4%) men. Invasive group catheterization rates were similar, with less revascularization among women (73.4% of invasive‐assigned women revascularized versus 81.2% of invasive‐assigned men; P<0.001). Women had less coronary artery disease: multivessel in 60.0% of invasive‐assigned women and 74.8% of invasive‐assigned men, and no ≥50% stenosis in 12.3% versus 4.5% (P<0.001). In the conservative group, 4‐year catheterization rates were 26.3% of women versus 25.6% of men (P=0.72). Guideline‐directed medical therapy use was lower among women with fewer risk factor goals attained. There were no sex differences in the primary outcome (adjusted hazard ratio [HR] for women versus men, 0.93 [95% CI, 0.77–1.13]; P=0.47) or the major secondary outcome of cardiovascular death/myocardial infarction (adjusted HR, 0.93 [95% CI, 0.76–1.14]; P=0.49), with no significant sex‐by‐treatment‐group interactions. Conclusions Women had less extensive coronary artery disease and, therefore, lower revascularization rates in the invasive group. Despite lower risk

Published
2024
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41. Comparing CMR Mapping Methods and Myocardial Patterns Toward Heart Failure Outcomes in Nonischemic Dilated Cardiomyopathy

Author

Vita, Tomas, Gräni, Christoph, Abbasi, Siddique A., Neilan, Tomas G., Rowin, Ethan, Kaneko, Kyoichi, Coelho-Filho, Otavio, Watanabe, Eri, Mongeon, Francois-Pierre, Farhad, Hoshang, Rassi, Carlos Henrique, Choi, Yuna L., Cheng, Kathleen, Givertz, Michael M., Blankstein, Ron, Steigner, Michael, Aghayev, Ayaz, Jerosch-Herold, Michael, and Kwong, Raymond Y.

Published
2019
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45. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

Author

Abdel-Mageed, Asim B., Adamidi, Catherine, Adelson, P. David, Akat, Kemal M., Alsop, Eric, Ansel, K. Mark, Arango, Jorge, Aronin, Neil, Avsaroglu, Seda Kilinc, Azizian, Azadeh, Balaj, Leonora, Ben-Dov, Iddo Z., Bertram, Karl, Bitzer, Markus, Blelloch, Robert, Bogardus, Kimberly A., Breakefield, Xandra Owens, Calin, George A., Carter, Bob S., Charest, Al, Chen, Clark C., Chitnis, Tanuja, Coffey, Robert J., Courtright-Lim, Amanda, Das, Saumya, Datta, Amrita, DeHoff, Peter, Diacovo, Thomas G., Erle, David J., Etheridge, Alton, Ferrer, Marc, Franklin, Jeffrey L., Freedman, Jane E., Galas, David J., Galeev, Timur, Gandhi, Roopali, Garcia, Aitor, Gerstein, Mark Bender, Ghai, Vikas, Ghiran, Ionita Calin, Giraldez, Maria D., Goga, Andrei, Gogakos, Tasos, Goilav, Beatrice, Gould, Stephen J., Guo, Peixuan, Gupta, Mihir, Hochberg, Fred, Huang, Bo, Huentelman, Matt, Hunter, Craig, Hutchins, Elizabeth, Jackson, Andrew R., Kalani, M. Yashar S., Kanlikilicer, Pinar, Karaszti, Reka Agnes, Van Keuren-Jensen, Kendall, Khvorova, Anastasia, Kim, Yong, Kim, Hogyoung, Kim, Taek Kyun, Kitchen, Robert, Kraig, Richard P., Krichevsky, Anna M., Kwong, Raymond Y., Laurent, Louise C., Lee, Minyoung, L’Etoile, Noelle, Levy, Shawn E., Li, Feng, Li, Jenny, Li, Xin, Lopez-Berestein, Gabriel, Lucero, Rocco, Mateescu, Bogdan, Matin, A.C., Max, Klaas E.A., McManus, Michael T., Mempel, Thorsten R., Meyer, Cindy, Milosavljevic, Aleksandar, Mondal, Debasis, Mukamal, Kenneth Jay, Murillo, Oscar D., Muthukumar, Thangamani, Nickerson, Deborah A., O’Donnell, Christopher J., Patel, Dinshaw J., Patel, Tushar, Patton, James G., Paul, Anu, Peskind, Elaine R., Phelps, Mitch A., Putterman, Chaim, Quesenberry, Peter J., Quinn, Joseph F., Raffai, Robert L., Ranabothu, Saritha, Rao, Shannon Jiang, Rodriguez-Aguayo, Cristian, Rosenzweig, Anthony, Roth, Matthew E., Rozowsky, Joel, Sabatine, Marc S., Sakhanenko, Nikita A., Saugstad, Julie Anne, Schmittgen, Thomas D., Shah, Neethu, Shah, Ravi, Shedden, Kerby, Shi, Jian, Sood, Anil K., Sopeyin, Anuoluwapo, Spengler, Ryan M., Spetzler, Robert, Srinivasan, Srimeenakshi, Subramanian, Sai Lakshmi, Suthanthiran, Manikkam, Tanriverdi, Kahraman, Teng, Yun, Tewari, Muneesh, Thistlethwaite, William, Tuschl, Thomas, Urbanowicz, Karolina Kaczor, Vickers, Kasey C., Voinnet, Olivier, Wang, Kai, Weaver, Alissa M., Wei, Zhiyun, Weiner, Howard L., Weiss, Zachary R., Williams, Zev, Wong, David T.W., Woodruff, Prescott G., Xiao, Xinshu, Yan, Irene K., Yeri, Ashish, Zhang, Bing, Zhang, Huang-Ge, Breakefield, Xandra O., Charest, Alain, Gerstein, Mark B., and Saugstad, Julie A.

