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Background: Culex pipiens pallens is a well-known mosquito vector for several diseases. Deltamethrin, a commonly used pyrethroid insecticide, has been frequently applied to manage adult Cx. pipiens pallens. However, mosquitoes can develop resistance to these insecticides as a result of insecticide misuse and, therefore, it is crucial to identify novel methods to control insecticide resistance. The relationship between commensal bacteria and vector resistance has been recently recognized. Bacteriophages (= phages) are effective tools by which to control insect commensal bacteria, but there have as yet been no studies using phages on adult mosquitoes. In this study, we isolated an Aeromonas phage vB AhM-LH that specifically targets resistance-associated symbiotic bacteria in mosquitoes. We investigated the impact of Aeromonas phage vB AhM-LH in an abundance of Aeromonas hydrophila in the gut of Cx. pipiens pallens and its effect on the status of deltamethrin resistance. Methods: Phages were isolated on double-layer agar plates and their biological properties analyzed. Phage morphology was observed by transmission electron microscopy (TEM) after negative staining. The phage was then introduced into the mosquito intestines via oral feeding. The inhibitory effect of Aeromonas phage vB AhM-LH on Aeromonas hydrophila in mosquito intestines was assessed through quantitative real-time PCR analysis. Deltamethrin resistance of mosquitoes was assessed using WHO bottle bioassays. Results: An Aeromonas phage vB AhM-LH was isolated from sewage and identified as belonging to the Myoviridae family in the order Caudovirales using TEM. Based on biological characteristics analysis and in vitro antibacterial experiments, Aeromonas phage vB AhM-LH was observed to exhibit excellent stability and effective bactericidal activity. Sequencing revealed that the Aeromonas phage vB AhM-LH genome comprises 43,663 bp (51.6% CG content) with 81 predicted open reading frames. No integrase-related gene was detected in the vB AH-LH genome, which marked it as a potential biological antibacterial. Finally, we found that Aeromonas phage vB AhM-LH could significantly reduce deltamethrin resistance in Cx. pipiens pallens, in both the laboratory and field settings, by decreasing the abundance of Aeromonas hydrophila in their midgut. Conclusions: Our findings demonstrate that Aeromonas phage vB AhM-LH could effectively modulate commensal bacteria Aeromonas hydrophila in adult mosquitoes, thus representing a promising strategy to mitigate mosquito vector resistance. [ABSTRACT FROM AUTHOR]

This paper utilized the hydrothermal method and freeze-drying technology to prepare the macroscopic aerogel structure and powder structure of MOF-808/RGO. Through comparative analysis of aspects such as photocatalytic CO 2 reduction performance, electron transfer efficiency, macroscopic structure, and microstructure, it has been discovered that aerogel structure can provide favorable conditions for mass transfer of CO 2 and water molecules, and light propagation. The introduction of RGO successfully captures electrons and the reduction reaction occurs on the surface of the material. [Display omitted] • Macroscopic aerogel and powder structures of the MOF-808/RGO composite photocatalysts were fabricated separately and used for comparison. • The photocatalytic performance of the MOF-808/RGO macroscopic aerogels in reducing CO 2 to CO was approximately 16 times that of MOF-808 and 12 times that of RGO. • The aerogel structure provides an abundance of pore structures within the material. • The presence of the aerogel structure successfully enhanced the photothermal and photoelectric conversion efficiencies of the composite photocatalysts. Three-dimensional (3D) macroscopic aerogels have emerged as a critical component in the realm of photocatalysis. Maximizing the integration of materials can result in enhanced efficiency and selectivity in photocatalytic processes. In this investigation, we fabricated MOF-808/reduced graphene oxide (RGO) 3D macroscopic aerogel composite materials employing the techniques of hydrothermal synthesis and freeze-drying. The results revealed that the macroscopic aerogel material exhibited the highest performance in CO 2 reduction to CO, particularly when the concentration of RGO was maintained at 5 mg mL−1. In addition, we synthesized powder materials of MR-5 composite photocatalysts and conducted a comparative analysis in terms of photocatalytic CO 2 reduction performance and electron transfer efficiency. The results show that the macroscopic aerogel material boasts a high specific surface area, an abundant internal pore structure, and increased active sites. These attributes collectively enhance light energy utilization, and electron transfer rates, thereby, improving photothermal and photoelectric conversion efficiencies. Furthermore, we conducted in-situ FT-IR measurements and found that the M/R-5 aerogel exhibited the best CO 2 adsorption capacity under a CO 2 flow rate of 10 mL min−1. The density functional theory results demonstrate the correlation between the formation pathway of the product and the charge transfer pathway. This study provides useful ideas for realizing photocatalytic CO 2 reduction of macroscopic aerogel materials in gas–solid reaction mode. [ABSTRACT FROM AUTHOR]

A novel photonic crystal fiber (PCF) sensor for refractive index detection based on polydimethylsiloxane (PDMS) is presented in this research, as well as designs for single-channel and dual-channel structures for this PDMS-PCF sensor. The proposed structures can be used to develop sensors with biocompatible polymers. The performance of the single-channel PDMS-PCF sensor was studied, and it was found that adjusting parameters such as pore diameter, lattice constant, distance between the D-shaped structure and the fiber core, and the radius of gold nanoparticles can optimize the sensor's performance. The findings indicate that the detection range of the single-channel photonic crystal is 1.21–1.27. The maximum wavelength sensitivity is 10,000 nm/RIU with a resolution of 1 × 10 − 5 RIU, which is gained when the refractive index is set to 1.27. Based on the results of the single-channel PCF, a dual-channel PDMS-PCF sensor is designed. The refractive index detection range of the proposed sensor is 1.2–1.28. The proposed sensor has a maximum wavelength sensitivity of 13,000 nm/RIU and a maximum resolution of 7.69 × 10 − 6 RIU at a refractive index of 1.28. The designed PDMS-PCF holds tremendous potential for applications in the analysis and detection of substances in the human body in the future. [ABSTRACT FROM AUTHOR]

With the in-depth study of solid-state batteries (SSBs), various in situ and ex situ characterization technologies have been widely used to study them. The performance and reliability of SSBs are limited by the formation and evolution of lithium dendrites at the interfaces between solid electrodes and solid electrolytes. We propose a new method based on optical coherence tomography (OCT) for in situ characterization of the internal state of solid-state batteries. OCT is a low-loss, high-resolution, non-invasive imaging technique that can provide real-time monitoring of cross-sectional images of internal structures of SSBs. The morphology, growth, and evolution of lithium dendrites at different stages of cycling under various conditions can be visualized and quantified by OCT. Furthermore, we validate and correlate the OCT results with scanning electron microscopy (SEM) and XPS, proving the accuracy and effectiveness of the OCT characterization method. We reveal the interfacial phenomena and challenges in SSBs and demonstrate the feasibility and advantages of OCT as a powerful tool for in situ and operando imaging of battery interfaces. This study provides new insights into the mechanisms and factors that affect SSB performance, safety, and lifetime, and suggests possible solutions for improvement and application in the field of applied energy. [ABSTRACT FROM AUTHOR]

Ischemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion. However, the vascular mechanism underlying this hypoperfusion is largely unknown, and no approach is available to actively promote optimal reperfusion to treat no-reflow. Here, by combining two-photon laser scanning microscopy (2PLSM) and a mouse middle cerebral arteriolar occlusion (MCAO) model, we find myogenic vasomotion deficits correlated with post-ischemic cerebral circulation interruptions and no-reflow. Transient occlusion-induced transient loss of mitochondrial membrane potential (ΔΨm) permanently impairs mitochondria-endoplasmic reticulum (ER) contacts and abolish Ca2+ oscillation in smooth muscle cells (SMCs), the driving force of myogenic spontaneous vasomotion. Furthermore, tethering mitochondria and ER by specific overexpression of ME-Linker in SMCs restores cytosolic Ca2+ homeostasis, remotivates myogenic spontaneous vasomotion, achieves optimal reperfusion, and ameliorates neurological injury. Collectively, the maintaining of arteriolar myogenic vasomotion and mitochondria-ER contacts in SMCs, are of critical importance in preventing post-ischemic no-reflow. The no-reflow phenomenon after stroke is attributed to damaged spontaneous vasomotion of cerebral arterioles, which can be alleviated by maintaining mitochondria-ER contact-dependent Ca2+ oscillation. [ABSTRACT FROM AUTHOR]

