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4. Free Triiodothyronine Connected With Metabolic Changes in Patients With Coronary Artery Disease by Interacting With Other Functional Indicators

Author

Tian, Xiao-xue, primary, Zheng, Shu-fen, additional, Liu, Ju-e, additional, Wu, Yuan-yuan, additional, Lin, Lu, additional, Chen, Hong-mei, additional, Li, Li-wen, additional, Qin, Min, additional, Wang, Zi-xian, additional, Zhu, Qian, additional, Lai, Wei-hua, additional, and Zhong, Shilong, additional

Published
2021
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5. UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease

Author

Lei, He-Ping, primary, Qin, Min, additional, Cai, Li-Yun, additional, Wu, Hong, additional, Tang, Lan, additional, Liu, Ju-E, additional, Deng, Chun-Yu, additional, Liu, Yi-Bin, additional, Zhu, Qian, additional, Li, Han-Ping, additional, Hu, Wei, additional, Yang, Min, additional, Zhu, Yi-Zhun, additional, and Zhong, Shi-Long, additional

Published
2021
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6. Plasma miR-142 accounting for the missing heritability of CYP3A4/5 functionality is associated with pharmacokinetics of clopidogrel

Author

Tang, Qian-Jie, primary, Lin, Hao-Ming, additional, He, Guo-Dong, additional, Liu, Ju-E, additional, Wu, Hong, additional, Li, Xin-Xin, additional, Zhong, Wan-Ping, additional, Tang, Lan, additional, Meng, Jin-Xiu, additional, Zhang, Meng-Zhen, additional, Li, Han-Ping, additional, Chen, Ji-Yan, additional, Zhong, Shi-Long, additional, and Wang, Lai-You, additional

Published
2016
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7. The independent contribution of miRNAs to the missing heritability in CYP3A4/5 functionality and the metabolism of atorvastatin

Author

Liu, Ju-E, primary, Ren, Bin, additional, Tang, Lan, additional, Tang, Qian-Jie, additional, Liu, Xiao-Ying, additional, Li, Xin, additional, Bai, Xue, additional, Zhong, Wan-Ping, additional, Meng, Jin-Xiu, additional, Lin, Hao-Ming, additional, Wu, Hong, additional, Chen, Ji-Yan, additional, and Zhong, Shi-Long, additional

Published
2016
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8. Plasma miR-142 accounting for the missing heritability of CYP3A4/5functionality is associated with pharmacokinetics of clopidogrel

Author

Tang, Qian-Jie, Lin, Hao-Ming, He, Guo-Dong, Liu, Ju-E, Wu, Hong, Li, Xin-Xin, Zhong, Wan-Ping, Tang, Lan, Meng, Jin-Xiu, Zhang, Meng-Zhen, Li, Han-Ping, Chen, Ji-Yan, Zhong, Shi-Long, and Wang, Lai-You

Abstract

Aim:To investigate whether plasma miRNAs targeting CYP3A4/5have an impact on the variance of pharmacokinetics of clopidogrel. Materials & methods:The contribution of 13 miRNAs to the CYP3A4/5gene expression and activity was investigated in 55 liver tissues. The association between plasma miRNAs targeting CYP3A4/5mRNA and clopidogrel pharmacokinetics was analyzed in 31 patients with coronary heart disease who received 300 mg loading dose of clopidogrel. Results:Among 13 miRNAs, miR-142 was accounting for 12.2 (p 0.002) CYP3A4mRNA variance and 9.4 (p 0.005) CYP3A5mRNA variance, respectively. Plasma miR-142 was negatively associated with H4 Cmax(r -0.5269; p 0.0040) and associated with H4 AUC0–4h(r -0.4986; p 0.0069) after 300 mg loading dose of clopidogrel in coronary heart disease patients. Conclusion:miR-142 could account for a part of missing heritability of CYP3A4/5functionality related to clopidogrel activation.

Published
2016
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