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BackgroundCandidemia is increasing in frequency and is associated with high mortality. We sought to determine the burden of illness, the population it affects and its resistance profile in our region.MethodsThe Calgary Zone (CZ) provides all care for residents of Calgary and surrounding communities (~ 1.69 million) via five tertiary hospitals each served by a common single laboratory for acute care microbiology. All adult patients in the CZ with at least one Candida spp.-positive blood culture between January 1, 2010, and December 31, 2018, were identified using microbiological data from Calgary Lab Services, the laboratory that processes > 95% of all blood culture samples in the CZ, were reviewed for the study.ResultsThe overall annual incidence of candidemia among individuals living in the CZ was 3.8 per 100,000 persons (Median age 61 years (IQR 48-72) and 221/455 (47.4%) were female). C. albicans was the most common species (50.6%), followed by C. glabrata, (24.0%). No other species accounted for more than 7% of cases. Overall mortality at 30, 90, and 365 days was 32.2, 40.1, and 48.1% respectively. Mortality rate did not differ by Candida species. Of individuals who developed candidemia, more than 50% died within the next year. No new resistance pattern has emerged in the most common Candida species in Calgary, Alberta.ConclusionsIn Calgary, Alberta, the incidence of candidemia has not increased in the last decade. C. albicans was the most common species and it remains susceptible to fluconazole.

Although compact fluorescent lamps (CFLs) have been in the market for a long time, many of them do not achieve the same power factor as the incandescent lamps do, which appears to be a significant problem for the utility with the current widespread use of CFLs for household lightings. A single-stage single-switch electronic ballast with active power factor correction is presented in this study for CFL applications. Unlike other single-switch ballast circuits, the presented integrated dual-boost converter circuit can produce a symmetric bipolar square-wave voltage, thus generating a near-pure high-frequency sinusoidal voltage on the lamp, which is beneficial to the CFL lifetime. Moreover, its soft-switching variant can achieve the ZVZC turn-on and ZV turn-off for the MOSFET to improve the conversion efficiency. Detailed operating principles and circuit analysis of the proposed circuit have been provided in this study. Simulation and experimental results on a prototype of a 15 W CFL validate the theoretical analysis and highlight the merits of the presented work. [ABSTRACT FROM AUTHOR]

A novel dimmable high-power-factor compact fluorescent lamp (CFL) electronic ballast that is compatible with standard incandescent lamp dimmers is proposed in this paper. In the proposed system, the dimming controller uses the phase angle of the dimmer as the input feedforward parameter for the duty ratio control of the switch in the power circuit. As a result, a wide range of light output can be achieved with a small range of phase angles of the phase-cut dimmer. The ballast power circuit is a single-switch single-stage resonant inverter, which is essentially a fusion of a SEPIC converter and a single-switch current-fed inverter. Detailed operating principles of the proposed system will be discussed in this paper. System stability analysis that includes the effects of the phase-cut dimmer is also provided. Experimental results are given for a 13-W CFL to demonstrate and highlight the merits of the proposed work. [ABSTRACT FROM AUTHOR]

A single-stage dimmable electronic ballast with very high power factor and high efficiency is presented in this paper. A compact lamp power circuit is designed by integrating a buck-boost power factor corrector with a current-fed resonant inverter. This integration produces a single power-processing unit that minimizes the number of circuit components. The proposed resonant inverter reduces the circulating current in the resonant tank and allows simple gate drivers to be used so that isolation devices can be eliminated. With the buck-boost stage operating in the discontinuous conduction mode (DCM), a close-to-unity power factor is achieved for different lamp-power conditions. A small-signal analysis is presented, and a simple variable frequency controller is developed using the modified 555 timer to provide dimming operations. Simulation and experimental waveforms are provided to highlight the merits of the proposed circuit for a 40-W compact fluorescent lamp. [ABSTRACT FROM AUTHOR]

Resonant inverters are connected to a high-frequency ac (HFAC) bus, where power is delivered to different locations for points-of-use power management. Such a power distribution system subjects to more perturbations and load uncertainties than inverters operating with single load. A novel voltage control method is proposed in this paper for a high-frequency full-bridge resonant inverter with series-parallel resonant tank. A modified one-cycle controlled phase-shift modulation is proposed to effectively compensate the input line variations. The uncertainty model of the high frequency resonant inverter is developed and analyzed with the resonant circuit component tolerance, input line and load variations taken into design considerations. The voltage feedback controller is designed based on the H∞ robust control theory and is implemented with analog discrete devices. The proposed control scheme has the advantages of fast response for both input line and load perturbations. It also ensures a wide range of system stability and guarantees robustness of the power converter. Both simulations and experimental results are provided to verify with the theoretical analysis through an experimental prototype of a full-bridge resonant inverter with an output power of 150-W operating at 1 MHz and an output voltage of 28 V (rms). [ABSTRACT FROM AUTHOR]