Search

Your search keyword '"Liew, Aaron"' showing total 161 results
Start Over Author "Liew, Aaron" Search Limiters Full Text
161 results on '"Liew, Aaron"'

1. Marrow changes and reduced proliferative capacity of mesenchymal stromal cells from patients with “no-option” critical limb ischemia; observations on feasibility of the autologous approach from a clinical trial

Author

Mohamed, Sara Azhari, Duffy, Aoife, McInerney, Veronica, Krawczyk, Janusz, Hayat, Amjad, Naughton, Sean, Finnerty, Andrew, Holohan, Miriam, Liew, Aaron, Tubassam, Muhammad, Walsh, Stewart Redmond, O'Brien, Timothy, and Howard, Linda

Published
2022
Full Text
View/download PDF

2. Methodological considerations in injury burden of disease studies across Europe: a systematic literature review

Author

Charalampous, Periklis, Pallari, Elena, Gorasso, Vanessa, von der Lippe, Elena, Devleesschauwer, Brecht, Pires, Sara M., Plass, Dietrich, Idavain, Jane, Ngwa, Che Henry, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Majdan, Marek, Ádám, Balázs, AlKerwi, Ala’a, Cilovic-Lagarija, Seila, Clarsen, Benjamin, Corso, Barbara, Cuschieri, Sarah, Dopelt, Keren, Economou, Mary, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gkitakou, Artemis, Gulmez, Hakan, Hynds, Paul, Isola, Gaetano, Jakobsen, Lea S., Kabir, Zubair, Kissimova-Skarbek, Katarzyna, Knudsen, Ann Kristin, Konar, Naime Meriç, Ladeira, Carina, Lassen, Brian, Liew, Aaron, Majer, Marjeta, Mechili, Enkeleint A., Mereke, Alibek, Monasta, Lorenzo, Mondello, Stefania, Morgado, Joana Nazaré, Nena, Evangelia, Ng, Edmond S. W., Niranjan, Vikram, Nola, Iskra Alexandra, O’Caoimh, Rónán, Petrou, Panagiotis, Pinheiro, Vera, Ortiz, Miguel Reina, Riva, Silvia, Samouda, Hanen, Santos, João Vasco, Santoso, Cornelia Melinda Adi, Milicevic, Milena Santric, Skempes, Dimitrios, Sousa, Ana Catarina, Speybroeck, Niko, Tozija, Fimka, Unim, Brigid, Uysal, Hilal Bektaş, Vaccaro, Fabrizio Giovanni, Varga, Orsolya, Vasic, Milena, Violante, Francesco Saverio, Wyper, Grant M. A., Polinder, Suzanne, and Haagsma, Juanita A.

Published
2022
Full Text
View/download PDF

3. Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function

Author

Sabbah, Shereen, Liew, Aaron, Brooks, Augustin M., Kundu, Rhiannon, Reading, James L., Flatt, Anneliese, Counter, Claire, Choudhary, Pratik, Forbes, Shareen, Rosenthal, Miranda J., Rutter, Martin K., Cairns, Stephanie, Johnson, Paul, Casey, John, Peakman, Mark, Shaw, James A., and Tree, Timothy I.M.

Published
2021
Full Text
View/download PDF

6. A RAND/UCLA-Modified VAS Study on Telemedicine, Telehealth, and Virtual Care in Daily Clinical Practice of Vascular Medicine

Author

Pillon, Sergio, Gomatou, Georgia, Dimakakos, Evangelos, Stanek, Agata, Pécsvárady, Zsolt, Kozak, Matija, Wautrecht, Jean-Claude, Farkas, Katalin, Schernthaner, Gerit Holger, Catalano, Mariella, Blinc, Ales, Gerotziafas, Grigorios G.T., Poredoš, Pavel, De Marchi, Sergio, Gschwandtner, Michael Eduard, Kolossvary, Endre, Sprynger, Muriel, Fazeli, Bahare, Liew, Aaron, Marschang, Peter, Szuba, Andrzej, Suput, Dusan, Edmonds, Michael, Manu, Chris, Schaefer, Christian Alexander, Marakomichelakis, George, Vrkić Kirhmajer, Majda, Spaak, Jonas, Kotteas, Elias, Lessiani, Gianfranco, Colgan, Mary Paola, Righini, Marc, Lichtenberg, Michael, Schlager, Oliver, Canning, Caitriona, Marcoccia, Antonella, Kollias, Anastasios, Spreafico, Alberta, Pillon, Sergio, Gomatou, Georgia, Dimakakos, Evangelos, Stanek, Agata, Pécsvárady, Zsolt, Kozak, Matija, Wautrecht, Jean-Claude, Farkas, Katalin, Schernthaner, Gerit Holger, Catalano, Mariella, Blinc, Ales, Gerotziafas, Grigorios G.T., Poredoš, Pavel, De Marchi, Sergio, Gschwandtner, Michael Eduard, Kolossvary, Endre, Sprynger, Muriel, Fazeli, Bahare, Liew, Aaron, Marschang, Peter, Szuba, Andrzej, Suput, Dusan, Edmonds, Michael, Manu, Chris, Schaefer, Christian Alexander, Marakomichelakis, George, Vrkić Kirhmajer, Majda, Spaak, Jonas, Kotteas, Elias, Lessiani, Gianfranco, Colgan, Mary Paola, Righini, Marc, Lichtenberg, Michael, Schlager, Oliver, Canning, Caitriona, Marcoccia, Antonella, Kollias, Anastasios, and Spreafico, Alberta

Abstract

Background: Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views of experts and propose clinical practice recommendations on the possible applications of telemedicine in vascular medicine. Methods: A clinical guidance group proposed a set of 67 clinical practice recommendations based on the synthesis of current evidence and expert opinion. The Telemedicine Vascular Medicine Working Group included 32 experts from Europe evaluating the appropriateness of each clinical practice recommendation based on published RAND/UCLA methodology in two rounds. Results: In the first round, 60.9% of clinical practice recommendations were rated as appropriate, 35.9% as uncertain, and 3.1% as inappropriate. The strongest agreement (a median value of 10) was reached on statements regarding the usefulness of telemedicine during the 2019 coronavirus disease (COVID-19) pandemic, its usefulness for geographical areas that are difficult to access, and the superiority of video calls compared to phone calls only. The lowest degree of agreement (a median value of 2) was reported on statements regarding the utility of telemedicine being limited to the COVID-19 pandemic and regarding the applicability of teleconsultation in the diagnosis and management of abdominal aortic aneurysm. In the second round, 11 statements were re-evaluated to reduce variability. Conclusions: This study highlights the levels of agreement and the points that raise concern on the use of telemedicine in vascular medicine. It emphasizes the need for further clarification on various issues, including infrastructure, logistics, and legislation., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2024

