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145 results on '"Lone, Nazir I"'

1. Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization

Author

Taquet, Maxime, Skorniewska, Zuzanna, Hampshire, Adam, Chalmers, James D., Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Leavy, Olivia C., Richardson, Matthew, Elneima, Omer, McAuley, Hamish J. C., Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M., Harris, Victoria C., Houchen-Wolloff, Linzy, Greening, Neil J., Mansoori, Parisa, Harrison, Ewen M., Docherty, Annemarie B., Lone, Nazir I., Quint, Jennifer, Sattar, Naveed, Brightling, Christopher E., Wain, Louise V., Evans, Rachael E., Geddes, John R., and Harrison, Paul J.

Published
2023
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4. Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study

Author

Docherty, Annemarie B, Farrell, James, Thorpe, Mathew, Egan, Conor, Dunn, Sarah, Norman, Lisa, Shaw, Catherine A, Law, Andrew, Leeming, Gary, Norris, Lucy, Brooks, Andrew, Prodan, Bianca, MacLeod, Ruairidh, Baxter, Robert, Morris, Carole, Rennie, Diane, Oosthuyzen, Wilna, Semple, Malcolm G, Baillie, J Kenneth, Pius, Riinu, Seth, Sohan, Harrison, Ewen M, and Lone, Nazir I

Published
2023
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5. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

Author

Abel, K., Adamali, H., Adeloye, D., Adeyemi, O., Adrego, R., Aguilar Jimenez, L.A., Ahmad, S., Ahmad Haider, N., Ahmed, R., Ahwireng, N., Ainsworth, M., Al-Sheklly, B., Alamoudi, A., Ali, M., Aljaroof, M., All, A.M., Allan, L., Allen, R.J., Allerton, L., Allsop, L., Almeida, P., Altmann, D., Alvarez Corral, M., Amoils, S., Anderson, D., Antoniades, C., Arbane, G., Arias, A., Armour, C., Armstrong, L., Armstrong, N., Arnold, D., Arnold, H., Ashish, A., Ashworth, A., Ashworth, M., Aslani, S., Assefa-Kebede, H., Atkin, C., Atkin, P., Aul, R., Aung, H., Austin, L., Avram, C., Ayoub, A., Babores, M., Baggott, R., Bagshaw, J., Baguley, D., Bailey, L., Baillie, J.K., Bain, S., Bakali, M., Bakau, M., Baldry, E., Baldwin, D., Baldwin, M., Ballard, C., Banerjee, A., Bang, B., Barker, R.E., Barman, L., Barratt, S., Barrett, F., Basire, D., Basu, N., Bates, M., Bates, A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., Drury, H.J.C., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A.-M., Guillen Guio, B., Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., Henson, H.H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, L., Holmes, K., Holmes, M., Holroyd-Hind, B., Holt, L., Hormis, A., Horsley, A., Hosseini, A., Hotopf, M., Houchen-Wolloff, L., Howard, K., Howard, L.S., Howell, A., Hufton, E., Hughes, A.D., Hughes, J., Hughes, R., Humphries, A., Huneke, N., Hurditch, E., Hurst, J., Husain, M., Hussell, T., Hutchinson, J., Ibrahim, W., Ilyas, F., Ingham, J., Ingram, L., Ionita, D., Isaacs, K., Ismail, K., Jackson, T., Jacob, J., James, W.Y., Jang, W., Jarman, C., Jarrold, I., Jarvis, H., Jastrub, R., Jayaraman, B., Jenkins, R.G., Jezzard, P., Jiwa, K., Johnson, C., Johnson, S., Johnston, D., Jolley, C.J., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, M.G., Jones, S., Jose, S., Kabir, T., Kaltsakas, G., Kamwa, V., Kanellakis, N., Kaprowska, S., Kausar, Z., Keenan, N., Kelly, S., Kemp, G., Kerr, S., Kerslake, H., Key, A.L., Khan, F., Khunti, K., Kilroy, S., King, B., King, C., Kingham, L., Kirk, J., Kitterick, P., Klenerman, P., Knibbs, L., Knight, S., Knighton, A., Kon, O., Kon, S., Kon, S.S., Koprowska, S., Korszun, A., Koychev, I., Kurasz, C., Kurupati, P., Laing, C., Lamlum, H., Landers, G., Langenberg, C., Lasserson, D., Lavelle-Langham, L., Lawrie, A., Lawson, C., Layton, A., Lea, A., Leavy, O.C., Lee, D., Lee, J.-H., Lee, E., Leitch, K., Lenagh, R., Lewis, D., Lewis, J., Lewis, K.E., Lewis, V., Lewis-Burke, N., Li, X., Light, T., Lightstone, L., Lilaonitkul, W., Lim, L., Linford, S., Lingford-Hughes, A., Lipman, M., Liyanage, K., Lloyd, A., Logan, S., Lomas, D., Lone, N.I., Loosley, R., Lord, J.M., Lota, H., Lovegrove, W., Lucey, A., Lukaschuk, E., Lye, A., Lynch, C., MacDonald, S., MacGowan, G., Macharia, I., Mackie, J., Macliver, L., Madathil, S., Madzamba, G., Magee, N., Magtoto, M.M., Mairs, N., Majeed, N., Major, E., Malein, F., Malim, M., Mallison, G., D-C Man, W., Mandal, S., Mangion, K., Manisty, C., Manley, R., March, K., Marciniak, S., Marino, P., Mariveles, M., Marks, M., Marouzet, E., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martineau, A., Martinez, L.M., Maskell, N., Matila, D., Matimba-Mupaya, W., Matthews, L., Mbuyisa, A., McAdoo, S., McAllister-Williams, H., McArdle, A., McArdle, P., McAulay, D., McCann, G.P., McCormick, J., McCormick, W., McCourt, P., McGarvey, L., McGee, C., Mcgee, K., McGinness, J., McGlynn, K., McGovern, A., McGuinness, H., McInnes, I.B., McIntosh, J., McIvor, E., McIvor, K., McLeavey, L., McMahon, A., McMahon, M.J., McMorrow, L., Mcnally, T., McNarry, M., McNeill, J., McQueen, A., McShane, H., Mears, C., Megson, C., Megson, S., Mehta, P., Meiring, J., Melling, L., Mencias, M., Menzies, D., Merida Morillas, M., Michael, A., Miller, C., Milligan, L., Mills, C., Mills, G., Mills, N.L., Milner, L., Misra, S., Mitchell, J., Mohamed, A., Mohamed, N., Mohammed, S., Molyneaux, P.L., Monteiro, W., Moriera, S., Morley, A., Morrison, L., Morriss, R., Morrow, A., Moss, A.J., Moss, P., Motohashi, K., Msimanga, N., Mukaetova-Ladinska, E., Munawar, U., Murira, J., Nanda, U., Nassa, H., Nasseri, M., Neal, A., Needham, R., Neill, P., Neubauer, S., Newby, D.E., Newell, H., Newman, T., Newman, J., Newton-Cox, A., Nicholson, T., Nicoll, D., Nikolaidis, A., Nolan, C.M., Noonan, M.J., Norman, C., Novotny, P., Nunag, J., Nwafor, L., Nwanguma, U., Nyaboko, J., O'Brien, C., O'Donnell, K., O'Regan, D., O’Brien, L., Odell, N., Ogg, G., Olaosebikan, O., Oliver, C., Omar, Z., Openshaw, P.J.M., Orriss-Dib, L., Osborne, L., Osbourne, R., Ostermann, M., Overton, C., Owen, J., Oxton, J., Pack, J., Pacpaco, E., Paddick, S., Painter, S., Pakzad, A., Palmer, S., Papineni, P., Paques, K., Paradowski, K., Pareek, M., Parekh, D., Parfrey, H., Pariante, C., Parker, S., Parkes, M., Parmar, J., Patale, S., Patel, B., Patel, M., Patel, S., Pattenadk, D., Pavlides, M., Payne, S., Pearce, L., Pearl, J.E., Peckham, D., Pendlebury, J., Peng, Y., Pennington, C., Peralta, I., Perkins, E., Peterkin, Z., Peto, T., Petousi, N., Petrie, J., Pfeffer, P., Phipps, J., Pimm, J., Piper Hanley, K., Pius, R., Plant, H., Plein, S., Plekhanova, T., Plowright, M., Poinasamy, K., Polgar, O., Poll, L., Porter, J.C., Porter, J., Portukhay, S., Powell, N., Prabhu, A., Pratt, J., Price, A., Price, C., Price, D., Price, L., Prickett, A., Propescu, J., Prosper, S., Pugmire, S., Quaid, S., Quigley, J., Quint, J., Qureshi, H., Qureshi, I.N., Radhakrishnan, K., Rahman, N.M., Ralser, M., Raman, B., Ramos, A., Ramos, H., Rangeley, J., Rangelov, B., Ratcliffe, L., Ravencroft, P., Reddington, A., Reddy, R., Reddy, A., Redfearn, H., Redwood, D., Reed, A., Rees, M., Rees, T., Regan, K., Reynolds, W., Ribeiro, C., Richards, A., Richardson, E., Richardson, M., Rivera-Ortega, P., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Roche, L., Roddis, C., Rodger, J., Ross, A., Ross, G., Rossdale, J., Rostron, A., Rowe, A., Rowland, A., Rowland, J., Rowland, M.J., Rowland-Jones, S.L., Roy, K., Roy, M., Rudan, I., Russell, R., Russell, E., Saalmink, G., Sabit, R., Sage, E.K., Samakomva, T., Samani, N., Sampson, C., Samuel, K., Samuel, R., Sanderson, A., Sapey, E., Saralaya, D., Sargant, J., Sarginson, C., Sass, T., Sattar, N., Saunders, K., Saunders, R.M., Saunders, P., Saunders, L.C., Savill, H., Saxon, W., Sayer, A., Schronce, J., Schwaeble, W., Scott, J.T., Scott, K., Selby, N., Semple, M.G., Sereno, M., Sewell, T.A., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Sharpe, M., Shashaa, S., Shaw, A., Shaw, K., Shaw, V., Sheikh, A., Shelton, S., Shenton, L., Shevket, K., Shikotra, A., Short, J., Siddique, S., Siddiqui, S., Sidebottom, J., Sigfrid, L., Simons, G., Simpson, J., Simpson, N., Singapuri, A., Singh, C., Singh, S., Singh, S.J., Sissons, D., Skeemer, J., Slack, K., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Soares, M., Solano, T.S., Solly, R., Solstice, A.R., Soulsby, T., Southern, D., Sowter, D., Spears, M., Spencer, L.G., Speranza, F., Stadon, L., Stanel, S., Steele, N., Steiner, M., Stensel, D., Stephens, G., Stephenson, L., Stern, M., Stewart, I., Stimpson, R., Stockdale, S., Stockley, J., Stoker, W., Stone, R., Storrar, W., Storrie, A., Storton, K., Stringer, E., Strong-Sheldrake, S., Stroud, N., Subbe, C., Sudlow, C.L., Suleiman, Z., Summers, C., Summersgill, C., Sutherland, D., Sykes, D.L., Sykes, R., Talbot, N., Tan, A.L., Tarusan, L., Tavoukjian, V., Taylor, A., Taylor, C., Taylor, J., Te, A., Tedd, H., Tee, C.J., Teixeira, J., Tench, H., Terry, S., Thackray-Nocera, S., Thaivalappil, F., Thamu, B., Thickett, D., Thomas, C., Thomas, D.C., Thomas, S., Thomas, A.K., Thomas-Woods, T., Thompson, T., Thompson, A.A.R., Thornton, T., Thorpe, M., Thwaites, R.S., Tilley, J., Tinker, N., Tiongson, G.F., Tobin, M., Tomlinson, J., Tong, C., Toshner, M., Touyz, R., Tripp, K.A., Tunnicliffe, E., Turnbull, A., Turner, E., Turner, S., Turner, V., Turner, K., Turney, S., Turtle, L., Turton, H., Ugoji, J., Ugwuoke, R., Upthegrove, R., Valabhji, J., Ventura, M., Vere, J., Vickers, C., Vinson, B., Wade, E., Wade, P., Wain, L.V., Wainwright, T., Wajero, L.O., Walder, S., Walker, S., Wall, E., Wallis, T., Walmsley, S., Walsh, J.A., Walsh, S., Warburton, L., Ward, T.J.C., Warwick, K., Wassall, H., Waterson, S., Watson, E., Watson, L., Watson, J., Weir McCall, J., Welch, C., Welch, H., Welsh, B., Wessely, S., West, S., Weston, H., Wheeler, H., White, S., Whitehead, V., Whitney, J., Whittaker, S., Whittam, B., Whitworth, V., Wight, A., Wild, J., Wilkins, M., Wilkinson, D., Williams, B., Williams, N., Williams, J., Williams-Howard, S.A., Willicombe, M., Willis, G., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Window, N., Witham, M., Wolf-Roberts, R., Wood, C., Woodhead, F., Woods, J., Wootton, D.G., Wormleighton, J., Worsley, J., Wraith, D., Wrey Brown, C., Wright, C., Wright, L., Wright, S., Wyles, J., Wynter, I., Xu, M., Yasmin, N., Yasmin, S., Yates, T., Yip, K.P., Young, B., Young, S., Young, A., Yousuf, A.J., Zawia, A., Zeidan, L., Zhao, B., Zheng, B., Zongo, O., McAuley, Hamish J.C., Evans, Rachael A., Bolton, Charlotte E., Brightling, Christopher E., Chalmers, James D., Docherty, Annemarie B., Elneima, Omer, Greenhaff, Paul L., Gupta, Ayushman, Harris, Victoria C., Harrison, Ewen M., Ho, Ling-Pei, Horsley, Alex, Houchen-Wolloff, Linzy, Jolley, Caroline J., Leavy, Olivia C., Lone, Nazir I., Man, William D-C, Marks, Michael, Parekh, Dhruv, Poinasamy, Krisnah, Quint, Jennifer K., Raman, Betty, Richardson, Matthew, Saunders, Ruth M., Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Singh, Sally J., Steiner, Michael, Tan, Ai Lyn, Wain, Louise V., Welch, Carly, Whitney, Julie, Witham, Miles D., Lord, Janet, and Greening, Neil J.

