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NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types. Bioinformatics analysis revealed that NUP155 was upregulated in 26 types of cancer. Additionally, NUP155 upregulation was strongly correlated with advanced pathological or clinical stages and poor prognosis in several cancers. Furthermore, NUP155 was significantly and positively correlated with DNA methylation, tumor mutational burden, microsatellite instability, and stemness score in most cancers. Additionally, NUP155 was also found to be involved in TIME and closely associated with tumor infiltrating immune cells and immunoregulation-related genes. Functional enrichment analysis revealed a strong correlation between NUP155 and immunomodulatory pathways, especially antigen processing and presentation. The role of NUP155 in breast cancer has not been examined. This study, for the first time, demonstrated that NUP155 was upregulated in breast invasive carcinoma (BRCA) cells and revealed its oncogenic role in BRCA using molecular biology experiments. Thus, our study highlights the potential value of NUP155 as a biomarker in the assessment of prognostic prediction, tumor microenvironment and immunotherapeutic response in pan-cancer. [ABSTRACT FROM AUTHOR]

The paper studies the magnetic field distribution of three degree-of-freedom (3-DOF) permanent magnet (PM) spherical motor adopting the 3-D magnetic equivalent circuits (MEC) method. Compared with the analytical method and finite element analysis (FEA) method, the MEC has such desirable attributes as moderate computational effort and reasonable accuracy. The model of PM spherical motor is evenly meshed into elements in spherical coordinates, and the expressions of reluctances and magnetomotive force (MMF) sources in the element have been deduced. Given that magnetic field of the PM spherical motor distributes in the whole space, to reduce the number of elements and increase the solving speed, an approximate equipotential surface is adopted based on the simplified magnetic circuit, and the different magnetic boundary conditions are represented by the corresponding states of nodes and branches of the elements. Finally, the MEC network, which represents half of the magnetic pole and the corresponding air region of the motor, is built. Flux density distribution is calculated by means of the proposed model and verified by the FEA method. [ABSTRACT FROM PUBLISHER]

The chemical fixation of CO2 with epoxides to form cyclic carbonates was carried out with excellent selectivity and yield in the presence of Brønsted acidic ionic liquids without using additional organic solvents and co-catalyst. The acidic strength of ionic liquids was determined and its effect on the synthesis of cyclic carbonates was investigated. The reaction conditions (temperature, CO2 pressure and reaction time) were optimized, and the Brønsted acidic ionic liquids showed highly catalytic activity under the optimal reaction conditions. A plausible reaction mechanism was suggested and it was demonstrated that the carboxylic group in Brønsted acidic ionic liquids had synergetic effect with halide. Moreover, the catalyst could be used five times without significant decrease in its catalytic activity. [ABSTRACT FROM AUTHOR]

The health effects of odors emitted from the human environment have received some discussion in the literature. Little has been written, however, about the health effects of odor emissions from renovation. The authors therefore conducted a cross-sectional study with a simple randomized sampling design. The sample was selected from a building-and-construction registry that registered all building and domestic renovation applications in Tianjin, China. Information on demographics, physical symptoms, and health status was collected via personal interviews. Air samples were also collected from each household for chemical analysis. Data were analyzed with weighted logistic-regression models. A significant association was found between exposure to odor emission and unspecific physical symptoms. After potential confounders were adjusted for, it was found that people who had been exposed to moderate-to-strong odor emissions from renovations were about four times more likely to report experiencing unspecific discomfort than were people who had been exposed to weak odor emissions (odds ratio = 4.05; 95 percent confidence interval = 1.49-11.03). The results indicate that odor emissions from domestic renovation have a detrimental effect on human physical health. This effect seemed to be independent from that generated by chemicals. Implications and prevention strategies are discussed. [ABSTRACT FROM AUTHOR]