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Your search keyword '"Liang, Wei‐Feng"' showing total 18 results
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18 results on '"Liang, Wei‐Feng"'

1. An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir

Author

Liu, Yi-Qi, primary, Zhang, Chi, additional, Li, Jia-Wen, additional, Cao, Li-Hua, additional, Zhang, Zhan-Qing, additional, Zhao, Wei-Feng, additional, Shang, Qing-Hua, additional, Zhang, Da-Zhi, additional, Ma, An-Lin, additional, Xie, Qing, additional, Gui, Hong-Lian, additional, Zhang, Guo, additional, Liu, Ying-Xia, additional, Shang, Jia, additional, Xie, Shi-Bin, additional, Li, Jun, additional, Zhang, Xu-Qing, additional, Zou, Zhi-Qiang, additional, Chen, Yu-Ping, additional, Zhang, Zong, additional, Zhang, Ming-Xiang, additional, Cheng, Jun, additional, Zhang, Fu-Chun, additional, Huang, Li-Hua, additional, Li, Jia-Bin, additional, Meng, Qing-Hua, additional, Yu, Hai-Bin, additional, Mi, Yu-Qiang, additional, Peng, Yan-Zhong, additional, Wang, Zhi-Jin, additional, Chen, Li-Ming, additional, Meng, Fan-Ping, additional, Ren, Wan-Hua, additional, Bai, Lang, additional, Zeng, Yi-Lan, additional, Fan, Rong, additional, Lou, Xian-Zhi, additional, Liang, Wei-Feng, additional, Liu, Hui, additional, Zhuang, Hui, additional, Zhao, Hong, additional, and Wang, Gui-Qiang, additional

Published
2022
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10. Gravity variation associated with Wenchuan earthquake in western Sichuan

Author

Xu Yunma, Liu Fang, Liang Wei-Feng, and Zhu Yiqing

Subjects
lcsh:QB275-343, Gravity (chemistry), gravity variation, lcsh:Geodesy, lcsh:QC801-809, crustal movement, Active fault, western Sichuan, Geodesy, Physics::Geophysics, lcsh:Geophysics. Cosmic physics, Tectonics, High Energy Physics::Theory, General Relativity and Quantum Cosmology, Geophysics, Wenchuan earthquake, Gravitational field, Homogeneous, gravity observation, Computers in Earth Sciences, Variation (astronomy), Seismology, Geology, Earth-Surface Processes
Abstract

Based on the data of mobile gravity observation from 1998 to 2008 in western Sichuan, spatial dynamic variation results of regional gravity field are obtained. The relationship between the gravity variation features and Wenchuan M s8.0 earthquake is systematically analyzed. The results show: 1) Gravity variation is closely related to active fault tectonics, and gravity measurement can better reflect material migration following crustal tectonic activity near active fault. 2) The gravity field appeared a wider range regional gravity variation during Wenchuan earthquake occurrence. The dynamic patterns of gravity field demonstrates the evolution process of gravity field: quasi – homogeneous state—non – homogeneous state—earthquake occurrence.

Published
2011
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11. Coxsackievirus A16 induced neurological disorders in young gerbils which could serve as a new animal model for vaccine evaluation

Author

Sun, Yi-Sheng, primary, Li, Ya-jing, additional, Xia, Yong, additional, Xu, Fang, additional, Wang, Wei-wei, additional, Yang, Zhang-Nv, additional, Lu, Hang-Jing, additional, Chen, Zhi-Ping, additional, Miao, Zi-Ping, additional, Liang, Wei-Feng, additional, Xu, Zhi-Yao, additional, Dong, Hong-Jun, additional, Qiu, Dan-Hong, additional, Zhu, Zhi-Yong, additional, van der Veen, Stijn, additional, Qian, Jie, additional, Zhou, Bin, additional, Yao, Ping-Ping, additional, and Zhu, Han-Ping, additional

Published
2016
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12. Enterovirus 71 Infection Causes Severe Pulmonary Lesions in Gerbils, Meriones unguiculatus, Which Can Be Prevented by Passive Immunization with Specific Antisera

Author

Xu, Fang, primary, Yao, Ping-Ping, additional, Xia, Yong, additional, Qian, Lei, additional, Yang, Zhang-Nv, additional, Xie, Rong-Hui, additional, Sun, Yi-Sheng, additional, Lu, Hang-Jing, additional, Miao, Zi-Ping, additional, Li, Chan, additional, Li, Xiao, additional, Liang, Wei-Feng, additional, Huang, Xiao-Xiao, additional, Xia, Shi-Chang, additional, Chen, Zhi-Ping, additional, Jiang, Jian-Min, additional, Zhang, Yan-Jun, additional, Mei, Ling-Ling, additional, Liu, She-Lan, additional, Gu, Hua, additional, Xu, Zhi-Yao, additional, Fu, Xiao-Fei, additional, Zhu, Zhi-Yong, additional, and Zhu, Han-Ping, additional

Published
2015
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13. Viral genome and antiviral drug sensitivity analysis of two patients from a family cluster caused by the influenza A(H7N9) virus in Zhejiang, China, 2013

Author

Gao, Hai Nv, primary, Yao, Hang Ping, additional, Liang, Wei Feng, additional, Wu, Xiao Xin, additional, Wu, Hai Bo, additional, Wu, Nan Ping, additional, Yang, Shi Gui, additional, Zhang, Qiong, additional, Su, Kun Kai, additional, Guo, Jing, additional, Zheng, Shu Fa, additional, Zhu, Yi Xin, additional, Chen, Hong Lin, additional, Yuen, Kwok-yung, additional, and Li, Lan Juan, additional

Published
2014
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16. An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir.

Author

Liu YQ, Zhang C, Li JW, Cao LH, Zhang ZQ, Zhao WF, Shang QH, Zhang DZ, Ma AL, Xie Q, Gui HL, Zhang G, Liu YX, Shang J, Xie SB, Li J, Zhang XQ, Zou ZQ, Chen YP, Zhang Z, Zhang MX, Cheng J, Zhang FC, Huang LH, Li JB, Meng QH, Yu HB, Mi YQ, Peng YZ, Wang ZJ, Chen LM, Meng FP, Ren WH, Bai L, Zeng YL, Fan R, Lou XZ, Liang WF, Liu H, Zhuang H, Zhao H, and Wang GQ

Abstract

Background and Aims: Chronic hepatitis B (CHB) can cause liver fibrosis and lead to cirrhosis and cancer. As the effectiveness of antiviral therapy to reverse liver fibrosis is limited, We aimed to evaluate the effect of An-Luo-Hua-Xian pill (ALHX) on fibrosis regression in CHB patients treated with entecavir (ETV)., Methods: Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX (ETV+ALHX) between October 1, 2013 and December 31, 2020. Demographic, laboratory, and liver histology data before and after 78 weeks of treatment were collected. The Ishak fibrosis score (F) was used and fibrosis regression required a decrease in F of ≥1 after treatment., Results: A total of 780 patients were enrolled, and 394 with a second liver biopsy after treatment were included in the per-protocol population, 132 in ETV group and 262 in ETV+ALHX group. After 78 weeks of treatment, the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients: 124/211 (58.8%) vs. 45/98 (45.9%), p =0.035. The percentage of patients with a decreased liver stiffness measurement (LSM) was higher in the ETV+ALHX group: 156/211 (73.9%) vs. 62/98 (63.%), p =0.056. Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression [odds ratio (OR)=1.94, p =0.018], and a family history of hepatocellular carcinoma was on the contrary. (OR=0.41, p =0.031)., Conclusions: ETV combined with ALHX increased liver fibrosis regression in CHB patients., Competing Interests: The authors have no conflict of interests related to this publication., (© 2023 Authors.)

Published
2023
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18. PCR restriction fragment length polymorphism in detection of YMDD variants of viral polymerase in hepatitis B virus patients treated with lamivudine.

Author

Yang DH, Liang WF, Xie YJ, Zhao NF, and Fan J

Subjects
Adolescent, Adult, Amino Acid Motifs, Aspartic Acid genetics, Base Sequence, Child, Drug Resistance genetics, Hepatitis B virology, Hepatitis B virus metabolism, Humans, Methionine genetics, Middle Aged, Tyrosine genetics, DNA-Directed DNA Polymerase genetics, Genetic Variation, Hepatitis B drug therapy, Lamivudine therapeutic use, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Reverse Transcriptase Inhibitors therapeutic use
Abstract

Objective: To analyse the emergence of YMDD motif (tyrosine-methionine-aspartate-aspartate) variants in patients with hepatitis B treated with lamivudine., Methods: The amino acid substitution from methionine or isoleucine at the YMDD motif at the HBV polymerase gene is a main mutation resistant to lamivudine treatment. Generated from a fragment of domain C of the polymerase gene, patients' HBV DNA, which had been positive previously became positive again ever since it had been negative during lamivudine therapy. Variants were detected by cleavage of the products of the three PCRs with following enzymes: FokI, SspI, Alw441. The results of PCR-RELP were analysed by 8.4% polypropylene acidemide gel electrophoresis. PCR-RFLP assay was compared to direct sequencing., Results: HBV DNA was positive again in 33 patients and positive for one year in 2 patients. YMDD variants were detected in serum 14 of 35 patients, YIDD variants in 4, YVDD variants in 6, and YI/MDD variants in 1; all were in concordance with the results of direct sequencing. The samples of other 3 patients showed YI/VDD mutations, as shown by direct sequencing. The results of PCR-RFLP assay of the mixed sera of YIDD and YVDD variants were similar to those sera of YI/VDD variants., Conclusion: PCR-RFLP is suitable for rapid detection of YMDD variants of viral polymerase in hepatitis B virus patients treated with lamivudine.

Published
2002

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