Published
2023
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7. Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study

Author

Plekhanova, Tatiana, Rowlands, Alex V., Evans, Rachael A., Edwardson, Charlotte L., Bishop, Nicolette C., Bolton, Charlotte E., Chalmers, James D., Davies, Melanie J., Daynes, Enya, Dempsey, Paddy C., Docherty, Annemarie B., Elneima, Omer, Greening, Neil J., Greenwood, Sharlene A., Hall, Andrew P., Harris, Victoria C., Harrison, Ewen M., Henson, Joseph, Ho, Ling-Pei, Horsley, Alex, Houchen-Wolloff, Linzy, Khunti, Kamlesh, Leavy, Olivia C., Lone, Nazir I., Marks, Michael, Maylor, Ben, McAuley, Hamish J. C., Nolan, Claire M., Poinasamy, Krisnah, Quint, Jennifer K., Raman, Betty, Richardson, Matthew, Sargeant, Jack A., Saunders, Ruth M., Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Steiner, Michael, Stensel, David J., Wain, Louise V., Whitney, Julie, Wootton, Dan G., Brightling, Christopher E., Man, William D-C., Singh, Sally J., and Yates, Tom

Published
2022
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9. Long COVID and cardiovascular disease: a prospective cohort study

Author

Lawson, Claire Alexandra, primary, Moss, Alastair James, additional, Arnold, Jayanth Ranjit, additional, Bagot, Catherine, additional, Banerjee, Amitava, additional, Berry, Colin, additional, Greenwood, John, additional, Hughes, Alun D, additional, Khunti, Kamlesh, additional, Mills, Nicholas L, additional, Neubauer, Stefan, additional, Raman, Betty, additional, Sattar, Naveed, additional, Leavy, Olivia C, additional, Richardson, Matthew, additional, Elneima, Omer, additional, McAuley, Hamish JC, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Sereno, Marco, additional, Saunders, Ruth, additional, Harris, Victoria, additional, Houchen-Wolloff, Linzy, additional, Greening, Neil J, additional, Harrison, Ewen, additional, Docherty, Annemarie B, additional, Lone, Nazir I, additional, Quint, Jennifer Kathleen, additional, Chalmers, James, additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Marks, Michael, additional, Poinasamy, Krisnah, additional, Evans, Rachael, additional, Wain, Louise V, additional, Brightling, Chris, additional, and McCann, Gerry P, additional

Published
2024
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10. 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study.

Author

Leavy, Olivia C, Russell, Richard J, Harrison, Ewen M, Lone, Nazir I, Kerr, Steven, Docherty, Annemarie B, Sheikh, Aziz, Richardson, Matthew, Elneima, Omer, Greening, Neil J, Harris, Victoria Claire, Houchen-Wolloff, Linzy, McAuley, Hamish J C, Saunders, Ruth M, Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Aul, Raminder, Beirne, Paul, Bolton, Charlotte E, Brown, Jeremy S, Choudhury, Gourab, Diar Bakerly, Nawar, Easom, Nicholas, Echevarria, Carlos, Fuld, Jonathan, Hart, Nick, Hurst, John R, Jones, Mark, Parekh, Dhruv, Pfeffer, Paul, Rahman, Najib M, Rowland-Jones, Sarah, Shah, Ajay M, Wootton, Dan G, Jolley, Caroline, Thompson, A A Roger, Chalder, Trudie, Davies, Melanie J, De Soyza, Anthony, Geddes, John R, Greenhalf, William, Heller, Simon, Howard, Luke, Jacob, Joseph, Jenkins, R Gisli, Lord, Janet M, Man, Will D-C, McCann, Gerry P, Neubauer, Stefan, Openshaw, Peter J M, Porter, Joanna, Rowland, Matthew J, Scott, Janet T, Semple, Malcolm G, Singh, Sally J, Thomas, David, Toshner, Mark, Lewis, Keir, Heaney, Liam G, Briggs, Andrew, Zheng, Bang, Thorpe, Mathew, Quint, Jennifer K, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Wain, Louise V, Brightling, Christopher E, Evans, Rachael A, Leavy, Olivia C, Russell, Richard J, Harrison, Ewen M, Lone, Nazir I, Kerr, Steven, Docherty, Annemarie B, Sheikh, Aziz, Richardson, Matthew, Elneima, Omer, Greening, Neil J, Harris, Victoria Claire, Houchen-Wolloff, Linzy, McAuley, Hamish J C, Saunders, Ruth M, Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Aul, Raminder, Beirne, Paul, Bolton, Charlotte E, Brown, Jeremy S, Choudhury, Gourab, Diar Bakerly, Nawar, Easom, Nicholas, Echevarria, Carlos, Fuld, Jonathan, Hart, Nick, Hurst, John R, Jones, Mark, Parekh, Dhruv, Pfeffer, Paul, Rahman, Najib M, Rowland-Jones, Sarah, Shah, Ajay M, Wootton, Dan G, Jolley, Caroline, Thompson, A A Roger, Chalder, Trudie, Davies, Melanie J, De Soyza, Anthony, Geddes, John R, Greenhalf, William, Heller, Simon, Howard, Luke, Jacob, Joseph, Jenkins, R Gisli, Lord, Janet M, Man, Will D-C, McCann, Gerry P, Neubauer, Stefan, Openshaw, Peter J M, Porter, Joanna, Rowland, Matthew J, Scott, Janet T, Semple, Malcolm G, Singh, Sally J, Thomas, David, Toshner, Mark, Lewis, Keir, Heaney, Liam G, Briggs, Andrew, Zheng, Bang, Thorpe, Mathew, Quint, Jennifer K, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Wain, Louise V, Brightling, Christopher E, and Evans, Rachael A

Abstract

In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute COVID-19 would be associated with improved health-related quality of life (HRQoL) 1 year after discharge. Adults admitted to hospital between February 2020 and March 2021 for COVID-19 and meeting current guideline recommendations for dexamethasone treatment were included using two prospective UK cohort studies (Post-hospitalisation COVID-19 and the International Severe Acute Respiratory and emerging Infection Consortium). HRQoL, assessed by the EuroQol-Five Dimensions-Five Levels utility index (EQ-5D-5L UI), pre-hospital and 1 year after discharge were compared between those receiving corticosteroids or not after propensity weighting for treatment. Secondary outcomes included patient-reported recovery, physical and mental health status, and measures of organ impairment. Sensitivity analyses were undertaken to account for survival and selection bias. Of the 1888 participants included in the primary analysis, 1149 received corticosteroids. There was no between-group difference in EQ-5D-5L UI at 1 year (mean difference 0.004, 95% CI -0.026-0.034). A similar reduction in EQ-5D-5L UI was seen at 1 year between corticosteroid exposed and nonexposed groups (mean±sd change -0.12±0.22 -0.11±0.22). Overall, there were no differences in secondary outcome measures. After sensitivity analyses modelled using a cohort of 109 318 patients admitted to hospital with COVID-19, EQ-5D-5L UI at 1 year remained similar between the two groups. Systemic corticosteroids for acute COVID-19 have no impact on the large reduction in HRQoL 1 year after hospital discharge. Treatments to address the persistent reduction in HRQoL are urgently needed.

