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Measuring evapotranspiration (ET) components in cotton fields under mulched drip irrigation is needed to improve water use efficiency and promote the development of water-saving agriculture. In this study, an Eddy Covariance (EC) system was used to observe the water-carbon fluxes of cotton fields under mulched drip irrigation in an arid region during two years (2021–2022). The Underlying Water Use Efficiency (uWUE) method was used to partition the ET into transpiration (T) and evaporation (E) in order to reveal the changing characteristics of ET and its components in cotton fields under mulched drip irrigation and analyze the effects of environmental factors on each component. The results showed that the diurnal variation of ET was the same as gross primary productivity (GPP), and their course of change showed a bimodal curve at budding, blooming, and boll stages. The relationship of T at different growth stages was the same as ET, which is blooming and boll stage > budding stage > boll opening stage > seedling stage. ET and its components were mainly affected by temperature (Tair) and net radiation (Rn). This study can provide a theoretical and practical basis for the application of uWUE in cotton fields under mulched drip irrigation and a scientific basis for the rational allocation of water resources and the formulation of a scientific water-saving irrigation system for farmland in an arid region. [ABSTRACT FROM AUTHOR]

The Ordos Basin's southern part is a composite zone made up of numerous continental blocks and has long been influenced by surrounding tectonism. However, only a few studies have investigated the existence of southern provenance supply and the basin's southern boundary in the Middle Jurassic Zhiluo Formation. Based on sandstone detrital zircon U-Pb dating and zircon rare earth element analyses, net-sand ratio maps, paleocurrent direction and the field outcrop survey, this study establishes the source area and boundary of the Zhiluo Formation in the southern basin, and discusses the tectonic events. The study shows that the four main age peaks in the detrital spectra occurs at 2283 Ma, 1788 Ma, 432.5 Ma and 218.7 Ma, with a few of the zircons dated at 794.5–1235.2 Ma. The North Qilian orogenic belt (N-QLOB), the western part of the North Qinling orogenic belt (NQOB), and the southern margin of the North China Block (SNCB) contributed to the provenance. According to an integrated analysis of the provenance and tectonic background of continental blocks in the basin's southern margin, the boundary of the basin in the depositional period of the Zhiluo Formation should reach the N-QLOB in the southwest, the NQOB in the south, and the Sanmenxia–Lushan fault belt in the southeast. On the basis of the aforementioned findings, the tectonic evolution of the continental blocks at the southern periphery of the Ordos Basin was restored. [ABSTRACT FROM AUTHOR]

Abstract Background Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however, its role is yet to be fully established. Furthermore, it is not clear whether MMP-13 can be used as an independent breast cancer biomarker. This study was conducted to assess the expression profile of MMP-13 protein in invasive breast carcinomas to determine its diagnostic and prognostic significance, as well as its correlation with other biomarkers including estrogen receptor (ER), progesterone receptor (PR), Her-2/neu, MMP-2, MMP-9, tissue inhibitor of MMP-1 and -2 (TIMP-1 and TIMP-2). Methods Immunohistochemistry (IHC) was performed on paraffin-embedded tissue microarray specimens from 263 breast carcinomas. The intensity and the extent of IHC were scored by pathologists. The correlation of the gene expression profiles with the patients' clinicopathological features and clinical outcomes were analyzed for statistical significance. Results MMP-13 protein was detected in the cytoplasm of malignant cells and peritumoral stromal cells. MMP-13 expression by tumor cells (p < 0.001) and stromal fibroblasts (p < 0.001) both correlated with carcinoma infiltration of lymph nodes. MMP-13 also correlated with the expression of Her-2/neu (p = 0.015) and TIMP-1 (p < 0.010), respectively in tumor cells. Tumor-derived, but not stromal fibroblast-derived, MMP-13 correlated with aggressive tumor phenotypes. Moreover, high levels of MMP-13 expression were associated with decreased overall survival. In parallel, the prognostic value of MMP-13 expressed by peritumoral fibroblasts seems less significant. Our data suggest that lymph node status, tumor size, Her-2/neu expression, TIMP-1 and MMP-13 expression in cancer cells are independent prognostic factors. Conclusion Tumor-derived, but not stromal fibroblast-derived, MMP-13 correlated with aggressive tumor phenotypes, and inversely correlated with overall survival of breast cancer patients. MMP-13 may serve as an independent prognostic factor for invasive breast cancer patients. MMP-13 may be particularly useful as a prognostic marker when evaluated along with Her-2/neu and lymph node status.

Context.—: Eosinophilic solid and cystic renal cell carcinoma is now defined in the 5th edition of the 2022 World Health Organization classification of urogenital tumors., Objective.—: To perform morphologic, immunohistochemical, and preliminary genetic studies about this new entity in China for the purpose of understanding it better., Design.—: The study includes 18 patients from a regional tertiary oncology center in northern China (Tianjin, China). We investigated the clinical and immunohistochemical features of these cases., Results.—: The mean age of patients was 49.6 years and the male to female ratio was 11:7. Macroscopically, 1 case had the classic cystic and solid appearance whereas the others appeared purely solid. Microscopically, all 18 tumors shared similar solid and focal macrocystic or microcystic growth pattern, and the cells were characterized by voluminous and eosinophilic cytoplasm, along with coarse amphophilic stippling. Immunohistochemically, most of the tumors had a predominant cytokeratin (CK) 20-positive feature, ranging from focal cytoplasmic staining to diffuse membranous accentuation. Initially, we separated these cases into different immunohistochemical phenotypes. Group 1 (7 of 18; 38.5%) was characterized by positive phospho-4EBP1 and phospho-S6, which can imply hyperactive mechanistic target of rapamycin complex 1 (mTORC1) signaling. Group 2 (4 of 18; 23%) was negative for NF2, probably implying a germline mutation of NF2. Group 3 (7 of 18; 38.5%) consisted of the remaining cases. One case had metastatic spread and exhibited an aggressive clinical course, and we detected cyclin-dependent kinase inhibitor 2A (CDKN2A) mutation in this case; other patients were alive and without disease progression., Conclusions.—: Our research proposes that eosinophilic solid and cystic renal cell carcinoma exhibits prototypical pathologic features with CK20 positivity and has aggressive potential., Competing Interests: The authors have no relevant financial interest in the products or companies described in this article., (© 2024 College of American Pathologists.)