Published
2019
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46. Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial

Author

Reynolds, Harmony R., primary, Cyr, Derek D., additional, Merz, C. Noel Bairey, additional, Shaw, Leslee J., additional, Chaitman, Bernard R., additional, Boden, William E., additional, Alexander, Karen P., additional, Rosenberg, Yves D., additional, Bangalore, Sripal, additional, Stone, Gregg W., additional, Held, Claes, additional, Spertus, John, additional, Goetschalckx, Kaatje, additional, Bockeria, Olga, additional, Newman, Jonathan D., additional, Berger, Jeffrey S., additional, Elghamaz, Ahmed, additional, Lopes, Renato D., additional, Min, James K., additional, Berman, Daniel S., additional, Picard, Michael H., additional, Kwong, Raymond Y., additional, Harrington, Robert A., additional, Thomas, Boban, additional, O'Brien, Sean M., additional, Maron, David J., additional, Hochman, Judith S., additional, Mavromatis, Kreton, additional, Linefsky, Jason, additional, Miller, Todd, additional, Banerjee, Subhash, additional, Reynolds, Harmony R., additional, Donnino, Robert M., additional, Phillips, Lawrence M., additional, Saric, Muhamed, additional, Abdul‐Nour, Khaled, additional, Stone, Peter H., additional, Jang, James J., additional, Yee, Gennie, additional, Weitz, Steven, additional, Arnold, Suzanne, additional, O’Keefe, James Henry, additional, Shapiro, Michael D., additional, El‐Hajjar, Mohammad, additional, Sidhu, Mandeep S., additional, Fein, Steven A., additional, Torosoff, Mikhail T., additional, Lyubarova, Radmila, additional, Mookherjee, Sulagna, additional, Drzymalski, Krzysztof, additional, McFalls, Edward O., additional, Garcia, Santiago A., additional, Bertog, Stefan C., additional, Siddiqui, Rizwan A., additional, Ishani, Areef, additional, Hansen, Ronnell A., additional, Khouri, Michel Georges, additional, Goldberg, Jonathan L., additional, Goldweit, Richard, additional, Cohen, Ronny A., additional, Mirrer, Brooks, additional, Navarro, Victor, additional, Winchester, David E., additional, Kronenberg, Marvin, additional, Rogal, Philip, additional, McFarren, Christopher, additional, Heitner, John F., additional, Dauber, Ira M., additional, Cannan, Charles, additional, Sudarshan, Sriram, additional, Mehta, Puja K., additional, McDaniel, Michael, additional, Lerakis, Stamatios, additional, Quyyumi, Arshed, additional, Wenger, Nanette K., additional, Hedgepeth, Chester M., additional, Hurlburt, Heather, additional, Rosen, Alan, additional, Sahul, Zakir, additional, Booth, David, additional, Leung, Steve, additional, Abdel‐Latif, Ahmed, additional, Reda, Hassan, additional, Ziada, Khaled, additional, Setty, Sampoornima, additional, Barua, Rajat S., additional, Hage, Fadi, additional, Caldeira, Christiano, additional, Davies, James E., additional, Leesar, Massoud, additional, Heo, Jaekyeong, additional, Iskandrian, Amy, additional, Al Solaiman, Firas, additional, Singh, Satinder, additional, Dajani, Khaled, additional, Der Mesropian, Paul, additional, Sacco, Joseph, additional, McCandless, Brian, additional, Orgera, Marisa, additional, Arif, Imran, additional, Kerr, Hanan, additional, Trejo (Gutierrez), Jorge F., additional, Fletcher, Gerald, additional, Lane, Gary E., additional, Neeson, Lynn M., additional, Parikh, Pragnesh P., additional, Pollak, Peter M., additional, Shapiro, Brian P., additional, Landolfo, Kevin, additional, Gemignani, Anthony, additional, O’Rourke, Daniel, additional, Meadows, Judith L., additional, Call, Jason T., additional, Hannan, Joseph, additional, Bojar, Robert, additional, Kumar, Deepti, additional, Mukai, John, additional, Martin, Edward T., additional, Vorobiof, Gabriel, additional, Moorman, Alec, additional, Kinlay, Scott, additional, Hamburger, Robert J., additional, Rocco, Thomas P., additional, Bhatt, Deepak L., additional, Croce, Kevin, additional, Quin, Jacquelyn A., additional, Anumpa, Jati, additional, Zenati, Marco, additional, Faxon, David P., additional, Rayos, Glenn, additional, Seedhom, Ashraf, additional, Sullenberger, Lance, additional, Kumkumian, Gregory, additional, Sedlis, Steven P., additional, Donnino, Robert M., additional, Lorin, Jeffrey, additional, Tamis‐Holland, Jacqueline E., additional, Kornberg, Robert, additional, Leber, Robert, additional, Saba, Souheil, additional, Lee, Michael W., additional, Small, Delano R., additional, Nona, Wassim, additional, Alexander, Patrick B., additional, Rehman, Iram, additional, Badami, Umesh, additional, Marzo, Kevin, additional, Robbins, Inga H., additional, Levite, Howard A., additional, Shetty, Sanjay, additional, Patel, Mayuri, additional, Hamroff, Glenn S., additional, Little, Raymond W., additional, Zimbelman, Brandi D., additional, Lui, Charles Y., additional, Smith, Brigham R., additional, Vezina, Daniel P., additional, Khor, Lillian L., additional, Abraham, Josephine D., additional, Bull, David A., additional, McKellar, Stephen