7. European Collaborative and Interprofessional Capability Framework for Prevention and Management of Frailty—a consensus process supported by the Joint Action for Frailty Prevention (ADVANTAGE) and the European Geriatric Medicine Society (EuGMS)

Author

Roller-Wirnsberger, Regina, Lindner, Sonja, Liew, Aaron, O’Caoimh, Ronan, Koula, Maria-Lamprini, Moody, Dawn, Espinosa, Juan Manuel, van Durme, Thérèse, Dimitrov, Plamen, Benjak, Tomislav, Nicolaidou, Elena, Hammar, Teija, Vanhecke, Eliane, Junius-Walker, Ulrike, Csizmadia, Péter, Galluzzo, Lucia, Macijauskienė, Jūratė, Salem, Mohamed, Rietman, Liset, Ranhoff, Anette Hylen, Targowski, Tomasz, de Arriaga, Miguel Telo, Bozdog, Elena, Gabrovec, Branko, Hendry, Anne, Martin, Finbarr C., and Rodriguez-Mañas, Leocadio

Published
2020
Full Text
View/download PDF

8. A RAND/UCLA-Modified VAS Study on Telemedicine, Telehealth, and Virtual Care in Daily Clinical Practice of Vascular Medicine

Author

Pillon, Sergio, primary, Gomatou, Georgia, additional, Dimakakos, Evangelos, additional, Stanek, Agata, additional, Pecsvarady, Zsolt, additional, Kozak, Matija, additional, Wautrecht, Jean-Claude, additional, Farkas, Katalin, additional, Schernthaner, Gerit-Holger, additional, Catalano, Mariella, additional, Blinc, Aleš, additional, Gerotziafas, Grigorios, additional, Poredoš, Pavel, additional, De Marchi, Sergio, additional, Gschwandtner, Michael E., additional, Kolossváry, Endre, additional, Sprynger, Muriel, additional, Fazeli, Bahar, additional, Liew, Aaron, additional, Marschang, Peter, additional, Szuba, Andrzej, additional, Suput, Dusan, additional, Edmonds, Michael, additional, Manu, Chris, additional, Schaefer, Christian Alexander, additional, Marakomichelakis, George, additional, Vrkić Kirhmajer, Majda, additional, Spaak, Jonas, additional, Kotteas, Elias, additional, Lessiani, Gianfranco, additional, Colgan, Mary Paola, additional, Righini, Marc, additional, Lichtenberg, Michael, additional, Schlager, Oliver, additional, Canning, Caitriona, additional, Marcoccia, Antonella, additional, Kollias, Anastasios, additional, and Spreafico, Alberta, additional

Published
2024
Full Text
View/download PDF

10. No More Venous Ulcers—What More Can We Do?

Author

Stanek, Agata, primary, Mosti, Giovanni, additional, Nematillaevich, Temirov, additional, Valesky, Eva, additional, Planinšek Ručigaj, Tanja, additional, Boucelma, Malika, additional, Marakomichelakis, George, additional, Liew, Aaron, additional, Fazeli, Bahar, additional, Catalano, Mariella, additional, and Patel, Malay, additional

Published
2023
Full Text
View/download PDF

13. Comparing frailty prevalence between countries: validation of the Global Burden of Disease study Frailty Index (GBD-FI) in the survey of health, ageing and retirement in Europe.

Author

O'Donovan, Mark R, Devleesschauwer, Brecht, Sezgin, Duygu, Liew, Aaron, Kabir, Zubair, and O'Caoimh, Rónán

Subjects
CONFIDENCE intervals, GLOBAL burden of disease, RESEARCH methodology evaluation, COMPARATIVE studies, SURVEYS, AGING, DISEASE prevalence, DESCRIPTIVE statistics, RETIREMENT, PREDICTIVE validity, SECONDARY analysis
Abstract

Background Accurate comparable prevalence proportions are required to better understand the epidemiology of frailty. Estimates in many countries are missing or incomparable. The Global Burden of Disease Frailty Index (GBD-FI) applies the deficit accumulation model to generate frailty scores from items available in the Global Burden of Disease study. Objective To externally validate the GBD-FI. Methods Data were obtained from the Survey of Health Ageing and Retirement in Europe (SHARE). A 20-item modified GBD-FI was compared with established frailty measures: a 70-item frailty index (FI-70), the Clinical Frailty Scale (CFS), Frailty Phenotype (FP) and SHARE-FI. Area under receiver operating characteristic curves (AUC) were fitted to examine diagnostic accuracy for frailty and predictive validity for 2-year mortality. Results In total, 31,624 participants aged ≥50 years from 15 countries were included. Frailty prevalence was 22% using the GBD-FI (ranging from 8% in Switzerland to 41% in Poland). The GBD-FI had good to excellent diagnostic accuracy for frailty, irrespective of approach; the AUC ranged from 0.86 (95% confidence interval: 0.85–0.87) measuring frailty using the CFS to 0.94 (0.93–0.94) with the FI-70. The GBD-FI had similar accuracy for 2-year mortality (AUC 0.71, 0.69–0.74) compared with the CFS (0.73; P  = 0.186), FP (0.73; P  = 0.392) and SHARE-FI (0.70; P  = 0.255) but lower than the FI-70 (0.76; P  < 0.001). Conclusion The GBD-FI demonstrated concurrent and predictive validity, suggesting it is a valid measure of frailty. It has the potential to be an efficient, replicable and consistent approach to comparing frailty between countries and regions across time using GBD data. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

15. The burden of breast, cervical, and colon and rectum cancer in the Balkan countries, 1990–2019 and forecast to 2030.

Author

Todorovic, Jovana, Stamenkovic, Zeljka, Stevanovic, Aleksandar, Terzic, Natasa, Kissimova-Skarbek, Katarzyna, Tozija, Fimka, Mechili, Enkeleint A., Devleesschauwer, Brecht, Terzic-Supic, Zorica, Vasic, Milena, Bjegovic-Mikanovic, Vesna, Santric-Milicevic, Milena, Liew, Aaron, Mentis, Alexios Fotios, Mereke, Alibek, Sousa, Ana Catarina, Manda, Ana Laura, Gkitakou, Artemis, Adam, Balazs, and Oancea, Bogdan

