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Your search keyword '"Loes P C, Hoebers"' showing total 3 results
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3 results on '"Loes P C, Hoebers"'

1. Long‐Term Survival and Angina After Chronic Total Occlusion Percutaneous Coronary Intervention Compared With Medical Therapy: A Meta‐Analysis

Author

Casper F. Coerkamp, Anna van Veelen, Kambis A. Mashayekhi, Sinisa M. Stojkovic, Stefan A. Juricic, Bimmer E. P. M. Claessen, René J. van der Schaaf, Loes P. C. Hoebers, Joelle Elias, and José P. S. Henriques

Subjects
chronic total occlusion, medical therapy, meta‐analysis, percutaneous coronary intervention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2024
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2. No evidence for cardiac dysfunction in Kif6 mutant mice.

Author

Abdul Hameed, Ellen Bennett, Barbara Ciani, Loes P C Hoebers, Roy Milner, Allan Lawrie, Sheila E Francis, and Andrew J Grierson

Subjects
Medicine, Science
Abstract

A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction. No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on cardiac function in mice. Kif6 mutant mice were generated and verified. Cardiac function was assessed by serial echocardiography at baseline, after ageing and after exercise. Lipid levels were also measured. No discernable adverse lipid or cardiac phenotype was detected in Kif6 mutant mice. These data suggest that dysfunction of Kif6 is linked to other more complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function.

Published
2013
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3. No evidence for cardiac dysfunction in Kif6 mutant mice

Author

Allan Lawrie, Sheila E. Francis, Loes P. C. Hoebers, Barbara Ciani, Roy Milner, Abdul G. Hameed, Andrew J. Grierson, and Ellen J. Bennett

Subjects
Cardiac function curve, medicine.medical_specialty, Pathology, Anatomy and Physiology, Mouse, Mutant, Myocardial Infarction, Kinesins, lcsh:Medicine, Biology, medicine.disease_cause, Cardiovascular, Cardiovascular System, Molecular Genetics, Mice, Model Organisms, Internal medicine, medicine, Genetics, Animals, Humans, Myocardial infarction, lcsh:Science, Heart Failure, Clinical Genetics, Mutation, Multidisciplinary, lcsh:R, Heart, Animal Models, medicine.disease, Phenotype, Lipids, Mice, Mutant Strains, Cardiovascular physiology, Endocrinology, Ageing, Echocardiography, Genetics of Disease, KIF6, cardiovascular system, Medicine, lcsh:Q, Research Article
Abstract

A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction.\ud No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on\ud cardiac function in mice. Kif6 mutant mice were generated and verified. Cardiac function was assessed by serial\ud echocardiography at baseline, after ageing and after exercise. Lipid levels were also measured. No discernable adverse lipid\ud or cardiac phenotype was detected in Kif6 mutant mice. These data suggest that dysfunction of Kif6 is linked to other more\ud complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function.

Published
2013

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