H., additional, Kotter, John, additional, Hu, Bob, additional, Labovitz, Arthur J., additional, Berlowitz, Michael, additional, Matar, Fadi, additional, Rodriguez, Fatima, additional, Schnittger, Ingela, additional, Fearon, William F., additional, Deedwania, Prakash, additional, Reddy, Kiran, additional, Sweeny, Joseph, additional, Spizzieri, Christopher, additional, Hochberg, Claudia P., additional, Salerno, William D., additional, Wyman, Ray, additional, Zarka, Amer, additional, Shah, Anil V., additional, Haldis, Thomas, additional, Kohn, Jeffrey A., additional, Girotra, Saket, additional, Almousalli, Omar, additional, Krishnam, Mayil S., additional, Milliken, Jeffrey C., additional, Patel, Pranav M., additional, Seto, Arnold H., additional, Harley, Kevin T., additional, Gibson, Michael A., additional, Allen, Byron J., additional, Coram, Rita, additional, Thomas, Sabu, additional, Schwartz, Ronald G., additional, Chen, Wei, additional, El Shahawy, Mahfouz, additional, Stafford, James, additional, Abernethy, William B., additional, Zurick, Andrew, additional, Meyer, Thomas M., additional, Morford, Ronald G., additional, Rutkin, Bruce, additional, Bokhari, Sabahat, additional, Sokol, Seth I., additional, Meisner, Jay, additional, Hamzeh, Ihab, additional, Misra, Arunima, additional, Wall, Matthew, additional, De Rosen, Veronica Lenges, additional, Alam, Mahboob, additional, Turner, Michael C., additional, Mulhearn, Thomas J., additional, Good, Arnold P., additional, Shammas, Nicolas W., additional, Chilton, Robert, additional, Nguyen, Patricia K., additional, Jezior, Matthew, additional, Gordon, Paul C., additional, Crain, Thomas, additional, Stenberg, Robert, additional, Pedalino, Ronald P., additional, Wiesel, Joseph, additional, Juang, George J., additional, Al‐Amoodi, Mohammed, additional, Wohns, David, additional, Lader, Ellis W., additional, Mumma, Michael, additional, Dharmarajan, Lekshmi, additional, McGarvey, Joseph F. X., additional, Downes, Thomas R., additional, Luckasen, Gary J., additional, Cheong, Benjamin, additional, Potluri, Srinivasa, additional, Mastouri, Ronald A., additional, Breall, Jeffery A., additional, Revtyak, George E., additional, Bazeley, Jonathan W., additional, Li, Dayuan, additional, Giedd, Kenneth, additional, Old, Wayne, additional, Burt, Francis, additional, Sokhon, Kozhaya, additional, Gopal, Deepika, additional, Valeti, Uma S., additional, Kobashigawa, Jon, additional, Govindan, Sajeev Chakanalil, additional, Nair, Rajesh Gopalan, additional, Manjunath, Cholenahally Nanjappa, additional, Moorthy, Nagaraja, additional, Manjunath, Satvic Cholenahally, additional, Narayanappa, Suryaprakash, additional, Pandit, Neeraj, additional, Nath, Ranjit Kumar, additional, Dwivedi, S. K., additional, Narain, V. S., additional, Chandra, Sharad, additional, Wander, Gurpreet S., additional, Tandon, Rohit, additional, Ralhan, Sarju, additional, Aslam, Naved, additional, Goyal, Abhishek, additional, Bhargava, Balram, additional, Karthikeyan, G., additional, Ramakrishnan, S., additional, Seth, Sandeep, additional, Yadav, Rakesh, additional, Singh, Sandeep, additional, Roy, Ambuj, additional, Parakh, Neeraj, additional, Verma, Sunil Kumar, additional, Narang, Rajiv, additional, Mishra, Sundeep, additional, Naik, Nitish, additional, Sharma, Gautam, additional, Choudhary, Shiv Kumar, additional, Patel, Chetan, additional, Gulati, Gurpreet, additional, Sharma, Sanjeev, additional, Bahl, V. K., additional, Mathew, Anoop, additional, Punnoose, Eapen, additional, Gadkari, Milind Avdhoot, additional, Gadage, Siddharth, additional, Pillay, Tapan Umesh, additional, Satheesh, Santhosh, additional, Mathur, Atul, additional, Kaul, Upendra, additional, Christopher, Johann, additional, Menon, Rajeev, additional, Kumar, Nirmal, additional, Oomman, Abraham, additional, Mao, Robert, additional, Solomon, Hilda, additional, Naik, Sudhir, additional, Khan, Sajeeda Parveen, additional, Grant, Purvez, additional, Kachru, Ranjan, additional, Ajit Kumar, V. K., additional, Ganapathi, Sanjay, additional, Jayakumar, K., additional, Sivadasanpillai, Harikrishnan, additional, Sasidharan, Bijulal, additional, Kapilamoorthy, T. R., additional, Polamuri, Praneeth, additional, Senior, Roxy, additional, Gurunathan, Sothinathan, additional, Karogiannis, Nikolaos, additional, Shah, Benoy N., additional, Trimlett, Richard HJ, additional, Rubens, Michael B., additional, Nicol, Edward D., additional, Mittal, Tarun K., additional, Hampson, Reinette, additional, Gamma, Reto Andreas, additional, de Belder, Mark A., additional, Thambyrajah, Jeet, additional, Nageh, Thuraia, additional, Davies, John R., additional, Lindsay, Steven J., additional, Kurian, John, additional, Jamil, Haqeel, additional, Raheem, Osama, additional, Hoye, Angela, additional, Donnelly, Patrick, additional, Valecka, Bernardas, additional, Chauhan, Anoop, additional, Barr, Craig, additional, Alfakih, Khaled, additional, Byrne, Jonathan, additional, Webb, Ian, additional, Henriksen, Peter, additional, OKane, Peter, additional, de