Search

Your search keyword '"Li, Taolang"' showing total 48 results
Start Over Author "Li, Taolang" Search Limiters Full Text
48 results on '"Li, Taolang"'

18. The role of HMGB1 in digestive cancer

Author

Chen, Xiangqi, primary, Liu, Qian, additional, Wu, Enqing, additional, Ma, Zhiyuan, additional, Tuo, Biguang, additional, Terai, Shuji, additional, Li, Taolang, additional, and Liu, Xuemei, additional

Published
2023
Full Text
View/download PDF

21. Role of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases

Author

Liu, Xi, Ma, Zhiyuan, Deng, Zilin, Yi, Zhiqiang, Tuo, Biguang, Li, Taolang, and Liu, Xuemei

Subjects
Review Article
Abstract

Spasmolytic polypeptide-expressing metaplasia (SPEM) is a trefoil factor 2-expressing metaplasia in the fundic glands that resembles the fundic metaplasia of deep antral glandular cells and arises mainly from transdifferentiation of mature chief cells as well as mucous neck cells or isthmic stem cells. SPEM participates in the regulation of gastric mucosal injury, including focal and diffuse injury. This review focuses on the origin, models, and regulatory mechanisms of SPEM and on its role in the development of gastric mucosal injury. We hope to provide new prospects for the prevention and treatment of gastric mucosal diseases from the perspective of cell differentiation and transformation.

Published
2023

22. Abstract P1-11-18: The efficacy and safety of trastuzumab and pertuzumab in combination with different chemotherapy regimens for neoadjuvant treatment of HER2-posotive breast cancer: a multi-center real-world study in China

Author

Qi, Xiaowei, primary, Hu, Hong, additional, wenlin, chen, additional, yan, xu, additional, shu, liu, additional, yanman, fang, additional, Li, Taolang, additional, jia, ming, additional, sihai, zhou, additional, fan, chai, additional, yueyang, liang, additional, yuanming, fan, additional, Zhang, Yi, additional, Tang, Peng, additional, jun, jiang, additional, jianyun, nie, additional, Chen, Li, additional, and Wang, Shushu, additional

Published
2023
Full Text
View/download PDF

31. Physiological and Pathophysiological Roles of Ion Transporter-Mediated Metabolism in the Thyroid Gland and in Thyroid Cancer

Author

Wang,Hu, Ma,Zhiyuan, Cheng,Xiaoming, Tuo,Biguang, Liu,Xuemei, and Li,Taolang

Subjects
OncoTargets and Therapy
Abstract

Hu Wang,1 Zhiyuan Ma,1 Xiaoming Cheng,1 Biguang Tuo,2,3 Xuemei Liu,2,3 Taolang Li1 1Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; 2Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; 3Digestive Disease Institute of Guizhou Province, Zunyi, People’s Republic of ChinaCorrespondence: Taolang LiDepartment of Thyroid and Breast Surgery, Affiliated Hospital, Zunyi Medical University, Zunyi 563003, People’s Republic of ChinaEmail 0078029@sina.comXuemei LiuDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical University, Zunyi 563003, People’s Republic of ChinaEmail onlyoneliuxuemei@163.comAbstract: Thyroid cancer is the most common type of endocrine tumor and has shown an increasing annual incidence, especially among women. Patients with thyroid cancer have a good prognosis, with a high five-year survival rate; however, the recurrence rate and disease status of thyroid cancer remain a burden for patients, which compels us to further elucidate the pathogenesis of this disease. Recently, ion transporters have gradually become a hot topic in the field of thyroid gland biology and cancer research. Additionally, alterations in the metabolic state of tumor cells and protein molecules have gradually become the focus of scientific research. This review focuses on the progress in understanding the physiological and pathophysiological roles of ion transporter-mediated metabolism in both the thyroid gland and thyroid cancer. We also hope to shed light on new targets for the treatment and prognosis of thyroid cancer.Keywords: thyroid cancer, metabolism, ion transporters, physiology and pathophysiology, regulation factors

Published
2020

39. Physiological Significance of Ion Transporters and Channels in the Stomach and Pathophysiological Relevance in Gastric Cancer

