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29 results on '"Liu, Guojian"'

3. Research on time-varying evolution law of overburden stress field and fracture field in shallow coal seam mining

Author

DU Minghao, NING Jianguo, WANG Jun, SHI Xinshuai, LIU Guojian, and YANG Fuqian

Subjects
surrounding rock of stope, crack field-stress field, mohr-coulomb criterion, rock fracture, principal stress difference, Mining engineering. Metallurgy, TN1-997
Abstract

The mining stress formed in the surrounding rock after coal seam mining is the root cause of the damage and fracture of the stope surrounding rock. In order to study the evolution characteristics of mining stress and the fracture process of overlying strata on the mining face, a numerical model was established to simulate the evolution law of stress field and fracture field in the mining process of the working face by taking the 40101 mining face of Gaoliang Coal Mine as an example. The results show that the relationship between rock collapse and failure can be judged by using Mohr-Coulomb criterion to analyze the variation law of the difference between maximum and minimum principal stresses. The correctness of the time-varying evolution of fracture field and stress field in working face mining can be verified by comparing the numerical simulation results with the field measured results.

Published
2023
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10. Modeling and Analysis of 12-Pulse Inverter in Shipboard or Aircraft

Author

Che Yanbo, Liu Guojian, Xu Jianmei, and Zhao Yuancheng

Subjects
Naval architecture. Shipbuilding. Marine engineering, VM1-989
Abstract

With the development of DC distribution system within the isolated power system of a ship or an aircraft, more constant frequency loads will be supplied by inverters connected to DC main bus. In the operating mode conversion process of an isolated power system, inverters will inevitably suffer from serious disturbance and affect the stability of the system. Therefore, it is important to establish a model of the inverter that reflects its dynamic characteristics and based on which to conduct the stability analysis. This paper proposes a 12-pulse inverter model based on the generalized state space averaging (GSSA) method. This model can overcome the limitations of 12-pulse inverter state space averaging (SSA) model in transient analysis with good accuracy and fast analysis ability effectively. Three kinds of models for a 12-pulse aircraft inverter are built in MATLAB, namely GSSA model, SSA model and detail device model. The simulation results show the high accuracy of GSSA model in stability analysis. This study provides an effective analytical tool for stability analysis of 12-pulse inverter and also provides a reference for inverter modeling research of isolated power system such as in aircraft or ship.

Published
2017
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23. A bispecific antibody targeting HER2 and PD-L1 inhibits tumor growth with superior efficacy

Author

Xinyuan Liu, Yue Cui, Mei-Qing Feng, Lei Tang, Yi-Li Chen, Liu Guojian, Xingchen Dong, Chunhe Wang, and Yifeng Hung

Subjects
Receptor, ErbB-2, Programmed Cell Death 1 Receptor, Biochemistry, Antibodies, Monoclonal, Murine-Derived, Mice, ADCC, antibody-dependent cell-mediated cytotoxicity, DC, dendritic cell, Antineoplastic Agents, Immunological, human epidermal growth factor receptor 2 (HER2), Antibodies, Bispecific, BLI, biolayer interferometry, HER2, human epidermal growth factor receptor 2, skin and connective tissue diseases, Cytotoxicity, SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, Antibody-dependent cell-mediated cytotoxicity, GEJC, gastroesophageal junction cancer, biology, Chemistry, PD-1/PD-L1, programmed cell death protein 1 and programmed cell death ligand 1, BTC, biliary tract cancer, CRC, colorectal cancer, GC, gastric cancer, VH, variable heavy, Signal transduction, mAbs, monoclonal antibodies, Research Article, PBMC, peripheral blood mononuclear cell, BC, breast cancer, medicine.drug_class, antibody-dependent cell-mediated cytotoxicity, NSCLC, non-small-cell lung cancer, DSF, differential scanning fluorimetry, Monoclonal antibody, Peripheral blood mononuclear cell, MLR, mixed lymphocyte reaction, breast cancer, In vivo, Cell Line, Tumor, PD-L1, medicine, Animals, Humans, CDC, complement-dependent cytotoxicity, Molecular Biology, Antibody-Dependent Cell Cytotoxicity, VL, variable light, Neoplasms, Experimental, Cell Biology, Xenograft Model Antitumor Assays, MOA, mechanisms of action, In vitro, BsAbs, bispecific antibodies, programmed death ligand 1, Cancer research, biology.protein, SEC, size exclusion chromatography
Abstract

Activation of the programmed cell death protein 1 and programmed cell death ligand 1 (PD-1/PD-L1) signaling axis plays important roles in intrinsic or acquired resistance to human epidermal growth factor receptor 2 (HER2)-directed therapies in the clinic. Therefore, therapies simultaneously targeting both HER2 and PD-1/PD-L1 signaling pathways are of great significance. Here, aiming to direct the anti-PD-L1 responses towards HER2-expressing tumor cells, we constructed a humanized bispecific IgG1 subclass antibody targeting both HER2 and PD-L1 (HER2/PD-L1; BsAb), which displayed satisfactory purity, thermostability, and serum stability. We found that BsAb showed enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity in vitro. In the late phase of peripheral blood mononuclear cell (PBMC)-humanized HER2+ tumor xenograft models, BsAb showed superior therapeutic efficacies as compared to monoclonal antibodies (mAbs) or combination treatment strategies. In cynomolgus monkeys, BsAb showed favorable pharmacokinetics and toxicity profiles when administered at a 10 mg/kg dosage. Thus, HER2/PD-L1 BsAb was demonstrated as a potentially effective option for managing HER2+ and trastuzumab-resistant tumors in the clinic. We propose that the enhanced anti-tumor activities of BsAb in vivo may be due to direct inhibition of HER2 signaling or activation of T cells.

Published
2021

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