Silva, Ramesh, additional, Conway, Dwayne S. G., additional, Sirker, Alexander A, additional, Hoole, Stephen P., additional, Witherow, Fraser N., additional, Johnston, Nicola, additional, Harbinson, Mark, additional, Walsh, Simon, additional, Douglas, Hanna, additional, Luckie, Matthew, additional, Sobolewska, Jolanta, additional, Jeetley, Paramjit, additional, Patel, Niket, additional, Kotecha, Tushar, additional, Travill, Christopher, additional, Karimullah, Iqbal, additional, Al‐Bustami, Mahmud, additional, Braganza, Denise, additional, Henderson, Robert, additional, Pointon, Kate, additional, Naik, Surendra, additional, Mathew, Thomas, additional, Berry, Colin, additional, Collison, Damien, additional, Roditi, Giles, additional, Moriarty, Andrew J., additional, Glover, Jason D., additional, Pradhan, Jiwan, additional, Mikhail, Ghada, additional, Francis, Darrel P., additional, Gosselin, Gilbert, additional, Diaz, Ariel, additional, Rheault, Philippe, additional, Barrero, Miguel, additional, Gagné, Carl‐Éric, additional, Pépin‐Dubois, Yanek, additional, Costa, Ricardo, additional, Sia, Ying Tung, additional, Lemay, Catherine, additional, Gisbert, Alejandro, additional, Gervais, Pierre, additional, Rheault, Alain, additional, Phaneuf, Denis Carl, additional, Garg, Pallav, additional, Chow, Benjamin J. W., additional, Hessian, Renee C., additional, Beanlands, Rob S., additional, Davies, Richard F., additional, Bainey, Kevin R., additional, Cheema, Asim N., additional, Bagai, Akshay, additional, Wald, Ron, additional, Goodman, Shaun, additional, Graham, John Joseph, additional, Peterson, Mark, additional, Chow, Chi‐Ming, additional, Abramson, Beth, additional, Cheema, Asim Nazir, additional, Vakani, Mohammad Tariq, additional, Cha, James, additional, Howarth, Andrew G, additional, Wong, Graham, additional, Uxa, Amar, additional, Galiwango, Paul, additional, Kassam, Saleem, additional, Mukherjee, Ashok, additional, Ricci, A. Joseph, additional, Lam, Andy, additional, Mehta, Shamir, additional, Udell, Jacob, additional, Généreux, Philippe, additional, Hameed, Adnan, additional, Daba, Ledjalem, additional, Hueb, Whady, additional, Rezende, Paulo Cury, additional, Silva, Expedito Eustáquio Ribeiro, additional, Hueb, Alexandre Ciappina, additional, Smanio, Paola Emanuela Poggio, additional, de Quadros, Alexandre Schaan, additional, Kalil, Renato Abdala Karam, additional, da Costa Vieira, José Luiz, additional, Grossmann, Gabriel, additional, de Oliveira, Pedro Píccaro, additional, Bridi, Leonardo, additional, Savaris, Simone, additional, Vitola, João V., additional, Cerci, Rodrigo J., additional, Farias, Fabio R., additional, Fernandes, Miguel M., additional, Marin‐Neto, José Antonio, additional, Schmidt, André, additional, de Oliveira Lima Filho, Moysés, additional, Oliveira, Ricardo Mendes, additional, Chierice, João Reynaldo Abbud, additional, Polanczyk, Carísi A., additional, Furtado, Mariana V., additional, Smidt, Luis F., additional, Carvalho, Antonio Carlos, additional, Pucci, Gustavo, additional, Lyra, Flavio, additional, Junior, Alvaro Rabelo Alves, additional, Dracoulakis, Marianna D. A., additional, Lima, Rodolfo G. S. D, additional, Figueiredo, Estevao, additional, Caramori, Paulo Ricardo, additional, Tumelero, Rogerio, additional, Dall’Orto, Frederico, additional, Mesquita, Claudio T., additional, Colafranseschi, Alexandre S., additional, Oliveira, Amarino C., additional, Carvalho, Luiz A., additional, Palazzo, Isabella C., additional, Sousa, Andre S., additional, da Silva, Expedito Eustáquio Ribeiro, additional, de Barros, Pedro Gabriel Melo, additional, de Pádua Silva Baptista, Luciana, additional, Rodrigues, Marcelo Jamus, additional, de Resende, Marcos Valério Coimbra, additional, Saraiva, Jose Francisco, additional, Costantini, Costantino, additional, Demkow, Marcin, additional, Pracon, Radoslaw, additional, Kepka, Cezary, additional, Teresinska, Anna, additional, Kryczka, Karolina, additional, Henzel, Jan, additional, Solecki, Mateusz, additional, Kaczmarska, Edyta, additional, Mazurek, Tomasz, additional, Drozdz, Jaroslaw, additional, Czarniak, Bartosz, additional, Frach, Malgorzata, additional, Szymczyk, Konrad, additional, Niedzwiecka, Iwona, additional, Sobczak, Sebastian, additional, Ciurus, Tomasz, additional, Jakubowski, Piotr, additional, Misztal‐Teodorczyk, Magdalena, additional, Teodorczyk, Dawid, additional, Fratczak, Aleksandra, additional, Szkopiak, Marcin, additional, Lebioda, Patrycja, additional, Wlodarczyk, Michal, additional, Plachcinska, Anna, additional, Kusmierek, Jacek, additional, Miller, Magdalena, additional, Marciniak, Halina, additional, Wojtczak‐Soska, Karolina, additional, Luczak, Katarzyna, additional, Tarchalski, Tomasz, additional, Cichocka‐Radwan, Anna, additional, Szwed, Hanna, additional, Szulczyk, Grazyna