Published
2024

11. Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airways diseases in the UK: a multicentre, longitudinal cohort study (PHOSP-COVID)

Author

Elneima, Omer, primary, Hurst, John R, additional, Echevarria, Carlos, additional, Quint, Jennifer K, additional, Walker, Samantha, additional, Siddiqui, Salman, additional, Novotny, Petr, additional, Pfeffer, Paul E, additional, Brown, Jeremy S, additional, Shankar-Hari, Manu, additional, McAuley, Hamish JC, additional, Leavy, Olivia C, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Sereno, Marco, additional, Richardson, Matthew, additional, Saunders, Ruth M, additional, Harris, Victoria C, additional, Houchen-Wolloff, Linzy, additional, Greening, Neil J, additional, Harrison, Ewen M, additional, Docherty, Annemarie B, additional, Lone, Nazir I, additional, Chalmers, James D, additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Marks, Michael, additional, Poinasamy, Krisnah, additional, Raman, Betty, additional, Evans, Rachael A, additional, Wain, Louise V, additional, Sheikh, Aziz, additional, Brightling, Chris E, additional, De Soyza, Anthony, additional, and Heaney, Liam G, additional

Published
2024
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14. 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study.

Author

Leavy, Olivia C., Russell, Richard J., Harrison, Ewen M., Lone, Nazir I., Kerr, Steven, Docherty, Annemarie B., Sheikh, Aziz, Richardson, Matthew, Elneima, Omer, Greening, Neil J., Harris, Victoria Claire, Houchen-Wolloff, Linzy, McAuley, Hamish J. C., Saunders, Ruth M., Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Aul, Raminder, Beirne, Paul, and Bolton, Charlotte E.

Published
2024
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15. EPidemiology Of Cardiogenic sHock in Scotland (EPOCHS): A multicentre, prospective observational study of the prevalence, management and outcomes of cardiogenic shock in Scotland

Author

Warren, Alex, primary, McCall, Philip, additional, Proudfoot, Alastair, additional, Gillon, Stuart, additional, Abu-Arafeh, Ahmad, additional, McKnight, Angus John, additional, Mudie, Rosemary, additional, Armstrong, David, additional, Tzolos, Evangelos, additional, Livesey, John Andrew, additional, Sinclair, Andrew, additional, Baston, Veronica, additional, Dalzell, Jonathan, additional, Owen, Deborah, additional, Fleming, Lucy, additional, Scott, Ian, additional, Puxty, Alex, additional, Lee, Matthew MY, additional, Walker, Fiona, additional, Hobson, Simon, additional, Campbell, Euan, additional, Kinsella, Michael, additional, McGinnigle, Eilidh, additional, Docking, Robert, additional, Price, Grant, additional, Ramsay, Alex, additional, Bauld, Richard, additional, Herron, Suzanne, additional, Lone, Nazir I, additional, Mills, Nicholas L, additional, and Hartley, Louise, additional

Published
2023
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16. Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury

Author

Taquet, Maxime, primary, Skorniewska, Zuzanna, additional, Zetterberg, Henrik, additional, Geddes, John R, additional, Mummery, Catherine J, additional, Chalmers, James D, additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Marks, Michael, additional, Poinasamy, Krisnah, additional, Raman, Betty, additional, Leavy, Olivia C, additional, Richardson, Matthew, additional, Elneima, Omer, additional, McAuley, Hamish J C, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Sereno, Marco, additional, Saunders, Ruth M, additional, Harris, Victoria Claire, additional, Houchen-Wolloff, Linzy, additional, Mansoori, Parisa, additional, Greening, Neil J, additional, Harrison, Ewen M, additional, Docherty, Annemarie B, additional, Lone, Nazir I, additional, Quint, Jennifer, additional, Greenhalf, William, additional, Wain, Louise V, additional, Brightling, Christopher E, additional, Evans, Rachael E, additional, Harrison, Paul J, additional, and Koychev, Ivan, additional

Published
2023
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17. Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK

Author

Walsh, Timothy Simon, primary, Aitken, Leanne M, additional, McKenzie, Cathrine A, additional, Boyd, Julia, additional, Macdonald, Alix, additional, Giddings, Annabel, additional, Hope, David, additional, Norrie, John, additional, Weir, Christopher, additional, Parker, Richard Anthony, additional, Lone, Nazir I, additional, Emerson, Lydia, additional, Kydonaki, Kalliopi, additional, Creagh-Brown, Benedict, additional, Morris, Stephen, additional, McAuley, Daniel Francis, additional, Dark, Paul, additional, Wise, Matt P, additional, Gordon, Anthony C, additional, Perkins, Gavin, additional, Reade, Michael, additional, Blackwood, Bronagh, additional, MacLullich, Alasdair, additional, Glen, Robert, additional, and Page, Valerie J, additional

Published
2023
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19. EPidemiology Of Cardiogenic sHock in Scotland (EPOCHS): A multicentre, prospective observational study of the prevalence, management and outcomes of cardiogenic shock in Scotland

Author

Warren, Alex, McCall, Philip, Proudfoot, Alastair, Gillon, Stuart, Abu-Arafeh, Ahmad, McKnight, Angus John, Mudie, Rosemary, Armstrong, David, Tzolos, Evangelos, Livesey, John Andrew, Sinclair, Andrew, Baston, Veronica, Dalzell, Jonathan, Owen, Deborah, Fleming, Lucy, Scott, Ian, Puxty, Alex, Lee, Matthew MY, Walker, Fiona, Hobson, Simon, Campbell, Euan, Kinsella, Michael, McGinnigle, Eilidh, Docking, Robert, Price, Grant, Ramsay, Alex, Bauld, Richard, Herron, Suzanne, Lone, Nazir I, Mills, Nicholas L, and Hartley, Louise

Abstract

Background: Despite high rates of cardiovascular disease in Scotland, the prevalence and outcomes of patients with cardiogenic shock are unknown.Methods: We undertook a prospective observational cohort study of consecutive patients with cardiogenic shock admitted to the intensive care unit (ICU) or coronary care unit at 13 hospitals in Scotland for a 6-month period. Denominator data from the Scottish Intensive Care Society Audit Group were used to estimate ICU prevalence; data for coronary care units were unavailable. We undertook multivariable logistic regression to identify factors associated with in-hospital mortality.Results: In total, 247 patients with cardiogenic shock were included. After exclusion of coronary care unit admissions, this comprised 3.0% of all ICU admissions during the study period (95% confidence interval [CI] 2.6%–3.5%). Aetiology was acute myocardial infarction (AMI) in 48%. The commonest vasoactive treatment was noradrenaline (56%) followed by adrenaline (46%) and dobutamine (40%). Mechanical circulatory support was used in 30%. Overall in-hospital mortality was 55%. After multivariable logistic regression, age (odds ratio [OR] 1.04, 95% CI 1.02–1.06), admission lactate (OR 1.10, 95% CI 1.05–1.19), Society for Cardiovascular Angiographic Intervention stage D or E at presentation (OR 2.16, 95% CI 1.10–4.29) and use of adrenaline (OR 2.73, 95% CI 1.40–5.40) were associated with mortality.Conclusions: In Scotland the prevalence of cardiogenic shock was 3% of all ICU admissions; more than half died prior to discharge. There was significant variation in treatment approaches, particularly with respect to vasoactive support strategy.

Published
2024
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20. biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial

Author

Dark, Paul, primary, Perkins, Gavin D, additional, McMullan, Ronan, additional, McAuley, Danny, additional, Gordon, Anthony C, additional, Clayton, Jonathan, additional, Mistry, Dipesh, additional, Young, Keith, additional, Regan, Scott, additional, McGowan, Nicola, additional, Stevenson, Matt, additional, Gates, Simon, additional, Carlson, Gordon L, additional, Walsh, Tim, additional, Lone, Nazir I, additional, Mouncey, Paul R, additional, Singer, Mervyn, additional, Wilson, Peter, additional, Felton, Tim, additional, Marshall, Kay, additional, Hossain, Anower M., additional, and Lall, Ranjit, additional

Published
2023
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21. Characteristics and risk factors for post-COVID breathlessness after hospitalisation for COVID-19

Author

Daines, Luke, Zheng, Bang, Elneima, Omer, Harrison, Ewen M, Lone, Nazir I, Hurst, John R., Brown, Jeremy S, Sapey, Elizabeth, Chalmers, James D., Quint, Jennifer K, Pfeffer, Paul E., Siddiqui, Salman, Walker, Samantha, Poinasamy, Krisnah, McAuley, Hamish, Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Docherty, Annemarie B, Marks, Michael, Toshner, Mark, Howard, Luke S, Horsley, Alex, Jenkins, Gisli, Porter, Joanna C, Ho, Ling-Pei, Raman, Betty, Wain, Louise V, Brightling, Christopher E, Evans, Rachael A, Heaney, Liam G, De Soyza, Anthony, and Sheikh, Aziz

Abstract

BACKGROUND: Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation.METHODS: PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0-10. We defined post-COVID-19 breathlessness as an increase in score of ≥1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness.RESULTS: We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for post-COVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14-2.44), pre-existing depression/anxiety (adjusted OR 1.58, 95% CI 1.06-2.35), female sex (adjusted OR 1.56, 95% CI 1.21-2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00-1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35-0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14-0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63-0.69) and good calibration (calibration slope 1.00, 95% CI 0.80-1.21).CONCLUSIONS: Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.

