15 results on '"López-Ortiz S"'
Search Results
2. Forage Availability and Body Condition Affect Intake of Lupine (Lupinus leucophyllus) by Grazing Cattle
- Author
-
Lopez-Ortiz, S., Pfister, J.A., Launchbaugh, K.L., and Gay, C.C.
- Published
- 2007
- Full Text
- View/download PDF
3. The pH Effect on the Growth of Hexagonal and Monoclinic Hydroxyapatite Synthesized by the Hydrothermal Method
- Author
-
López-Ortiz, S., primary, Mendoza-Anaya, D., additional, Sánchez-Campos, D., additional, Fernandez-García, M. E., additional, Salinas-Rodríguez, E., additional, Reyes-Valderrama, M. I., additional, and Rodríguez-Lugo, V., additional
- Published
- 2020
- Full Text
- View/download PDF
4. Tasa de ovulación sincronizada con PGF2α y dinámica folicular en vacas criollo lechero tropical
- Author
-
Guerrero, H.L.J., Pérez-Hernández, P., López-Ortiz, S., Montiel Palacios, F., Estrella-García, A., and Ahuja Aguirre, C.
- Subjects
Ovulation ,Ciclo estrual ,Estrous cycle ,Ovulación - Abstract
Se sincronizó el estro en 36 vacas Criollo Lechero Tropical (CLT) cíclicas y lactantes utilizando PGF2α y se determinó el momento de inicio y final del estro, y el tiempo (TO) y tasa de ovulación (TAO). Posteriormente, durante el ciclo estrual natural siguiente al sincronizado se determinó la dinámica folicular (DF) y la duración del ciclo (DC). El TO después del final del estro sincronizado fue 16,5±3,6 h y la TAO 100%. En el ciclo estrual natural, 93% de vacas presentó tres ondas foliculares y 7% dos ondas, y la DC fue 22 y 19 días, respectivamente. Las vacas CLT mostraron buena respuesta a la sincronización con PGF2α, y la DF y DC fueron similares a otras razas Bos taurus productoras de carne y lecheras. Estrus was synchronized in 36 cyclic and lactating Criollo Lechero Tropical (CLT) cows using PGF2α, and the time of start and end of estrus, time of ovulation (TO) and ovulation rate (TAO) were recorded. Also, the follicular dynamics (DF) and the duration of estrus (DC) were determined during the natural estrous cycle that followed the synchronized one. The TO following the end of the synchronized estrus was 16.5±3.6 h and TAO was 100%. In the natural estrous cycle, 93% of the cows showed three follicular waves and 7% showed two waves, and DC was 22 and 19 days, respectively. The CLT cows showed good response to synchronization with PGF2α, and the DF and DC were similar to other dairy and beef Bos taurus breeds.
- Published
- 2011
5. Tasa de ovulación sincronizada con PGF2A y dinámica folicular en vacas criollo lechero tropical
- Author
-
Guerrero, H.L.J, Pérez-Hernández, P., López-Ortiz, S, Montiel Palacios, F., Estrella-García, A., Ahuja Aguirre, C., Guerrero, H.L.J, Pérez-Hernández, P., López-Ortiz, S, Montiel Palacios, F., Estrella-García, A., and Ahuja Aguirre, C.
- Abstract
Estrus was synchronized in 36 cyclic and lactating Criollo Lechero Tropical (CLT) cows using PGF2a, and the time of start and end of estrus, time of ovulation (TO) and ovulation rate (TAO) were recorded. Also, the follicular dynamics (DF) and the duration of estrus (DC) were determined during the natural estrous cycle that followed the synchronized one. The TO following the end of the synchronized estrus was 16.5±3.6 h and TAO was 100%. In the natural estrous cycle, 93% of the cows showed three follicular waves and 7% showed two waves, and DC was 22 and 19 days, respectively. The CLT cows showed good response to synchronization with PGF2a, and the DF and DC were similar to other dairy and beef Bos taurus breeds., Se sincronizó el estro en 36 vacas Criollo Lechero Tropical (CLT) cíclicas y lactantes utilizando PGF2a y se determinó el momento de inicio y final del estro, y el tiempo (TO) y tasa de ovulación (TAO). Posteriormente, durante el ciclo estrual natural siguiente al sincronizado se determinó la dinámica folicular (DF) y la duración del ciclo (DC). El TO después del final del estro sincronizado fue 16,5±3,6 h y la TAO 100%. En el ciclo estrual natural, 93% de vacas presentó tres ondas foliculares y 7% dos ondas, y la DC fue 22 y 19 días, respectivamente. Las vacas CLT mostraron buena respuesta a la sincronización con PGF2a, y la DF y DC fueron similares a otras razas Bos taurus productoras de carne y lecheras.