Anna, additional, Witkowski, Adam, additional, Kukula, Krzysztof, additional, Celinska‐Spodar, Malgorzta, additional, Zalewska, Joanna, additional, Gajos, Grzegorz, additional, Bury, Krzysztof, additional, Pruszczyk, Piotr, additional, Roik, Marek, additional, Loboz‐Grudzien, Krystyna, additional, Sokalski, Leszek, additional, Brzezinska, Barbara, additional, Lesiak, Maciej, additional, Lanocha, Magdalena, additional, Reczuch, Krzysztof W., additional, Kalarus, Zbigniew, additional, Swiatkowski, Andrzej, additional, Szulik, Mariola, additional, Musial, Wlodzimierz J., additional, Bockeria, Leo, additional, Petrosyan, Karen, additional, Trifonova, Tatiana, additional, Chernyavskiy, Alexander M., additional, Kretov, Evgeniy I., additional, Grazhdankin, Igor O., additional, Bershtein, Leonid L., additional, Sayganov, Sergey A., additional, Kuzmina‐Krutetskaya, Anastasia M., additional, Zbyshevskaya, Elizaveta V., additional, Katamadze, Nana O., additional, Demchenko, Elena A., additional, Kozlov, Pavel S., additional, Kozulin, Vikentiy Y., additional, Lubinskaya, Ekaterina I., additional, Lopez‐Sendon, Jose, additional, Castro, Almudena, additional, Salicio, Elena Refoyo, additional, Guzman, Gabriela, additional, Galeote, Gabriel, additional, Valbuena, Silvia, additional, Peteiro, Jesús, additional, Martínez‐Ruíz, María Dolores, additional, Pérez‐Fernández, Ruth, additional, Cuenca‐Castillo, José J., additional, Flores‐Ríos, Xacobe, additional, Prada‐Delgado, Óscar, additional, Barge‐Caballero, Gonzalo, additional, Juanatey, Jose Ramon Gonzalez, additional, Bayarri, Miguel Souto, additional, Nuñez, Virginia Pubull, additional, Sanchez, Raymundo Ocaranza, additional, Alvarez, Belen Cid, additional, Gil, Carlos Peña, additional, Monzonis, Amparo Martinez, additional, Sionis, Alessandro, additional, Perales, Montserrat Vila, additional, Padró, Josep Maria, additional, Peñaranda, Antonio Serra, additional, Picart, Joan García, additional, Iglesias, Antonino Ginel, additional, Marimon, Xavier Garcia‐Moll, additional, Lladó, Guillem Pons, additional, Costa, Francesc Carreras, additional, Miro, Vicente, additional, Diez, Jose L., additional, Calvillo, Pilar, additional, Ortuño, F. Marin, additional, Chávarri, M. Valdés, additional, Montolliu, A. Tello, additional, Bermudez, E. Pinar, additional, De La Morena, G., additional, Blancas, Montserrat Gracida, additional, Luena, Jose Enrique Castillo, additional, Fernandez‐Aviles, Francisco, additional, Chen, Jiyan, additional, Wu, Yongjian, additional, Ma, Yitong, additional, Yang, Yining, additional, Ji, Zheng, additional, Yang, Xinchun, additional, Lin, Wenhua, additional, Zeng, Hesong, additional, Fu, Xin, additional, Yang, Bin, additional, Wang, Songtao, additional, Cheng, Gong, additional, Zhao, Yulan, additional, Fang, Xuehua, additional, Zeng, Qiutang, additional, Su, Xi, additional, Li, Qingxian, additional, Nie, Shao‐ping, additional, Yu, Qin, additional, Wang, Jian’an, additional, Zhang, Shuyang, additional, Liu, Zhenyu, additional, Perna, Gian Piero, additional, Marini, Marco, additional, Gabrielli, Gabriele, additional, Provasoli, Stefano, additional, Verna, Edoardo, additional, Monti, Lorenzo, additional, Nardi, Barbara, additional, Di Chiara, Antonio, additional, Mortara, Andrea, additional, Galvani, Marcello, additional, Ottani, Filippo, additional, Sicuro, Marco, additional, Calabro, Paolo, additional, Formisano, Tiziana, additional, Tarantini, Giuseppe, additional, Cucchini, Umberto, additional, Andres, Anto Luigi, additional, Racca, Emanuela, additional, Briguori, Carlo, additional, Amati, Roberto, additional, Vergoni, William, additional, Russo, Aldo, additional, Fanelli, Raffaele, additional, Poh, Kian‐Keong, additional, Chai, Ping, additional, Lau, Titus, additional, Loh, Joshua P., additional, Tay, Edgar L., additional, Teoh, Kristine, additional, Teo, Lynette L., additional, Ong, Ching‐Ching, additional, Wong, Raymond C., additional, Loh, Poay‐Huan, additional, Kofidis, Theodoros, additional, Chan, Wan Xian, additional, Chan, Koo Hui, additional, Foo, David, additional, Kong, Jason Loh Kwok, additional, Er, Ching Min, additional, Jafary, Fahim Haider, additional, Chua, Terrance, additional, Doerr, Rolf, additional, Stumpf, Juergen, additional, Matschke, Klaus, additional, Simonis, Gregor, additional, Kadalie, Clemens T., additional, Sechtem, Udo, additional, Ong, Peter, additional, Schulze, P. Christian, additional, Goebel, Bjoern, additional, Lenk, Karsten, additional, Nickenig, Georg, additional, Schuchlenz, Herwig, additional, Weikl, Stefan, additional, Lang, Irene Marthe, additional, Huber, Kurt, additional, Jakl‐Kotauschek, Gabriele, additional, Vertes, Andras, additional, Varga, Albert, additional, Fontos, Geza, additional, Merkely, Bela, additional, Kerecsen, Gabor, additional, Hinic, Sasa, additional, Zdravkovic, Marija, additional, Mudrenovic, Vladan, additional, Crnokrak, Bogdan, additional, Beleslin, Branko D., additional, Boskovic, Nikola N., additional, Petrovic, Marija T., additional, Dobric, Milan R., additional, Markovic, Zeljko