Subjects
RECTAL cancer, COLON cancer, BOX-Jenkins forecasting, GLOBAL burden of disease, CARDIOVASCULAR system
Abstract

Background: Despite effective prevention and control strategies, in countries of the Balkan region, cancers are the second leading cause of mortality, closely following circulatory system diseases. Objective: To describe trends in the burden of breast, cervical, and colon and rectum cancer in the Balkan region and per country between 1990 and 2019, including a forecast to 2030. Methods: We described the 2019 Global Burden of Disease (GBD) estimates for breast, cervical, and colon and rectum cancers in eleven Balkan countries over the period 1990–2019, including incidence, years lived with disability (YLD), years of life lost (YLL), and disability-adjusted life years (DALYs) rates per 100,000 population and accompanied 95% uncertainty interval. With the Autoregressive Integrated Moving Average, we forecasted these rates per country up to 2030. Results: In the Balkan region, the highest incidence and DALYs rates in the study period were for colon and rectum, and breast cancers. Over the study period, the DALYs rates for breast cancer per 100,000 population were the highest in Serbia (reaching 670.84 in 2019) but the lowest in Albania (reaching 271.24 in 2019). In 2019, the highest incidence of breast cancer (85 /100,000) and highest YLD rate (64 /100,000) were observed in Greece. Romania had the highest incidence rates, YLD rates, DALY rates, and YLL rates of cervical cancer, with respective 20.59%, 23.39% 4.00%, and 3.47% increases for the 1990/2019 period, and the highest forecasted burden for cervical cancer in 2030. The highest incidence rates, YLD rates and DALY rates of colon and rectum cancers were continuously recorded in Croatia (an increase of 130.75%, 48.23%, and 63.28%, respectively), while the highest YLL rates were in Bulgaria (an increase of 63.85%). The YLL rates due to colon and rectum cancers are forecasted to progress by 2030 in all Balkan countries. Conclusion: As most of the DALYs burden for breast, cervical, and colon and rectum cancer is due to premature mortality, the numerous country-specific barriers to cancer early detection and quality and care continuum should be a public priority of multi-stakeholder collaboration in the Balkan region. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

17. Methodological considerations in injury burden of disease studies across Europe:a systematic literature review

Author

Charalampous, Periklis, Pallari, Elena, Gorasso, Vanessa, von der Lippe, Elena, Devleesschauwer, Brecht, Pires, Sara M., Plass, Dietrich, Idavain, Jane, Ngwa, Che Henry, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Majdan, Marek, Ádám, Balázs, AlKerwi, Ala’a, Cilovic-Lagarija, Seila, Clarsen, Benjamin, Corso, Barbara, Cuschieri, Sarah, Dopelt, Keren, Economou, Mary, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gkitakou, Artemis, Gulmez, Hakan, Hynds, Paul, Isola, Gaetano, Jakobsen, Lea S., Kabir, Zubair, Kissimova-Skarbek, Katarzyna, Knudsen, Ann Kristin, Konar, Naime Meriç, Ladeira, Carina, Lassen, Brian, Liew, Aaron, Majer, Marjeta, Mechili, Enkeleint A., Mereke, Alibek, Monasta, Lorenzo, Mondello, Stefania, Morgado, Joana Nazaré, Nena, Evangelia, Ng, Edmond S.W., Niranjan, Vikram, Nola, Iskra Alexandra, O’Caoimh, Rónán, Petrou, Panagiotis, Pinheiro, Vera, Ortiz, Miguel Reina, Riva, Silvia, Samouda, Hanen, Santos, João Vasco, Santoso, Cornelia Melinda Adi, Milicevic, Milena Santric, Skempes, Dimitrios, Sousa, Ana Catarina, Speybroeck, Niko, Tozija, Fimka, Unim, Brigid, Uysal, Hilal Bektaş, Vaccaro, Fabrizio Giovanni, Varga, Orsolya, Vasic, Milena, Violante, Francesco Saverio, Wyper, Grant M.A., Polinder, Suzanne, Haagsma, Juanita A., Charalampous, Periklis, Pallari, Elena, Gorasso, Vanessa, von der Lippe, Elena, Devleesschauwer, Brecht, Pires, Sara M., Plass, Dietrich, Idavain, Jane, Ngwa, Che Henry, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Majdan, Marek, Ádám, Balázs, AlKerwi, Ala’a, Cilovic-Lagarija, Seila, Clarsen, Benjamin, Corso, Barbara, Cuschieri, Sarah, Dopelt, Keren, Economou, Mary, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gkitakou, Artemis, Gulmez, Hakan, Hynds, Paul, Isola, Gaetano, Jakobsen, Lea S., Kabir, Zubair, Kissimova-Skarbek, Katarzyna, Knudsen, Ann Kristin, Konar, Naime Meriç, Ladeira, Carina, Lassen, Brian, Liew, Aaron, Majer, Marjeta, Mechili, Enkeleint A., Mereke, Alibek, Monasta, Lorenzo, Mondello, Stefania, Morgado, Joana Nazaré, Nena, Evangelia, Ng, Edmond S.W., Niranjan, Vikram, Nola, Iskra Alexandra, O’Caoimh, Rónán, Petrou, Panagiotis, Pinheiro, Vera, Ortiz, Miguel Reina, Riva, Silvia, Samouda, Hanen, Santos, João Vasco, Santoso, Cornelia Melinda Adi, Milicevic, Milena Santric, Skempes, Dimitrios, Sousa, Ana Catarina, Speybroeck, Niko, Tozija, Fimka, Unim, Brigid, Uysal, Hilal Bektaş, Vaccaro, Fabrizio Giovanni, Varga, Orsolya, Vasic, Milena, Violante, Francesco Saverio, Wyper, Grant M.A., Polinder, Suzanne, and Haagsma, Juanita A.