- Published
- 2011
6. Tasa de ovulación sincronizada con PGF2α y dinámica folicular en vacas criollo lechero tropical
- Author
-
Guerrero, H.L.J., primary, Pérez-Hernández, P., additional, López-Ortiz, S., additional, Montiel Palacios, F., additional, Estrella-García, A., additional, and Ahuja Aguirre, C., additional
- Published
- 2011
- Full Text
- View/download PDF
7. Sincronización del estro con PGF2a y conducta estrual en vacas Criollo Lechero Tropical
- Author
-
Guerrero, H.L.J., primary, Pérez-Hernández, P., additional, López-Ortiz, S., additional, Montiel Palacios, F., additional, Estrella-García, A., additional, and Ahuja Aguirre, C., additional
- Published
- 2011
- Full Text
- View/download PDF
8. Tasa de ovulación sincronizada con PGF2A y dinámica folicular en vacas criollo lechero tropical
- Author
-
Guerrero, H. L. J., primary, Pérez-Hernández, P., additional, López-Ortiz, S., additional, Montiel Palacios, F., additional, Estrella-García, A., additional, and Ahuja Aguirre, C., additional
- Published
- 2010
- Full Text
- View/download PDF
9. Aerobic capacity and muscle proteome: Insights from a mouse model.
- Author
-
Plaza-Florido A, Santos-Lozano A, López-Ortiz S, Gálvez BG, Arenas J, Martín MA, Valenzuela PL, Pinós T, Lucia A, and Fiuza-Luces C
- Abstract
We explored the association between aerobic capacity (AC) and the skeletal muscle proteome of McArdle (n = 10) and wild-type (n = 8) mice, as models of intrinsically 'low' and 'normal' AC, respectively. AC was determined as total distance achieved in treadmill running until exhaustion. The quadriceps muscle proteome was studied using liquid chromatography with tandem mass spectrometry, with the Search Tool for the Retrieval of Interacting Genes/Proteins database used to generate protein-protein interaction (PPI) networks and enrichment analyses. AC was significantly associated (P-values ranging from 0.0002 to 0.049) with 73 (McArdle) and 61 (wild-type) proteins (r-values from -0.90 to 0.94). These proteins were connected in PPI networks that enriched biological processes involved in skeletal muscle structure/function in both groups (false discovery rate <0.05). In McArdle mice, the proteins associated with AC were involved in skeletal muscle fibre differentiation/development, lipid oxidation, mitochondrial function and calcium homeostasis, whereas in wild-type animals AC-associated proteins were related to cytoskeleton structure (intermediate filaments), cell cycle regulation and endocytic trafficking. Two proteins (WEE2, THYG) were associated with AC (negatively and positively, respectively) in both groups. Only 14 of the 132 proteins (∼11%) associated with AC in McArdle or wild-type mice were also associated with those previously reported to be modified by aerobic training in these mice, providing preliminary evidence for a large divergence in the muscle proteome signature linked to aerobic training or AC, irrespective of AC (intrinsically low or normal) levels. Our findings might help to gain insight into the molecular mechanisms underlying AC at the muscle tissue level., (© 2024 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
- Published
- 2024
- Full Text
- View/download PDF
10. Conservative, Non-pharmacological Interventions for Pain Management in Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Author
-
Musso-Daury L, Pascual Fernández T, López-Ortiz S, Pico De Las Heras M, Emanuele E, Lista S, Matey-Rodríguez C, and Santos-Lozano A
- Abstract
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effectiveness of conservative, non-pharmacological interventions for chronic pain management in children and adolescents with juvenile idiopathic arthritis (JIA). A comprehensive search strategy was implemented across PubMed, PEDro, and Web of Science databases, utilizing predefined terms and strict inclusion and exclusion criteria. The initial search yielded 1,308 studies, which were subsequently narrowed to 65 relevant articles. Following a rigorous evaluation, 14 studies met the inclusion criteria for final review, with an average PEDro scale score of 6.1/10, indicating fair to good methodological quality. The included RCTs focused on various interventions, including physical exercise (five studies), hydrotherapy (three studies), orthoses (two studies), online cognitive behavior therapy for pain management (two studies), low-level laser therapy (one study), and video games (one study). A random-effects model meta-analysis was performed for interventions and outcome