Z., additional, Mladenovic, Ana S., additional, Cemerlic‐Adjic, Nada, additional, Davidovic, Goran, additional, Vucic, Rada, additional, Dekleva, Milica Nikola, additional, Stankovic, Goran, additional, Apostolovic, Svetlana, additional, Escobedo, Jorge, additional, Baleón‐Espinosa, Rubén, additional, Campos‐Santaolalla, Arturo S., additional, Durán‐Cortés, Elihú, additional, Flores‐Palacios, José M., additional, García‐Rincón, Andrés, additional, Jiménez‐Santos, Moisés, additional, Peñafiel, Joaquín V., additional, Ortega‐Ramírez, José A., additional, Valdespino‐Estrada, Aquiles, additional, Rosas, Erick Alexánderson, additional, Selvanayagam, Joseph B., additional, Joseph, Majo X., additional, Thambar, Suku T., additional, Beltrame, John F., additional, Hillis, Graham S., additional, Thuaire, Christophe, additional, Dutoiu, Téodora, additional, Steg, Philippe Gabriel, additional, Juliard, Jean‐Michel, additional, Slama, Michel S., additional, El Mahmoud, Rami, additional, Nicollet, Eric, additional, Goube, Pascal, additional, Barone‐Rochette, Gilles, additional, Furber, Alain, additional, Bière, Loïc, additional, Laucevicius, Aleksandras, additional, Celutkiene, Jelena, additional, Kedhi, Elvin, additional, Timmer, Jorik, additional, Hermanides, Rik, additional, Kaplan, Eliza, additional, Riezebos, Robert K., additional, Samadi, Pouneh, additional, van Dongen, Elise, additional, Niehe, Sander R., additional, Suryapranata, Harry, additional, van Vugt, Stijn, additional, Ramos, Ruben, additional, Cacela, Duarte, additional, Santana, Ana, additional, Fiarresga, Antonio, additional, Sousa, Lidia, additional, Marques, Hugo, additional, Patricio, Lino, additional, Bernanrdes, Luis, additional, Rio, Pedro, additional, Carvalho, Ramiro, additional, Ferreira, Rui, additional, Silva, Tiago, additional, Rodrigues, Ines, additional, Modas, Pedro, additional, Portugal, Guilherme, additional, Fragata, Jose, additional, Pinto, Fausto J., additional, Menezes, Miguel Nobre, additional, Lopes, Guilhermina Cantinho, additional, Almeida, Ana Gomes, additional, Silva, Pedro Canas, additional, Nobre, Angelo, additional, Francisco, Ana Rita, additional, Ferreira, Nuno, additional, Lopes, Ricardo L., additional, Guzman, Luis, additional, Figal, Julio César, additional, Méndiz, Oscar, additional, Cortés, Claudia, additional, Favaloro, Roberto René, additional, Alvarez, Carlos, additional, Courtis, Javier, additional, Zeballos, Gabriela, additional, Schiavi, Lilia, additional, Rubio, Mariano, additional, Devlin, Gerard Patrick, additional, Fisher, Raewyn, additional, Stewart, Ralph Alan Huston, additional, White, Harvey Douglas, additional, Benatar, Jocelyne, additional, Kedev, Sasko, additional, Mitevska, Irena Peovska, additional, Kostovska, Elizabeta Srbinovska, additional, Pejkov, Hristo, additional, Eggers, Kai, additional, Frostfelt, Gunnar, additional, Johnston, Nina, additional, Olsowka, Maciej, additional, Åkerblom, Axel, additional, Soveri, Inga, additional, Aspberg, Johannes, additional, Sharir, Tali, additional, Elian, Dan, additional, Kerner, Arthur, additional, Massalha, Samia, additional, Fukuda, Keiichi, additional, Kohsaka, Shun, additional, Yasuda, Satoshi, additional, Nishimura, Shigeyuki, additional, Van de Werf, Frans, additional, Claes, Kathleen, additional, Hung, Chung‐Lieh, additional, Yun, Chun‐Ho, additional, Hou, Charles Jia‐Yin, additional, Kuo, Jen‐Yuan, additional, Yeh, Hung‐I, additional, Hung, Ta‐Chuan, additional, Li, Jiun‐Yi, additional, Chien, Chen‐Yen, additional, Tsai, Cheng‐Ting, additional, Liu, Chun‐Chieh, additional, Yu, Fa‐Chang, additional, Lin, Yueh‐Hung, additional, Lan, Wei‐Ren, additional, Yen, Chih‐Hsuan, additional, Tsai, Jui‐Peng, additional, Sung, Kuo‐Tzu, additional, Ntsekhe, Mpiko, additional, Pandie, Shaheen, additional, Viljoen, Charle A., additional, De Andrade, Marianne, additional, Moccetti, Tiziano, additional, Rossi, M. Grazia, additional, Abdelhamid, Magdy, additional, Adel, Ahmed, additional, Kamal, Ahmed, additional, Mahrous, Hossam, additional, El Kaffas, Sameh, additional, El Fishawy, Hussien, additional, Pop, Calin, additional, Claudia, Matei, additional, Popescu, Bogdan A., additional, Ginghina, Carmen, additional, Deleanu, Dan, additional, Iliescu, Vlad A., additional, Al‐Mallah, Mouaz H., additional, Aljzeeri, Ahmed, additional, Najm, Hani, additional, Alghamdi, Ali, additional, Ramos, Walter Enrique Mogrovejo, additional, Kuanprasert, Srun, additional, Prommintikul, Arintaya, additional, Nawarawong, Weerachai, additional, Woragidpoonpol, Surin, additional, Tepsuwan, Thitipong, additional, Taksaudom, Noppon, additional, Rimsukcharoenchai, Chataroon, additional, Euathrongchit, Juntima, additional, Wannasopha, Yutthaphan, additional, Yamwong, Sukit, additional, Sritara, Piyamitr, additional, Aramcharoen, Suthara, additional, Meemuk, Krissada, additional, Khairuddin, Ahmad, additional, Hadi, Hafidz Abd, additional, and Yahaya, Shaiful Azmi, additional

