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2. Catheter‐based ablation to improve outcomes in patients with atrial fibrillation and heart failure with preserved ejection fraction: Rationale and design of the CABA‐HFPEF‐DZHK27 trial.

Author

Parwani, Abdul S., Kääb, Stefan, Friede, Tim, Tilz, Roland Richard, Bauersachs, Johann, Frey, Norbert, Hindricks, Gerhard, Lewalter, Thorsten, Rienstra, Michiel, Rillig, Andreas, Scherr, Daniel, Steven, Daniel, Kirchhof, Paulus, and Pieske, Burkert

Subjects
ACUTE coronary syndrome, HEART failure patients, CATHETER ablation, MEDICAL care, HEART failure
Abstract

Aims: Atrial fibrillation (AF) is common in heart failure (HF) and negatively impacts outcomes. The role of ablation‐based rhythm control in patients with AF and HF with preserved (HFpEF) or mildly reduced ejection fraction (HFmrEF) is not known. The CABA‐HFPEF‐DZHK27 (CAtheter‐Based Ablation of atrial fibrillation compared to conventional treatment in patients with Heart Failure with Preserved Ejection Fraction) trial will determine whether early catheter ablation for AF can prevent adverse cardiovascular outcomes in patients with HFpEF or HFmrEF. Methods: CABA‐HFPEF‐DZHK27 (NCT05508256) is an investigator‐initiated, prospective, randomized, open, interventional multicentre strategy trial with blinded outcome assessment. Approximately 1548 patients with paroxysmal or persistent AF diagnosed within 24 months prior to enrolment and HFpEF or HFmrEF will be randomized to early catheter ablation within 4 weeks after randomization or to usual care. All patients receive anticoagulation, rate control, and HF management according to current guideline recommendations. Usual care can include rhythm control in symptomatic patients. Patients will be followed until the end of the trial for the primary outcome, a composite of cardiovascular death, stroke, and total unplanned hospitalizations for HF or acute coronary syndrome. The safety outcome comprises complications of catheter ablation and death. The trial is powered for a rate ratio of 0.75 (two‐sided alpha = 0.05, 1‐beta = 0.8). Conclusion: CABA‐HFPEF‐DZHK27 will define the role of systematic and early catheter ablation in patients with AF and HFpEF or HFmrEF. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Influence of Meteorological Parameters on the Prevalence of TEE Detected Left Atrial Appendage Thrombi.

Author

Lecker, Franziska, Tiemann, Klaus, Lewalter, Thorsten, and Jilek, Clemens

Subjects
TRANSESOPHAGEAL echocardiography, LEFT heart atrium, ATMOSPHERIC pressure, ISCHEMIC stroke, HUMIDITY
Abstract

(1) Background: Meteorological factors seem to exert various effects on human health, influencing the occurrence of diseases such as thromboembolic events and strokes. Low atmospheric pressure in summer may be associated with an increased likelihood of ischemic stroke. The aim of this study was to investigate the potential impact of meteorological conditions on left atrial appendage (LAA) thrombus formation. (2) Methods: A total of 131 patients were included, diagnosed with a first instance of thrombus via 3D transesophageal echocardiography (TEE) between February 2009 and February 2019. Months with frequent thrombus diagnoses of at least 10 thrombi per month were categorized as frequent months (F-months), while months with fewer than 10 thrombus diagnoses per month were labelled as non-frequent months (N-months). The analysis focused on differences in meteorological parameters in two-week and four-week periods before the diagnosis. (3) Results: F-months were predominantly observed in spring and summer (April, May, June, and July), as well as in February and November. During F-months, a higher absolute temperature difference, lower relative humidity, longer daily sunshine duration, and greater wind speed maximum were observed in the two- and four-week periods rather than for N-months. In the two-week period, average temperatures, equivalent temperatures, and temperature maxima were also significantly higher during F-months than N-months. (4) Conclusion: Thrombi in the left atrial appendage are more prevalent during periods characterized by high absolute temperature differences, low relative humidity, and long daily sunshine duration. [ABSTRACT FROM AUTHOR]

Published
2024
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5. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, Hugh, Hindricks, Gerhard, Cappato, Riccardo, Kim, Young-Hoon, Saad, Eduardo B., Aguinaga, Luis, Akar, Joseph G., Badhwar, Vinay, Brugada, Josep, Camm, John, Chen, Peng-Sheng, Chen, Shih-Ann, Chung, Mina K., Nielsen, Jens Cosedis, Curtis, Anne B., Davies, D. Wyn, Day, John D., d’Avila, André, de Groot, N.M.S. (Natasja), Di Biase, Luigi, Duytschaever, Mattias, Edgerton, James R., Ellenbogen, Kenneth A., Ellinor, Patrick T., Ernst, Sabine, Fenelon, Guilherme, Gerstenfeld, Edward P., Haines, David E., Haissaguerre, Michel, Helm, Robert H., Hylek, Elaine, Jackman, Warren M., Jalife, Jose, Kalman, Jonathan M., Kautzner, Josef, Kottkamp, Hans, Kuck, Karl Heinz, Kumagai, Koichiro, Lee, Richard, Lewalter, Thorsten, Lindsay, Bruce D., Macle, Laurent, Mansour, Moussa, Marchlinski, Francis E., Michaud, Gregory F., Nakagawa, Hiroshi, Natale, Andrea, Nattel, Stanley, Okumura, Ken, Packer, Douglas, Pokushalov, Evgeny, Reynolds, Matthew R., Sanders, Prashanthan, Scanavacca, Mauricio, Schilling, Richard, Tondo, Claudio, Tsao, Hsuan-Ming, Verma, Atul, Wilber, David J., and Yamane, Teiichi