Published
2023
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22. sj-docx-1-inc-10.1177_17511437231169193 – Supplemental material for biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial

Author

Dark, Paul, Perkins, Gavin D, McMullan, Ronan, McAuley, Danny, Gordon, Anthony C, Clayton, Jonathan, Mistry, Dipesh, Young, Keith, Regan, Scott, McGowan, Nicola, Stevenson, Matt, Gates, Simon, Carlson, Gordon L, Walsh, Tim, Lone, Nazir I, Mouncey, Paul R, Singer, Mervyn, Wilson, Peter, Felton, Tim, Marshall, Kay, Hossain, Anower M., and Lall, Ranjit

Subjects
111708 Health and Community Services, FOS: Clinical medicine, Cardiology, 110323 Surgery, FOS: Health sciences, 110305 Emergency Medicine
Abstract

Supplemental material, sj-docx-1-inc-10.1177_17511437231169193 for biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial by Paul Dark, Gavin D Perkins, Ronan McMullan, Danny McAuley, Anthony C Gordon, Jonathan Clayton, Dipesh Mistry, Keith Young, Scott Regan, Nicola McGowan, Matt Stevenson, Simon Gates, Gordon L Carlson, Tim Walsh, Nazir I Lone, Paul R Mouncey, Mervyn Singer, Peter Wilson, Tim Felton, Kay Marshall, Anower M. Hossain and Ranjit Lall in Journal of the Intensive Care Society

Published
2023
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23. sj-docx-2-inc-10.1177_17511437231169193 – Supplemental material for biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial

Author

Dark, Paul, Perkins, Gavin D, McMullan, Ronan, McAuley, Danny, Gordon, Anthony C, Clayton, Jonathan, Mistry, Dipesh, Young, Keith, Regan, Scott, McGowan, Nicola, Stevenson, Matt, Gates, Simon, Carlson, Gordon L, Walsh, Tim, Lone, Nazir I, Mouncey, Paul R, Singer, Mervyn, Wilson, Peter, Felton, Tim, Marshall, Kay, Hossain, Anower M., and Lall, Ranjit

Subjects
111708 Health and Community Services, FOS: Clinical medicine, Cardiology, 110323 Surgery, FOS: Health sciences, 110305 Emergency Medicine
Abstract

Supplemental material, sj-docx-2-inc-10.1177_17511437231169193 for biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial by Paul Dark, Gavin D Perkins, Ronan McMullan, Danny McAuley, Anthony C Gordon, Jonathan Clayton, Dipesh Mistry, Keith Young, Scott Regan, Nicola McGowan, Matt Stevenson, Simon Gates, Gordon L Carlson, Tim Walsh, Nazir I Lone, Paul R Mouncey, Mervyn Singer, Peter Wilson, Tim Felton, Kay Marshall, Anower M. Hossain and Ranjit Lall in Journal of the Intensive Care Society

Published
2023
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24. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