Published
2024
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47. Quantification of Right Ventricular Amyloid Burden with 18F-florbetapir PET/CT and its Association with Right Ventricular Dysfunction and Outcomes in Light-Chain Amyloidosis

Author

Datar, Yesh, primary, Clerc, Olivier F, additional, Cuddy, Sarah A M, additional, Kim, Sirwoo, additional, Taylor, Alexandra, additional, Neri, Jocelyn Canseco, additional, Benz, Dominik C, additional, Bianchi, Giada, additional, Yee, Andrew J, additional, Sanchorawala, Vaishali, additional, Ruberg, Frederick L, additional, Landau, Heather, additional, Liao, Ronglih, additional, Kijewski, Marie Foley, additional, Jerosch-Herold, Michael, additional, Kwong, Raymond Y, additional, Di Carli, Marcelo F, additional, Falk, Rodney H, additional, and Dorbala, Sharmila, additional

Published
2024
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48. Visceral Adiposity and the Risk of Metabolic Syndrome Across Body Mass Index The MESA Study

Author

Shah, Ravi V, Murthy, Venkatesh L, Abbasi, Siddique A, Blankstein, Ron, Kwong, Raymond Y, Goldfine, Allison B, Jerosch-Herold, Michael, Lima, João AC, Ding, Jingzhong, and Allison, Matthew A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Aging, Prevention, Clinical Research, Heart Disease, Cardiovascular, Obesity, Biomedical Imaging, Nutrition, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Metabolic and endocrine, Cancer, Adiposity, Aged, Biomarkers, Blood Glucose, Blood Pressure, Body Mass Index, Chi-Square Distribution, Humans, Incidence, Intra-Abdominal Fat, Lipids, Male, Metabolic Syndrome, Middle Aged, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Risk Assessment, Risk Factors, Tomography, X-Ray Computed, United States, cardiometabolic risk, metabolic syndrome, obesity, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThis study sought to evaluate differential effects of visceral fat (VF) and subcutaneous fat and their effects on metabolic syndrome (MetS) risk across body mass index (BMI) categories.BackgroundThe regional distribution of adipose tissue is an emerging risk factor for cardiometabolic disease, although serial changes in fat distribution have not been extensively investigated. VF and its alterations over time may be a better marker for risk than BMI in normal weight and overweight or obese individuals.MethodsWe studied 1,511 individuals in the MESA (Multi-Ethnic Study of Atherosclerosis) with adiposity assessment by computed tomography (CT). A total of 253 participants without MetS at initial scan underwent repeat CT (median interval 3.3 years). We used discrete Cox regression with net reclassification to investigate whether baseline and changes in VF area are associated with MetS.ResultsHigher VF was associated with cardiometabolic risk and coronary artery calcification, regardless of BMI. After adjustment, VF was more strongly associated with incident MetS than subcutaneous fat regardless of weight, with a 28% greater MetS hazard per 100 cm(2)/m VF area and significant net reclassification (net reclassification index: 0.44, 95% confidence interval [CI]: 0.29 to 0.60) over clinical risk. In individuals with serial imaging, initial VF (hazard ratio: 1.24 per 100 cm(2)/m, 95% CI: 1.08 to 1.44 per 100 cm(2)/m, p = 0.003) and change in VF (hazard ratio: 1.05 per 5% change, 95% CI: 1.01 to 1.08 per 5% change, p = 0.02) were associated with MetS after adjustment. Changes in subcutaneous fat were not associated with incident MetS after adjustment for clinical risk and VF area.ConclusionsVF is modestly associated with BMI. However, across BMI, a single measure of and longitudinal change in VF predict MetS, even accounting for weight changes. Visceral adiposity is essential to assessing cardiometabolic risk, regardless of age, race, or BMI, and may serve as a marker and target of therapy in cardiometabolic disease.