measures that were comparable across at least three RCTs. Physical exercise interventions met this criterion and were thus subjected to meta-analytic evaluation. The pooled analysis demonstrated a statistically significant beneficial effect of exercise interventions on chronic pain (mean difference (MD) = -1.37, 95% CI = -2.19 to -0.55, p < 0.01). Subgroup analyses further supported the efficacy of exercise compared to both other active interventions (MD = -1.37, 95% CI = -2.25 to -0.5, p < 0.01) and control conditions (MD = -1.69, 95% CI = -3.09 to -0.29, p = 0.02). These findings suggest that conservative, non-pharmacological interventions, particularly physical exercise, show promise as a component of a multidisciplinary pain management strategy for patients with JIA. While further high-quality research is needed to bolster the evidence base, our findings highlight the potential efficacy of integrating physical exercise interventions into comprehensive pain management strategies for this pediatric population., Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Musso-Daury et al.)
- Published
- 2024
- Full Text
- View/download PDF
11. Tracking neuroinflammatory biomarkers in Alzheimer's disease: a strategy for individualized therapeutic approaches?
- Author
-
Lista S, Imbimbo BP, Grasso M, Fidilio A, Emanuele E, Minoretti P, López-Ortiz S, Martín-Hernández J, Gabelle A, Caruso G, Malaguti M, Melchiorri D, Santos-Lozano A, Imbimbo C, Heneka MT, and Caraci F
- Subjects
- Humans, Animals, Neuroinflammatory Diseases drug therapy, Neuroinflammatory Diseases metabolism, Precision Medicine methods, Alzheimer Disease metabolism, Alzheimer Disease drug therapy, Biomarkers metabolism
- Abstract
Background: Recent trials of anti-amyloid-β (Aβ) monoclonal antibodies, including lecanemab and donanemab, in early Alzheimer disease (AD) showed that these drugs have limited clinical benefits and their use comes with a significant risk of serious adverse events. Thus, it seems crucial to explore complementary therapeutic approaches. Genome-wide association studies identified robust associations between AD and several AD risk genes related to immune response, including but not restricted to CD33 and TREM2. Here, we critically reviewed the current knowledge on candidate neuroinflammatory biomarkers and their role in characterizing the pathophysiology of AD., Main Body: Neuroinflammation is recognized to be a crucial and contributing component of AD pathogenesis. The fact that neuroinflammation is most likely present from earliest pre-stages of AD and co-occurs with the deposition of Aβ reinforces the need to precisely define the sequence and nature of neuroinflammatory events. Numerous clinical trials involving anti-inflammatory drugs previously yielded unfavorable outcomes in early and mild-to-moderate AD. Although the reasons behind these failures remain unclear, these may include the time and the target selected for intervention. Indeed, in our review, we observed a stage-dependent neuroinflammatory process in the AD brain. While the initial activation of glial cells counteracts early brain Aβ deposition, the downregulation in the functional state of microglia occurs at more advanced disease stages. To address this issue, personalized neuroinflammatory modulation therapy is required. The emergence of reliable blood-based neuroinflammatory biomarkers, particularly glial fibrillary acidic protein, a marker of reactive astrocytes, may facilitate the classification of AD patients based on the ATI(N) biomarker framework. This expands upon the traditional classification of Aβ ("A"), tau ("T"), and neurodegeneration ("N"), by incorporating a novel inflammatory component ("I")., Conclusions: The present review outlines the current knowledge on potential neuroinflammatory biomarkers and, importantly, emphasizes the role of longitudinal analyses, which are needed to accurately monitor the dynamics of cerebral inflammation. Such a precise information on time and place will be required before anti-inflammatory therapeutic interventions can be considered for clinical evaluation. We propose that an effective anti-neuroinflammatory therapy should specifically target microglia and astrocytes, while considering the individual ATI(N) status of patients., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
12. Effects of physical exercise on physical function in older adults in residential care: a systematic review and network meta-analysis of randomised controlled trials.