This paper proposes a directly self-starting second-order s-sub-step explicit method, within which the three novel members are developed and analyzed for demonstration. The novel explicit schemes can output second-order accelerations for general structures, which cannot be achieved for the directly self-starting single- and two-sub-step algorithms. Each explicit algorithm achieves controllable algorithmic dissipation and adjustable bifurcation points. As a result, the novel explicit algorithms impose two algorithmic parameters, ρb and Ωb, to control numerical dissipation and bifurcation point, respectively. The parameter ρb, denoting the spectral radius at the bifurcation point, controls numerical dissipation, whereas the parameter Ωb, denoting the bifurcation point, adjusts the amount of dissipation imposed in the low-frequency range. This paper provides users with two recommended selections of Ωb. Apart from these desirable features, each novel explicit algorithm attains the maximum stability bound, 2 × s where s denotes the number of sub-steps. The four- and five-sub-step algorithms perform optimization to reduce numerical low-frequency dissipation. As the number of sub-steps increases, the novel explicit algorithms can have better numerical characteristics without an increase in the computational effort. Numerical examples are simulated to validate the performance and superiority of the novel explicit algorithms. [ABSTRACT FROM AUTHOR]

In recent years, owing to the continuous development of polymer nanofiber manufacturing technology, various nanofibers with different structural characteristics have emerged, allowing their application in the field of sensing to continually expand. Integrating polymer nanofibers with optical sensors takes advantage of the high sensitivity, fast response, and strong immunity to electromagnetic interference of optical sensors, enabling widespread use in biomedical science, environmental monitoring, food safety, and other fields. This paper summarizes the research progress of polymer nanofibers in optical sensors, classifies and analyzes polymer nanofiber optical sensors according to different functions (fluorescence, Raman, polarization, surface plasmon resonance, and photoelectrochemistry), and introduces the principles, structures, and properties of each type of sensor and application examples in different fields. This paper also looks forward to the future development directions and challenges of polymer nanofiber optical sensors, and provides a reference for in-depth research of sensors and industrial applications of polymer nanofibers. [ABSTRACT FROM AUTHOR]

In this paper, locally resonant membrane with attached resonators is introduced to duct system to achieve good noise control effect especially in low frequency range. A rigorous analytical model based on modal expansion method is developed to investigate the vibroacoustic coupling characteristic of proposed duct-membrane-resonator system. The corresponding theoretical results show a good agreement with numerical simulation. The velocity distribution, sound transmission loss curve, and the mechanism behind are discussed and explained deeply. It is found that the attached resonators on the membrane can lead to new transmission loss peak which is related to but not exactly equal to the resonance frequency of attached resonator itself. Correspondence between zero equivalent density mass and transmission loss peak is achieved at the non-antisymmetric modes. Compared to single resonator, multi-resonators system can realize more transmission loss peaks for better sound transmission effect. In principle, ultra-low frequency noise reduction and arbitrarily adjustable frequency can be achieved by changing the frequency, position, and number of exerted resonators, which provide a new approach for duct noise control. [ABSTRACT FROM AUTHOR]

SNX5 is a protein that is involved in endosomal sorting, signal transduction and endocytosis pathways. However, the roles of fish SNX5 were largely unknown. In this study, we identified an SNX5 homolog (EcSNX5) from an orange-spotted grouper (E. coioides) and investigated its role during viral infection. EcSNX5 encoded 412 amino acids with a PX domain and a BAR domain. In addition, it shared high identities with other known fish SNX5. Through quantitative real-time polymerase chain reaction (qRT-PCR), the high expression of EcSNX5 was observed in the head, kidney and heart. After stimulation with the red-spotted grouper nervous necrosis virus (RGNNV) in vitro, EcSNX5 expression was significantly induced. After RGNNV infection in vitro, EcSNX5 overexpression enhanced the expression of RGNNV genes, including coat protein (CP) and RNA-dependent RNA polymerase (RdRp). EcSNX5 knockdown downregulates expression of CP and RdRp. The TCID50 assay showed a higher viral titer when EcSNX5 is over expressed. Moreover, EcSNX5 overexpression could reduce the expression of interferon genes (IRF1, IRF3, IRF7, MX1, ISG15, ISG56, MDA5 and TRIF) and inflammatory genes (IL6, IL8, IL-1β and TNF-α). EcSNX5 knockdown could promote the expression of interferon factors and inflammatory factors. Moreover, EcSNX5 overexpression suppresses the expression of autophagy genes (LC3-II, BECN1, ATG5 and ATG16L1) and upregulates the expression of apoptosis genes (Bax, BNIP3), but EcSNX5 knockdown had the opposite effect. According to the subcellular localization, EcSNX5 is localized in the cytoplasm and co-localizaed with RGNNV CP protein. The results showed EcSNX5 can influence viral infections by regulating the expression of interferon factors and inflammatory factors as well as adjusting virus-induced autophagy. These data will contribute to a better understanding of the immune response of fish during virus infection. [ABSTRACT FROM AUTHOR]

The International Global Navigation Satellite Systems Service (IGS) ionospheric total electron content (TEC) data are used to study the periodic perturbation in the ionosphere during the 2019 Antarctic sudden stratospheric warming (SSW) event, a rare Southern Hemisphere minor SSW event in the last 40 years. A 14.5 day periodic signal with a zonal wavenumber of 0 is observed in the mesosphere and the lower thermosphere (MLT) region and the ionosphere during this SSW period, which could be related to the lunar tide. The 14.5 day periodic disturbance in the IGS TEC exhibits local time dependence and latitudinal variation, with the maximum amplitude appearing between 1000 and 1600 LT in the equatorial ionization anomaly (EIA) crest regions. Additionally, the 14.5 day periodic oscillation shows an obvious longitudinal variability, with the weakest amplitude appearing in the longitudinal region of 30° W–60° E. [ABSTRACT FROM AUTHOR]

Background: Salmonella typhimurium (S.T), as an important foodborne bacterial pathogen, can cause diarrhea and gastroenteritis in humans and animals. Numerous studies have confirmed that exopolysaccharides (EPSs) have various biological functions, but the mechanism through which EPSs improve the immunity of animals against the invasion of pathogenic bacteria is unclear. Here, we explored the protective effect of EPSs of Lactobacillus rhamnosus GG (LGG) on the S.T-infected intestine. Methods: Mice received adequate food and drinking water for one week before the start of the experiment. After 7 d of prefeeding, 2×108 CFU/mL S.T solution and an equivalent volume of saline (control group) were given orally for 1 d. On the fourth day, the mice were treated with 0.5 mg/mL EPSs, 1.0 mg/mL EPSs, 2.0 mg/mL EPSs, or 2.0 mg/mL penicillin for 7 d. Finally, the body and relative organ weight, histological staining, and the levels of antioxidant enzyme activity and inflammatory cytokines were determined. Results: The S.T-infected mice exhibited symptoms of decreased appetite, somnolence, diarrhea and flagging spirit. Treatment with EPSs and penicillin improved the weight loss of the mice, and the high dose of EPSs showed the best therapeutic effect. EPSs significantly ameliorated S.T-induced ileal injury in mice. High-dose EPSs were more effective than penicillin for alleviating ileal oxidative damage induced by S.T. The mRNA levels of inflammatory cytokines in the ileum of mice showed that the regulatory effects of EPSs on inflammatory cytokines were better than those of penicillin. EPSs could inhibit the expression and activation of key proteins of the TLR4/NF-κB/MAPK pathway and thereby suppress the level of S.T-induced ileal inflammation. Conclusions: EPSs attenuate S.T-induced immune responses by inhibiting the expression of key proteins in the TLR4/NF-κB/MAPK signaling pathway. Moreover, EPSs could promote bacterial aggregation into clusters, which may be a potential strategy for reducing the bacterial invasion of intestinal epithelial cells. [ABSTRACT FROM AUTHOR]

Benign prostatic hyperplasia (BPH) is a common male condition that impacts many men's quality of life by generating lower urinary tract symptoms (LUTS). In recent years, inflammation has become very common in the prostate, and BPH with inflammation has a higher International Prostate Symptom Score (IPSS) score and an enlarged prostate. Chronic inflammation leads to tissue damage and the release of pro-inflammatory cytokines, which play an important role in the pathogenesis of BPH. We will focus on current advancements in pro-inflammatory cytokines in BPH, as well as the future of pro-inflammatory cytokine research. [ABSTRACT FROM AUTHOR]

