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13. Serum Pigment Epithelium-Derived Factor Levels are Associated with Estradiol and Decrease After Adjusting for Alanine Aminotransferase in Chinese Women Based on Multiple Linear Regression Analysis

Author

Li,Cuiliu, Zhang,Yunna, Gao,Fang, Li,Cuiliu, Zhang,Yunna, and Gao,Fang

Abstract

Cuiliu Li, Yunna Zhang, Fang Gao The Second Department of Endocrinology, Cangzhou Central Hospital, Cangzhou, 061001, People’s Republic of ChinaCorrespondence: Cuiliu Li, Tel +8603172075935, Email licuiliu1989@163.comPurpose: To assess changes in pigment epithelium-derived factor (PEDF) levels in patients with metabolic syndrome (MetS) and to investigate sexual dimorphism in serum PEDF levels and their relationships with estradiol.Methods: A total of 318 individuals (145 men, 173 women) who underwent health examinations in our department were selected. Serum PEDF, estradiol and other metabolic parameters were determined. Homeostasis model assessment of insulin resistance (HOMA- IR) and homeostasis model assessment of β-cell function (HOMA-β) were calculated to evaluate insulin resistance and β-cell function, respectively. Multiple linear regression analysis was used to analyse the factors influencing serum PEDF.Results: Serum PEDF levels were significantly higher in subjects with MetS in both men and women (12.09± 2.75 vs 8.97± 3.19 μg/mL in men and 11.31± 2.79 vs 8.40± 2.32 μg/mL in women, MetS vs non-MetS, P< 0.001). Correlation analysis showed that serum PEDF levels were significantly correlated with body mass index (BMI), waist circumference, waist-to-hip ratio, diastolic blood pressure (DBP), fasting and 2-h postprandial glucose, fasting and 2-h postprandial insulin, HOMA-β, HOMA-IR, hemoglobin A1c (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid (UA), triacylglycerol (TG) and high-density lipoprotein cholesterol (HDL-C). Elevated ALT, HOMA-IR and TG were significant predictors of increased PEDF concentrations. In women, estradiol was inversely correlated with PEDF levels (r=− 0.25, P=0.011), and the association was no longer significant after adjustment for ALT.Conclusion: PEDF could be used as a biomarker of MetS in both men and women. This study reported for the first time that circulating PEDF displays se

Published
2022

16. The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.

Author

Su N, Zhao N, Wang G, Wang L, Zhang Y, Li R, Liu Y, Yang X, Li C, and Hou M

Subjects
Female, Humans, Male, Middle Aged, Adiponectin blood, Blood Glucose metabolism, Diabetes Mellitus, Type 2 blood, Diabetic Angiopathies blood, Lipid Metabolism, Receptors, Adiponectin blood
Abstract

Background/aims: The present study aimed to investigate the serum levels of adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 diabetes mellitus (T2DM) combined with macrovascular complications (MVC), as well as their correlation with clinical parameters., Methods: A total of 60 T2DM patients were divided into 2 groups according to the presence of MVC: T2DM + MVC group (n=30) and T2DM group (n=30). Additionally, 30 healthy people were selected as control group (NC group). Clinical data and biological parameters were detected and recorded. T test was performed to compare the differences between two groups, and the results were corrected using Bonferroni method. Meanwhile, the correlation analysis and multiple stepwise regression analysis were used to analyze the association of APN and AdipoR1 with clinical factors., Results: The levels of APN and AdipoR1 were significantly decreased in T2DM group and T2DM + MVC group compared with NC group, with the lowest value in T2DM + MVC group (all P<0.01). Serum APN levels were positively correlated with FINS and TG (r = 0.412, 0.316, respectively; both P<0.05), and negatively correlated with SBP, DBP and LDL-C (r = -0.292, -0.383, -0.334, respectively; all P<0.05). Serum levels of AdipoR1 were positively correlated with APN (r = 0.726, P<0.01), and negatively correlated with BMI, SBP, DBP, FBG, TC and LDL-C (r = -0.440, -0.446, -0.374, -0.444, -0.344, -0.709, respectively; all P<0.01)., Conclusion: Serum levels of APN and AdipoR1 are significantly lower in T2DM group and T2DM + MVC group, showing lowest value in T2DM + MVC group. APN and AdipoR1 levels may influence glucose and lipid metabolism in T2DM patients., Competing Interests: The authors declare to have no competing interests., (© Copyright by the Author(s). Published by Cell Physiol Biochem Press.)

Published
2019
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