Abstract

Background: Calculating the disease burden due to injury is complex, as it requires many methodological choices. Until now, an overview of the methodological design choices that have been made in burden of disease (BoD) studies in injury populations is not available. The aim of this systematic literature review was to identify existing injury BoD studies undertaken across Europe and to comprehensively review the methodological design choices and assumption parameters that have been made to calculate years of life lost (YLL) and years lived with disability (YLD) in these studies. Methods: We searched EMBASE, MEDLINE, Cochrane Central, Google Scholar, and Web of Science, and the grey literature supplemented by handsearching, for BoD studies. We included injury BoD studies that quantified the BoD expressed in YLL, YLD, and disability-adjusted life years (DALY) in countries within the European Region between early-1990 and mid-2021. Results: We retrieved 2,914 results of which 48 performed an injury-specific BoD assessment. Single-country independent and Global Burden of Disease (GBD)-linked injury BoD studies were performed in 11 European countries. Approximately 79% of injury BoD studies reported the BoD by external cause-of-injury. Most independent studies used the incidence-based approach to calculate YLDs. About half of the injury disease burden studies applied disability weights (DWs) developed by the GBD study. Almost all independent injury studies have determined YLL using national life tables. Conclusions: Considerable methodological variation across independent injury BoD assessments was observed; differences were mainly apparent in the design choices and assumption parameters towards injury YLD calculations, implementation of DWs, and the choice of life table for YLL calculations. Development and use of guidelines for performing and reporting of injury BoD studies is crucial to enhance transparency and comparability

Published
2022

18. Thromboembolic Disease in Patients With Cancer and COVID-19:Risk Factors, Prevention and Practical Thromboprophylaxis Recommendations–State-of-the-Art

Author

Dimakakos, Evangelos, Gomatou, Georgia, Catalano, Mariella, Olinic, Dan Mircea, Spyropoulos, Alex C., Falanga, Anna, Maraveyas, Anthony, Liew, Aaron, Schulman, Sam, Belch, Jill, Gerotziafas, Grigorios, Marschang, Peter, Cosmi, Benilde, Spaak, Jonas, Syrigos, Konstantinos, Dimakakos, Evangelos, Gomatou, Georgia, Catalano, Mariella, Olinic, Dan Mircea, Spyropoulos, Alex C., Falanga, Anna, Maraveyas, Anthony, Liew, Aaron, Schulman, Sam, Belch, Jill, Gerotziafas, Grigorios, Marschang, Peter, Cosmi, Benilde, Spaak, Jonas, and Syrigos, Konstantinos

Abstract

Cancer and COVID-19 are both well-established risk factors predisposing to thrombosis. Both disease entities are correlated with increased incidence of venous thrombotic events through multifaceted pathogenic mechanisms involving the interaction of cancer cells or SARS-CoV2 on the one hand and the coagulation system and endothelial cells on the other hand. Thromboprophylaxis is recommended for hospitalized patients with active cancer and high-risk outpatients with cancer receiving anticancer treatment. Universal thromboprophylaxis with a high prophylactic dose of low molecular weight heparins (LMWH) or therapeutic dose in select patients, is currently indicated for hospitalized patients with COVID-19. Also, prophylactic anticoagulation is recommended for outpatients with COVID-19 at high risk for thrombosis or disease worsening. However, whether there is an additive risk of thrombosis when a patient with cancer is infected with SARSCoV2 remains unclear. In the current review, we summarize and critically discuss the literature regarding the epidemiology of thrombotic events in patients with cancer and concomitant COVID-19, the thrombotic risk assessment, and the recommendations on thromboprophylaxis for this subgroup of patients. Current data do not support an additive thrombotic risk for patients with cancer and COVID-19. Of note, patients with cancer have less access to intensive care unit care, a setting associated with high thrombotic risk. Based on current evidence, patients with cancer and COVID-19 should be assessed with well-established risk assessment models for medically ill patients and receive thromboprophylaxis, preferentially with LMWH, according to existing recommendations. Prospective trials on well-characterized populations do not exist.

Published
2022

20. Burden of non-communicable disease studies in Europe: a systematic review of data sources and methodological choices

Author

Mereke, Alibek, Von Der Lippe, Elena, Pires, Sara M, Plass, Dietrich, Gorasso, Vanessa, Charalampous, Periklis, Majer, Marjeta, Liew, Aaron, Ladeira, Carina, Mechili, Enkeleint A, Padron-Monedero, Alicia, O'caoimh, Rónán, Konar, Naime Meriç, Knudsen, Ann Kristin, Kabir, Zubair, Jakobsen, Lea S, Isola, Gaetano, Hynds, Paul, Hengl, Brigita, Gissler, Mika, Gazzelloni, Federica, García-González, Juan Manuel, Freitas, Alberto, Fischer, Florian, Eikemo, Terje Andreas, Dahm, Christina C, Cuschieri, Sarah, Breitner, Susanne, Bølling, Anette Kocbach, Bikbov, Boris, Alkerwi, Ala’A, Ádám, Balázs, Haagsma, Juanita A, Devleesschauwer, Brecht, Sarmiento, Rodrigo, Santi-Cano, María José, Noguer, Isabel, Ngwa, Che Henry, Morgado, Joana Nazaré, Kissimova-Skarbek, Katarzyna, Idavain, Jane, O’Donovan, Mark Ryan, Ortiz, Alberto, Pallari, Elena, Petrou, Panagiotis, Ortiz, Miguel Reina, Riva, Silvia, Samouda, Hanène, Santos, João V, Adi Santoso, Cornelia Melinda, Schmitt, Tugce, Skempes, Dimitrios, Sousa, Ana Catarina, Stevanovic, Aleksandar, Terzic, Gerhard Sulo Natasa, Terzic-Supic, Zorica, Todorovic, Jovana, Tozija, Fimka, Unim, Brigid, Van Wilder, Lisa, Varga, Orsolya, Violante, Francesco S, Wyper, Grant M A, Mevsim, Vildan, Niranjan, Vikram, Ng, Edmond S W, Nena, Evangelia, Mondello, Stefania, Monasta, Lorenzo, Mitchell, Louise, Milicevic, Milena Santric, Repositório da Universidade de Lisboa, and COST Action CA18218

Subjects
Burden of non-communicable diseases, Base de datos bibliográfica, Information Storage and Retrieval, Global Health, Disability-adjusted life years, Europe/epidemiology, Global Burden of Disease, Chronic diseases -- Risk factors -- Europe, SDG 3 - Good Health and Well-being, Medicine and Health Sciences, Humans, Non-communicable diseases, ddc:610, Noncommunicable Diseases, Cost of illness -- Europe, Disability-adjusted life years -- Europe, Public Health, Environmental and Occupational Health, Burden of disease, Noncommunicable Diseases/epidemiology, Burden of Disease methodology, Europe, European Burden of Disease Network, Enfermedades no transmisibles, Global burden of disease -- Europe, Medical care, Cost of -- Europe -- Case studies, Quality-Adjusted Life Years, non-communicable disease studies, 610 Medizin und Gesundheit
Abstract