Author

McAuley, Hamish J.C., primary, Evans, Rachael A., additional, Bolton, Charlotte E., additional, Brightling, Christopher E., additional, Chalmers, James D., additional, Docherty, Annemarie B., additional, Elneima, Omer, additional, Greenhaff, Paul L., additional, Gupta, Ayushman, additional, Harris, Victoria C., additional, Harrison, Ewen M., additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Houchen-Wolloff, Linzy, additional, Jolley, Caroline J., additional, Leavy, Olivia C., additional, Lone, Nazir I., additional, Man, William D-C, additional, Marks, Michael, additional, Parekh, Dhruv, additional, Poinasamy, Krisnah, additional, Quint, Jennifer K., additional, Raman, Betty, additional, Richardson, Matthew, additional, Saunders, Ruth M., additional, Sereno, Marco, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Singh, Sally J., additional, Steiner, Michael, additional, Tan, Ai Lyn, additional, Wain, Louise V., additional, Welch, Carly, additional, Whitney, Julie, additional, Witham, Miles D., additional, Lord, Janet, additional, Greening, Neil J., additional, Abel, K., additional, Adamali, H., additional, Adeloye, D., additional, Adeyemi, O., additional, Adrego, R., additional, Aguilar Jimenez, L.A., additional, Ahmad, S., additional, Ahmad Haider, N., additional, Ahmed, R., additional, Ahwireng, N., additional, Ainsworth, M., additional, Al-Sheklly, B., additional, Alamoudi, A., additional, Ali, M., additional, Aljaroof, M., additional, All, A.M., additional, Allan, L., additional, Allen, R.J., additional, Allerton, L., additional, Allsop, L., additional, Almeida, P., additional, Altmann, D., additional, Alvarez Corral, M., additional, Amoils, S., additional, Anderson, D., additional, Antoniades, C., additional, Arbane, G., additional, Arias, A., additional, Armour, C., additional, Armstrong, L., additional, Armstrong, N., additional, Arnold, D., additional, Arnold, H., additional, Ashish, A., additional, Ashworth, A., additional, Ashworth, M., additional, Aslani, S., additional, Assefa-Kebede, H., additional, Atkin, C., additional, Atkin, P., additional, Aul, R., additional, Aung, H., additional, Austin, L., additional, Avram, C., additional, Ayoub, A., additional, Babores, M., additional, Baggott, R., additional, Bagshaw, J., additional, Baguley, D., additional, Bailey, L., additional, Baillie, J.K., additional, Bain, S., additional, Bakali, M., additional, Bakau, M., additional, Baldry, E., additional, Baldwin, D., additional, Baldwin, M., additional, Ballard, C., additional, Banerjee, A., additional, Bang, B., additional, Barker, R.E., additional, Barman, L., additional, Barratt, S., additional, Barrett, F., additional, Basire, D., additional, Basu, N., additional, Bates, M., additional, Bates, A., additional, Batterham, R., additional, Baxendale, H., additional, Bayes, H., additional, Beadsworth, M., additional, Beckett, P., additional, Beggs, M., additional, Begum, M., additional, Beirne, P., additional, Bell, D., additional, Bell, R., additional, Bennett, K., additional, Beranova, E., additional, Bermperi, A., additional, Berridge, A., additional, Berry, C., additional, Betts, S., additional, Bevan, E., additional, Bhui, K., additional, Bingham, M., additional, Birchall, K., additional, Bishop, L., additional, Bisnauthsing, K., additional, Blaikely, J., additional, Bloss, A., additional, Bolger, A., additional, Bolton, C.E., additional, Bonnington, J., additional, Botkai, A., additional, Bourne, C., additional, Bourne, M., additional, Bramham, K., additional, Brear, L., additional, Breen, G., additional, Breeze, J., additional, Briggs, A., additional, Bright, E., additional, Brightling, C.E., additional, Brill, S., additional, Brindle, K., additional, Broad, L., additional, Broadley, A., additional, Brookes, C., additional, Broome, M., additional, Brown, A., additional, Brown, J., additional, Brown, J.S., additional, Brown, M., additional, Brown, V., additional, Brugha, T., additional, Brunskill, N., additional, Buch, M., additional, Buckley, P., additional, Bularga, A., additional, Bullmore, E., additional, Burden, L., additional, Burdett, T., additional, Burn, D., additional, Burns, G., additional, Burns, A., additional, Busby, J., additional, Butcher, R., additional, Butt, A., additional, Byrne, S., additional, Cairns, P., additional, Calder, P.C., additional, Calvelo, E., additional, Carborn, H., additional, Card, B., additional, Carr, C., additional, Carr, L., additional, Carson, G., additional, Carter, P., additional, Casey, A., additional, Cassar, M., additional, Cavanagh, J., additional, Chablani, M., additional, Chalder, T., additional, Chalmers, J.D., additional, Chambers, R.C., additional, Chan, F., additional, Channon, K.M., additional, Chapman, K., additional, Charalambou, A., additional, Chaudhuri, N., additional, Checkley, A., additional, Chen, J., additional, Cheng, Y., additional, Chetham, L., additional, Childs, C., additional, Chilvers, E.R., additional, Chinoy, H., additional, Chiribiri, A., additional, Chong-James, K., additional, Choudhury, G., additional, Choudhury, N., additional, Chowienczyk, P., additional, Christie, C., additional, Chrystal, M., additional, Clark, D., additional, Clark, C., additional, Clarke, J., additional, Clohisey, S., additional, Coakley, G., additional, Coburn, Z., additional, Coetzee, S., additional, Cole, J., additional, Coleman, C., additional, Conneh, F., additional, Connell, D., additional, Connolly, B., additional, Connor, L., additional, Cook, A., additional, Cooper, B., additional, Cooper, J., additional, Cooper, S., additional, Copeland, D., additional, Cosier, T., additional, Coulding, M., additional, Coupland, C., additional, Cox, E., additional, Craig, T., additional, Crisp, P., additional, Cristiano, D., additional, Crooks, M.G., additional, Cross, A., additional, Cruz, I., additional, Cullinan, P., additional, Cuthbertson, D., additional, Daines, L., additional, Dalton, M., additional, Daly, P., additional, Daniels, A., additional, Dark, P., additional, Dasgin, J., additional, David, A., additional, David, C., additional, Davies, E., additional, Davies, F., additional, Davies, G., additional, Davies, G.A., additional, Davies, K., additional, Davies, M.J., additional, Dawson, J., additional, Daynes, E., additional, De Soyza, A., additional, Deakin, B., additional, Deans, A., additional, Deas, C., additional, Deery, J., additional, Defres, S., additional, Dell, A., additional, Dempsey, K., additional, Denneny, E., additional, Dennis, J., additional, Dewar, A., additional, Dharmagunawardena, R., additional, Diar-Bakerly, N., additional, Dickens, C., additional, Dipper, A., additional, Diver, S., additional, Diwanji, S.N., additional, Dixon, M., additional, Djukanovic, R., additional, Dobson, H., additional, Dobson, S.L., additional, Docherty, A.B., additional, Donaldson, A., additional, Dong, T., additional, Dormand, N., additional, Dougherty, A., additional, Dowling, R., additional, Drain, S., additional, Draxlbauer, K., additional, Drury, K., additional, Drury, H.J.C., additional, Dulawan, P., additional, Dunleavy, A., additional, Dunn, S., additional, Dupont, C., additional, Earley, J., additional, Easom, N., additional, Echevarria, C., additional, Edwards, S., additional, Edwardson, C., additional, El-Taweel, H., additional, Elliott, A., additional, Elliott, K., additional, Ellis, Y., additional, Elmer, A., additional, Elneima, O., additional, Evans, D., additional, Evans, H., additional, Evans, J., additional, Evans, R., additional, Evans, R.A., additional, Evans, R.I., additional, Evans, T., additional, Evenden, C., additional, Evison, L., additional, Fabbri, L., additional, Fairbairn, S., additional, Fairman, A., additional, Fallon, K., additional, Faluyi, D., additional, Favager, C., additional, Fayzan, T., additional, Featherstone, J., additional, Felton, T., additional, Finch, J., additional, Finney, S., additional, Finnigan, J., additional, Finnigan, L., additional, Fisher, H., additional, Fletcher, S., additional, Flockton, R., additional, Flynn, M., additional, Foot, H., additional, Foote, D., additional, Ford, A., additional, Forton, D., additional, Fraile, E., additional, Francis, C., additional, Francis, R., additional, Francis, S., additional, Frankel, A., additional, Fraser, E., additional, Free, R., additional, French, N., additional, Fu, X., additional, Fuld, J., additional, Furniss, J., additional, Garner, L., additional, Gautam, N., additional, Geddes, J.R., additional, George, J., additional, George, P., additional, Gibbons, M., additional, Gill, M., additional, Gilmour, L., additional, Gleeson, F., additional, Glossop, J., additional, Glover, S., additional, Goodman, N., additional, Goodwin, C., additional, Gooptu, B., additional, Gordon, H., additional, Gorsuch, T., additional, Greatorex, M., additional, Greenhaff, P.L., additional, Greenhalf, W., additional, Greenhalgh, A., additional, Greening, N.J., additional, Greenwood, J., additional, Gregory, H., additional, Gregory, R., additional, Grieve, D., additional, Griffin, D., additional, Griffiths, L., additional, Guerdette, A.-M., additional, Guillen Guio, B., additional, Gummadi, M., additional, Gupta, A., additional, Gurram, S., additional, Guthrie, E., additional, Guy, Z., additional, Henson, H.H., additional, Hadley, K., additional, Haggar, A., additional, Hainey, K., additional, Hairsine, B., additional, Haldar, P., additional, Hall, I., additional, Hall, L., additional, Halling-Brown, M., additional, Hamil, R., additional, Hancock, A., additional, Hancock, K., additional, Hanley, N.A., additional, Haq, S., additional, Hardwick, H.E., additional, Hardy, E., additional, Hardy, T., additional, Hargadon, B., additional, Harrington, K., additional, Harris, E., additional, Harris, V.C., additional, Harrison, E.M., additional, Harrison, P., additional, Hart, N., additional, Harvey, A., additional, Harvey, M., additional, Harvie, M., additional, Haslam, L., additional, Havinden-Williams, M., additional, Hawkes, J., additional, Hawkings, N., additional, Haworth, J., additional, Hayday, A., additional, Haynes, M., additional, Hazeldine, J., additional, Hazelton, T., additional, Heaney, L.G., additional, Heeley, C., additional, Heeney, J.L., additional, Heightman, M., additional, Heller, S., additional, Henderson, M., additional, Hesselden, L., additional, Hewitt, M., additional, Highett, V., additional, Hillman, T., additional, Hiwot, T., additional, Ho, L.P., additional, Hoare, A., additional, Hoare, M., additional, Hockridge, J., additional, Hogarth, P., additional, Holbourn, A., additional, Holden, S., additional, Holdsworth, L., additional, Holgate, D., additional, Holland, M., additional, Holloway, L., additional, Holmes, K., additional, Holmes, M., additional, Holroyd-Hind, B., additional, Holt, L., additional, Hormis, A., additional, Horsley, A., additional, Hosseini, A., additional, Hotopf, M., additional, Houchen-Wolloff, L., additional, Howard, K., additional, Howard, L.S., additional, Howell, A., additional, Hufton, E., additional, Hughes, A.D., additional, Hughes, J., additional, Hughes, R., additional, Humphries, A., additional, Huneke, N., additional, Hurditch, E., additional, Hurst, J., additional, Husain, M., additional, Hussell, T., additional, Hutchinson, J., additional, Ibrahim, W., additional, Ilyas, F., additional, Ingham, J., additional, Ingram, L., additional, Ionita, D., additional, Isaacs, K., additional, Ismail, K., additional, Jackson, T., additional, Jacob, J., additional, James, W.Y., additional, Jang, W., additional, Jarman, C., additional, Jarrold, I., additional, Jarvis, H., additional, Jastrub, R., additional, Jayaraman, B., additional, Jenkins, R.G., additional, Jezzard, P., additional, Jiwa, K., additional, Johnson, C., additional, Johnson, S., additional, Johnston, D., additional, Jolley, C.J., additional, Jones, D., additional, Jones, G., additional, Jones, H., additional, Jones, I., additional, Jones, L., additional, Jones, M.G., additional, Jones, S., additional, Jose, S., additional, Kabir, T., additional, Kaltsakas, G., additional, Kamwa, V., additional, Kanellakis, N., additional, Kaprowska, S., additional, Kausar, Z., additional, Keenan, N., additional, Kelly, S., additional, Kemp, G., additional, Kerr, S., additional, Kerslake, H., additional, Key, A.L., additional, Khan, F., additional, Khunti, K., additional, Kilroy, S., additional, King, B., additional, King, C., additional, Kingham, L., additional, Kirk, J., additional, Kitterick, P., additional, Klenerman, P., additional, Knibbs, L., additional, Knight, S., additional, Knighton, A., additional, Kon, O., additional, Kon, S., additional, Kon, S.S., additional, Koprowska, S., additional, Korszun, A., additional, Koychev, I., additional, Kurasz, C., additional, Kurupati, P., additional, Laing, C., additional, Lamlum, H., additional, Landers, G., additional, Langenberg, C., additional, Lasserson, D., additional, Lavelle-Langham, L., additional, Lawrie, A., additional, Lawson, C., additional, Layton, A., additional, Lea, A., additional, Leavy, O.C., additional, Lee, D., additional, Lee, J.-H., additional, Lee, E., additional, Leitch, K., additional, Lenagh, R., additional, Lewis, D., additional, Lewis, J., additional, Lewis, K.E., additional, Lewis, V., additional, Lewis-Burke, N., additional, Li, X., additional, Light, T., additional, Lightstone, L., additional, Lilaonitkul, W., additional, Lim, L., additional, Linford, S., additional, Lingford-Hughes, A., additional, Lipman, M., additional, Liyanage, K., additional, Lloyd, A., additional, Logan, S., additional, Lomas, D., additional, Lone, N.I., additional, Loosley, R., additional, Lord, J.M., additional, Lota, H., additional, Lovegrove, W., additional, Lucey, A., additional, Lukaschuk, E., additional, Lye, A., additional, Lynch, C., additional, MacDonald, S., additional, MacGowan, G., additional, Macharia, I., additional, Mackie, J., additional, Macliver, L., additional, Madathil, S., additional, Madzamba, G., additional, Magee, N., additional, Magtoto, M.M., additional, Mairs, N., additional, Majeed, N., additional, Major, E., additional, Malein, F., additional, Malim, M., additional, Mallison, G., additional, D-C Man, W., additional, Mandal, S., additional, Mangion, K., additional, Manisty, C., additional, Manley, R., additional, March, K., additional, Marciniak, S., additional, Marino, P., additional, Mariveles, M., additional, Marks, M., additional, Marouzet, E., additional, Marsh, S., additional, Marshall, B., additional, Marshall, M., additional, Martin, J., additional, Martineau, A., additional, Martinez, L.M., additional, Maskell, N., additional, Matila, D., additional, Matimba-Mupaya, W., additional, Matthews, L., additional, Mbuyisa, A., additional, McAdoo, S., additional, McAllister-Williams, H., additional, McArdle, A., additional, McArdle, P., additional, McAulay, D., additional, McCann, G.P., additional, McCormick, J., additional, McCormick, W., additional, McCourt, P., additional, McGarvey, L., additional, McGee, C., additional, Mcgee, K., additional, McGinness, J., additional, McGlynn, K., additional, McGovern, A., additional, McGuinness, H., additional, McInnes, I.B., additional, McIntosh, J., additional, McIvor, E., additional, McIvor, K., additional, McLeavey, L., additional, McMahon, A., additional, McMahon, M.J., additional, McMorrow, L., additional, Mcnally, T., additional, McNarry, M., additional, McNeill, J., additional, McQueen, A., additional, McShane, H., additional, Mears, C., additional, Megson, C., additional, Megson, S., additional, Mehta, P., additional, Meiring, J., additional, Melling, L., additional, Mencias, M., additional, Menzies, D., additional, Merida Morillas, M., additional, Michael, A., additional, Miller, C., additional, Milligan, L., additional, Mills, C., additional, Mills, G., additional, Mills, N.L., additional, Milner, L., additional, Misra, S., additional, Mitchell, J., additional, Mohamed, A., additional, Mohamed, N., additional, Mohammed, S., additional, Molyneaux, P.L., additional, Monteiro, W., additional, Moriera, S., additional, Morley, A., additional, Morrison, L., additional, Morriss, R., additional, Morrow, A., additional, Moss, A.J., additional, Moss, P., additional, Motohashi, K., additional, Msimanga, N., additional, Mukaetova-Ladinska, E., additional, Munawar, U., additional, Murira, J., additional, Nanda, U., additional, Nassa, H., additional, Nasseri, M., additional, Neal, A., additional, Needham, R., additional, Neill, P., additional, Neubauer, S., additional, Newby, D.E., additional, Newell, H., additional, Newman, T., additional, Newman, J., additional, Newton-Cox, A., additional, Nicholson, T., additional, Nicoll, D., additional, Nikolaidis, A., additional, Nolan, C.M., additional, Noonan, M.J., additional, Norman, C., additional, Novotny, P., additional, Nunag, J., additional, Nwafor, L., additional, Nwanguma, U., additional, Nyaboko, J., additional, O'Brien, C., additional, O'Donnell, K., additional, O'Regan, D., additional, O’Brien, L., additional, Odell, N., additional, Ogg, G., additional, Olaosebikan, O., additional, Oliver, C., additional, Omar, Z., additional, Openshaw, P.J.M., additional, Orriss-Dib, L., additional, Osborne, L., additional, Osbourne, R., additional, Ostermann, M., additional, Overton, C., additional, Owen, J., additional, Oxton, J., additional, Pack, J., additional, Pacpaco, E., additional, Paddick, S., additional, Painter, S., additional, Pakzad, A., additional, Palmer, S., additional, Papineni, P., additional, Paques, K., additional, Paradowski, K., additional, Pareek, M., additional, Parekh, D., additional, Parfrey, H., additional, Pariante, C., additional, Parker, S., additional, Parkes, M., additional, Parmar, J., additional, Patale, S., additional, Patel, B., additional, Patel, M., additional, Patel, S., additional, Pattenadk, D., additional, Pavlides, M., additional, Payne, S., additional, Pearce, L., additional, Pearl, J.E., additional, Peckham, D., additional, Pendlebury, J., additional, Peng, Y., additional, Pennington, C., additional, Peralta, I., additional, Perkins, E., additional, Peterkin, Z., additional, Peto, T., additional, Petousi, N., additional, Petrie, J., additional, Pfeffer, P., additional, Phipps, J., additional, Pimm, J., additional, Piper Hanley, K., additional, Pius, R., additional, Plant, H., additional, Plein, S., additional, Plekhanova, T., additional, Plowright, M., additional, Poinasamy, K., additional, Polgar, O., additional, Poll, L., additional, Porter, J.C., additional, Porter, J., additional, Portukhay, S., additional, Powell, N., additional, Prabhu, A., additional, Pratt, J., additional, Price, A., additional, Price, C., additional, Price, D., additional, Price, L., additional, Prickett, A., additional, Propescu, J., additional, Prosper, S., additional, Pugmire, S., additional, Quaid, S., additional, Quigley, J., additional, Quint, J., additional, Qureshi, H., additional, Qureshi, I.N., additional, Radhakrishnan, K., additional, Rahman, N.M., additional, Ralser, M., additional, Raman, B., additional, Ramos, A., additional, Ramos, H., additional, Rangeley, J., additional, Rangelov, B., additional, Ratcliffe, L., additional, Ravencroft, P., additional, Reddington, A., additional, Reddy, R., additional, Reddy, A., additional, Redfearn, H., additional, Redwood, D., additional, Reed, A., additional, Rees, M., additional, Rees, T., additional, Regan, K., additional, Reynolds, W., additional, Ribeiro, C., additional, Richards, A., additional, Richardson, E., additional, Richardson, M., additional, Rivera-Ortega, P., additional, Roberts, K., additional, Robertson, E., additional, Robinson, E., additional, Robinson, L., additional, Roche, L., additional, Roddis, C., additional, Rodger, J., additional, Ross, A., additional, Ross, G., additional, Rossdale, J., additional, Rostron, A., additional, Rowe, A., additional, Rowland, A., additional, Rowland, J., additional, Rowland, M.J., additional, Rowland-Jones, S.L., additional, Roy, K., additional, Roy, M., additional, Rudan, I., additional, Russell, R., additional, Russell, E., additional, Saalmink, G., additional, Sabit, R., additional, Sage, E.K., additional, Samakomva, T., additional, Samani, N., additional, Sampson, C., additional, Samuel, K., additional, Samuel, R., additional, Sanderson, A., additional, Sapey, E., additional, Saralaya, D., additional, Sargant, J., additional, Sarginson, C., additional, Sass, T., additional, Sattar, N., additional, Saunders, K., additional, Saunders, R.M., additional, Saunders, P., additional, Saunders, L.C., additional, Savill, H., additional, Saxon, W., additional, Sayer, A., additional, Schronce, J., additional, Schwaeble, W., additional, Scott, J.T., additional, Scott, K., additional, Selby, N., additional, Semple, M.G., additional, Sereno, M., additional, Sewell, T.A., additional, Shah, A., additional, Shah, K., additional, Shah, P., additional, Shankar-Hari, M., additional, Sharma, M., additional, Sharpe, C., additional, Sharpe, M., additional, Shashaa, S., additional, Shaw, A., additional, Shaw, K., additional, Shaw, V., additional, Sheikh, A., additional, Shelton, S., additional, Shenton, L., additional, Shevket, K., additional, Shikotra, A., additional, Short, J., additional, Siddique, S., additional, Siddiqui, S., additional, Sidebottom, J., additional, Sigfrid, L., additional, Simons, G., additional, Simpson, J., additional, Simpson, N., additional, Singapuri, A., additional, Singh, C., additional, Singh, S., additional, Singh, S.J., additional, Sissons, D., additional, Skeemer, J., additional, Slack, K., additional, Smith, A., additional, Smith, D., additional, Smith, S., additional, Smith, J., additional, Smith, L., additional, Soares, M., additional, Solano, T.S., additional, Solly, R., additional, Solstice, A.R., additional, Soulsby, T., additional, Southern, D., additional, Sowter, D., additional, Spears, M., additional, Spencer, L.G., additional, Speranza, F., additional, Stadon, L., additional, Stanel, S., additional, Steele, N., additional, Steiner, M., additional, Stensel, D., additional, Stephens, G., additional, Stephenson, L., additional, Stern, M., additional, Stewart, I., additional, Stimpson, R., additional, Stockdale, S., additional, Stockley, J., additional, Stoker, W., additional, Stone, R., additional, Storrar, W., additional, Storrie, A., additional, Storton, K., additional, Stringer, E., additional, Strong-Sheldrake, S., additional, Stroud, N., additional, Subbe, C., additional, Sudlow, C.L., additional, Suleiman, Z., additional, Summers, C., additional, Summersgill, C., additional, Sutherland, D., additional, Sykes, D.L., additional, Sykes, R., additional, Talbot, N., additional, Tan, A.L., additional, Tarusan, L., additional, Tavoukjian, V., additional, Taylor, A., additional, Taylor, C., additional, Taylor, J., additional, Te, A., additional, Tedd, H., additional, Tee, C.J., additional, Teixeira, J., additional, Tench, H., additional, Terry, S., additional, Thackray-Nocera, S., additional, Thaivalappil, F., additional, Thamu, B., additional, Thickett, D., additional, Thomas, C., additional, Thomas, D.C., additional, Thomas, S., additional, Thomas, A.K., additional, Thomas-Woods, T., additional, Thompson, T., additional, Thompson, A.A.R., additional, Thornton, T., additional, Thorpe, M., additional, Thwaites, R.S., additional, Tilley, J., additional, Tinker, N., additional, Tiongson, G.F., additional, Tobin, M., additional, Tomlinson, J., additional, Tong, C., additional, Toshner, M., additional, Touyz, R., additional, Tripp, K.A., additional, Tunnicliffe, E., additional, Turnbull, A., additional, Turner, E., additional, Turner, S., additional, Turner, V., additional, Turner, K., additional, Turney, S., additional, Turtle, L., additional, Turton, H., additional, Ugoji, J., additional, Ugwuoke, R., additional, Upthegrove, R., additional, Valabhji, J., additional, Ventura, M., additional, Vere, J., additional, Vickers, C., additional, Vinson, B., additional, Wade, E., additional, Wade, P., additional, Wain, L.V., additional, Wainwright, T., additional, Wajero, L.O., additional, Walder, S., additional, Walker, S., additional, Wall, E., additional, Wallis, T., additional, Walmsley, S., additional, Walsh, J.A., additional, Walsh, S., additional, Warburton, L., additional, Ward, T.J.C., additional, Warwick, K., additional, Wassall, H., additional, Waterson, S., additional, Watson, E., additional, Watson, L., additional, Watson, J., additional, Weir McCall, J., additional, Welch, C., additional, Welch, H., additional, Welsh, B., additional, Wessely, S., additional, West, S., additional, Weston, H., additional, Wheeler, H., additional, White, S., additional, Whitehead, V., additional, Whitney, J., additional, Whittaker, S., additional, Whittam, B., additional, Whitworth, V., additional, Wight, A., additional, Wild, J., additional, Wilkins, M., additional, Wilkinson, D., additional, Williams, B., additional, Williams, N., additional, Williams, J., additional, Williams-Howard, S.A., additional, Willicombe, M., additional, Willis, G., additional, Willoughby, J., additional, Wilson, A., additional, Wilson, D., additional, Wilson, I., additional, Window, N., additional, Witham, M., additional, Wolf-Roberts, R., additional, Wood, C., additional, Woodhead, F., additional, Woods, J., additional, Wootton, D.G., additional, Wormleighton, J., additional, Worsley, J., additional, Wraith, D., additional, Wrey Brown, C., additional, Wright, C., additional, Wright, L., additional, Wright, S., additional, Wyles, J., additional, Wynter, I., additional, Xu, M., additional, Yasmin, N., additional, Yasmin, S., additional, Yates, T., additional, Yip, K.P., additional, Young, B., additional, Young, S., additional, Young, A., additional, Yousuf, A.J., additional, Zawia, A., additional, Zeidan, L., additional, Zhao, B., additional, Zheng, B., additional, and Zongo, O., additional