This paper focuses mainly on developing single-step explicit integration algorithms considering the implicit treatment of velocity. A novel explicit algorithm (GSSI) is proposed and recommended as a self-starting dissipative alternative to the central difference methods in transient analysis. GSSI not only shares the same advantages as the central difference methods, such as second-order accuracy and computational cost, but also achieves flexible dissipation control and self-starting property. Remarkably, GSSI provides a significantly larger stability bound than the central difference methods in the damped case. GSSI imposes two algorithmic parameters ( ρ s and ρ b ) to flexibly adjust numerical dissipation at the bifurcation point. In general, the ρ b controls numerical dissipation at the bifurcation point, while the ρ s further adjusts the amount of dissipation in the low-frequency range. Spectral analysis and numerical examples are given solved to show the superiority of GSSI over the existing single-step explicit methods with respect to accuracy, stability, and dissipation control. [ABSTRACT FROM AUTHOR]

• This paper constructs and analyzes a composite s -sub-step explicit method. • Seven explicit schemes in the present method are developed and compared. • Each explicit scheme is second-order accurate and provides maximal stability bound. • Each explicit scheme (s > 1) can control numerical dissipation at the bifurcation point. This paper constructs a composite s -sub-step explicit method and analyzes second-order accuracy, conditional stability, and dissipation control at the bifurcation point. In the present s -sub-step method, each explicit scheme achieves identical second-order accuracy for analyzing general structures and provides maximal stability bound, that is 2 × s where s denotes the number of sub-steps. Except for the single-sub-step case, each explicit scheme achieves dissipation control at the bifurcation point. After registering second-order accuracy and controllable numerical dissipation, the composite multi-sub-step explicit method should be well-designed to reach maximal stability bound. The analysis reveals that as the number of sub-steps increases, the developed explicit schemes can reduce numerical low-frequency dissipation and enlarge stability. Under the same computational cost, the advantage of reducing low-frequency dissipation and enlarging stability is gradually weakened with the increase of sub-steps, so the first seven explicit schemes are only developed and compared in this paper. Some typical experiments are provided to confirm the methods' numerical performance. The proposed explicit schemes are more accurate and efficient for some models than existing second-order algorithms of that class. [ABSTRACT FROM AUTHOR]

Neoadjuvant therapy (NAT) treats early‐stage breast cancers, especially triple‐negative breast cancers (TNBCs). NAT improves pathological complete response (pCR) rates for different breast cancer patients. Recently, immune checkpoint inhibitors that target programmed death 1 (PD‐1) or programmed death ligand 1 (PD‐L1) in combination with NAT have shown antitumor activity in patients with early breast cancer. However, the tumor immune microenvironment (TME) in different subtypes of breast cancers, like TNBC, hormone receptor‐positive (HR+), and human epidermal growth factor receptor 2 amplified (HER2+) and its changes by NAT remain to be fully characterized. We analyzed pre‐NAT tumor biopsies from TNBC (n = 27), HR+ (n = 24), and HER2+ (n = 30) breast cancer patients who received NAT, followed by surgery. The different immune makers (PD‐1, PD‐L1, CD3, and CD8) of tumor‐infiltrating lymphocytes (TILs) were identified with immunofluorescence‐based microenvironment analysis. TILs within cancer parenchyma (iTILs) and in cancer stroma (sTILs) were counted separately. We found that PD‐L1+ cells in tumor and stroma were significantly higher in TNBC patients than in others. PD‐L1+ sTILs were significantly higher in pCR than in non‐pCR patients of all the subtypes. The infiltration scores of B‐cell memory, T‐cell CD4+ memory activated, T‐cell follicular helper, and Macrophage M0 and M1 were relatively higher in TNBC patients, indicating immunoreactive TME in TNBC. Analysis of TCGA‐BRCA RNA‐seq indicated that PD‐L1 was highly expressed in TNBC patients compared with HR+ and HER2+ patients. Higher PD‐L1 expression in TNBC patients was associated with significantly longer overall survival (OS). Our results demonstrated that PD‐L1 expression level of iTILs and sTILs is highest in TNBC among breast cancers. TNBC patients had significantly different immunoreactive TME compared with HR+ and HER2+ patients, suggesting potentially favorable outcomes for immunotherapy in these patients. Also, PD‐L1+ could be a powerful predictor of pCR in TNBC patients after NAT. [ABSTRACT FROM AUTHOR]

Background: Several studies have explored the relationship between intratumoral microvessel density (MVD) and the risk of postoperative biochemical recurrence (BCR) in prostate cancer (PCa), although the results are contradictory. Therefore, we conducted a meta‐analysis to investigate the effect of MVD on BCR in PCa. Method: We searched PubMed, MEDLINE, Science Direct/Elsevier, the Cochrane Library, CNKI, and EMBase databases from inception through January 2022, with no year or language restrictions, and used NOS guidelines to evaluate the quality of the 19 eligible studies. The derived hazard ratio (HR) and 95% confidence interval (95%CI) were used to assess each endpoint. Data synthesis was performed with RevMan to assess the prognostic value of MVD in PCa and its heterogeneity, while the publication bias was examined using STATA 16.0. Results: Our meta‐analysis included 19 articles (4 for T1‐2, 6 for T1‐3, and 9 for T1‐4) on postoperative biochemical recurrence of PCa, among which, 3933 patients were pooled. The predictive ability of intratumoral MVD for different stages of PCa on BCR was T1‐2 (HR, 2.46; 95% CI, 1.08–5.58; p = 0.03; I2 = 83%), T1‐3 (HR, 2.38, 95% CI, 1.41–4.01; p = 0.001; I2 = 82%), T1‐4 (HR, 1.61; 95% CI, 1.19–2.19; p = 0.002; I2 = 61%).The subgroup analyses based on European and immunohistochemical antibody none‐factor VII were consistent with primary one. Sensitivity analysis excluding those studies judged to be at high risk of bias in T1‐2 showed a HR of 2.99[1.70,5.27] (I2 = 38%, p = 0.0001), demonstrating the robustness of risk estimates of MVD for the assessment of biochemical recurrence. Conclusion: Microvessel density is a predictor of BCR among patients with PCa, and earlier T stage PCa with a stronger MVD is associated with BCR. Further studies are needed to investigate neoangiogenesis in different T stages of PCa and whether MVD will be of benefit to the EAU‐recommended tool for biochemical recurrence risk assessment. [ABSTRACT FROM AUTHOR]

To investigate the relationship between histological prostatitis (HP) and clinical parameters related to benign prostatic hyperplasia (BPH) in male. The clinical data of 196 BPH patients who underwent transurethral resection of the prostate were collected. According to the results of hematoxylin-eosin (H&E) staining of prostate tissue, patients were divided into two groups: BPH with HP group and BPH without HP group. Differences in acute urinary retention (AUR), prostate volume (PV), serum sex hormones, lower urinary tract symptoms (LUTS) related parameters, and systemic inflammation indicators were compared between the two groups. SPSS software v.25 was used for statistical analysis. Compared with the BPH without HP group, the BPH with HP group had greater AUR rate, PV, total IPSS, and IPSS-storage in BPH with HP group (p < 0.05). However, there were no significant differences in IPSS-voiding, post-void residual volume, maximum urinary flow rate, serum sex hormones, and systemic inflammation indicators between the two groups (p > 0.05). This study suggests that patients with HP have larger PV, more severe LUTS, and a higher risk of AUR. HP is closely related to BPH and may be a key factor in the occurrence and clinical progress of BPH. [ABSTRACT FROM AUTHOR]

Background: Many studies explored the prognostic value of the modified Glasgow Prognostic Score (mGPS) in urothelial carcinoma (UC), but the results are controversial. This study aimed to quantify the relationship between pretreatment mGPS and survival in patients with UC. Methods: A systematic literature search was conducted using Embase, PubMed, and Web of Science to identify eligible studies published before August 2022. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to assess the association between pretreatment mGPS and the prognosis of UC. Results: Thirteen eligible studies involving 12,524 patients were included. A high mGPS was significantly associated with poor overall survival (mGPS 1/0: HR = 1.33, 95% CI 1.12–1.58, p = 0.001; mGPS 2/0: HR = 2.02, 95% CI 1.43–2.84, p < 0.0001), progression-free survival (mGPS 1/0: HR = 1.26, 95% CI 1.03–1.53, p = 0.021; mGPS 2/0: HR = 1.76, 95% CI 1.12–2.77, p = 0.013), recurrence-free survival (mGPS 1/0: HR = 1.36, 95% CI 1.18–1.56, p < 0.0001; mGPS 2/0: HR = 1.70, 95% CI 1.44–2.000, p < 0.0001), and cancer-specific survival (mGPS 2/0: HR = 1.81, 95% CI 1.30–2.52, p < 0.0001). A subgroup analysis of OS also yielded similar results. Conclusions: Evidence suggests that high pretreatment mGPS in UC is closely related to poor survival. Pre-treatment mGPS is a powerful independent prognostic factor in patients with UC. [ABSTRACT FROM AUTHOR]

