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11 results on '"Lian, Fulin"'

2. Rho Family Proteins: Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion (Adv. Sci. 14/2020)

Author

Sun, Zhongya, primary, Zhang, Hao, additional, Zhang, Yuanyuan, additional, Liao, Liping, additional, Zhou, Wen, additional, Zhang, Fengcai, additional, Lian, Fulin, additional, Huang, Jing, additional, Xu, Pan, additional, Zhang, Rukang, additional, Lu, Wenchao, additional, Zhu, Mingrui, additional, Tao, Hongru, additional, Yang, Feng, additional, Ding, Hong, additional, Chen, Shijie, additional, Yue, Liyan, additional, Zhou, Bing, additional, Zhang, Naixia, additional, Tan, Minjia, additional, Jiang, Hualiang, additional, Chen, Kaixian, additional, Liu, Bo, additional, Liu, Chuanpeng, additional, Dang, Yongjun, additional, and Luo, Cheng, additional

Published
2020
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3. Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

Author

Sun, Zhongya, primary, Zhang, Hao, additional, Zhang, Yuanyuan, additional, Liao, Liping, additional, Zhou, Wen, additional, Zhang, Fengcai, additional, Lian, Fulin, additional, Huang, Jing, additional, Xu, Pan, additional, Zhang, Rukang, additional, Lu, Wenchao, additional, Zhu, Mingrui, additional, Tao, Hongru, additional, Yang, Feng, additional, Ding, Hong, additional, Chen, Shijie, additional, Yue, Liyan, additional, Zhou, Bing, additional, Zhang, Naixia, additional, Tan, Minjia, additional, Jiang, Hualiang, additional, Chen, Kaixian, additional, Liu, Bo, additional, Liu, Chuanpeng, additional, Dang, Yongjun, additional, and Luo, Cheng, additional

Published
2020
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4. A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression

Author

Wang, Yingcong, primary, Huang, Jing, additional, Li, Bo, additional, Xue, Han, additional, Tricot, Guido, additional, Hu, Liangning, additional, Xu, Zhijian, additional, Sun, Xiaoxiang, additional, Chang, Shuaikang, additional, Gao, Lu, additional, Tao, Yi, additional, Xu, Hongwei, additional, Xie, Yongsheng, additional, Xiao, Wenqin, additional, Yu, Dandan, additional, Kong, Yuanyuan, additional, Chen, Gege, additional, Sun, Xi, additional, Lian, Fulin, additional, Zhang, Naixia, additional, Wu, Xiaosong, additional, Mao, Zhiyong, additional, Zhan, Fenghuang, additional, Zhu, Weiliang, additional, and Shi, Jumei, additional

Published
2020
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5. Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening

Author

Zhang, Dan, primary, Han, Jie, additional, Lu, Wenchao, additional, Lian, Fulin, additional, Wang, Jun, additional, Lu, Tian, additional, Tao, Hongru, additional, Xiao, Senhao, additional, Zhang, Fengcai, additional, Liu, Yu-Chih, additional, Liu, Rongfeng, additional, Zhang, Naixia, additional, Jiang, Hualiang, additional, Chen, Kaixian, additional, Zhao, Chunshen, additional, and Luo, Cheng, additional

Published
2019
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6. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Author

Huang, Yue, primary, Su, Rui, additional, Sheng, Yue, additional, Dong, Lei, additional, Dong, Ze, additional, Xu, Hongjiao, additional, Ni, Tengfeng, additional, Zhang, Zijie Scott, additional, Zhang, Tao, additional, Li, Chenying, additional, Han, Li, additional, Zhu, Zhenyun, additional, Lian, Fulin, additional, Wei, Jiangbo, additional, Deng, Qiangqiang, additional, Wang, Yungui, additional, Wunderlich, Mark, additional, Gao, Zhiwei, additional, Pan, Guoyu, additional, Zhong, Dafang, additional, Zhou, Hu, additional, Zhang, Naixia, additional, Gan, Jianhua, additional, Jiang, Hualiang, additional, Mulloy, James C., additional, Qian, Zhijian, additional, Chen, Jianjun, additional, and Yang, Cai-Guang, additional

Published
2019
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7. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

Author

Wu, Dang, primary, Wang, Wanyan, additional, Chen, Wuyan, additional, Lian, Fulin, additional, Lang, Li, additional, Huang, Ying, additional, Xu, Yechun, additional, Zhang, Naixia, additional, Chen, Yinbin, additional, Liu, Mingyao, additional, Nussinov, Ruth, additional, Cheng, Feixiong, additional, Lu, Weiqiang, additional, and Huang, Jin, additional

Published
2018
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8. Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer

Author

Guo, Zhong-Qiang, primary, Zheng, Tong, additional, Chen, Baoen, additional, Luo, Cheng, additional, Ouyang, Sisheng, additional, Gong, Shouzhe, additional, Li, Jiafei, additional, Mao, Liu-Liang, additional, Lian, Fulin, additional, Yang, Yong, additional, Huang, Yue, additional, Li, Li, additional, Lu, Jing, additional, Zhang, Bidong, additional, Zhou, Luming, additional, Ding, Hong, additional, Gao, Zhiwei, additional, Zhou, Liqun, additional, Li, Guoqiang, additional, Zhou, Ran, additional, Chen, Ke, additional, Liu, Jingqiu, additional, Wen, Yi, additional, Gong, Likun, additional, Ke, Yuwen, additional, Yang, Shang-Dong, additional, Qiu, Xiao-Bo, additional, Zhang, Naixia, additional, Ren, Jin, additional, Zhong, Dafang, additional, Yang, Cai-Guang, additional, Liu, Jiang, additional, and Jiang, Hualiang, additional

Published
2016
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11. ¹H-NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotocin.

Author

Zhao L, Gao H, Lian F, Liu X, Zhao Y, and Lin D

Subjects
Analysis of Variance, Animals, Diabetes Mellitus, Experimental pathology, Diabetic Nephropathies pathology, Kidney pathology, Magnetic Resonance Spectroscopy, Male, Metabolome, Rats, Rats, Sprague-Dawley, Urinalysis, Diabetes Mellitus, Experimental metabolism, Diabetic Nephropathies metabolism, Energy Metabolism physiology, Kidney metabolism
Abstract

Elucidation of the metabolic profiling in diabetic nephropathy (DN) rats is of great assistance for understanding the pathogenesis of DN. In this study, ¹H-nuclear magnetic resonance (NMR)-based metabonomics combined with HPLC measurements was used to quantitatively analyze the metabolic changes in urine and kidney extracts from diabetic 2-wk and 8-wk rats induced by streptozotocin (STZ). Pattern recognition analysis of either urine or kidney extracts indicated that the two diabetic groups were separated obviously from the control group, suggesting that the metabolic profiles of the diabetic groups were markedly different from the control. The diabetic 8-wk rats showed lower levels of creatine, dimethylamine, and higher levels of ascorbate, succinate, lactate, citrate, allantoin, 2-ketoglutarate, and 3-hydrobutyrate (3-HB) in the urine samples. Moreover, the diabetic 8-wk rats displayed lower levels of succinate, creatine, myo-inositol, alanine, lactate, and ATP, and higher levels of 3-HB and glucose in the kidney extracts. The observed metabolic changes imply the enhanced pathways of either lipid or ketone body synthesis and decreased pathways of either tricarboxylic acid cycle or glycolysis in DN rats compared with the control. Our results suggest that the energy metabolic changes are associated with the pathogenic process of DN.

Published
2011
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