Published
2023
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25. Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19

Author

Daines, Luke, primary, Zheng, Bang, additional, Elneima, Omer, additional, Harrison, Ewen, additional, Lone, Nazir I., additional, Hurst, John R., additional, Brown, Jeremy S., additional, Sapey, Elizabeth, additional, Chalmers, James D., additional, Quint, Jennifer K., additional, Pfeffer, Paul, additional, Siddiqui, Salman, additional, Walker, Samantha, additional, Poinasamy, Krisnah, additional, McAuley, Hamish, additional, Sereno, Marco, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Docherty, Annemarie B., additional, Marks, Michael, additional, Toshner, Mark, additional, Howard, Luke S., additional, Horsley, Alex, additional, Jenkins, Gisli, additional, Porter, Joanna C., additional, Ho, Ling-Pei, additional, Raman, Betty, additional, Wain, Louise V., additional, Brightling, Christopher E., additional, Evans, Rachael A., additional, Heaney, Liam G., additional, De Soyza, Anthony, additional, and Sheikh, Aziz, additional

Published
2022
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26. Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales

Author

Swann, Olivia V, primary, Lone, Nazir I, additional, Harrison, Ewen M, additional, Tomlinson, Laurie A, additional, Walker, Alex J, additional, Seaborne, Michael J, additional, Pollock, Louisa, additional, Farrell, James, additional, Hall, Peter S, additional, Seth, Sohan, additional, Williams, Thomas C, additional, Preston, Jennifer, additional, Ainsworth, J. Samantha, additional, Semple, Freya F, additional, Baillie, J Kenneth, additional, Katikireddi, Srinivasa V, additional, Akbari, Ashley, additional, Lyons, Ronan, additional, Simpson, Colin R, additional, Semple, Malcolm G, additional, Goldacre, Ben, additional, Brophy, Sinead, additional, Sheikh, Aziz, additional, and Docherty, Annemarie B, additional

Published
2022
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27. Higher clinical acuity and 7-day hospital mortality in non-COVID-19 acute medical admissions: prospective observational study

Author

Lyall, Marcus J and Lone, Nazir I

Subjects
Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Ambulances, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, death/mortality, Severity of Illness Index, Time-to-Treatment, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Renal injury, Hospital Administration, Acute care, Severity of illness, medicine, Humans, Hospital Mortality, Prospective Studies, 030212 general & internal medicine, Original Research, Aged, SARS-CoV-2, business.industry, Incidence (epidemiology), Confounding, Age Factors, Patient Acuity, Acute kidney injury, COVID-19, General Medicine, Middle Aged, medicine.disease, United Kingdom, Socioeconomic Factors, Communicable Disease Control, Cohort, Emergency medicine, Emergency Medicine, Day hospital, Female, Observational study, acute care, business, Biomarkers
Abstract

ObjectivesTo understand the effect of COVID-19 lockdown measures on severity of illness and mortality in non-COVID-19 acute medical admissions.DesignA prospective observational study.Setting3 large acute medical receiving units in NHS Lothian, Scotland.ParticipantsNon-COVID-19 acute admissions (n=1682) were examined over the first 31 days after the implementation of the COVID-19 lockdown policy in the UK on 23 March 2019. Patients admitted over a matched interval in the previous 5 years were used as a comparator cohort (n=14 954).Main outcome measuresPatient demography, biochemical markers of clinical acuity and 7-day hospital inpatient mortality.ResultsNon-COVID-19 acute medical admissions reduced by 44.9% across all three sites in comparison with the mean of the preceding 5 years (pConclusionsThese data demonstrate a significant reduction in non-COVID-19 acute medical admissions during the early weeks of lockdown. Patients admitted during this period were of higher clinical acuity with a higher incidence of early inpatient mortality.