Published
2014

49. T1 Measurements for Detection of Expansion of the Myocardial Extracellular Volume in Chronic Obstructive Pulmonary Disease

Author

Neilan, Tomas G, Bakker, Jessie P, Sharma, Bhavneesh, Owens, Robert L, Farhad, Hoshang, Shah, Ravi V, Abbasi, Siddique A, Kohli, Puja, Wilson, Joel, DeMaria, Anthony, Jerosch-Herold, Michael, Kwong, Raymond Y, and Malhotra, Atul

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lung, Women's Health, Chronic Obstructive Pulmonary Disease, Clinical Research, Heart Disease, Cardiovascular, 4.2 Evaluation of markers and technologies, 6.1 Pharmaceuticals, Respiratory, Aged, Cardiovascular Diseases, Exercise Test, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Prognosis, Pulmonary Disease, Chronic Obstructive, Retrospective Studies, Ventricular Function, Left, Ventricular Remodeling, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundWe aimed to assess whether chronic obstructive pulmonary disease (COPD) is associated with expansion of the myocardial extracellular volume (ECV) using T1 measurements.MethodsAdult COPD patients Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 2 or higher and free of known cardiovascular disease were recruited. All study patients underwent measures of pulmonary function, 6-minute walk test, serum measures of inflammation, overnight polysomnography, and a contrast cardiac magnetic resonance study.ResultsEight patients with COPD were compared with 8 healthy control subjects. The mean predicted forced expiratory volume at 1 second of COPD subjects was 68%. Compared with control subjects, patients had normal left ventricular (LV) and right ventricular size, mass, and function. However, compared with control subjects, the LV remodelling index (median, 0.87; interquartile range [IQR], 0.71-1.14; vs median, 0.62; IQR, 0.60-0.77; P ¼ 0.03) and active left atrial emptying fraction was increased (median, 46; IQR, 41-49; vs median, 38; IQR, 33-43; P ¼ 0.005), and passive left atrial emptying fraction was reduced (median, 24; IQR, 20-30; vs median, 44; IQR, 31-51; P ¼ 0.007). The ECV was increased in patients with COPD (median, 0.32; IQR, 0.05; vs median, 0.27; IQR, 0.05; P = 0.001). The ECV showed a strong positive association with LV remodelling (r = 0.72; P = 0.04) and an inverse association with the 6-minute walk duration (r = -0.79; P = 0.02) and passive left atrial emptying fraction (r = -0.68; P = 0.003).ConclusionsExpansion of the ECV, suggestive of diffuse myocardial fibrosis, is present in COPD and is associated with LV remodelling, and reduced left atrial function and exercise capacity.

Published
2014

50. Obesity and sleep apnea are independently associated with adverse left ventricular remodeling and clinical outcome in patients with atrial fibrillation and preserved ventricular function

Author

Shah, Ravi V, Abbasi, Siddique A, Heydari, Bobak, Farhad, Hoshang, Dodson, John A, Bakker, Jessie P, John, Roy M, Veves, Aristidis, Malhotra, Atul, Blankstein, Ron, Jerosch-Herold, Michael, Kwong, Raymond Y, and Neilan, Tomas G

Subjects
Biomedical and Clinical Sciences, Medical Physiology, Cardiovascular Medicine and Haematology, Lung, Sleep Research, Obesity, Aging, Cardiovascular, Heart Disease, 6.1 Pharmaceuticals, Aged, Atrial Fibrillation, Body Mass Index, Disease Progression, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Prevalence, Prognosis, Retrospective Studies, Sleep Apnea Syndromes, Time Factors, Ventricular Function, Left, Ventricular Remodeling, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

AimsObesity is associated with the development of atrial fibrillation (AF), and both obesity and AF are independently associated with the development of heart failure with preserved ejection fraction. We tested the hypothesis that sleep apnea (SA) would have a body mass index (BMI) independent association with adverse left ventricular (LV) remodeling and clinical outcomes in patients with AF and preserved LV function.Methods and resultsFrom 720 consecutive patients with AF, 403 patients without myocardial disease (preserved LV function) were identified and followed up for 3.3 ± 1.5 years. The primary outcome was a combination of all-cause mortality/heart failure hospitalization. Left ventricular mass and LV mass-to-volume ratio were higher in patients with SA and obesity (P < .0001 for all). Body mass index (β per log = .47; P < .0001) and SA (β = .05; P = .045) were independently associated with LV mass index. Patients with treated SA had a lower LV mass index (but not LV mass-to-volume ratio) compared with untreated (P = .002). In a best overall multivariable model, SA therapy (β = -.129; P = .001) and BMI (β per log = .373; P = .0007) had opposing associations with LV mass index. Sleep apnea (hazard ratio [HR] = 2.94; P = .0004) and BMI (HR per 1 kg/m(2) = 1.08; P = .004) were associated with clinical outcome in unadjusted analysis. Only SA was associated with clinical outcome in a best overall multivariable model (HR = 2.14; P = .02).ConclusionSleep apnea and obesity are independently associated with adverse LV remodeling and clinical outcomes in patients with preserved LV function, whereas continuous positive airway pressure therapy is associated with a beneficial effect on LV remodeling. Research investigating SA therapies in patients at high risk for LV remodeling and heart failure is warranted.

Published
2014

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