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Background: As physical signals, mechanical cues regulate the neural cells in the brain. The mechanosensitive channels (MSCs) perceive the mechanical cues and transduce them by permeating specific ions or molecules across the plasma membrane, and finally trigger a series of intracellular bioelectrical and biochemical signals. Emerging evidence supports that wide‐distributed, high‐expressed MSCs like Piezo1 play important roles in several neurophysiological processes and neurological disorders. Aim s : To systematically conclude the functions of MSCs in the brain and provide a novel mechanobiological perspective for brain diseases. Method: We summarized the mechanical cues and MSCs detected in the brain and the research progress on the functional roles of MSCs in physiological conditions. We then concluded the pathological activation and downstream pathways triggered by MSCs in two categories of brain diseases, neurodegenerative diseases and place‐occupying damages. Finally, we outlined the methods for manipulating MSCs and discussed their medical potential with some crucial outstanding issues. Results: The MSCs present underlying common mechanisms in different brain diseases by acting as the "transportation hubs" to transduce the distinct signal patterns: the upstream mechanical cues and the downstream intracellular pathways. Manipulating the MSCs is feasible to alter the complicated downstream processes, providing them promising targets for clinical treatment. Conclusions: Recent research on MSCs provides a novel insight into brain diseases. The common mechanisms mediated by MSCs inspire a wide range of therapeutic potentials targeted on MSCs in different brain diseases. [ABSTRACT FROM AUTHOR]

In this paper the single-use protective clothing for medical use was sterilized by γ-ray irradiation. Compared with the non-irradiated control, the apparent morphology of PP melt-blown fiber and amboss had no fracture. According to the national standard of GB/T 19082-2009, the mechanical properties, resistance to synthetic blood penetration, resistance to water penetration and filtering efficiency were measured. The results showed that the post-irradiation effects did not decrease the resistance to synthetic blood penetration or water penetration. Moreover, the filtering efficiency remained higher than 99.8%. On the other hand, the mechanical properties were reduced significantly due to the degradation of poly chain of PP induced by γ-ray irradiation. It has been assured that the important properties of single-use protective clothing for medical use are still above the quality level after γ-ray irradiation sterilization process. which can supply reference for the produce single-use protection of clothing of medical purpose at high quality.

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a naturally sourced polymer with good biocompatibility and potential applications in biomedical field after sterilization. Radiation sterilization technology has been extensively applied on medical products. However, for polymer-based biomedical materials, gamma irradiation can cause random chain scission on the polymer backbone. In this paper, we studied the effect of gamma irradiation on the mechanical and thermal properties of PHBHHx. The tensile strength and fracture strain of PHBHHx decreased after irradiation, while the brittleness increased after irradiation. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) results showed that the melting temperatures of irradiated PHBHHx are lower than the non-irradiated films, but the irradiated specimen shows a higher decomposition temperature than non-irradiated PHBHHx.

Metal phthalocyanine (MPc) has a great saturation response value, but its low conductivity and slow response speed limit its practical application. A novel hybrid material composed of graphene quantum dots (GQDs) and metal phthalocyanine derivatives has been obtained. GQDs can be anchored onto the surface of MPc nanofibers through π-π stacking. The response to NO 2 can be significantly enhanced under certain component proportion matching, which is much better than their respective response to NO 2 . The introduction of GQDs greatly increases the conductivity of phthalocyanine fibers, leading to a faster response of the hybrid material. In addition, the reproducibility, selectivity and stability of the hybrid materials are excellent, and the minimum response concentration can reach 50 ppb. Ultra-low-power laser irradiation was used to solve the problem of slow recovery of metal phthalocyanine. Overall, we present the advantages of combining MPc nanofibers with GQDs and pave a new avenue for the application of MPc-GQD hybrids in the gas sensing field., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)