Published
2021
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29. Additional file 2 of Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study

Author

Plekhanova, Tatiana, Rowlands, Alex V., Evans, Rachael A., Edwardson, Charlotte L., Bishop, Nicolette C., Bolton, Charlotte E., Chalmers, James D., Davies, Melanie J., Daynes, Enya, Dempsey, Paddy C., Docherty, Annemarie B., Elneima, Omer, Greening, Neil J., Greenwood, Sharlene A., Hall, Andrew P., Harris, Victoria C., Harrison, Ewen M., Henson, Joseph, Ho, Ling-Pei, Horsley, Alex, Houchen-Wolloff, Linzy, Khunti, Kamlesh, Leavy, Olivia C., Lone, Nazir I., Marks, Michael, Maylor, Ben, McAuley, Hamish J. C., Nolan, Claire M., Poinasamy, Krisnah, Quint, Jennifer K., Raman, Betty, Richardson, Matthew, Sargeant, Jack A., Saunders, Ruth M., Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Steiner, Michael, Stensel, David J., Wain, Louise V., Whitney, Julie, Wootton, Dan G., Brightling, Christopher E., Man, William D-C., Singh, Sally J., and Yates, Tom

Abstract

Additional file 2. Supplementary material.

Published
2022
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32. Multimorbidity and its relationship with long-term outcomes following critical care discharge: a prospective cohort study

Author

McPeake, Joanne, Quasim, Tara, Henderson, Philip, Leyland, Alastair H., Lone, Nazir I., Walters, Matthew, Iwashyna, Theodore J., and Shaw, Martin

Abstract

Background: \ud Survivors of critical illness have poor long-term outcomes with subsequent increases in healthcare utilisation. Less is known about the interplay between multimorbidity and long-term outcomes.\ud \ud Research Question: \ud How do baseline patient demographics impact mortality and healthcare utilisation in the year following discharge from critical care?\ud \ud Study design and methods: \ud Using data from a prospectively collected cohort, we employed propensity score matching to assess differences in outcomes between patients with a critical care encounter and patients admitted to the hospital without critical care. Long-term mortality was examined via nationally linked data as was hospital resource use in the year following hospital discharge. The cause of death was also examined.\ud \ud Results: \ud This analysis included 3112 participants. There was no difference in long-term mortality between the critical care and hospital cohorts (adjusted HR: 1.09 (95% CI: 0.90-1.32), p=0.39). Pre-hospitalisation emotional health issues such as a clinical diagnosis of depression, were associated with increased long-term mortality (HR:1.49 (95% CI: 1.14-1.96), p

Published
2021

33. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Author

Evans, Rachael A, McAuley, Hamish, Harrison, Ewen M, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Elneima, Omer, Docherty, Annemarie B, Lone, Nazir I, Leavy, Olivia C, Daines, Luke, Baillie, J Kenneth, Brown, Jeremy S, Chalder, Trudie, De Soyza, Anthony, Diar Bakerly, Nawar, Easom, Nicholas, Geddes, John R, Greening, Neil J, Hart, Nick, Heaney, Liam G, Heller, Simon, Howard, Luke, Hurst, John R, Jacob, Joseph, Jenkins, R Gisli, Jolley, Caroline, Kerr, Steven, Kon, Onn M, Lewis, Keir, Lord, Janet M, McCann, Gerry P, Neubauer, Stefan, Openshaw, Peter JM, Parekh, Dhruv, Pfeffer, Paul, Rahman, Najib M, Raman, Betty, Richardson, Matthew, Rowland, Matthew, Semple, Malcolm G, Shah, Ajay M, Singh, Sally J, Sheikh, Aziz, Thomas, David, Toshner, Mark, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Wain, Louise V, Brightling, Christopher E, and PHOSP-COVID Collaborative Group

Abstract

BACKGROUND: The impact of COVID-19 on physical and mental health and employment after hospitalisation with acute disease is not well understood. The aim of this study was to determine the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes. METHODS: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a multicentre, long-term follow-up study of adults (aged ≥18 years) discharged from hospital in the UK with a clinical diagnosis of COVID-19, involving an assessment between 2 and 7 months after discharge, including detailed recording of symptoms, and physiological and biochemical testing. Multivariable logistic regression was done for the primary outcome of patient-perceived recovery, with age, sex, ethnicity, body-mass index, comorbidities, and severity of acute illness as covariates. A post-hoc cluster analysis of outcomes for breathlessness, fatigue, mental health, cognitive impairment, and physical performance was done using the clustering large applications k-medoids approach. The study is registered on the ISRCTN Registry (ISRCTN10980107). FINDINGS: We report findings for 1077 patients discharged from hospital between March 5 and Nov 30, 2020, who underwent assessment at a median of 5·9 months (IQR 4·9-6·5) after discharge. Participants had a mean age of 58 years (SD 13); 384 (36%) were female, 710 (69%) were of white ethnicity, 288 (27%) had received mechanical ventilation, and 540 (50%) had at least two comorbidities. At follow-up, only 239 (29%) of 830 participants felt fully recovered, 158 (20%) of 806 had a new disability (assessed by the Washington Group Short Set on Functioning), and 124 (19%) of 641 experienced a health-related change in occupation. Factors associated with not recovering were female sex, middle age (40-59 years), two or more comorbidities, and more severe acute illness. The magnitude of the persistent health burden was substantial but only weakly associated with the severity of acute illness. Four clusters were identified with different severities of mental and physical health impairment (n=767): very severe (131 patients, 17%), severe (159, 21%), moderate along with cognitive impairment (127, 17%), and mild (350, 46%). Of the outcomes used in the cluster analysis, all were closely related except for cognitive impairment. Three (3%) of 113 patients in the very severe cluster, nine (7%) of 129 in the severe cluster, 36 (36%) of 99 in the moderate cluster, and 114 (43%) of 267 in the mild cluster reported feeling fully recovered. Persistently elevated serum C-reactive protein was positively associated with cluster severity. INTERPRETATION: We identified factors related to not recovering after hospital admission with COVID-19 at 6 months after discharge (eg, female sex, middle age, two or more comorbidities, and more acute severe illness), and four different recovery phenotypes. The severity of physical and mental health impairments were closely related, whereas cognitive health impairments were independent. In clinical care, a proactive approach is needed across the acute severity spectrum, with interdisciplinary working, wide access to COVID-19 holistic clinical services, and the potential to stratify care. FUNDING: UK Research and Innovation and National Institute for Health Research.

Published
2021

34. Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Author

Docherty, Annemarie B, Mulholland, Rachel H, Lone, Nazir I, Cheyne, Christopher P, De Angelis, Daniela, Diaz-Ordaz, Karla, Donegan, Cara, Drake, Thomas M, Dunning, Jake, Funk, Sebastian, García-Fiñana, Marta, Girvan, Michelle, Hardwick, Hayley E, Harrison, Janet, Ho, Antonia, Hughes, David M, Keogh, Ruth H, Kirwan, Peter D, Leeming, Gary, Nguyen Van-Tam, Jonathan S, Pius, Riinu, Russell, Clark D, Spencer, Rebecca G, Tom, Brian Dm, Turtle, Lance, Openshaw, Peter Jm, Baillie, J Kenneth, Harrison, Ewen M, Semple, Malcolm G, and ISARIC4C Investigators

Abstract

BACKGROUND: Mortality rates in hospitalised patients with COVID-19 in the UK appeared to decline during the first wave of the pandemic. We aimed to quantify potential drivers of this change and identify groups of patients who remain at high risk of dying in hospital. METHODS: In this multicentre prospective observational cohort study, the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK recruited a prospective cohort of patients with COVID-19 admitted to 247 acute hospitals in England, Scotland, and Wales during the first wave of the pandemic (between March 9 and Aug 2, 2020). We included all patients aged 18 years and older with clinical signs and symptoms of COVID-19 or confirmed COVID-19 (by RT-PCR test) from assumed community-acquired infection. We did a three-way decomposition mediation analysis using natural effects models to explore associations between week of admission and in-hospital mortality, adjusting for confounders (demographics, comorbidities, and severity of illness) and quantifying potential mediators (level of respiratory support and steroid treatment). The primary outcome was weekly in-hospital mortality at 28 days, defined as the proportion of patients who had died within 28 days of admission of all patients admitted in the observed week, and it was assessed in all patients with an outcome. This study is registered with the ISRCTN Registry, ISRCTN66726260. FINDINGS: Between March 9, and Aug 2, 2020, we recruited 80 713 patients, of whom 63 972 were eligible and included in the study. Unadjusted weekly in-hospital mortality declined from 32·3% (95% CI 31·8-32·7) in March 9 to April 26, 2020, to 16·4% (15·0-17·8) in June 15 to Aug 2, 2020. Reductions in mortality were observed in all age groups, in all ethnic groups, for both sexes, and in patients with and without comorbidities. After adjustment, there was a 32% reduction in the risk of mortality per 7-week period (odds ratio [OR] 0·68 [95% CI 0·65-0·71]). The higher proportions of patients with severe disease and comorbidities earlier in the first wave (March and April) than in June and July accounted for 10·2% of this reduction. The use of respiratory support changed during the first wave, with gradually increased use of non-invasive ventilation over the first wave. Changes in respiratory support and use of steroids accounted for 22·2%, OR 0·95 (0·94-0·95) of the reduction in in-hospital mortality. INTERPRETATION: The reduction in in-hospital mortality in patients with COVID-19 during the first wave in the UK was partly accounted for by changes in the case-mix and illness severity. A significant reduction in in-hospital mortality was associated with differences in respiratory support and critical care use, which could partly reflect accrual of clinical knowledge. The remaining improvement in in-hospital mortality is not explained by these factors, and could be associated with changes in community behaviour, inoculum dose, and hospital capacity strain. FUNDING: National Institute for Health Research and the Medical Research Council.

Published
2021

35. sj-pdf-1-inc-10.1177_17511437211052226 – Supplemental Material for Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial

Author

Pauley, Ellen, Drake, Thomas M, Griffith, David M, Sigfrid, Louise, Lone, Nazir I, Harrison, Ewen M, Baillie, J Kenneth, Scott, Janet T, Walsh, Timothy S, Semple, Malcolm G, and Docherty, Annemarie B

Subjects
111708 Health and Community Services, FOS: Clinical medicine, Cardiology, 110323 Surgery, FOS: Health sciences, 110305 Emergency Medicine
Abstract

Supplemental Material, sj-pdf-1-inc-10.1177_17511437211052226 for Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial by Ellen Pauley, Thomas M Drake, David M Griffith, Louise Sigfrid, Nazir I Lone, Ewen M Harrison, J Kenneth Baillie, Janet T Scott, Timothy S Walsh, Malcolm G Semple and Annemarie B Docherty in Journal of the Intensive Care Society

Published
2021
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36. Society of Critical Care Medicine’s international consensus conference on prediction and identification of long-term impairments after critical illness

Author

Mikkelsen, Mark E., Still, Mary, Anderson, Brian J., Bienvenu, O. Joseph, Brodsky, Martin B., Brummel, Nathan, Butcher, Brad, Clay, Alison S., Felt, Hali, Ferrante, Lauren E., Haines, Kimberley J., Harhay, Michael O., Hope, Aluko A., Hopkins, Ramona O., Hosey, Megan, Hough, Catherine \\'Terri\\' L., Jackson, James C., Johnson, Annie, Khan, Babar, Lone, Nazir I., MacTavish, Pamela, McPeake, Joanne, Montgomery-Yates, Ashley, Needham, Dale M., Netzer, Giora, Schorr, Christa, Skidmore, Becky, Stollings, Joanna L., Umberger, Reba, Critical Care Registered Nurse-Knowledge, Andrews, Adair, Iwashyna, Theodore J., and Sevin, Carla M.