Published
2017
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6. Influence of Heart Rate and Change in Wavefront Direction through Pacing on Conduction Velocity and Voltage Amplitude in a Porcine Model: A High-Density Mapping Study.

Author

Wilhelm, Theresa Isabelle, Lewalter, Thorsten, Reiser, Judith, Werner, Julia, Keil, Andreas, Oesterlein, Tobias, Gleirscher, Lukas, Tiemann, Klaus, and Jilek, Clemens

Subjects
*HEART beat, *CARDIAC pacing, *RIGHT heart atrium, *VOLTAGE, *VELOCITY
Abstract

Background: Understanding the dynamics of conduction velocity (CV) and voltage amplitude (VA) is crucial in cardiac electrophysiology, particularly for substrate-based catheter ablations targeting slow conduction zones and low voltage areas. This study utilizes ultra-high-density mapping to investigate the impact of heart rate and pacing location on changes in the wavefront direction, CV, and VA of healthy pig hearts. Methods: We conducted in vivo electrophysiological studies on four healthy juvenile pigs, involving various pacing locations and heart rates. High-resolution electroanatomic mapping was performed during intrinsic normal sinus rhythm (NSR) and electrical pacing. The study encompassed detailed analyses at three levels: entire heart cavities, subregions, and localized 5-mm-diameter circular areas. Linear mixed-effects models were used to analyze the influence of heart rate and pacing location on CV and VA in different regions. Results: An increase in heart rate correlated with an increase in conduction velocity and a decrease in voltage amplitude. Pacing influenced conduction velocity and voltage amplitude. Pacing also influenced conduction velocity and voltage amplitude, with varying effects observed based on the pacing location within different heart cavities. Pacing from the right atrium (RA) decreased CV in all heart cavities. The overall CV and VA changes in the whole heart cavities were not uniformly reflected in all subregions and subregional CV and VA changes were not always reflected in the overall analysis. Overall, there was a notable variability in absolute CV and VA changes attributed to pacing. Conclusions: Heart rate and pacing location influence CV and VA within healthy juvenile pig hearts. Subregion analysis suggests that specific regions of the heart cavities are more susceptible to pacing. High-resolution mapping aids in detecting regional changes, emphasizing the substantial physiological variations in CV and VA. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

Author

Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, Kirchhof, Paulus, Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, and Kirchhof, Paulus

Abstract

Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.

Published
2023
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10. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation:the 8th AFNET/EHRA consensus conference

Author

Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, Kirchhof, Paulus, Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, and Kirchhof, Paulus

Abstract

Aims Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. Methods and results This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Conclusions Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.

Published
2023

12. Atrial Fibrillation can adversely impact Heart Failure with Preserved Ejection Fraction by its association with Heart Failure Progression and Mortality: A Post-Hoc Propensity Score–Matched Analysis of the TOPCAT Americas Trial

Author

Saksena, Sanjeev, primary, Slee, April, additional, Natale, Andrea, additional, Lakkireddy, Dhanunjaya R, additional, Shah, Dipen, additional, Di Biase, Luigi, additional, Lewalter, Thorsten, additional, Nagarakanti, Rangadham, additional, and Santangeli, Pasquale, additional

Published
2023
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13. Is spontaneous echo contrast associated with device-related thrombus or embolic events after left atrial appendage occlusion? Insights from the multicenter German LAARGE registry

Author

Fastner, Christian, Müller, Claus, Brachmann, Johannes, Lewalter, Thorsten, Akin, Ibrahim, Sievert, Horst, Käunicke, Matthias, Zeymer, Uwe, Hochadel, Matthias, Schneider, Steffen, Senges, Jochen, Erkapic, Damir, and Weiß, Christian

Subjects
Medizin
Abstract

Background: Interventional left atrial appendage occlusion (LAAO) provides an alternative to oral anticoagulation (OAC) for prophylaxis of thromboembolic events (TEs) in nonvalvular atrial fibrillation patients, predominantly in those with high bleeding risk and contraindications for long-term OAC. Although spontaneous echo contrast (SEC) is a well-known risk factor for atrial thrombus formation, little is known about whether this means an increased risk of device-related thrombus (DRT) or TEs following LAAO. Methods: This substudy of the prospective, multicenter German LAARGE registry assessed two groups according to absence (SEC −) or presence of SEC (SEC +) in preprocedural cardiac imaging. Clinical and echocardiographic parameters were registered up to 1 year after LAAO. Results: Five hundred eighty-eight patients (SEC − 85.5 vs. SEC + 14.5%) were included. More SEC + patients were implanted for OAC non-compliance (11.8 vs. 4.6%, p = 0.008) and a higher proportion received only antiplatelet therapy without OAC at hospital discharge (96.5 vs. 86.0%, p = 0.007). The SEC + patients had larger LA diameters (50 (47; 54) vs. 47 (43; 51) mm, p < 0.001), wider LAA ostia (21 (19; 23) vs. 20 (17; 22) mm at 45°, p = 0.011), and lower left ventricular ejection fraction (50 (45; 60) vs. 60 (50; 60) %, p < 0.001) on admission. Procedural success was very high in both groups (98.1%, p = 1.00). Periprocedural major adverse cardiac and cerebrovascular events and other major complications were rare in both groups (3.8 vs. 4.7%, p = 0.76). At follow-up, DRT was only detected in the SEC − group (3.8 vs. 0%, p = 1.00). The rates of TEs (SEC − 1.2 vs. SEC + 0%, p = 1.00) after hospital discharge and 1-year mortality (SEC − 12.0 vs. SEC + 11.8%, p = 0.96) were not significantly different between the two groups. Conclusions: Presence of SEC at baseline was not associated with an increased rate of DRT or TEs at 1-year follow-up after LAAO in LAARGE. in press

Published
2023

14. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference

Author

Kotecha, Dipak, Breithardt, Günter, Camm, A John, Lip, Gregory Y H, Schotten, Ulrich, Ahlsson, Anders, Arnar, David, Atar, Dan, Auricchio, Angelo, Bax, Jeroen, Benussi, Stefano, Blomstrom-Lundqvist, Carina, Borggrefe, Martin, Boriani, Giuseppe, Brandes, Axel, Calkins, Hugh, Casadei, Barbara, Castellá, Manuel, Chua, Winnie, Crijns, Harry, Dobrev, Dobromir, Fabritz, Larissa, Feuring, Martin, Freedman, Ben, Gerth, Andrea, Goette, Andreas, Guasch, Eduard, Haase, Doreen, Hatem, Stephane, Haeusler, Karl Georg, Heidbuchel, Hein, Hendriks, Jeroen, Hunter, Craig, Kääb, Stefan, Kespohl, Stefanie, Landmesser, Ulf, Lane, Deirdre A, Lewalter, Thorsten, Mont, Lluís, Nabauer, Michael, Nielsen, Jens C, Oeff, Michael, Oldgren, Jonas, Oto, Ali, Pison, Laurent, Potpara, Tatjana, Ravens, Ursula, Richard-Lordereau, Isabelle, Rienstra, Michiel, Savelieva, Irina, Schnabel, Renate, Sinner, Moritz F, Sommer, Philipp, Themistoclakis, Sakis, Van Gelder, Isabelle C, Vardas, Panagiotis E, Verma, Atul, Wakili, Reza, Weber, Evelyn, Werring, David, Willems, Stephan, Ziegler, André, Hindricks, Gerhard, and Kirchhof, Paulus

Published
2018
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16. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, Hugh, Hindricks, Gerhard, Cappato, Riccardo, Kim, Young-Hoon, Saad, Eduardo B, Aguinaga, Luis, Akar, Joseph G, Badhwar, Vinay, Brugada, Josep, Camm, John, Chen, Peng-Sheng, Chen, Shih-Ann, Chung, Mina K, Cosedis Nielsen, Jens, Curtis, Anne B, Davies, D Wyn, Day, John D, d’Avila, André, (Natasja) de Groot, N M S, Di Biase, Luigi, Duytschaever, Mattias, Edgerton, James R, Ellenbogen, Kenneth A, Ellinor, Patrick T, Ernst, Sabine, Fenelon, Guilherme, Gerstenfeld, Edward P, Haines, David E, Haissaguerre, Michel, Helm, Robert H, Hylek, Elaine, Jackman, Warren M, Jalife, Jose, Kalman, Jonathan M, Kautzner, Josef, Kottkamp, Hans, Kuck, Karl Heinz, Kumagai, Koichiro, Lee, Richard, Lewalter, Thorsten, Lindsay, Bruce D, Macle, Laurent, Mansour, Moussa, Marchlinski, Francis E, Michaud, Gregory F, Nakagawa, Hiroshi, Natale, Andrea, Nattel, Stanley, Okumura, Ken, Packer, Douglas, Pokushalov, Evgeny, Reynolds, Matthew R, Sanders, Prashanthan, Scanavacca, Mauricio, Schilling, Richard, Tondo, Claudio, Tsao, Hsuan-Ming, Verma, Atul, Wilber, David J, Yamane, Teiichi, Blomström-Lundqvist, Carina, De Paola, Angelo A V, Kistler, Peter M, Lip, Gregory Y H, Peters, Nicholas S, Pisani, Cristiano F, Raviele, Antonio, Saad, Eduardo B, Satomi, Kazuhiro, Stiles, Martin K, and Willems, Stephan