Background: Assessment of disability-adjusted life years (DALYs) resulting from non-communicable diseases (NCDs) requires specific calculation methods and input data. The aims of this study were to (i) identify existing NCD burden of disease (BoD) activities in Europe; (ii) collate information on data sources for mortality and morbidity; and (iii) provide an overview of NCD-specific methods for calculating NCD DALYs. Methods: NCD BoD studies were systematically searched in international electronic literature databases and in grey literature. We included all BoD studies that used the DALY metric to quantify the health impact of one or more NCDs in countries belonging to the European Region. Results: A total of 163 BoD studies were retained: 96 (59%) were single-country or sub-national studies and 67 (41%) considered more than one country. Of the single-country studies, 29 (30%) consisted of secondary analyses using existing Global Burden of Disease (GBD) results. Mortality data were mainly derived (49%) from vital statistics. Morbidity data were frequently (40%) drawn from routine administrative and survey datasets, including disease registries and hospital discharge databases. The majority (60%) of national BoD studies reported mortality corrections. Multimorbidity adjustments were performed in 18% of national BoD studies. Conclusion: The number of national NCD BoD assessments across Europe increased over time, driven by an increase in BoD studies that consisted of secondary data analysis of GBD study findings. Ambiguity in reporting the use of NCD-specific BoD methods underlines the need for reporting guidelines of BoD studies to enhance the transparency of NCD BoD estimates across Europe., peer-reviewed

Published
2022
Full Text
View/download PDF

21. Additional file 1 of Methodological considerations in injury burden of disease studies across Europe: a systematic literature review

Author

Charalampous, Periklis, Pallari, Elena, Gorasso, Vanessa, von der Lippe, Elena, Devleesschauwer, Brecht, Pires, Sara M., Plass, Dietrich, Idavain, Jane, Ngwa, Che Henry, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Majdan, Marek, Ádám, Balázs, AlKerwi, Ala’a, Cilovic-Lagarija, Seila, Clarsen, Benjamin, Corso, Barbara, Cuschieri, Sarah, Dopelt, Keren, Economou, Mary, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gkitakou, Artemis, Gulmez, Hakan, Hynds, Paul, Isola, Gaetano, Jakobsen, Lea S., Kabir, Zubair, Kissimova-Skarbek, Katarzyna, Knudsen, Ann Kristin, Konar, Naime Meriç, Ladeira, Carina, Lassen, Brian, Liew, Aaron, Majer, Marjeta, Mechili, Enkeleint A., Mereke, Alibek, Monasta, Lorenzo, Mondello, Stefania, Morgado, Joana Nazaré, Nena, Evangelia, Ng, Edmond S. W., Niranjan, Vikram, Nola, Iskra Alexandra, O’Caoimh, Rónán, Petrou, Panagiotis, Pinheiro, Vera, Ortiz, Miguel Reina, Riva, Silvia, Samouda, Hanen, Santos, João Vasco, Santoso, Cornelia Melinda Adi, Milicevic, Milena Santric, Skempes, Dimitrios, Sousa, Ana Catarina, Speybroeck, Niko, Tozija, Fimka, Unim, Brigid, Uysal, Hilal Bektaş, Vaccaro, Fabrizio Giovanni, Varga, Orsolya, Vasic, Milena, Violante, Francesco Saverio, Wyper, Grant M. A., Polinder, Suzanne, and Haagsma, Juanita A.

Abstract

Additional file 1. Search strategy and grey literature search and overview of studies.

Published
2022
Full Text
View/download PDF

23. The Diagnostic Accuracy and Clinimetric Properties of Screening Instruments to Identify Frail Older Adults Attending Emergency Departments: A Protocol for a Mixed Methods Systematic Review and Meta-Analysis

Author

Moloney, Elizabeth, primary, Sezgin, Duygu, additional, O’Donovan, Mark, additional, Adja, Kadjo Yves Cedric, additional, McGrath, Keith, additional, Liew, Aaron, additional, Lenzi, Jacopo, additional, Gori, Davide, additional, O’Connor, Kieran, additional, Molloy, David William, additional, Flanagan, Evelyn, additional, McLoughlin, Darren, additional, Fantini, Maria Pia, additional, Timmons, Suzanne, additional, and O’Caoimh, Rónán, additional

Published
2022
Full Text
View/download PDF

24. Milestones in thromboangiitis obliterans: a position paper of the VAS-European independent foundation in angiology/vascular medicine

Author

Fazeli, Bahare Poredos, Pavel Patel, Malay Klein-Weigel, Peter Catalano, Mariella Stephen, Edwin Al Salman, Mussaad M. Altarazi, Louay Bashar, Abul H. Chua, Benjamin and Colgan, Mary P. Cvjetko, Ivan Desai, Sanjay Dimakakos, Evangelos P. Erer, Dilek Farkas, Katalin Fowkes, Gerry R. and Gerotziafas, Grigorios Hussein, Emad Ionac, Mihai Iwai, Takehisa Karahan, Oguz Kolossvary, Endre Kota, Albert and Kozak, Matija Kroger, Knut Kumar, Prabhu P. Liew, Aaron and Malecki, Rafal Najafi, Mohammad H. Olinic, Dan-Mircea and Pandey, Sandeep R. Pecsvarady, Zsolt Ravari, Hassan Samuel, Vimalin Schernthaner, Gerit Selvaraj, Dheepak and Sermsathanasawadi, Nuttawut Sharebiani, Hiva Stanek, Agata and Szuba, Andrzej Taheri, Hossein Wautrecht, Jean C. Zor Hakan, Mustafa

Subjects
education
Abstract

1School of Medicine, Division of Inflammation and Inflammatory Diseases, Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 2Slovenia Academic Research Center, Slovenian Medical Academy, Medical Association of Slovenia and SMA, Ljubljana, Slovenia; 3Department of Vascular Surgery, Apollo-CVHF Hospital, Ahmedabad, India; 4Clinic of Angiology, Zentrum f iota ir Innere Medizin II, Ernst von Bergmann Klinikum, Potsdam, Germany; 5Unit of Angiology, Department of Biomedical Science, Research Center on Vascular Disease, L. Sacco Hospital, University of Milan, Milan, Italy; 6Department of Vascular Surgery, Sultan Qaboos University Hospital, Muscat, Oman; 7Division of Vascular Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia; 8Varicose Veins and Vascular Polyclinic (VVVC), Damascus, Syria; 9National Institute of Cardiovascular Diseases and Hospital, Dhaka, Bangladesh; 10Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; 11Department of Vascular Surgery, St. James's Hospital/Trinity College Dublin, Dublin, Ireland; 12Department of Vascular Surgery, University Hospital Mekur, Zagreb, Croatia; 13Department of Vascular and Endovascular Surgery, Ramaiah Medical College Hospital, Bangalore, India; 14Unit of Vascular Surgery, Third Department of Internal Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece; 15Department of Cardiovascular Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey; 16Department of Angiology, St. Imre University Teaching Hospital, Budapest, Hungary; 17Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, UK; 18Hematology and Thrombosis Center, Hopitaux Universitaires de l'Est Parisien, Assistance Publique Hopitaux de Paris, Faculty of Medicine

Published
2021

30. Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation : A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

Author

Maffi, Paola, Lundgren, Torbjorn, Tufveson, Gunnar, Rafael, Ehab, Shaw, James A. M., Liew, Aaron, Saudek, Frantisek, Witkowski, Piotr, Golab, Karolina, Bertuzzi, Federico, Gustafsson, Bengt, Daffonchio, Luisa, Ruffini, Pier Adelchi, Piemonti, Lorenzo, Nano, Rita, Mercalli, Alessia, Lampasona, Vito, Magistretti, Paola, Sordi, Valeria, Antonio, Secchi, Antonioli, Barbara, Galuzzi, Marta, Tosca, Marta Cecilia, De Carlis, Luciano, Colussi, Giacomo, Korsgren, Olle, Pollard, Helena, Maffi, Paola, Lundgren, Torbjorn, Tufveson, Gunnar, Rafael, Ehab, Shaw, James A. M., Liew, Aaron, Saudek, Frantisek, Witkowski, Piotr, Golab, Karolina, Bertuzzi, Federico, Gustafsson, Bengt, Daffonchio, Luisa, Ruffini, Pier Adelchi, Piemonti, Lorenzo, Nano, Rita, Mercalli, Alessia, Lampasona, Vito, Magistretti, Paola, Sordi, Valeria, Antonio, Secchi, Antonioli, Barbara, Galuzzi, Marta, Tosca, Marta Cecilia, De Carlis, Luciano, Colussi, Giacomo, Korsgren, Olle, and Pollard, Helena

Abstract

OBJECTIVE: Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS: A phase 3, multicenter, randomized, double-blind, parallel-assignment study () was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition to immunosuppression. Primary outcome was the area under the curve (AUC) for C-peptide during the mixed-meal tolerance test at day 75 +/- 5 after the first and day 365 +/- 14 after the last transplant. Secondary end points included insulin independence and standard measures of glycemic control. RESULTS: The intention-to-treat analysis did not show a significant difference in C-peptide AUC at both day 75 (27 on reparixin vs. 18 on placebo, P = 0.99) and day 365 (24 on reparixin vs. 15 on placebo, P = 0.71). There was no statistically significant difference between treatment groups at any time point for any secondary variable. Analysis of patient subsets showed a trend for a higher percentage of subjects retaining insulin independence for 1 year after a single islet infusion in patients receiving reparixin as compared with patients receiving placebo (26.7% vs. 0%, P = 0.09) when antithymocyte globulin was used as induction immunosuppression. CONCLUSIONS: In this first double-blind randomized trial, islet transplantation data obtained with reparixin do not support a role of CXCR1/2 inhibition in preventing islet inflammation-mediated damage.

Published
2020
Full Text
View/download PDF

31. Characterization of pre-transplant psychosocial burden in an integrated national islet transplant program

Author

Liew, Aaron Y. L., Holmes-Truscott, Elizabeth, Flatt, Anneliese J. S., Bennett, Denise, Crookston, Robert, Pimkova, Mirka, Birtles, Linda, Casey, John, Pernet, Andrew, Wood, Ruth C., Choudhary, Pratik, Forbes, Shareen, Rutter, Martin K., Rosenthal, Miranda, Johnson, Paul, Shaw, James A. M., Speight, Jane, Liew, Aaron Y. L., Holmes-Truscott, Elizabeth, Flatt, Anneliese J. S., Bennett, Denise, Crookston, Robert, Pimkova, Mirka, Birtles, Linda, Casey, John, Pernet, Andrew, Wood, Ruth C., Choudhary, Pratik, Forbes, Shareen, Rutter, Martin K., Rosenthal, Miranda, Johnson, Paul, Shaw, James A. M., and Speight, Jane

Published
2020

32. European Collaborative and Interprofessional Capability Framework for Prevention and Management of Frailty-a consensus process supported by the Joint Action for Frailty Prevention (ADVANTAGE) and the European Geriatric Medicine Society (EuGMS).

Author

UCL - SSS/IRSS - Institut de recherche santé et société, Roller-Wirnsberger, Regina, Lindner, Sonja, Liew, Aaron, O'Caoimh, Ronan, Koula, Maria-Lamprini, Moody, Dawn, Espinosa, Juan Manuel, Van Durme, Thérèse, Dimitrov, Plamen, Benjak, Tomislav, Nicolaidou, Elena, Hammar, Teija, Vanhecke, Eliane, Junius-Walker, Ulrike, Csizmadia, Péter, Galluzzo, Lucia, Macijauskienė, Jūratė, Salem, Mohamed, Rietman, Liset, Ranhoff, Anette Hylen, Targowski, Tomasz, de Arriaga, Miguel Telo, Bozdog, Elena, Gabrovec, Branko, Hendry, Anne, Martin, Finbarr C, Rodriguez-Mañas, Leocadio, UCL - SSS/IRSS - Institut de recherche santé et société, Roller-Wirnsberger, Regina, Lindner, Sonja, Liew, Aaron, O'Caoimh, Ronan, Koula, Maria-Lamprini, Moody, Dawn, Espinosa, Juan Manuel, Van Durme, Thérèse, Dimitrov, Plamen, Benjak, Tomislav, Nicolaidou, Elena, Hammar, Teija, Vanhecke, Eliane, Junius-Walker, Ulrike, Csizmadia, Péter, Galluzzo, Lucia, Macijauskienė, Jūratė, Salem, Mohamed, Rietman, Liset, Ranhoff, Anette Hylen, Targowski, Tomasz, de Arriaga, Miguel Telo, Bozdog, Elena, Gabrovec, Branko, Hendry, Anne, Martin, Finbarr C, and Rodriguez-Mañas, Leocadio

Abstract

BACKGROUND: Interprofessional collaborative practice (ICP) is currently recommended for the delivery of high-quality integrated care for older people. Frailty prevention and management are key elements to be tackled on a multi-professional level. AIM: This study aims to develop a consensus-based European multi-professional capability framework for frailty prevention and management. METHODS: Using a modified Delphi technique, a consensus-based framework of knowledge, skills and attitudes for all professions involved in the care pathway of older people was developed within two consultation rounds. The template for the process was derived from competency frameworks collected in a comprehensive approach from EU-funded projects of the European Commission (EC) supported best practice models for health workforce development. RESULTS: The agreed framework consists of 25 items structured in 4 domains of capabilities. Content covers the understanding about frailty, skills for screening and assessment as well as management procedures for every profession involved. The majority of items focused on interprofessional collaboration, communication and person-centred care planning. DISCUSSION: This framework facilitates clarification of professionals' roles and standardizes procedures for cross-sectional care processes. Despite a lack of evidence for educational interventions, health workforce development remains an important aspect of quality assurance in health care systems. CONCLUSIONS: The multi-professional capability framework for frailty prevention and management incorporated interprofessional collaborative practice, consistent with current recommendations by the World Health Organization, Science Advice for Policy by European Academies and the European Commission.

Published
2020

33. Characterization of pre-transplant psychosocial burden in an integrated national islet transplant program

Author

Liew, Aaron YL, primary, Holmes-Truscott, Elizabeth, additional, Flatt, Anneliese JS, additional, Bennett, Denise, additional, Crookston, Robert, additional, Pimkova, Mirka, additional, Birtles, Linda, additional, Casey, John, additional, Pernet, Andrew, additional, Wood, Ruth C, additional, Choudhary, Pratik, additional, Forbes, Shareen, additional, Rutter, Martin K, additional, Rosenthal, Miranda, additional, Johnson, Paul, additional, Shaw, James AM, additional, and Speight, Jane, additional

Published
2020
Full Text
View/download PDF

39. 269 Early Identification of Frailty: Developing an International Delphi Consensus for a Definition of Pre-frailty

Author

Sezgin, Duygu, primary, O’Donovan, Mark, additional, Wong, Jean Woo, additional, Bandeen-Roche, Karen, additional, Liotta, Giuseppe, additional, Fairhall, Nicola, additional, Laso, Angel Rodríguez, additional, Apóstolo, João, additional, Clarnette, Roger, additional, Holland, Carol, additional, Roller-Wirnsberger, Regina, additional, Illario, Maddalena, additional, Mañas, Leocadio Rodríguez, additional, Vollenbroek-Hutten, Miriam, additional, Yavuz, Burcu Balam, additional, Balci, Cafer, additional, Pernas, Francisco Orfila, additional, Paul, Costança, additional, Ahern, Emer, additional, Romero-Ortuno, Roman, additional, Molloy, William, additional, Cooney, Maria Therese, additional, O’Shea, Diarmuid, additional, Cooke, John, additional, Lang, Deirdre, additional, Hendry, Anne, additional, Rockwood, Kenneth, additional, Clegg, Andrew, additional, Liew, Aaron, additional, and O’Caoimh, Rónán, additional

Published
2019
Full Text
View/download PDF

41. Early identification of frailty:developing an international Delphi consensus for a definition of pre-frailty

Author

Sezgin, Duygu, O'Donovan, Mark, Wong, Jean Woo, Bandeen-Roche, Karen, Liotta, Giuseppe, Fairhall, Nicola, Rodriguez Laso, Angel, Apostolo, Joao, Clarnette, Roger, Holland, Carol, Roller-Wirnsberger, Regina, Illario, Maddalena, Rodriguez Manas, Leocadio, Vollenbroek-Hutten, Miriam, Yavuz, Burcu Balam, Balci, Cafer, Orfila Pernas, Francisco, Paul, Costanca, Ahern, Emer, Romero-Ortuno, Roman, Molloy, William, Cooney, Maria Therese, O'Shea, Diarmuid, Cooke, John, Lang, Deirdre, Hendry, Anne, Rockwood, Kenneth, Clegg, Andrew, Liew, Aaron, O'Caoimh, Ronan, Sezgin, Duygu, O'Donovan, Mark, Wong, Jean Woo, Bandeen-Roche, Karen, Liotta, Giuseppe, Fairhall, Nicola, Rodriguez Laso, Angel, Apostolo, Joao, Clarnette, Roger, Holland, Carol, Roller-Wirnsberger, Regina, Illario, Maddalena, Rodriguez Manas, Leocadio, Vollenbroek-Hutten, Miriam, Yavuz, Burcu Balam, Balci, Cafer, Orfila Pernas, Francisco, Paul, Costanca, Ahern, Emer, Romero-Ortuno, Roman, Molloy, William, Cooney, Maria Therese, O'Shea, Diarmuid, Cooke, John, Lang, Deirdre, Hendry, Anne, Rockwood, Kenneth, Clegg, Andrew, Liew, Aaron, and O'Caoimh, Ronan

Published
2019

42. Early identification of frailty : developing an international Delphi consensus for a definition of pre-frailty

Author

Sezgin, Duygu, O'Donovan, Mark, Wong, Jean Woo, Bandeen-Roche, Karen, Liotta, Giuseppe, Fairhall, Nicola, Rodriguez Laso, Angel, Apostolo, Joao, Clarnette, Roger, Holland, Carol, Roller-Wirnsberger, Regina, Illario, Maddalena, Rodriguez Manas, Leocadio, Vollenbroek-Hutten, Miriam, Yavuz, Burcu Balam, Balci, Cafer, Orfila Pernas, Francisco, Paul, Costanca, Ahern, Emer, Romero-Ortuno, Roman, Molloy, William, Cooney, Maria Therese, O'Shea, Diarmuid, Cooke, John, Lang, Deirdre, Hendry, Anne, Rockwood, Kenneth, Clegg, Andrew, Liew, Aaron, O'Caoimh, Ronan, Sezgin, Duygu, O'Donovan, Mark, Wong, Jean Woo, Bandeen-Roche, Karen, Liotta, Giuseppe, Fairhall, Nicola, Rodriguez Laso, Angel, Apostolo, Joao, Clarnette, Roger, Holland, Carol, Roller-Wirnsberger, Regina, Illario, Maddalena, Rodriguez Manas, Leocadio, Vollenbroek-Hutten, Miriam, Yavuz, Burcu Balam, Balci, Cafer, Orfila Pernas, Francisco, Paul, Costanca, Ahern, Emer, Romero-Ortuno, Roman, Molloy, William, Cooney, Maria Therese, O'Shea, Diarmuid, Cooke, John, Lang, Deirdre, Hendry, Anne, Rockwood, Kenneth, Clegg, Andrew, Liew, Aaron, and O'Caoimh, Ronan

Published
2019

43. Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies.

Author

O'Caoimh, Rónán, Sezgin, Duygu, O'Donovan, Mark R, Molloy, D William, Clegg, Andrew, Rockwood, Kenneth, and Liew, Aaron

Subjects
CINAHL database, CONFIDENCE intervals, FRAIL elderly, INFORMATION storage & retrieval systems, MEDICAL databases, MEDICAL information storage & retrieval systems, MEDLINE, META-analysis, ONLINE information services, POPULATION geography, SEX distribution, SYSTEMATIC reviews, OLD age
Abstract

Introduction The prevalence of frailty at population level is unclear. We examined this in population-based studies, investigating sources of heterogeneity. Methods PubMed, Embase, CINAHL and Cochrane Library databases were searched for observational population-level studies published between 1 January 1998 and 1 April 2020, including individuals aged ≥50 years, identified using any frailty measure. Prevalence estimates were extracted independently, assessed for bias and analysed using a random-effects model. Results In total, 240 studies reporting 265 prevalence proportions from 62 countries and territories, representing 1,755,497 participants, were included. Pooled prevalence in studies using physical frailty measures was 12% (95% CI = 11–13%; n  = 178), compared with 24% (95% CI = 22–26%; n  = 71) for the deficit accumulation model (those using a frailty index, FI). For pre-frailty, this was 46% (95% CI = 45–48%; n  = 147) and 49% (95% CI = 46–52%; n  = 29), respectively. For physical frailty, the prevalence was higher among females, 15% (95% CI = 14–17%; n  = 142), than males, 11% (95% CI = 10–12%; n  = 144). For studies using a FI, the prevalence was also higher in females, 29% (95% CI = 24–35%; n  = 34) versus 20% (95% CI = 16–24%; n  = 34), for males. These values were similar for pre-frailty. Prevalence increased according to the minimum age at study inclusion. Analysing only data from nationally representative studies gave a frailty prevalence of 7% (95% CI = 5–9%; n  = 46) for physical frailty and 24% (95% CI = 22–26%; n  = 44) for FIs. Conclusions Population-level frailty prevalence varied by classification and sex. Data were heterogenous and limited, particularly from nationally representative studies making the interpretation of differences by geographic region challenging. Common methodological approaches to gathering data are required to improve the accuracy of population-level prevalence estimates. Protocol registration PROSPERO-CRD42018105431. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

45. 300Frailty at Population Level in Europe: A Systematic Review and Meta-analysis

Author

Donovan, Mark O, primary, Sezgin, Duygu, additional, Galluzzo, Lucia, additional, Laso, Ángel Rodriguez, additional, Van der Heyden, Johan, additional, Ranhoff, Anette Hylen, additional, Koula, Maria, additional, Strandzheva, Mirela, additional, Ciutan, Marius, additional, Carriazo, Ana María, additional, Samaniego, Luz Lopez, additional, Carcaillon-Bentata, Laure, additional, Kennelly, Siobhán, additional, Liew, Aaron, additional, and O’Caoimh, Rónán, additional

Published
2018
Full Text
View/download PDF

49. Defining the characteristics of intermediate care models including transitional care: an international Delphi study

Author

Sezgin, Duygu, O’Caoimh, Rónán, O’Donovan, Mark R., Salem, Mohamed A., Kennelly, Siobhán, Samaniego, Luz Lopez, Carda, Cristina Arnal, Rodriguez-Acuña, Rafael, Inzitari, Marco, Hammar, Teija, Holditch, Claire, Bettger, Janet Prvu, Vernon, Martin, Carroll, Áine, Gradinger, Felix, Perman, Gaston, Wilson, Martin, Vella, Antoine, Cherubini, Antonio, Tucker, Helen, Fantini, Maria Pia, Onder, Graziano, Roller-Wirnsberger, Regina, Gutiérrez-Robledo, Luis Miguel, Cesari, Matteo, Bertoluci, Paula, Kieliszek, Magdalena, van der Vlegel-Brouwer, Wilma, Nelson, Michelle, Mañas, Leocadio Rodríguez, Antoniadou, Eleftheria, Barriere, François, Lindblom, Sebastian, Park, Grace, Pérez, Isidoro, Alguacil, Dolores, Lowdon, Douglas, Alkiza, Maria Eugenia, Bouzon, Cristina Alonso, Young, John, Carriazo, Ana, Liew, Aaron, and Hendry, Anne

Abstract

Background: Although there is growing utilisation of intermediate care to improve the health and well-being of older adults with complex care needs, there is no international agreement on how it is defined, limiting comparability between studies and reducing the ability to scale effective interventions. Aim: To identify and define the characteristics of intermediate care models. Methods: A scoping review, a modified two-round electronic Delphi study involving 27 multi-professional experts from 13 countries, and a virtual consensus meeting were conducted. Results: Sixty-six records were included in the scoping review, which identified four main themes: transitions, components, benefits and interchangeability. These formed the basis of the first round of the Delphi survey. After Round 2, 16 statements were agreed, refined and collapsed further. Consensus was established for 10 statements addressing the definitions, purpose, target populations, approach to care and organisation of intermediate care models. Discussion: There was agreement that intermediate care represents time-limited services which ensure continuity and quality of care, promote recovery, restore independence and confidence at the interface between home and acute services, with transitional care representing a subset of intermediate care. Models are best delivered by an interdisciplinary team within an integrated health and social care system where a single contact point optimises service access, communication and coordination. Conclusions: This study identified key defining features of intermediate care to improve understanding and to support comparisons between models and studies evaluating them. More research is required to develop operational definitions for use in different healthcare systems.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results