Abstract

Background: \ud After critical illness, new or worsening impairments in physical, cognitive, and/or mental health function are common among patients who have survived. Who should be screened for long-term impairments, what tools to use, and when remain unclear.\ud \ud Objectives: \ud Provide pragmatic recommendations to clinicians caring for adult survivors of critical illness related to screening for postdischarge impairments.\ud \ud Participants: \ud Thirty-one international experts in risk-stratification and assessment of survivors of critical illness, including practitioners involved in the Society of Critical Care Medicine’s Thrive Post-ICU Collaboratives, survivors of critical illness, and clinical researchers.\ud \ud Design: \ud Society of Critical Care Medicine consensus conference on post-intensive care syndrome prediction and assessment, held in Dallas, in May 2019. A systematic search of PubMed and the Cochrane Library was conducted in 2018 and updated in 2019 to complete an original systematic review and to identify pre-existing systematic reviews.\ud \ud Meeting Outcomes: \ud We concluded that existing tools are insufficient to reliably predict post-intensive care syndrome. We identified factors before (e.g., frailty, preexisting functional impairments), during (e.g., duration of delirium, sepsis, acute respiratory distress syndrome), and after (e.g., early symptoms of anxiety, depression, or post-traumatic stress disorder) critical illness that can be used to identify patients at high-risk for cognitive, mental health, and physical impairments after critical illness in whom screening is recommended. We recommend serial assessments, beginning within 2–4 weeks of hospital discharge, using the following screening tools: Montreal Cognitive Assessment test; Hospital Anxiety and Depression Scale; Impact of Event Scale-Revised (post-traumatic stress disorder); 6-minute walk; and/or the EuroQol-5D-5L, a health-related quality of life measure (physical function).\ud \ud Conclusions: \ud Beginning with an assessment of a patient’s pre-ICU functional abilities at ICU admission, clinicians have a care coordination strategy to identify and manage impairments across the continuum. As hospital discharge approaches, clinicians should use brief, standardized assessments and compare these results to patient’s pre-ICU functional abilities (“functional reconciliation”). We recommend serial assessments for post-intensive care syndrome-related problems continue within 2–4 weeks of hospital discharge, be prioritized among high-risk patients, using the identified screening tools to prompt referrals for services and/or more detailed assessments.

Published
2020

37. Society of Critical Care Medicine’s International Consensus Conference on Prediction and Identification of Long-Term Impairments after Critical Illness

Author

Mikkelsen , Mark E., Still , Mary, Anderson , Brian J., and Lone, Nazir I

Abstract

Background: After critical illness, new or worsening impairments in physical, cognitive, and/or mental health function are common among patients who have survived. Who should be screened for long-term impairments, what tools to use, and when, remain unclear.Objectives: Provide pragmatic recommendations to clinicians caring for adult survivors of critical illness related to screening for post-discharge impairments. Participants: 31 international experts in risk-stratification and assessment of survivors of critical illness, including practitioners involved in the Society of Critical Care Medicine’s (SCCM) Thrive Post-ICU Collaboratives, survivors of critical illness, and clinical researchers.Design: SCCM consensus conference on post-intensive care syndrome (PICS) prediction and assessment, held in Dallas, in May, 2019. Meeting Outcomes: We concluded that existing tools are insufficient to reliably predict PICS. We identified factors before (e.g., frailty, pre-existing functional impairments), during (e.g., duration of delirium, sepsis, acute respiratory distress syndrome), and after (e.g., early symptoms of anxiety, depression, or post-traumatic stress disorder (PTSD)) critical illness that can be used to identify patients at high-risk for cognitive, mental health, and physical impairments after critical illness in whom screening is recommended. We recommend serial assessments, beginning within 2-4 weeks of hospital discharge, using the following screening tools: Montreal Cognitive Assessment test; Hospital Anxiety and Depression Scale; Impact of Event Scale-Revised (PTSD); 6-minute walk and/or the EuroQol-5D-5L (physical function). Conclusions: Beginning with an assessment of a patient’s pre-ICU functional abilities at ICU admission, clinicians have a care coordination strategy to identify and manage impairments across the continuum. As hospital discharge approaches, clinicians should use brief, standardized assessments and compare these results to patient’s pre-ICU functional abilities (“functional reconciliation”). We recommend serial assessments for PICS-related problems continue within 2-4 weeks of hospital discharge, be prioritized amongst high-risk patients, using the identified screening tools to prompt referrals for services and/or more detailed assessments.

Published
2020

39. What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol

Author

Sigfrid, Louise, primary, Cevik, Muge, additional, Jesudason, Edwin, additional, Lim, Wei Shen, additional, Rello, Jordi, additional, Amuasi, John, additional, Bozza, Fernando, additional, Palmieri, Carlo, additional, Munblit, Daniel, additional, Holter, Jan Cato, additional, Kildal, Anders Benjamin, additional, Reyes, Luis Felipe, additional, Russell, Clark D, additional, Ho, Antonia, additional, Turtle, Lance, additional, Drake, Thomas M, additional, Beltrame, Anna, additional, Hann, Katrina, additional, Bangura, Ibrahim Richard, additional, Fowler, Robert, additional, Lakoh, Sulaiman, additional, Berry, Colin, additional, Lowe, David J, additional, McPeake, Joanne, additional, Hashmi, Madiha, additional, Dyrhol-Riise, Anne Margarita, additional, Donohue, Chloe, additional, Plotkin, Daniel, additional, Hardwick, Hayley, additional, Elkheir, Natalie, additional, Lone, Nazir I, additional, Docherty, Annemarie, additional, Harrison, Ewen, additional, Baille, J Kenneth, additional, Carson, Gail, additional, Semple, Malcolm G, additional, and Scott, Janet T, additional

Published
2021
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40. Vaccine effectiveness of live attenuated and trivalent inactivated influenza vaccination in 2010/11 to 2015/16: the SIVE II record linkage study

Author

Simpson, Colin R, primary, Lone, Nazir I, additional, Kavanagh, Kim, additional, Englishby, Tanya, additional, Robertson, Chris, additional, McMenamin, Jim, additional, Wissman, Beatrix von, additional, Vasileiou, Eleftheria, additional, Butler, Christopher C, additional, Ritchie, Lewis D, additional, Gunson, Rory, additional, Schwarze, Jürgen, additional, and Sheikh, Aziz, additional

Published
2020
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46. Early Troponin I in critical illness and its association with hospital mortality: a cohort study:Early Troponin I in ICU and hospital mortality

Author

Docherty, Annemarie B., Sim, Malcolm, Oliveira, João, Adlam, Michael, Ostermann, Marlies, Walsh, Timothy S., Kinsella, John, and Lone, Nazir I.

Subjects
cardiovascular system, musculoskeletal system
Abstract

Background: Troponin I (TnI) is frequently elevated in critical illness, but its interpretation is unclear. Our primary objectives were to evaluate whether TnI is associated with hospital mortality, and if this association persists after adjusting for potential confounders. We also aimed to ascertain whether addition of TnI to the APACHE II risk prediction model improves its performance in general ICU populations. Methods: We performed an observational cohort study, with independent derivation and validation cohorts in two general level 3 ICU departments in the UK. Derivation cohort: 4.5 year cohort (2010-2014) of general ICU index admissions (n=1,349). Validation cohort: Secondary analysis of prospective study dataset (2010) (n=145). The primary exposure was plasma TnI concentration taken within 24 hours of ICU admission. The primary outcome was hospital mortality. We performed multivariate regression adjusting for components of the APACHE II model. We derived the risk prediction score from the multivariable model with TnI. Results: Hospital mortality was 37.3% (n=242) for patients with detectable TnI, compared with 14.6% (n=102) for patients without detectable TnI. There was a significant univariate association between TnI and hospital mortality (OR per doubling TnI 1.16, 95%CI 1.13, 1.20, p

Published
2017
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48. A Cross-sectional Study of Current Doctors' Performance in a Modified Version of a Medical School Admission Aptitude Test:The UKCAT

Author

Blackmur, James P., Lone, Nazir I., Stone, Oliver D, Webb, David J., and Dhaun, Neeraj

Subjects
education
Abstract

The 2-hour long United Kingdom Clinical Aptitude Test (UKCAT) is used by many universities in the United Kingdom as part of their selection process for undergraduate medical and dentistry degrees. We aimed to compare the performance of senior doctors in primary and secondary care and across a range of specialties, in a modified version of the medical school entrance examination-the mUKCAT. Lay people were also included in the study. Despite its widespread use, this is the first study that examines the performance of senior clinicians in the UKCAT.The study used a prospective cross-sectional design. It used mock questions from the UKCAT website to generate an mUKCAT that was anticipated to take 15 minutes to complete. In all, 167 doctors at consultant, general practitioner (GP), or specialty trainee grade and 26 lay people took part.The overall mean mUKCAT score of all participants was 2486 (69.1%). Of the total cohort, 126 (65.3%) scored above our designated threshold of 2368 and were deemed to have passed the mUKCAT. Excluding lay people, 113 (67.7%) of the 167 doctors scored above that threshold. Medical specialty was associated with overall score (P = 0.003), with anesthetists/intensive care physicians scoring highest (n = 20, mean score 2660) and GPs scoring lowest (n = 38, mean score 2302). Academics outperformed nonacademics (mean score of academics, n = 44 vs nonacademics, n = 123: 2750 vs 2406; P

Published
2016
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50. Evaluating the effectiveness, impact and safety of live attenuated and seasonal inactivated influenza vaccination: protocol for the Seasonal Influenza Vaccination Effectiveness II (SIVE II) study

Author

Simpson, Colin R, primary, Lone, Nazir I, additional, Kavanagh, Kimberley, additional, Robertson, Chris, additional, McMenamin, Jim, additional, von Wissmann, Beatrix, additional, Vasileiou, Eleftheria, additional, Butler, Chris, additional, Ritchie, Lewis D, additional, