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Objective Preliminary study on the protective effect of intraoperative direct electrical stimulation motor - evoked potential (DES - MEP) on motor function during brainstem tumor surgery. Methods Total 136 patients with brainstem tumor surgery from January 2017 to May 2020 were enrolled, including 68 patients treated with intraoperative routine electrophysiological monitoring combined with neuronavigation and 68 patients with DES - MEP combined with neuronavigation on the basis of routine electrophysiological monitoring. According to the changes of muscle strength (Lovett Muscle Strength Classification) before and after operation, the patients were judged to have new dyskinesia motor function or not. The true positive, false positive, true negative and false negative were judged by DES - MEP monitoring and postoperative motor function prognosis. The sensitivity and specificity, positive predictive value and negative predictive value, and accuracy of DES - MEP monitoring results in predicting postoperative motor function prognosis were calculated. Results Patients undergoing DES-MEP combined with routine electrophysiological monitoring had 16.18% (11/68) of severe new dyskinesia (Lovett Muscle Strength Classification reduction ≥ 2 grade) 2 weeks after surgery, which was lower than patients undergoing routine electrophysiological monitoring [32.35% (22/68); χ² = 4.841, P = 0.028]. There were 44 true positive cases, 4 false positive cases, 7 true negative cases, and 13 false negative cases detected by DES - MEP. The sensitivity and specificity of DES - MEP were 77.19% (44/57) and 7/11, the positive predictive value and negative predictive value of DES - MEP were 91.67% (44/48) and 35% (7/20), and accuracy of DES - MEP was 75% (51/68), respectively. Conclusions The application of DES - MEP in brainstem tumor surgery can effectively protect the brainstem motor function and make up for the deficiency of intraoperative neural monitoring technology in the protection of brainstem corticospinal tract function. [ABSTRACT FROM AUTHOR]

Background: Parkinson's disease (PD) is a common movement disorder for which diagnosis mainly depends on the medical history and clinical symptoms. Exosomes are now considered an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids, and genetic material. Long noncoding (lnc) RNA in exosomes plays a critical role in many diseases, including neurodegenerative disease. Aim: To study expression differences for lncRNAs in peripheral blood exosomes of PD patients compared with healthy individuals and to look for lncRNAs that might be related to the pathogenesis of PD. Materials and Methods: We recruited PD patients along with age‐ and sex‐matched healthy individuals as healthy controls and evaluated levels of lncRNAs extracted from exosomes in plasma samples via next‐generation sequencing and real‐time quantitative PCR. Correlation analysis was conducted for the clinical characteristics of PD patients and the expression of selected lncRNAs. Results: We found 15 upregulated and 24 downregulated exosomal lncRNAs in the PD group. According to bioinformatics analyses, we chose lnc‐MKRN2‐42:1 for further study. Interestingly, lnc‐MKRN2‐42:1 was positively correlated with the MDS‐UPDRS III score for PD patients. Conclusion: Our study suggested that lnc‐MKRN2‐42:1 may be involved in the occurrence and development of PD. [ABSTRACT FROM AUTHOR]