Author

Yuan, Dumin, Ma, Zhiyuan, Tuo, Biguang, Li, Taolang, and Liu, Xuemei

Subjects
Article Subject
Abstract

Gastric cancer (GC) is a highly invasive and fatal malignant disease that accounts for 5.7% of new global cancer cases and is the third leading cause of cancer-related death. Acid/base homeostasis is critical for organisms because protein and enzyme function, cellular structure, and plasma membrane permeability change with pH. Various ion transporters are expressed in normal gastric mucosal epithelial cells and regulate gastric acid secretion, ion transport, and fluid absorption, thereby stabilizing the differentiation and homeostasis of gastric mucosal epithelial cells. Ion transporter dysfunction results in disordered ion transport, mucosa barrier dysfunction, and acid/base disturbances, causing gastric acid-related diseases such as chronic atrophic gastritis (CAG) and GC. This review summarizes the physiological functions of multiple ion transporters and channels in the stomach, including Cl− channels, Cl−/HCO3− exchangers, sodium/hydrogen exchangers (NHEs), and potassium (K+) channels, and their pathophysiological relevance in GC.

Published
2020
Full Text
View/download PDF

46. Role of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases.

Author

Liu X, Ma Z, Deng Z, Yi Z, Tuo B, Li T, and Liu X

Abstract

Spasmolytic polypeptide-expressing metaplasia (SPEM) is a trefoil factor 2-expressing metaplasia in the fundic glands that resembles the fundic metaplasia of deep antral glandular cells and arises mainly from transdifferentiation of mature chief cells as well as mucous neck cells or isthmic stem cells. SPEM participates in the regulation of gastric mucosal injury, including focal and diffuse injury. This review focuses on the origin, models, and regulatory mechanisms of SPEM and on its role in the development of gastric mucosal injury. We hope to provide new prospects for the prevention and treatment of gastric mucosal diseases from the perspective of cell differentiation and transformation., Competing Interests: None., (AJCR Copyright © 2023.)

Published
2023

47. Role of succinylation modification in thyroid cancer and breast cancer.

Author

Mu R, Ma Z, Lu C, Wang H, Cheng X, Tuo B, Fan Y, Liu X, and Li T

Abstract

The incidence of thyroid cancer and breast cancer is increasing year by year, and the specific pathogenesis is unclear. Posttranslational modifications constitute an important regulatory mechanism that affects the function of almost all proteins, are essential for a diverse and well-functioning proteome and can integrate metabolism with physiological and pathological processes. In recent years, posttranslational modifications, which mainly include metabolic enzyme-mediated protein posttranslational modifications, such as methylation, phosphorylation, acetylation and succinylation, have become a research hotspot. Among these modifications, lysine succinylation is a newly discovered broad-spectrum, dynamic, non-enzymatic protein post-translational modification, and it plays an important regulatory role in a variety of tumors. Studies have shown that succinylation can affect the synthesis of thyroid hormones, and the regulation of this post-translational modification can inhibit the apoptosis and migration of thyroid cancer cell lines, and promote breast cancer cell proliferation, DNA damage repair and autophagy-related regulation. However, the specific regulatory mechanism of succinylation in thyroid cancer and breast cancer is currently unclear. Therefore, this article mainly reviews the research progress of succinylation modification in thyroid cancer and breast cancer. It is expected to provide new directions and targets for the prevention and treatment of thyroid cancer and breast cancer., Competing Interests: None., (AJCR Copyright © 2021.)

Published
2021

48. Function of ion transporters in maintaining acid-base homeostasis of the mammary gland and the pathophysiological role in breast cancer.

Author

Ma Z, Yuan D, Cheng X, Tuo B, Liu X, and Li T

Subjects
Carrier Proteins genetics, Female, Humans, Ion Transport, Breast Neoplasms metabolism, Carrier Proteins metabolism, Homeostasis physiology, Mammary Glands, Human physiology
Abstract

The incidence of breast cancer is increasing year by year, and the pathogenesis is still unclear. Studies have shown that the high metabolism of solid tumors leads to an increase in hypoxia, glycolysis, production of lactic acid and carbonic acid, and extracellular acidification; a harsh microenvironment; and ultimately to tumor cell death. Approximately 50% of locally advanced breast cancers exhibit hypoxia and/or local hypoxia, and acid-base regulatory proteins play an important role in regulating milk secretion and maintaining mammary gland physiological function. Therefore, ion transporters have gradually become a hot topic in mammary gland and breast cancer research. This review focuses on the research progress of ion transporters in mammary glands and breast cancer. We hope to provide new targets for the treatment and prognosis of breast cancer.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results