- Author
-
Valenzuela PL, Saco-Ledo G, Morales JS, Gallardo-Gómez D, Morales-Palomo F, López-Ortiz S, Rivas-Baeza B, Castillo-García A, Jiménez-Pavón D, Santos-Lozano A, Del Pozo Cruz B, and Lucia A
- Subjects
- Aged, Humans, Exercise Therapy methods, Muscle Strength physiology, Network Meta-Analysis, Randomized Controlled Trials as Topic, Aged, 80 and over, Exercise physiology, Hand Strength
- Abstract
Background: Physical exercise is effective at attenuating ageing-related physical decline in general, but evidence of its benefits for older adults in residential care, who often have functional dependency, multimorbidity, and polypharmacy, is inconclusive. We aimed to establish the effects of exercise interventions on the physical function of this population., Methods: For this systematic review and network meta-analysis, we searched PubMed, Web of Science, Cochrane Library, Rehabilitation & Sports Medicine Source, and SPORTDiscus to identify randomised controlled trials assessing the effects of exercise interventions (vs usual care) on physical function (ie, functional independence, physical performance, and other related measures, such as muscle strength, balance, or flexibility) in adults aged 60 years or older living in residential care. Relevant studies published in English or Spanish up to Jan 12, 2023, were included in the systematic review. The quality of studies was assessed using the Tool for the Assessment of Study Quality and Reporting in Exercise (TESTEX) score. A network meta-analysis was performed for physical function-related outcomes reported in at least ten studies, with subanalyses for specific intervention (ie, exercise type, training volume, and study duration) and participant (eg, having cognitive impairment or dementia, pre-frail or frail status, and being functionally dependent) characteristics. The study protocol was registered on PROSPERO (CRD42021247809)., Findings: 147 studies (11 609 participants, with mean ages ranging from 67 years [SD 9] to 92 years [2]) were included in the systematic review, and were rated as having overall good quality (median TESTEX score 9 [range 3-14]). In the meta-analysis (including 105 studies, n=7759 participants), exercise interventions were associated with significantly improved overall physical function, with a standardised mean difference [SMD] of 0·13 (95% credible interval [CrI] 0·04-0·21), which was confirmed in all analysed subpopulations. The strongest association was observed with 110-225 min per week of exercise, and the greatest improvements were observed with 170 min per week (SMD 0·36 [95% CrI 0·20-0·52]). No significant differences were found between exercise types. Subanalyses showed significant improvements for almost all analysed physical function-related outcomes (Barthel index, five-times sit-to-stand test, 30-s sit-to-stand test, knee extension, hand grip strength, bicep curl strength, Short Physical Performance Battery, 6-min walking test, walking speed, Berg balance scale, and sit-and-reach test). Large heterogeneity was found between and within studies in terms of population and intervention characteristics., Interpretation: Exercise interventions are associated with improved physical function in older adults in residential care, and should, therefore, be routinely promoted in long-term care facilities., Funding: None., Translation: For the Spanish translation of the abstract see Supplementary Materials section., Competing Interests: Declaration of interests We declare no competing interests., (Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
13. Validation and Determination of Physical Activity Intensity GT3X+ Cut-Points in Children and Adolescents with Physical Disabilities: Preliminary Results in a Cerebral Palsy Population.
- Author
-
Matey-Rodríguez C, López-Ortiz S, Peñín-Grandes S, Pinto-Fraga J, Valenzuela PL, Pico M, Fiuza-Luces C, Lista S, Lucia A, and Santos-Lozano A
- Abstract
Background: Children and adolescents with disabilities engage in low levels of moderate-to-vigorous intensity physical activity (MVPA), which may create the onset of a sedentary lifestyle. In light of this, MVPA levels must be quantified with a valid tool such as accelerometry. This study aimed to: (i) analyze the accuracy of Evenson cut-points by estimating MVPA and sedentary behavior (SB) in children and adolescents with disabilities; (ii) define new equations to estimate energy expenditure (EE) with the GT3X+ accelerometer in this population and particularly in those with cerebral palsy (CP); (iii) define specific GT3X+ cut-points to estimate MVPA in those with CP., Methods: A total of 23 children and adolescents with disabilities (10 ± 3 years; 44%females) participated in the study. GT3X+-counts and oxygen uptake (VO
2 ) were measured in four laboratory walking conditions., Results: (i) Evenson cut-points were accurate; (ii) new equations were defined to effectively predict EE; (iii) specific GT3X+ cut-points (VM ≥ 702 counts·min-1 ; Y-Axis ≥ 360 counts·min-1 ) were defined for estimating MVPA levels in children and adolescents with CP., Conclusions: The use of specific cut-points for ActiGraph GT3X+ seems to be accurate to estimate MVPA levels in children and adolescents with disabilities and, particularly, in those with CP, at least in laboratory conditions.- Published
- 2023
- Full Text
- View/download PDF
14. Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review.