Published
2018
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23. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference

Author

Schnabel, Renate B, primary, Marinelli, Elena Andreassi, additional, Arbelo, Elena, additional, Boriani, Giuseppe, additional, Boveda, Serge, additional, Buckley, Claire M, additional, Camm, A John, additional, Casadei, Barbara, additional, Chua, Winnie, additional, Dagres, Nikolaos, additional, de Melis, Mirko, additional, Desteghe, Lien, additional, Diederichsen, Søren Zöga, additional, Duncker, David, additional, Eckardt, Lars, additional, Eisert, Christoph, additional, Engler, Daniel, additional, Fabritz, Larissa, additional, Freedman, Ben, additional, Gillet, Ludovic, additional, Goette, Andreas, additional, Guasch, Eduard, additional, Svendsen, Jesper Hastrup, additional, Hatem, Stéphane N, additional, Haeusler, Karl Georg, additional, Healey, Jeff S, additional, Heidbuchel, Hein, additional, Hindricks, Gerhard, additional, Hobbs, F D Richard, additional, Hübner, Thomas, additional, Kotecha, Dipak, additional, Krekler, Michael, additional, Leclercq, Christophe, additional, Lewalter, Thorsten, additional, Lin, Honghuang, additional, Linz, Dominik, additional, Lip, Gregory Y H, additional, Løchen, Maja Lisa, additional, Lucassen, Wim, additional, Malaczynska-Rajpold, Katarzyna, additional, Massberg, Steffen, additional, Merino, Jose L, additional, Meyer, Ralf, additional, Mont, Lluıs, additional, Myers, Michael C, additional, Neubeck, Lis, additional, Niiranen, Teemu, additional, Oeff, Michael, additional, Oldgren, Jonas, additional, Potpara, Tatjana S, additional, Psaroudakis, George, additional, Pürerfellner, Helmut, additional, Ravens, Ursula, additional, Rienstra, Michiel, additional, Rivard, Lena, additional, Scherr, Daniel, additional, Schotten, Ulrich, additional, Shah, Dipen, additional, Sinner, Moritz F, additional, Smolnik, Rüdiger, additional, Steinbeck, Gerhard, additional, Steven, Daniel, additional, Svennberg, Emma, additional, Thomas, Dierk, additional, True Hills, Mellanie, additional, van Gelder, Isabelle C, additional, Vardar, Burcu, additional, Palà, Elena, additional, Wakili, Reza, additional, Wegscheider, Karl, additional, Wieloch, Mattias, additional, Willems, Stephan, additional, Witt, Henning, additional, Ziegler, André, additional, Daniel Zink, Matthias, additional, and Kirchhof, Paulus, additional

Published
2022
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26. Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies

Author

Tzikas, Apostolos, Holmes, David R., Jr, Gafoor, Sameer, Ruiz, Carlos E., Blomström-Lundqvist, Carina, Diener, Hans-Christoph, Cappato, Riccardo, Kar, Saibal, Lee, Randal J., Byrne, Robert A., Ibrahim, Reda, Lakkireddy, Dhanunjaya, Soliman, Osama I., Nabauer, Michael, Schneider, Steffen, Brachmann, Johannes, Saver, Jeffrey L., Tiemann, Klaus, Sievert, Horst, Camm, A. John, and Lewalter, Thorsten

Published
2017
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27. The Atrial Fibrillation Ablation Pilot Study: an European Survey on Methodology and results of catheter ablation for atrial fibrillation conducted by the European Heart Rhythm Association

