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2. Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway

Author

Geng, Wei, Lo, Chung-Mau, Ng, Kevin TP, Ling, Chang-Chun, Qi, Xiang, Li, Chang-Xian, Zhai, Yuan, Liu, Xiao-Bing, Ma, Yuen-Yuen, and Man, Kwan

Subjects
Cancer, Liver Disease, Rare Diseases, Transplantation, Organ Transplantation, Digestive Diseases, Liver Cancer, Chronic Liver Disease and Cirrhosis, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Apoptosis, Carcinoma, Hepatocellular, Chemokine CXCL10, Cisplatin, Disease Models, Animal, Drug Resistance, Neoplasm, Endoplasmic Reticulum Chaperone BiP, Endoplasmic Reticulum Stress, Enzyme-Linked Immunosorbent Assay, Humans, In Situ Nick-End Labeling, Liver Neoplasms, Liver Transplantation, Male, Mice, Mice, Nude, Neoplasm Recurrence, Local, Polymerase Chain Reaction, Rats, Xenograft Model Antitumor Assays, IP10, HCC, liver transplantation, cisplatin resistance, graft injury, Oncology and Carcinogenesis
Abstract

Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC). The acute-phase liver graft injury might potentially induce poor response to chemotherapy in recurrent HCC after liver transplantation. We here intended to explore the mechanism and to identify a therapeutic target to overcome such chemoresistance. The associations among graft injury, overexpression of IP10 and multidrug resistant genes were investigated in a rat liver transplantation model, and further validated in clinical cohort. The role of IP10 on HCC cell proliferation and tumor growth under chemotherapy was studied both in vitro and in vivo. The underlying mechanism was revealed by detecting the activation of endoplasmic reticulum (ER) stress signaling pathways. Moreover, the effect of IP10 neutralizing antibody sensitizing cisplatin treatment was further explored. In rat liver transplantation model, significant up-regulation of IP10 associated with multidrug resistant genes was found in small-for-size liver graft. Clinically, high expression of circulating IP10 was significant correlated with tumor recurrence in HCC patients underwent LDLT. Overexpression of IP10 promoted HCC cell proliferation and tumor growth under cisplatin treatment by activation of ATF6/Grp78 signaling. IP10 neutralizing antibody sensitized cisplatin treatment in nude mice. The overexpression of IP10, which induced by liver graft injury, may lead to cisplatin resistance via ATF6/Grp78 ER stress signaling pathway. IP10 neutralizing antibody could be a potential adjuvant therapy to sensitize cisplatin treatment.

Published
2015

9. Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence

Author

Qi, Xiang, primary, Ng, Kevin Tak-Pan, additional, Lian, Qizhou, additional, Li, Chang Xian, additional, Geng, Wei, additional, Ling, Chang Chun, additional, Yeung, Wai Ho, additional, Ma, Yuen Yuen, additional, Liu, Xiao Bing, additional, Liu, Hui, additional, Liu, Jiang, additional, Yang, Xin Xiang, additional, Lo, Chung Mau, additional, and Man, Kwan, additional

Published
2018
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10. Construction and Simulation on Traction Converter and Control System of EMU

Author

Sun Yannan, Li Chunying, and Li Chang-Xian

Subjects
EMU, Engineering, Traction control system, business.industry, Traction converter, General Medicine, law.invention, Control theory, law, Control system, Inverter, Rotor flux, transient current control, Transformer, business, MATLAB, computer, Induction motor, Pulse-width modulation, Engineering(all), computer.programming_language
Abstract

The traction converter and control system of EMU is constructed based on Matlab/Simulink. The system consists of a transformer, a rectifier, an inverter and an induction motor. The rectifier is controlled by the transient current control theory with SPWM technology. In the inverter the indirect rotor flux oriented control theory with current hysteretic band PWM strategy is adopted. Based on the system the traction control and constant speed control are tested. The simulation results present that the system is with good dynamic and steady state performance and fulfill the running demand of EMU.

Published
2012
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11. A hemoglobin-based oxygen carrier sensitized Cisplatin based chemotherapy in hepatocellular carcinoma

Author

Qi, Xiang, primary, Wong, Bing L., additional, Lau, Sze Hang, additional, Tak-Pan Ng, Kevin, additional, Kwok, Sui Yi, additional, Kin-Wai Sun, Chris, additional, Tzang, Fei Chuen, additional, Shao, Yan, additional, Li, Chang Xian, additional, Geng, Wei, additional, Ling, Chang Chun, additional, Ma, Yuen Yuen, additional, Liu, Xiao Bing, additional, Liu, Hui, additional, Liu, Jiang, additional, Yeung, Wai Ho, additional, Lo, Chung Mau, additional, and Man, Kwan, additional

Published
2017
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14. Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response

Author

Li, Chang Xian, primary, Lo, Chung Mau, additional, Lian, Qizhou, additional, Ng, Kevin Tak-Pan, additional, Liu, Xiao Bing, additional, Ma, Yuen Yuen, additional, Qi, Xiang, additional, Yeung, Oscar Wai Ho, additional, Tergaonkar, Vinay, additional, Yang, Xin Xiang, additional, Liu, Hui, additional, Liu, Jiang, additional, Shao, Yan, additional, and Man, Kwan, additional

Published
2016
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16. The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation

Author

Qi, Xiang, primary, Ng, Kevin Tak-Pan, additional, Shao, Yan, additional, Li, Chang Xian, additional, Geng, Wei, additional, Ling, Chang Chun, additional, Ma, Yuen Yuen, additional, Liu, Xiao Bing, additional, Liu, Hui, additional, Liu, Jiang, additional, Yeung, Wai Ho, additional, Lo, Chung Mau, additional, and Man, Kwan, additional

Published
2016
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17. Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma

Author

Qi, Xiang, primary, Ng, Kevin Tak Pan, additional, Lian, Qi Zhou, additional, Liu, Xiao Bing, additional, Li, Chang Xian, additional, Geng, Wei, additional, Ling, Chang Chun, additional, Ma, Yuen Yuen, additional, Yeung, Wai Ho, additional, Tu, Wen Wei, additional, Fan, Sheung Tat, additional, Lo, Chung Mau, additional, and Man, Kwan, additional

Published
2014
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18. Identification of Transmembrane Protein 98 as a Novel Chemoresistance-Conferring Gene in Hepatocellular Carcinoma

Author

Ng, Kevin Tak-Pan, primary, Lo, Chung Mau, additional, Guo, Dong Yong, additional, Qi, Xiang, additional, Li, Chang Xian, additional, Geng, Wei, additional, Liu, Xiao Bing, additional, Ling, Chang Chun, additional, Ma, Yuen Yuen, additional, Yeung, Wai Ho, additional, Shao, Yan, additional, Poon, Ronnie Tung-Ping, additional, Fan, Sheung Tat, additional, and Man, Kwan, additional

Published
2014
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19. A novel oxygen carrier “YQ23” suppresses the liver tumor metastasis by decreasing circulating endothelial progenitor cells and regulatory T cells

Author

Li, Chang Xian, primary, Wong, Bing L, additional, Ling, Chang Chun, additional, Ma, Yuen Yuen, additional, Shao, Yan, additional, Geng, Wei, additional, Qi, Xiang, additional, Lau, Sze Hang, additional, Kwok, Sui Yi, additional, Wei, Na, additional, Tzang, Fei Chuen, additional, Ng, Kevin TP, additional, Liu, Xiao Bing, additional, Lo, Chung Mau, additional, and Man, Kwan, additional

Published
2014
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23. CircUGP2 Suppresses Intrahepatic Cholangiocarcinoma Progression via p53 Signaling Through Interacting With PURB to Regulate ADGRB1 Transcription and Sponging miR-3191-5p.

Author

Chen RX, Liu SC, Kan XC, Wang YR, Wang JF, Wang TL, Li C, Jiang WJ, Chen YAL, Zhou T, Fan SL, Chang J, Xu X, Shi KH, Zhang YD, Wu MY, Yu Y, Li CX, and Li XC

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and its prognosis remains poor. Although growing numbers of studies have verified the involvement of circular RNAs (circRNAs) in various cancer types, their specific functions in ICC remain elusive. Herein, a circRNA, circUGP2 is identified by circRNA sequencing, which is downregulated in ICC tissues and correlated with patients' prognosis. Moreover, circUGP2 overexpression suppresses tumor progression in vitro and in vivo. Mechanistically, circUGP2 functions as a transcriptional co-activator of PURB over the expression of ADGRB1. It can also upregulate ADGRB1 expression by sponging miR-3191-5p. As a result, ADGRB1 prevents MDM2-mediated p53 polyubiquitination and thereby activates p53 signaling to inhibit ICC progression. Based on these findings, circUGP2 plasmid is encapsulated into a lipid nanoparticle (LNP) system, which has successfully targeted tumor site and shows superior anti-tumor effects. In summary, the present study has identified the role of circUGP2 as a tumor suppressor in ICC through regulating ADGRB1/p53 axis, and the application of LNP provides a promising translational strategy for ICC treatment., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Published
2024
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24. 'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice.

Author

Li CX, Yu B, Shi L, Geng W, Lin QB, Ling CC, Yang M, Ng KT, Huang JD, and Man K

Abstract

The antitumor properties of bacteria have been demonstrated over the past decades. However, the efficacy is limited and unclear. Furthermore, systemic infection remains a serious concern in bacteria treatment. In this study, the effect of YB1, a rationally designed 'obligate' anaerobic Salmonella typhimurium strain, on liver tumor growth and metastasis in a nude mouse orthotopic liver tumor model was investigated. The orthotopic liver tumor model was established in nude mice using the hepatocellular carcinoma cell line MHCC-97L. Two weeks after orthotopic liver tumor implantation, YB1, SL7207 and saline were respectively administered through the tail vein of the mice. Longitudinal monitoring of tumor growth and metastasis was performed using Xenogen IVIS, and direct measurements of tumor volume were taken 3 weeks after treatment. In vitro , MHCC-97L and PLC cells were incubated with YB1 or SL7207 under anaerobic conditions. YB1 was observed to invade tumor cells and induce tumor cell apoptosis and death. The results revealed that all mice in the YB1 group were alive 3 weeks after YB1 injection while all mice in the SL7207 group died within 11 days of the SL7207 injection. The body weight decreased by ~9% on day 1 after YB1 injection and but subsequently recovered. Liver tumor growth and metastases were significantly inhibited following YB1 treatment. By contrast to the control group, a large number of Gr1-positive cells were detected on days 1 to 21 following YB1 treatment. Furthermore, YB1 also effectively invaded tumor cells and induced tumor cell apoptosis and death. In conclusion, YB1 suppressed liver tumor growth and metastasis in a nude mice liver tumor model. The potential mechanism may be through enhancing innate immune response and inducing tumor cell apoptosis and cell death.

Published
2017
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