Type I interferon (IFN) has been identified in patients with Lyme disease, and its abundant expression in joint tissues of C3H mice precedes development of Lyme arthritis. Forward genetics using C3H mice with severe Lyme arthritis and C57BL/6 (B6) mice with mild Lyme arthritis identified the Borrelia burgdorferi arthritis-associated locus 1 (Bbaa1) on chromosome 4 (Chr4) as a regulator of B. burgdorferi-induced IFNβ expression and Lyme arthritis severity. B6 mice introgressed with the C3H allele for Bbaa1 (B6.C3-Bbaa1 mice) displayed increased severity of arthritis, which is initiated by myeloid lineage cells in joints. Using advanced congenic lines, the physical size of the Bbaa1 interval has been reduced to 2 Mbp, allowing for identification of potential genetic regulators. Small interfering RNA (siRNA)-mediated silencing identified Cdkn2a as the gene responsible for Bbaa1 allele-regulated induction of IFNβ and IFN-stimulated genes (ISGs) in bone marrow-derived macrophages (BMDMs). The Cdkn2a-encoded p19 alternative reading frame (p19ARF) protein regulates IFNβ induction in BMDMs as shown by siRNA silencing and overexpression of ARF. In vivo studies demonstrated that p19ARF contributes to joint-specific induction of IFNβ and arthritis severity in B. burgdorferi-infected mice. p19ARF regulates B. burgdorferi-induced IFNβ in BMDMs by stabilizing the tumor suppressor p53 and sequestering the transcriptional repressor BCL6. Our findings link p19ARF regulation of p53 and BCL6 to the severity of IFNβ-induced Lyme arthritis in vivo and indicate potential novel roles for p19ARF, p53, and BCL6 in Lyme disease and other IFN hyperproduction syndromes. Author summary: Lyme disease is caused by infection with the tick-transmitted bacterium Borrelia burgdorferi. Although different isolates of B. burgdorferi have distinct potential for dissemination and tissue invasion, factors intrinsic to the infected host also play an important role in directing the severity of Lyme disease. In the animal model, infected C3H mice develop severe Lyme arthritis following elevation of type I IFN in joint tissue, while in C57BL/6 (B6) mice arthritis is mild and not associated with type I IFN. We demonstrated that the Borrelia burgdorferi arthritis-associated locus 1 (Bbaa1) on chromosome 4 (Chr4) intrinsically controls the magnitude of IFNβ production and the severity of Lyme arthritis in C3H vs B6 mice. The Cdkn2a gene was positionally identified as the regulator of IFNβ within Bbaa1, and determined to function through its protein product p19 alternative reading frame (p19ARF). ARF regulates IFNβ expression and Lyme arthritis severity by modulating the activities of the tumor suppressor p53 and transcriptional repressor BCL6. Our study provides new insight and potential therapeutic targets for the investigation of type I IFN-dependent Lyme arthritis and other IFN-driven diseases. [ABSTRACT FROM AUTHOR]

Designing S-scheme heterojunctions is an effective method to improve the charge localization on the surface of photocatalysts. Their effective charge transport routes can be enhanced with the help of interfacial noble metal nanoparticles. Herein, an Ag/CuO@ZnIn 2 S 4 plasma S-scheme heterojunction with heterogeneous interfacial covalent bonds was successfully designed. The 15% Ag/CuO@ZnIn 2 S 4 has promising photocatalytic performance and stability with the highest CO and CH 4 yields of 6.9 and 54.4 µmol g−1 h−1 and CH 4 selectivity of 92.8%. It is evidenced that the photogenerated charge can be efficiently separated and transported due to the influence of both the S-scheme electron migration mode and the Cu-S covalent bond. The process is further accelerated by using precious metals as cocatalysts, which can then selectively convert CO 2 into CH 4. This research is expected to provide helpful information for engineering S-scheme heterojunction photocatalysts and investigating their charge transfer kinetics. [Display omitted] • Design of a S-scheme heterojunction to promote the separation of carriers. • Built the Cu-S bonds to accelerate the transfer of charges. • Utilizing the LSPR effect to generate hot electrons and enhance light absorption. • The Ag/CuO@ZnIn 2 S 4 photocatalysts can selectively reduce CO 2 to CH 4. [ABSTRACT FROM AUTHOR]

Objective: This study aims to evaluate the overall efficacy and safety between holmium laser enucleation of the prostate (HoLEP) and bipolar transurethral enucleation of the prostate (B-TUEP) for the treatment of benign prostatic hyperplasia (BPH).Method: We systematically searched electronic databases (PubMed, Scopus, Web of Science, and Cochrane Library) to identify eligible comparative studies as of July 2021. The parameters including perioperative results, complications, and functional outcomes were evaluated. RevMan version 5.4 was used for the analysis.Results: A total of 10 studies involving 1725 patients were included. HoLEP had lower operative time (p = .03), shorter catheterization time (p = .007), lower bladder irrigation time (p = .01), and higher enucleation weight (p = .01) compared with B-TUEP. However, there were no significant differences between the techniques regarding the length of stay (LOS), hemoglobin drop, transfusion rates, and complications. Furthermore, no significant differences were also observed in postoperative functional outcomes at 1, 3, 6, 12, or 24 months.Conclusions: HoLEP has more advantages in perioperative parameters compared with B-TUEP, but no significant differences are found regarding functional outcomes and complications. Large-scale studies with long-term follow-up are required to compare the outcomes of these two techniques. [ABSTRACT FROM AUTHOR]

Background: Acid-tolerant enteric pathogens can evade small intestinal acid barriers, colonize and infect the intestinal tract. However, broad-spectrum antibiotics are not the best therapeutic strategy because of the disruption of intestinal flora caused by its indiscriminate antimicrobial activity against beneficial and harmful bacteria. So that is what inspired us to combine pH regulation with nanotechnology to develop a pH-triggered site-targeted antimicrobial peptide with entrapping function. Results: A pH-triggered dual biological functional self-assembled peptide (SAP) was designed according to the features of amino-acid building blocks and the diagonal cation–π interaction principle. The results of characterization experiments showed that changes in pH conditions could trigger microstructural transformation of the nanopeptide from nanospheres to nanofibers. The subsequent antibacterial and toxicity experiments determined that SAP had great antimicrobial activity against Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, and Bacillus cereus above 15.6 μg/mL under acidic conditions by disrupting bacterial membrane integrity, excellent biocompatibility in vitro even at 250 μg/mL and high tolerance in physical environment. Moreover, at peptide concentrations greater than 62.5 μg/mL, SAP showed the entrapment property, which played an important role in phagocytic clearance in infection forces. Meanwhile, the in vivo results revealed that SAP possessed excellent therapeutic effect and good biosafety. Conclusions: Our study revealed the antibacterial activity of a short β-hairpin forming self-assembled peptide, and established an innovative design strategy for peptide-based nanomaterials and a new treatment strategy for gastrointestinal bacterial infections. [ABSTRACT FROM AUTHOR]

This paper further analyzes three Bathe algorithms (γ -Bathe, β 1 ∕ β 2 -Bathe and ρ ∞ -Bathe) with their unknown properties revealed. The analysis shows firstly that three Bathe algorithms can cover two common integration schemes, trapezoidal rule and backward Euler formula, and that the second-order β 1 ∕ β 2 -Bathe algorithm is algebraically identical to the ρ ∞ -Bathe algorithm. Via formulation of the generalized two-sub-step Newmark algorithm, it is shown that the common Newmark method cannot be considered as a special case of the ρ ∞ -Bathe algorithm. For wave propagation problems, optimal Courant–Friedrichs–Lewy (CFL) numbers for reducing dispersion errors are found for the three Bathe algorithms by considering spatial and temporal discretizations simultaneously, while the modified integration rules are used for the element mass and stiffness matrices to reduce the anisotropy in wave propagating directions. The recommended optimal algorithmic parameters are given for the three Bathe algorithms to help users effectively solve various dynamic and wave propagation problems. [ABSTRACT FROM AUTHOR]