Author

Arbelo, Elena, Brugada, Josep, Hindricks, Gerhard, Maggioni, Aldo P., Tavazzi, Luigi, Vardas, Panos, Laroche, Cécile, Anselme, Frédéric, Inama, Giuseppe, Jais, Pierre, Kalarus, Zbigniew, Kautzner, Josef, Lewalter, Thorsten, Mairesse, Georges H., Perez-Villacastin, Julian, Riahi, Sam, Taborsky, Milos, Theodorakis, George, Trines, Serge A., Brugada, Josep, Arbelo, Elena, Hindriks, Gerhard, Maggioni, Aldo P., Morgan, John, Tavazzi, Luigi, Vardas, Panos, Alonso, Angeles, Ferrari, Roberto, Komajda, Michel, Tavazzi, Luigi, Wood, David, Vardas, Panos, Brugada, Josep, Mairesse, Georges, Taborsky, Milos, Kautzner, Josef, Lewalter, Thorsten, Riahi, Sam, Jais, Pierre, Anselme, Frédéric, Theodorakis, George, Inama, Giuseppe, Trines, Serge, Kalarus, Zbigniew, Villacastin, Julian Perez, Maggioni, Aldo P., Manini, Malika, Gracia, Gérard, Laroche, Cécile, Missiamenou, Viviane, Taylor, Charles, Konte, Marème, Fiorucci, Emanuela, Lefrancq, Elin Folkesson, Glémot, Myriam, McNeill, Patti-Ann, Bois, Timothée, Heidbüchel, H., Nuyens, D., Boland, J., Dinraths, V., Herzet, J.-M., Hoffer, E., Malmendier, D., Massoz, M., Pourbaix, S., Ballant, E., Blommaert, D., Deceuninck, O., Dormal, F., Xhaet, O., De Potter, T., Geelen, P., Derycker, K., Duytschaever, M., Tavernier, R., Vandekerckhove, Y., Vankats, D., Bulava, A., Hanis, J., Sitek, D., Blahova, M., Cihak, R., Hanyasova, L., Jansova, H., Peichl, P., Tanzerova, M., Wichterle, D., Duda, J., Haman, L., Parizek, P., Coling, L., Neuzil, P., Petru, J., Sediva, L., Skoda, J., Chovancik, J., Fiala, M., Neuwirth, R., Karlsdottir, A., Pehrson, S., Gerdes, C., Jensen, H.K., Lukac, P., Nielsen, J. C., Hansen, J., Johannessen, A., Hansen, P. S., Pedersen, A.K., Heath, F.P., Hjortshoj, S., Thogersen, A.M., Da Costa, A., Martel, I., Romeyer-Bouchard, C., Sadki, N., Schmid, A., Haissaguerre, M., Hocini, M., Knecht, S., Sacher, F., Ait Said, M., Cauchemez, B., Ledoux, F., Thomas, O., Cebron, J.-P., Decarsin, N., Gras, D., Hervouet, S., Durand, C., Durand-Dubief, A., Poty, H., Babuty, D., Pierre, B., Albenque, J.-P., Boveda, S., Combes, N., Mas, R., Hermida, J-S., Kubala, M., Godin, B., Savouré, A., Soublin, Y., Defaye, P., Jacon, P., Brigadeau, F., Corbut, S., Flament-Balzola, F., Kacet, S., Klug, D., Lacroix, D., Copie, X., Gilles, L., Hocine, Z., Paziaud, O., Piot, O., Crocq, C., Kaballu, G., Le Moal, V., Lotton, P., Mabo, P., Pavin, D., Andronache, M., De Chillou, C., Magnin-Poull, I., Deharo, J.-C., Durand, C., Franceschi, F., Peyrouse, E., Prevot, S., Etchegoin, M., Extramiana, F., Leenhardt, A., Messali, A., Heine, T., Schneider, A., Winter, N., Brachmann, J., Ritscher, G., Schertel-Gruenler, B., Simon, H., Sinha, A.-M., Turschner, O., Wystrach, A., Stemberg, M., Kuck, K.-H., Metzner, A., Tilz, R., Wissner, E., Heitmann, K., Willems, S., Andresen, D., Mueller, S., Volkmer, M., Schmidt, B., Kostopoulou, A., Livanis, E., Voudris, V., Efremidis, M., Letsas, K., Tsikrikas, S., Christoforatou, E., Ioannidis, P., Katsivas, A., Kourouklis, S., Andrikopoulos, G., Rassias, I., Tzeis, S., Dakos, G., Paraskevaidis, S., Stavropoulos, G., Theofilogiannakos, E., Vassilikos, V.P., Bongiorni, M.G., Zucchelli, G., Raviele, A., Themistoclakis, S., Pratola, C., Tritto, M., Della Bella, P., Mazzone, P., Moltrasio, M., Tondo, C., Calo, L., De Luca, L., Guarracini, F., Lioy, E., Dozza, L., Frigoli, E., Giannelli, L., Pappone, C., Saviano, M., Schiavina, G., Vicedomini, G.G., De Ponti, R., Doni, L. A., Marazzi, R., Salerno-Uriarte, J.A., Tamborini, C., Anselmino, M., Ferraris, F., Gaita, F., Bertaglia, E., Brandolino, G., Zoppo, F., De Groot, N., Janse, P., Jordaens, L., Pison, L., Roos, C., Van Gelder, I., Manusama, R., Meijer, A., Van der Voort, P., Trines, S., Compier, Marieke G., Kazmierczak, J., Kornacewicz-Jach, Z., Wielusinski, M., Baran, J., Kulakowski, P., Dzidowski, M., Fuglewicz, A., Nowak, K., Pruszkowska-Skrzep, P., Wozniak, A., Nowak, S., Trusz-Gluza, M., Almendral, J., Atienza, F., Castellanos, E., De Diego, C., Ortiz, M., Moreno Planas, J., Perez Castellano, N., Benezet, J., Farre Muncharaz, J., Rubio Campal, J.M., Hernandez Madrid, A., Matia, R., Arana, E., Pedrote, A., Cozar, R., Peinado, R., Valverde, I., Arbelo, E., Berruezo, A., Calvo, N., Guiu, E., Husseini, S., and Mont Girbau, L.

Published
2014
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28. A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference

Author

Kirchhof, Paulus, Breithardt, Günter, Bax, Jeroen, Benninger, Gerlinde, Blomstrom-Lundqvist, Carina, Boriani, Giuseppe, Brandes, Axel, Brown, Helen, Brueckmann, Martina, Calkins, Hugh, Calvert, Melanie, Christoffels, Vincent, Crijns, Harry, Dobrev, Dobromir, Ellinor, Patrick, Fabritz, Larissa, Fetsch, Thomas, Freedman, S. Ben, Gerth, Andrea, Goette, Andreas, Guasch, Eduard, Hack, Guido, Haegeli, Laurent, Hatem, Stephane, Haeusler, Karl Georg, Heidbüchel, Hein, Heinrich-Nols, Jutta, Hidden-Lucet, Francoise, Hindricks, Gerd, Juul-Möller, Steen, Kääb, Stefan, Kappenberger, Lukas, Kespohl, Stefanie, Kotecha, Dipak, Lane, Deirdre A., Leute, Angelika, Lewalter, Thorsten, Meyer, Ralf, Mont, Lluis, Münzel, Felix, Nabauer, Michael, Nielsen, Jens C., Oeff, Michael, Oldgren, Jonas, Oto, Ali, Piccini, Jonathan P., Pilmeyer, Art, Potpara, Tatjana, Ravens, Ursula, Reinecke, Holger, Rostock, Thomas, Rustige, Joerg, Savelieva, Irene, Schnabel, Renate, Schotten, Ulrich, Schwichtenberg, Lars, Sinner, Moritz F., Steinbeck, Gerhard, Stoll, Monika, Tavazzi, Luigi, Themistoclakis, Sakis, Tse, Hung Fat, Van Gelder, Isabelle C., Vardas, Panagiotis E., Varpula, Timo, Vincent, Alphons, Werring, David, Willems, Stephan, Ziegler, André, Lip, Gregory Y.H., and Camm, A. John

Published
2016
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30. Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation

Author

Rudolph, Volker, Andrie, Rene P., Rudolph, Tanja K., Friedrichs, Kai, Klinke, Anna, Hirsch-Hoffmann, Birgit, Schwoerer, Alexander P., Lau, Denise, Fu, XiaoMing, Klingel, Karin, Sydow, Karsten, Didie, Michael, Seniuk, Anika, von Leitner, Eike-Christin, Szoecs, Katalin, Schrickel, Jan W., Treede, Hendrik, Wenzel, Ulrich, Lewalter, Thorsten, Nickenig, Georg, Zimmermann, Wolfram-Hubertus, Meinertz, Thomas, Boger, Rainer H., Reichenspurner, Hermann, Freeman, Bruce A., Eschenhagen, Thomas, Ehmke, Heimo, Hazen, Stanley L., Willems, Stephan, and Baldus, Stephan

Subjects
Care and treatment, Complications and side effects, Research, Causes of, Health aspects, Atrial fibrillation -- Causes of -- Care and treatment -- Research, Inflammation -- Complications and side effects -- Research, Enzyme inhibitors -- Health aspects -- Research
Abstract

Atrial fibrillation remains the most common arrhythmia in humans and stands out as a major contributor to morbidity and mortality (2-4). Despite recent advances in pharmacological and invasive strategies to [...], Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation (1). However, whether inflammation is the cause or the consequence of atrial fibrillation and which specific inflammatory mediators may increase the atria's susceptibility to fibrillation remain elusive. Here we provide experimental and clinical evidence for the mechanistic involvement of myeloperoxidase (MPO), a heme enzyme abundantly expressed by neutrophils, in the pathophysiology of atrial fibrillation. MPO-deficient mice pretreated with angiotensin II (Angll) to provoke leukocyte activation showed lower atrial tissue abundance of the MPO product 3-chlorotyrosine, reduced activity of matrix metalloproteinases and blunted atrial fibrosis as compared to wild-type mice. Upon right atrial electrophysiological stimulation, MPO-deficient mice were protected from atrial fibrillation, which was reversed when MPO was restored. Humans with atrial fibrillation had higher plasma concentrations of MPO and a larger MPO burden in right atrial tissue as compared to individuals devoid of atrial fibrillation. In the atria, MPO colocalized with markedly increased formation of 3-chlorotyrosine. Our data demonstrate that MPO is a crucial prerequisite for structural remodeling of the myocardium, leading to an increased vulnerability to atrial fibrillation.

Published
2010
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32. Dynamic risk assessment to improve quality of care in patients with atrial fibrillation : the 7th AFNET/EHRA Consensus Conference

Author

Fabritz, Larissa, Crijns, Harry J. G. M., Guasch, Eduard, Goette, Andreas, Häusler, Karl Georg, Kotecha, Dipak, Lewalter, Thorsten, Meyer, Christian, Potpara, Tatjana S., Rienstra, Michiel, Schnabel, Renate B., Willems, Stephan, Breithardt, Guenter, Camm, A. John, Chan, Anthony, Chua, Winnie, de Melis, Mirko, Dimopoulou, Christina, Dobrev, Dobromir, Easter, Christina, Eckardt, Lars, Haase, Doreen, Hatem, Stephane, Healey, Jeff S., Heijman, Jordi, Hohnloser, Stefan H., Huebner, Thomas, Ilyas, Bushra Saeed, Isaacs, Aaron, Kutschka, Ingo, Leclercq, Christophe, Lip, Gregory Y. H., Marinelli, Elena Andreassi, Merino, Jose L., Mont, Lluís, Nabauer, Michael, Oldgren, Jonas, Pürerfellner, Helmut, Ravens, Ursula, Savelieva, Irina, Sinner, Moritz F., Sitch, Alice, Smolnik, Rüdiger, Steffel, Jan, Stein, Kenneth, Stoll, Monika, Svennberg, Emma, Thomas, Dierk, Van Gelder, Isabelle C., Vardar, Burcu, Wakili, Reza, Wieloch, Mattias, Zeemering, Stef, Ziegler, Paul D., Heidbuchel, Hein, Hindricks, Gerhard, Schotten, Ulrich, Kirchhof, Paulus, Fabritz, Larissa, Crijns, Harry J. G. M., Guasch, Eduard, Goette, Andreas, Häusler, Karl Georg, Kotecha, Dipak, Lewalter, Thorsten, Meyer, Christian, Potpara, Tatjana S., Rienstra, Michiel, Schnabel, Renate B., Willems, Stephan, Breithardt, Guenter, Camm, A. John, Chan, Anthony, Chua, Winnie, de Melis, Mirko, Dimopoulou, Christina, Dobrev, Dobromir, Easter, Christina, Eckardt, Lars, Haase, Doreen, Hatem, Stephane, Healey, Jeff S., Heijman, Jordi, Hohnloser, Stefan H., Huebner, Thomas, Ilyas, Bushra Saeed, Isaacs, Aaron, Kutschka, Ingo, Leclercq, Christophe, Lip, Gregory Y. H., Marinelli, Elena Andreassi, Merino, Jose L., Mont, Lluís, Nabauer, Michael, Oldgren, Jonas, Pürerfellner, Helmut, Ravens, Ursula, Savelieva, Irina, Sinner, Moritz F., Sitch, Alice, Smolnik, Rüdiger, Steffel, Jan, Stein, Kenneth, Stoll, Monika, Svennberg, Emma, Thomas, Dierk, Van Gelder, Isabelle C., Vardar, Burcu, Wakili, Reza, Wieloch, Mattias, Zeemering, Stef, Ziegler, Paul D., Heidbuchel, Hein, Hindricks, Gerhard, Schotten, Ulrich, and Kirchhof, Paulus

Abstract

Aims The risk of developing atrial fibrillation (AF) and its complications continues to increase, despite good progress in preventing AF-related strokes. Methods and results This article summarizes the outcomes of the 7th Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA) held in Lisbon in March 2019. Sixty-five international AF specialists met to present new data and find consensus on pressing issues in AF prevention, management and future research to improve care for patients with AF and prevent AF-related complications. This article is the main outcome of an interactive, iterative discussion between breakout specialist groups and the meeting plenary. AF patients have dynamic risk profiles requiring repeated assessment and risk-based therapy stratification to optimize quality of care. Interrogation of deeply phenotyped datasets with outcomes will lead to a better understanding of the cardiac and systemic effects of AF, interacting with comorbidities and predisposing factors, enabling stratified therapy. New proposals include an algorithm for the acute management of patients with AF and heart failure, a call for a refined, data-driven assessment of stroke risk, suggestions for anticoagulation use in special populations, and a call for rhythm control therapy selection based on risk of AF recurrence. Conclusion The remaining morbidity and mortality in patients with AF needs better characterization. Likely drivers of the remaining AF-related problems are AF burden, potentially treatable by rhythm control therapy, and concomitant conditions, potentially treatable by treating these conditions. Identifying the drivers of AF-related complications holds promise for stratified therapy.

Published
2021
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33. Clinical risk predictors in atrial fibrillation patients following successful coronary stenting: ENTRUST-AF PCI sub-analysis

Author

Goette, Andreas, Eckardt, Lars, Valgimigli, Marco, Lewalter, Thorsten, Laeis, Petra, Reimitz, Paul-Egbert, Smolnik, Rüdiger, Zierhut, Wolfgang, Tijssen, Jan G, Vranckx, Pascal, Goette, Andreas, Eckardt, Lars, Valgimigli, Marco, Lewalter, Thorsten, Laeis, Petra, Reimitz, Paul-Egbert, Smolnik, Rüdiger, Zierhut, Wolfgang, Tijssen, Jan G, and Vranckx, Pascal

Abstract

Aims: This subgroup analysis of the ENTRUST-AF PCI trial (ClinicalTrials.gov Identifier: NCT02866175; Date of registration: August 2016) evaluated type of AF, and CHA2DS2-VASc score parameters as predictors for clinical outcome. Methods: Patients were randomly assigned after percutaneous coronary intervention (PCI) to either edoxaban (60 mg/30 mg once daily [OD]; n = 751) plus a P2Y12 inhibitor for 12 months or a vitamin K antagonist [VKA] (n = 755) plus a P2Y12 inhibitor and aspirin (100 mg OD, for 1-12 months). The primary outcome was a composite of major/clinically relevant non-major bleeding (CRNM) within 12 months. The composite efficacy endpoint consisted of cardiovascular death, stroke, systemic embolic events, myocardial infarction (MI), and definite stent thrombosis. Results: Major/CRNM bleeding event rates were 20.7%/year and 25.6%/year with edoxaban and warfarin, respectively (HR [95% CI]: 0.83 [0.654-1.047]). The event rates of composite outcome were 7.26%/year and 6.86%/year, respectively (HR [95% CI]): 1.06 [0.711-1.587]), and of overall net clinical benefit were 12.48%/year and 12.80%/year, respectively (HR [(95% CI]: 0.99 [(0.730; 1.343]). Increasing CHA2DS2-VASc score was associated with increased rates of all outcomes. CHA2DS2-VASc score ≥ 5 was a marker for stent thrombosis. Paroxysmal AF was associated with a higher occurrence of MI (4.87% versus 2.01%, p = 0.0024). Conclusion: After PCI in AF patients, increasing CHA2DS2-VASc score was associated with increased bleeding rates and CHA2DS2-VASc score (≥ 5) predicted the occurrence of stent thrombosis. Paroxysmal AF was associated with MI. These findings may have important clinical implications in AF patients.

Published
2021

34. Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia

Author

Roell, Wilhelm, Lewalter, Thorsten, Sasse, Philipp, Tallini, Yvonne N., Choi, Bum-Rak, Breitbach, Martin, Doran, Robert, Becher, Ulrich M., Hwang, Seong-Min, Bostani, Toktam, von Maltzahn, Julia, Hofmann, Andreas, Reining, Shaun, Eiberger, Britta, Gabris, Bethann, Pfeifer, Alexander, Welz, Armin, Willecke, Klaus, Salama, Guy, Schrickel, Jan W., Kotlikoff, Michael I., and Fleischmann, Bernd K.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Wilhelm Roell [1, 2, 9]; Thorsten Lewalter [3, 9]; Philipp Sasse [1, 9]; Yvonne N. Tallini [6]; Bum-Rak Choi [7]; Martin Breitbach [1]; Robert Doran [6]; Ulrich M. Becher [...]

Published
2007
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37. Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference

Author

Kirchhof, Paulus, Breithardt, Günter, Aliot, Etienne, Al Khatib, Sana, Apostolakis, Stavros, Auricchio, Angelo, Bailleul, Christophe, Bax, Jeroen, Benninger, Gerlinde, Blomstrom-Lundqvist, Carina, Boersma, Lucas, Boriani, Giuseppe, Brandes, Axel, Brown, Helen, Brueckmann, Martina, Calkins, Hugh, Casadei, Barbara, Clemens, Andreas, Crijns, Harry, Derwand, Roland, Dobrev, Dobromir, Ezekowitz, Michael, Fetsch, Thomas, Gerth, Andrea, Gillis, Anne, Gulizia, Michele, Hack, Guido, Haegeli, Laurent, Hatem, Stephane, Georg Häusler, Karl, Heidbüchel, Hein, Hernandez-Brichis, Jessica, Jais, Pierre, Kappenberger, Lukas, Kautzner, Joseph, Kim, Steven, Kuck, Karl-Heinz, Lane, Deirdre, Leute, Angelika, Lewalter, Thorsten, Meyer, Ralf, Mont, Lluis, Moses, Gregory, Mueller, Markus, Münzel, Felix, Näbauer, Michael, Nielsen, Jens Cosedis, Oeff, Michael, Oto, Ali, Pieske, Burkert, Pisters, Ron, Potpara, Tatjana, Rasmussen, Lars, Ravens, Ursula, Reiffel, James, Richard-Lordereau, Isabelle, Schäfer, Herbert, Schotten, Ulrich, Stegink, Wim, Stein, Kenneth, Steinbeck, Gerhard, Szumowski, Lukasz, Tavazzi, Luigi, Themistoclakis, Sakis, Thomitzek, Karen, Van Gelder, Isabelle C., von Stritzky, Berndt, Vincent, Alphons, Werring, David, Willems, Stephan, Lip, Gregory Y. H., and Camm, A. John

Published
2013
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46. ESC-EURObservational Research Programme: the Atrial Fibrillation Ablation Pilot Study, conducted by the European Heart Rhythm Association

Author

Arbelo, Elena, Brugada, Josep, Hindricks, Gerhard, Maggioni, Aldo, Tavazzi, Luigi, Vardas, Panos, Anselme, Frédéric, Inama, Giuseppe, Jais, Pierre, Kalarus, Zbigniew, Kautzner, Josef, Lewalter, Thorsten, Mairesse, Georges, Perez-Villacastin, Julian, Riahi, Sam, Taborsky, Milos, Theodorakis, George, and Trines, Serge

Published
2012
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