- Author
-
García-Chico C, López-Ortiz S, Peñín-Grandes S, Pinto-Fraga J, Valenzuela PL, Emanuele E, Ceci C, Graziani G, Fiuza-Luces C, Lista S, Lucia A, and Santos-Lozano A
- Abstract
Growing evidence suggests that, among the different molecular/cellular pathophysiological mechanisms associated with cancer, there are 14 hallmarks that play a major role, including: (i) sustaining proliferative signaling, (ii) evading growth suppressors, (iii) activating invasion and metastasis, (iv) enabling replicative immortality, (v) inducing angiogenesis, (vi) resisting cell death, (vii) reprogramming energy metabolism, (viii) evading immune destruction, (ix) genome instability and mutations, (x) tumor-promoting inflammation, (xi) unlocking phenotypic plasticity, (xii) nonmutational epigenetic reprogramming, (xiii) polymorphic microbiomes, and (xiv) senescent cells. These hallmarks are also associated with the development of breast cancer, which represents the most prevalent tumor type in the world. The present narrative review aims to describe, for the first time, the effects of physical activity/exercise on these hallmarks. In summary, an active lifestyle, and particularly regular physical exercise, provides beneficial effects on all major hallmarks associated with breast cancer, and might therefore help to counteract the progression of the disease or its associated burden.
- Published
- 2023
- Full Text
- View/download PDF
15. Physical Exercise and Alzheimer's Disease: Effects on Pathophysiological Molecular Pathways of the Disease.
- Author
-
López-Ortiz S, Pinto-Fraga J, Valenzuela PL, Martín-Hernández J, Seisdedos MM, García-López O, Toschi N, Di Giuliano F, Garaci F, Mercuri NB, Nisticò R, Emanuele E, Lista S, Lucia A, and Santos-Lozano A
- Subjects
- Alzheimer Disease genetics, Alzheimer Disease physiopathology, Alzheimer Disease rehabilitation, DNA Damage genetics, DNA Repair genetics, Diffusion Tensor Imaging methods, Humans, Magnetic Resonance Imaging methods, Neuroimaging methods, Signal Transduction genetics, Alzheimer Disease therapy, Exercise physiology, Oxidative Stress physiology
- Abstract
Alzheimer's disease (AD), the most common form of neurodegenerative dementia in adults worldwide, is a multifactorial and heterogeneous disorder characterized by the interaction of genetic and epigenetic factors and the dysregulation of numerous intracellular signaling and cellular/molecular pathways. The introduction of the systems biology framework is revolutionizing the study of complex diseases by allowing the identification and integration of cellular/molecular pathways and networks of interaction. Here, we reviewed the relationship between physical activity and the next pathophysiological processes involved in the risk of developing AD, based on some crucial molecular pathways and biological process dysregulated in AD: (1) Immune system and inflammation; (2) Endothelial function and cerebrovascular insufficiency; (3) Apoptosis and cell death; (4) Intercellular communication; (5) Metabolism, oxidative stress and neurotoxicity; (6) DNA damage and repair; (7) Cytoskeleton and membrane proteins; (8) Synaptic plasticity. Moreover, we highlighted the increasingly relevant role played by advanced neuroimaging technologies, including structural/functional magnetic resonance imaging, diffusion tensor imaging, and arterial spin labelling, in exploring the link between AD and physical exercise. Regular physical exercise seems to have a protective effect against AD by inhibiting different pathophysiological molecular pathways implicated in AD.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.