Due to its low calorific value, abnormal phenomena such as incomplete combustion and flameout may occur during the combustion process of biomass syngas. The applicability of adding hydrogen can assist in the combustion of biomass syngas in boilers to overcome the above defects, and the effects need to be investigated. In this study, a multi-mechanism model is employed to numerically simulate the flow and combustion of a horizontal boiler burning biomass syngas. The reliability verification of the model is conducted by comparing it with the experimental results of combustion in a domestic boiler with biomass syngas. From the views of multi-fields and synergy, the effects of hydrogen addition on the thermal performance and emissions of biomass syngas are further expounded. Two scenarios are taken into consideration: hydrogen addition at a constant fuel volume flow rate and constant heat input. The result indicates that hydrogen addition significantly affects the multi-field synergy, which is advantageous for improving the heat transfer performance and combustion efficiency of biomass syngas. However, when the hydrogen addition ratio exceeds 20% at a constant fuel volume flow rate and 25% at constant heat input, its impact may be reduced. When the hydrogen content increases, the outlet temperature of the combustion chamber decreases, and pollutant emissions are effectively controlled. The turbulent kinetic energy at the reversal section decreases, and the uniformity of the flow field improves. These results provide certain guidance for the efficient utilization of biomass syngas and the operation of boilers burning biomass syngas. [ABSTRACT FROM AUTHOR]

In recent years, large‐scale satellite networks have been studied emphatically due to its advantages in high throughput and low latency. Many companies and institutions are keen to build large‐scale low earth orbit satellite constellations to provide space‐based Internet services, which poses a great demand for the design of efficient and reliable routing schemes. Three attribute indexes to evaluate the performance of the satellites are proposed. With the Dempster–Shafer theory, the attributes can be fused for the routing decision‐making process. Based on the Message Identification divergence (M‐I divergence) measure method, a Belief Message Importance divergence based Routing algorithm is proposed. By adjusting the characteristic parameter, it can amplify the divergence between distance‐based evidence and others properly. In this way, Belief Message Importance divergence‐based Routing attempts to find the optimal shortest path according to the status of intermediate nodes. Compared with existing satellite routing schemes, the algorithm that is proposed can approach the optimal routing performance, increasing the throughput by 47.2% on average, and decreasing the total delay and packet drop rate by 59.5% and 42.1% on average, respectively. [ABSTRACT FROM AUTHOR]

Real-time digital polymerase chain reaction (qdPCR) provides enhanced precision in the field of molecular diagnostics by integrating absolute quantification with process information. However, the optimal reaction conditions are traditionally determined through multiple iterative of experiments. Therefore, we proposed a novel approach to precisely determine the optimal reaction conditions for qdPCR using a standard process, employing real-time fluorescence monitoring within microwells. The temperature-sensitive fluorophore intensity presented the real temperature of each microwell. This enabled us to determine the optimal denaturation and annealing time for qdPCR based on the corresponding critical temperatures derived from the melting curves and amplification efficiency, respectively. To confirm this method, we developed an ultrathin laminated chip (UTL chip) and chose a target that need to be absolutely quantitative. The UTL chip was designed using a fluid‒solid‒thermal coupling simulation model and exhibited a faster thermal response than a commercial dPCR chip. By leveraging our precise determination of reaction conditions and utilizing the UTL chip, 40 cycles of amplification were achieved within 18 min. This was accomplished by precisely controlling the denaturation temperature at 2 s and the annealing temperature at 10 s. Furthermore, the absolutely quantitative of DNA showed good correlation (R2 > 0.999) with the concentration gradient detection using the optimal reaction conditions with the UTL chip for qdPCR. Our proposed method can significantly improve the accuracy and efficiency of determining qdPCR conditions, which holds great promise for application in molecular diagnostics. [Display omitted] [ABSTRACT FROM AUTHOR]

Objective: This article aims to evaluate the diagnostic value of 68Gallium-PSMA positron emission tomography/computerized tomography (68Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a meta-analysis of diagnostic tests.Methods: We systematically retrieved articles from Web of Science, EMBASE, Cochrane Database, PubMed. The time limit is from the creation of the database until June 2019, and Stata 15 was used for calculation and statistical analyses.Results: Sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR) and 95% confidence intervals (CI) be used to evaluate the diagnostic value. A total of 10 studies were included in our meta-analysis, which included 701 individuals. The results of each consolidated summary are as follows: sensitivity of 0.84 (95% CI 0.55-0.95), specificity of 0.95 (95% CI 0.87-0.98), PLR and NLR was 17.19 (95% CI 6.27, 47.17) and 0.17 (95% CI 0.05-0.56), respectively. DOR of 100 (95% CI 18-545), AUC of 0.97 (95% CI 0.95-0.98).Conclusion: Our study demonstrates that 68Ga-PSMA PET/CT has a high overall diagnostic value for LN staging in patients with moderate and high-risk PCa. But our conclusions still require a larger sample size, multi-center prospective randomized controlled trial to verify. [ABSTRACT FROM AUTHOR]

Sample digital technology is a powerful method for absolute quantification of target molecules such as nucleic acids and proteins. The excellent sample stability and mass production capability has enabled the development of microwell array-based sample digitizing methods. However, in current microwell array chips, samples are loaded by the liquid scraping method, which requires complex manual operation and results in a low filling rate and limited hole filling uniformity. Here, we perform sample loading of a through-hole array chip by a microfluidics-driven method and design a double independent S-shaped flow channels sandwiched through-hole array chip. Because of the capillary force and capillary burst pressure, the sample flowing in the channel can be trapped into through-holes, but cannot flow through the other side. Via air flow and displacement of the remaining sample in the channel, the sample can be partitioned consistently, with zero surplus sample residue in the channel. We evaluated the actual performance of the sample-loading process: the chip enables 99.10% filling rate of 18 500 through-holes, with a grayscale coefficient of variation value of 6.03% determined from fluorescence images. In performing digital polymerase chain reaction on chip, the chip demonstrates good performance for the absolute quantification of target DNA. The simple and robust design of our chip, with excellent filling rate and microsample uniformity, indicates potential for use in a variety of sample digitization applications. [ABSTRACT FROM AUTHOR]

A novel family of composite sub-step algorithms with controllable numerical dissipations is proposed in this paper to obtain reliable numerical responses in structural dynamics. The new scheme is a self-starting, unconditionally stable and second-order-accurate two-sub-step algorithm with the same computational cost as the Bathe algorithm. The new algorithm can control continuously numerical dissipations in the high-frequency range in an intuitive way, and the ability of numerical dissipations can range from the non-dissipative trapezoidal rule to the asymptotic annihilating Bathe algorithm. Besides, the new algorithm only involves one free parameter and always achieves the identical effective stiffness matrices inside two sub-steps, which is not always achieved in three Bathe-type algorithms, to reduce the computational cost in the analysis of linear systems. Some numerical examples are given to show the superiority of the new algorithm over the Bathe algorithm and the CH- α algorithm. [ABSTRACT FROM AUTHOR]

• Further studies on the Bathe algorithm is given and hence a novel class of the Bathe-like algorithm is presented. • It provides a new family of algorithms with the optimal numerical characteristics. • It gives a novel family of algorithms, which can be regarded as the alternative to the original Bathe algorithm. • This study shows that the Bathe algorithm can reduce to the trapezoidal rule and the backward Euler formula. The Bathe algorithm is superior to the trapezoidal rule in solving nonlinear problems involving large deformations and long-time durations. Generally, the parameter γ = 2 − 2 is highly recommended due to its optimal numerical properties. This paper further studies this implicit composite sub-step algorithm and thus presents a class of the Bathe-like algorithm. It not only gives a novel family of composite algorithms whose numerical properties are the exactly same as the original Bathe algorithm with γ = 2 − 2 , but also provides the generalized alternative to the original Bathe algorithm with any γ. In this study, it has been shown that the Bathe-like algorithm, including the original Bathe algorithm, can reduce to two common single-step algorithms: the trapezoidal rule and the backward Euler formula. Besides, a new parameter called the algorithmic mode truncation factor is firstly defined to describe the numerical property of the Bathe-like algorithm and it can estimate which modes to be damped out. Finally, numerical experiments are provided to show the superiority of the Bathe-like algorithm over some existing methods. For example, the novel Bathe-like algorithms are superior to the original Bathe algorithm when solving the highly nonlinear pendulum. [ABSTRACT FROM AUTHOR]

• The new algorithm is second-order accurate, unconditionally stable (L-stable) and self-starting. • The new algorithm shares the identical effective stiffness matrices inside three sub-step. • There is no overshoot for the proposed algorithm when nonzero initial displacement and/or velocity are used. • The second-order accuracy is obtained in its final form, but it is not required in each sub-step. In this paper, a novel three sub-step composite algorithm with desired numerical properties is developed. The proposed method is a self-starting, unconditionally stable and second-order accurate implicit algorithm without overshoot. Particularly, the second-order accuracy in time is achieved in its final form, but it is not required in each sub-step. Its unique algorithmic parameter is analyzed to achieve the unconditional stability and it shares the identical effective stiffness matrix inside three sub-steps to save the computational cost in linear analyses. The same as the Bathe algorithm, the proposed algorithm is always L-stable, meaning that the spurious high-frequency modes can be effectively eliminated. Three numerical examples are simulated to illustrate the superiority of the proposed algorithm over some existing implicit algorithms. The first numerical simulation, solving a linear single-degree-of-freedom system, shows less period elongation errors and the second-order accuracy of the present scheme. The second one, a clamped-free bar excited by the end load, shows the ability of effectively damping out the unexpected high-frequency modes. The last example solves the nonlinear mass-spring system with variable degree-of-freedoms and illustrates that the composite sub-step algorithm can save more computational cost than the traditional implicit algorithm when the integration step size is selected appropriately. [ABSTRACT FROM AUTHOR]

Electrostatic interactions are important in non-contact atomic force microscopy (AFM) measurement. Previous reports had focused on the calculation of electrostatic interactions in AFM with metal and dielectric samples, and the present work extended the discussion to semiconductor samples based on Green's function theory and Debye-Hückel theory, considering sample dielectric polarization and free carriers at the same time. In order to enhance the calculation efficiency, an equivalent charge method was implemented and developed with a linear algebra-based algorithm. The calculation results of two limiting cases, metal and dielectric limit with infinite and zero carrier concentrations respectively, were in good agreement with the boundary element method. For a finite carrier concentration, it is found that the electrostatic force on the tip cone is quickly saturated whereas that on the tip apex slowly increases as the carrier concentration increases. On the other hand, the interaction radius on the sample surface is found independent of the sample free carriers, but it linearly increases as the tip-sample distance. Our work can be useful for the carrier concentration detection of semiconductor samples using non-contact electrical AFM modes such as Kelvin probe force microscopy and electrostatic force microscopy. [ABSTRACT FROM AUTHOR]

High selectivity and fast charge separation are two important factors for photocatalytic wastewater treatment. Herein, we prepared a molecular imprinted Ag/Ag 3 VO 4 /g-C 3 N 4 photocatalyst (MIP) that exhibited great specific recognition ability along with excellent photocatalytic activity. The ultrathin g-C 3 N 4 nanosheets with high surface are used to prepare. The Z-scheme Ag 3 VO 4 /g-C 3 N 4 heterostructure and the surface plasmon resonance of the photoreduced Ag0 together contributed to the improvement of the separation efficiency of photogenerated electrons and holes. In addition, MIP provides the specific recognition ability to preferentially adsorb the target pollutant. The selectivity of photocatalysis was evaluated by the degradation of oxytetracycline and tetracycline solutions. Photoluminescence and transient photocurrent measurements further prove the improved charge separation efficiency of MIP. A plausible photocatalytic reaction mechanism is proposed based on electron spin resonance measurement and the active species trapping experiments, where indicates that the main active species of this photocatalytic process are O 2 − and h+. This research provides an effective strategy for the simultaneous enhancement of selectivity and activity via molecular imprinting. [ABSTRACT FROM AUTHOR]

The interfacial regulation strategy between semiconductors can effectively promote the separation efficiency of photogenerated carriers and enhance photocatalytic activity under the synergistic effect. Herein, AgInS 2 QDs-MoS 2 /GO (AIS-MS/GO) composites were prepared by interfacial coupling of AgInS 2 QDs (AIS), hierarchical MoS 2 and ultrathin GO. Ultrathin GO successfully solved the agglomeration problem of AIS and hierarchical MoS 2. Moreover, the photogenerated carriers were effectively separated and transferred under the synergistic effect of the AIS-MS heterojunction and ultrathin GO, thus promoting tetracycline (TC) degradation and CO 2 reduction performance. The degradation rate of tetracycline (TC) reached 96.5 %, and the yields of CO and CH 4 in the CO 2 reduction products reached 52.6 and 28.5 μmol g–1, respectively, when using the optimized photocatalyst. In-situ FTIR analysis indicated that TC is gradually degraded by small molecules on the composite surface, and has excellent dissociation ability of water molecules during the CO 2 reduction process. This work provides a new vision for the rational design of heterojunction-based photocatalysts using the interfacial regulation strategy for enhancing interfacial charge separation and photocatalytic performance. [Display omitted] • AIS-MS/GO composites were prepared via the interfacial regulation strategy. • The photogenerated carriers were effectively separated and transferred under synergistic and interfacial effects. • The aggregation problem of AIS and hierarchical MoS 2 was effectively solved. • AIS-MS/GO composites achieve a 96.5 % TC degradation rate and 35.1 % selectivity for CH 4. [ABSTRACT FROM AUTHOR]

Highlights • The new algorithm is the second-order accurate, unconditionally stable (L-stable) and self-starting. • The new algorithm shares the identical effective stiffness matrices inside two sub-steps. • The new method does not involve any artificial parameters and additional variable, such as the Lagrange multipliers. • The new scheme achieves the same numerical properties as the Bathe algorithm, but requires less matrix-vector operations. Abstract This paper presents a new composite sub-steps algorithm for solving reliable numerical responses in structural dynamics. The newly developed algorithm is a two sub-steps, second-order accurate and unconditionally stable implicit algorithm with the same numerical properties as the Bathe algorithm. The detailed analysis of the stability and numerical accuracy is presented for the new algorithm, which shows that its numerical characteristics are identical to those of the Bathe algorithm. Hence, the new sub-steps scheme could be considered as an alternative to the Bathe algorithm. Meanwhile, the new algorithm possesses the following properties: (a) it produces the same accurate solutions as the Bathe algorithm for solving linear and nonlinear problems; (b) it does not involve any artificial parameters and additional variables, such as the Lagrange multipliers; (c) The identical effective stiffness matrices can be obtained inside two sub-steps; (d) it is a self-starting algorithm. Some numerical experiments are given to show the superiority of the new algorithm and the Bathe algorithm over the dissipative CH- α algorithm and the non-dissipative trapezoidal rule. [ABSTRACT FROM AUTHOR]

Graphical abstract Schematic illustration of the formation of CQDs/ZnO@HNTs in the whole synthetic process. Highlights • We have experimentally demonstrated the carbon incorporated ZnO via coupling CQDs. A notable transformation of burger-like CQD s /ZnO morphology was observed and the HNTs have been introduced to improve the dispersity of hybrid photocatalysts. • From efficiently modulation of band structure of CQD s -based materials, the as-prepared CQD s /ZnO@HNTs display a remarkable optical excitation in photogenerated reactive oxygen species (ROS). • This work provides an efficient and novel strategy for element incorporated with introduced inorganic quantum dots owing to the quantum size effect. • It also developed a new sight of CQD s participated phase tuning for semiconductors, offering a beneficial route for expanding the application of VLD photodegradation based on band-tuning semiconductors and other low-dimension materials. Abstract Environmentally friendly photodegradation of refractory pollutants utilizing semiconductor photocatalysis evolution exhibits satisfactory efficiency and low energy consumption, but some of its unbefitting band position largely limits practical applications. The controllable band structure tuning via coupling low-dimensional materials with enormous potential in semiconductor photocatalysis, notably attractive carbon quantum dots (CQDs) induced for a better utilization of low-energy photoexcitation of promising inherent optical properties and photocatalytic performance on organic pollutant degradation. Here, a CQDs modified ZnO hybrid materials was synthesized and the CQDs preluded carbon-incorporated burger-like ZnO nanoparticles clusters were presented thus demonstrated a specific doping-effect. The dispersity improved by loading halloysite nanotube (HNTs) for efficiently photocatalytic activity enhancement. Furthermore, the band structure, excitation and photocatalytic reactive oxygen species (ROS) generation were detected to reveal the photochemical properties and plausible mechanism of CQDs hybrid nanomaterials system. It is observed that the superoxide radical (O 2 −), and singlet oxygen(1O 2) are the principal ROS agents under UV–vis excitations. This work not only displays a CQDs modified system of expanding photo-response range to visible light but also throws a way for quantum elemental incorporated on the influence of band-tuning for semiconductor- dominated photocatalysts. [ABSTRACT FROM AUTHOR]

The growing demand from the extended reality and wearable electronics market has led to an increased focus on the development of flexible human-machine interfaces (HMI). These interfaces require efficient user input acquisition modules that can realize touch operation, handwriting input, and motion sensing functions. In this paper, we present a systematic review of triboelectric-based contact localization electronics (TCLE) which play a crucial role in enabling the lightweight and long-endurance designs of flexible HMI. We begin by summarizing the mainstream working principles utilized in the design of TCLE, highlighting their respective strengths and weaknesses. Additionally, we discuss the implementation methods of TCLE in realizing advanced functions such as sliding motion detection, handwriting trajectory detection, and artificial intelligence-based user recognition. Furthermore, we review recent works on the applications of TCLE in HMI devices, which provide valuable insights for guiding the design of application scene-specified TCLE devices. Overall, this review aims to contribute to the advancement and understanding of TCLE, facilitating the development of next-generation HMI for various applications. [ABSTRACT FROM AUTHOR]

As a typical wide-band-gap semiconductor, BiPO 4 (BPO) has a great potential for photocatalytical degradation of highly stable benzene (C 6 H 6 ) that has been regarded as a priority hazardous VOC substance in the indoor atmosphere. Hexagonal (H-BPO), monoclinic (M-BPO), and their mixture phase BiPO 4 (M/H-BPO) were selectively synthesized to study the effect of BPO phase structure on the degradation of C 6 H 6 . The samples were characterized by several techniques, including X-ray diffraction, FTIR spectroscopy, UV–vis diffuse reflection spectroscopy, N 2 absorption-desorption measurements, scanning/transmission electron microscopy, and X-ray photoelectron spectroscopy. The results indicated that the monoclinic phase was a thermodynamically stable phase. The band gap energy of H-BPO, M-BPO, and M/H-BPO was 3.74, 3.93 and 3.86 eV, respectively. A transformation from rice-like hexagonal BPO to monoclinic phase nanorods was realized through varying the hydrothermal temperature and the composition of the solvent. The degradation of C 6 H 6 was closely associated with the crystalline phase of BPO and the mineralization rates decreased in order of M– (7.3) > M/H– (1.51) > H-BPO (0.51 μmol·h −1 ·m −2 ). The rates were higher than that of well-known P25 (0.34 μmol·h −1 ·m −2 ). The highest activity of M-BPO could be ascribed to its intrinsic distortion of PO 4 tetrahedron and the largest band gap structure. OH, O 2 − , and photoinduced holes were the major oxidation species accounting for the destruction of C 6 H 6 . [ABSTRACT FROM AUTHOR]

One of current ideal thought to reduce the recombination of photogenerated electrons and holes from semiconductors is constructing Multi-dimensional semiconductor-carbon (S-C) heterostructures. As well as acting to photo-degrade the organic contaminant and decrease the toxicity, β-In 2 S 3 is chosen as a potential semiconductors for photocatalysts. Relative good photocatalytic properties delivered on β-In 2 S 3 , however, the fast recombination of photogenerated charge carriers are often appeared, causing reduced further application. Carbon quantum dots (CQDs) involve the introduction of plasma effect into the zero-dimensional nanomaterials in order to arouse an effect: either promoting the charge carriers transfer or plasma energy conversion of the photo-excited CQDs. However, state of the two components also encompass the poor quantum yield existed in the CQDs by its serious agglomeration. Thereby, the delivery of extraordinary ballistic electrical and thermal conductivity on single-walled carbon nanotubes (SWNTs), have shown potential for use in a variety of semiconductors decorating application. Herein, we show that a novel CQDs@In 2 S 3 /SWNTs composite in the Multi-dimensional (3D) hierarchical superstructures with an enhanced photocatalytic efficiency. The ESR analysis and free radicals trapping experiments indicated that the O 2 • − and h + were the main active species for the photocatalytic degradation. The potential photocatalytic mechanism of the three components is discussed and the direction in the plasma effect exhibited in CQDs is also considered, with a particular focus on photocatalytic area. [ABSTRACT FROM AUTHOR]

A series of nebula-like ZnO/CeO 2 @HNTs heterostructure photocatalysts were synthesized via a novel one-step wet-calcination method for degradation of tetracycline (TC) under simulated solar irradiation. TEM, HRTEM, XRD, FT-IR, XPS, DRS, PL, PC, EIS and ESR techniques were applied for characterization of samples. And the potential structure of new photodegradation products was studied by HPLC–MS analysis. The characterization results revealed the enhanced photocatalytic activity of ZnO/CeO 2 @HNTs heterostructure photocatalysts due to the delayed recombination of photogenerated electron-hole pairs. Moreover, surface oxidation state analysis demonstrates that Ce 3+ and Ce 4+ states coexist in CeO 2 , which enhance the separation of electron-hole pairs though cerium oxide shifting between CeO 2 and Ce 2 O 3 under photocatalytic process. In addition, the effects of the calcinating temperature, the molar ratio of ZnO to CeO 2 and the dosage of HNTs on photocatalytic activity of ZnO/CeO 2 @HNTs heterostructure photocatalysts were researched and the best possible values have been found. Furthermore, the photodegradation mechanism was systematically investigated by active species trapping experiment. It revealed that OH radicals play a little role while hole and O 2 − are the more major reactive species in the photodegradation process. [ABSTRACT FROM AUTHOR]

No literature has reported an explicit integration algorithm to achieve controllable numerical dissipation and identical third-order accuracy simultaneously. This paper develops two novel explicit integration algorithms to achieve this goal well without increasing computational complexity. In detail, two novel methods are identical third-order accuracy, so avoiding the order reduction for solving damped and forced vibrations, and both of them provide a full range of dissipation control via adjusting their unique algorithmic parameter. Apart from these two highlights, two novel methods embed another two enjoyably advantages. One is to present a significantly larger stability limit than the published third-order explicit schemes. Two novel methods provide the maximum stability limit, reaching 2 3 in the non-dissipative case, getting close to four. The other is to maintain a relatively little computational cost. Two novel methods require explicit solutions only twice within each time step. Therefore, two novel methods are significantly superior to other composite sub-step explicit schemes with respect to the accuracy, stability, dissipation control, and computational cost. Numerical examples are also performed to confirm the numerical performance and superiority of two novel explicit methods. • Two novel fully explicit methods are proposed based on the composite two-sub-step technique. • Two novel methods are identically third-order accurate for solving general structures. • Two novel methods can control numerical dissipation imposed at the bifurcation point. • Two novel methods provide a larger stability limit and require a relatively little computational cost. [ABSTRACT FROM AUTHOR]

Rickettsia is a genus of intracellular bacteria that causes a variety of diseases in humans and other mammals and associates with a diverse group of arthropods. Although Rickettsia appears to be common in ticks, most Rickettsia-tick relationships remain generally uncharacterized. The most intimate of these associations is Rickettsia species phylotype G021, a maternally and transstadially transmitted endosymbiont that resides in 100% of I. pacificus in California. We investigated the effects of this Rickettsia phylotype on I. pacificus reproductive fitness using selective antibiotic treatment. Ciprofloxacin was 10-fold more effective than tetracycline in eliminating Rickettsia from I. pacificus, and quantitative PCR results showed that eggs from the ciprofloxacin-treated ticks contained an average of 0.02 Rickettsia per egg cell as opposed to the average of 0.2 in the tetracycline-treated ticks. Ampicillin did not significantly affect the number of Rickettsia per tick cell in adults or eggs compared to the water-injected control ticks. We found no relationship between tick embryogenesis and rickettsial density in engorged I. pacificus females. Tetracycline treatment significantly delayed oviposition of I. pacificus ticks, but the antibiotic’s effect was unlikely related to Rickettsia. We also demonstrated that Rickettsia-free eggs could successfully develop into larvae without any significant decrease in hatching compared to eggs containing Rickettsia. No significant differences in the incubation period, egg hatching rate, and the number of larvae were found between any of the antibiotic-treated groups and the water-injected tick control. We concluded that Rickettsia species phylotype G021 does not have an apparent effect on embryogenesis, oviposition, and egg hatching of I. pacificus. [ABSTRACT FROM AUTHOR]

• Techno-economic feasibility of the hybrid PV/Wind/Biomass system for sustainable rural electrification have been demonstrated under both off-grid and on-grid modes, via a case study of a village in West China. • Impacts of future development of the village and changes in government incentive policy have been analyzed by performing sensitivity analysis. • Flexibility of the proposed HRES has been demonstrated by comparing off-grid and on-grid modes of the hybrid system. Reliable and sustainable power supply for remote rural areas is of vital importance for development of these areas. In this paper, the techno-economic feasibility and flexibility of hybrid renewable energy systems are demonstrated under both off-grid and on-grid modes for rural electrification, where a case study of a village in West China is presented. According to simulation and optimization results as well as sensitivity analysis, the most cost-competitive configuration is found by Hybrid Optimization of Multiple Energy resources (HOMER). Comparison of the off-grid and on-grid modes of the hybrid system has been carried out. The results demonstrate that a hybrid renewable energy system which comprises solar, wind and biomass is reliable and cost-effective regarding sustainable rural electrification. Moreover, environmental and social benefits can also be acquired by this system. The high capability of the proposed flexible design is demonstrated over conditions for both off-grid and on-grid modes. [ABSTRACT FROM AUTHOR]

An implicit family of composite s -sub-step integration algorithms is developed in this paper. The proposed composite s -sub-step scheme is firstly designed to satisfy two requirements. One is the directly self-starting property, eliminating any starting procedures and avoiding computing the initial acceleration vector. The other is identical effective stiffness matrices within each sub-step, embedding optimal spectral properties. The analysis reveals that the composite s -sub-step implicit schemes with s ≤ 6 can achieve s th-order of accuracy when embedding the dissipation control and unconditional stability simultaneously, and that in case of s ≥ 7 , the increase of accuracy requires more sub-steps. Then, only the first six economical composite multi-sub-step schemes are developed. Remarkably, two approaches are also constructed to output accurate accelerations, which is also regarded as another minor superiority. Unlike some published higher-order algorithms, the proposed methods do not suffer from the order reduction and they provide the designed order of accuracy for solving general structures. Linear and nonlinear examples are finally solved to confirm the numerical performance and superiority of the proposed methods. • Four high-order algorithms are proposed and do not suffer from the order reduction. • Each algorithm achieves identical effective stiffness matrices. • Each algorithm can control numerical high-frequency dissipation. • Each algorithm is directly self-starting and unconditionally stable. [ABSTRACT FROM AUTHOR]

Hypertension-related left ventricular hypertrophy is recognized as a good predictor of adverse cardiovascular events. However, the underlying mechanism of left ventricular hypertrophy is still not fully understood. This study employed liquid chromatography coupled with tandem mass spectrometry to investigate global changes in protein profile in myocardium of spontaneously hypertensive rat, a classical animal model of essential hypertension. There were 369 differentially expressed proteins in myocardium between spontaneously hypertensive rats and normotensive rats. Xenobiotic catabolic process, cholesterol binding and mitochondrial proton-transporting ATP synthase were found to be the most significantly enriched biological process, molecular function and cellular component terms of Gene Ontology, respectively. Drug metabolism-cytochrome P450 was revealed to be the most significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways. FYN proto-oncogene, Src family tyrosine kinase was found to have the most interactions with other proteins. Differentially expressed proteins involved in xenobiotic catabolic process, lipid transport and metabolism, mitochondrial function might be targets for further study of hypertension-related left ventricular hypertrophy. [ABSTRACT FROM AUTHOR]

Natural gas (NG) engines have very broad application prospects. The pilot-ignited NG diesel engine can be organized into two combustion modes according to the sequence of oil and gas injection: (1) High-pressure direct injection, where NG is mainly diffused combustion; and (2) partially premixed compression ignition, where NG is mainly premixed combustion. In this study, we used CONVERGE to explore the influence of the NG injection timing on the distribution of the mixture equivalence ratio, ignition characteristics, thermal efficiency, emission, and combustion reaction rate under the two combustion modes. We also used a multi-step soot model to analyze the particle mass and quantity. We showed herein that the NG injection timing significantly affects the mixture distribution in the cylinder, thereby consequently affecting the combustion process. Both very early and very late injection times were not conducive to NG combustion. In addition, the mass, quantity, and diameter of the soot produced by diffusion combustion were larger than those produced with premixed combustion. [ABSTRACT FROM AUTHOR]

A fiber-optics tapered sensor that is covered by an electrospinning polyvinyl alcohol (PVA) nanofiber film, is demonstrated to measure humidity and temperature simultaneously. A section multi-mode fiber (MMF) was sandwiched between two leading-in and out single mode fibers (SMFs), which was further tapered down to 29 μm to promote the humidity sensitivity of the sensor. A thin layer of electrospinning PVA nanofiber film was uniformly coated on the MMF taper region by electrospinning technology. In order to promote the humidity sensitivity and mechanical strength of electrospinning nanofibers, the carbon nanotubes (CNTs) were mixed into PVA to formed PVA/CNTs composite nanofiber film. A Fiber Bragg Grating (FBG) was cascaded with the humidity sensing fiber to monitor the ambient temperature simultaneously. The addition of CNTs effectively eliminated the cracks on the electrospinning nanofiber and made it more uniform and smoother. As experimental results show, the humidity sensitivity of the sensor with PVA/CNTs film was 0.0484 dB/%RH, an improvement of 31.16% compared to that of the sensor with PVA film, for which sensitivity is 0.0369 dB/%RH. The nanofiber humidity-sensitive film constructed using electrospinning had a satisfactory humidity response, special 3D structure and extensive application prospect. [ABSTRACT FROM AUTHOR]

To explore the fractal dimension, particle shape, and particle breakage of calcareous sand (CS) under multi-level ending pressure, a series of one-dimensional compression experiments along with microscope image recognition tests were performed. Test results demonstrated that compression behavior of CS was similar to that of silt soil for the reason that considerable particle breakage occurred under high-stress level. In unloading process, rebound index of tested specimens was in the range of 0.0027–0.0052 which suggested that irrecoverable plastic deformation consists of the main part of compression. The shape index sphericity ( S C ), aspect ratio ( A R ), convexity ( C X ), and overall regularity ( O R ) increased as increasing axial stress or decreasing average grain size. Besides, there existed a turning point of axial stress of 3200 kPa; these shape indexes increased rapidly first and then approached to a stable value after that. At present study, the surface and mass fractal dimension of tested specimens were in the range of 1.12–1.93 and 2.14–2.92, respectively. Both fractal dimension and relative breakage ratio increased logarithmically as increasing axial stress from 0 to 6400 kPa. In addition, an increase in the average grain size led to an increase in the relative breakage ratio and a decrease in fractal dimension which indicated that larger particles are more easily broken for the reason that the stress concentration between granular grains. Furthermore, there existed approximate linear relations between surface or mass fractal dimension with relative breakage ratio which might be helpful to quantitate the particle breakage of granular materials. [ABSTRACT FROM AUTHOR]

The direct injection of natural gas (NG), which is an important research direction in the development of NG engines, has the potential to improve thermal efficiency and emissions. When NG engines operate in low-load conditions, combustion efficiency decreases and hydrocarbon (HC) emissions increase due to lean fuel mixtures and slow flame propagation speeds. The effect of two combustion modes (partially premixed compression ignition (PPCI) and high pressure direct injection (HPDI)) on combustion processes was investigated by CFD (Computational Fluid Dynamics), with a focus on different injection strategies. In the PPCI combustion mode, NG was injected early in the compression stroke and premixed with air, and then the pilot diesel was injected to cause ignition near the top dead center. This combustion mode produced a faster heat release rate, but the HC emissions were higher, and the combustion efficiency was lower. In the HPDI combustion mode, the diesel was injected first and ignited, and then the NG was injected into the flame. This combustion mode resulted in higher emissions of NOx and soot, with a diffusion combustion in the cylinder. HC emissions significantly decreased. Compared with PPCI combustion, HPDI had a higher thermal efficiency. [ABSTRACT FROM AUTHOR]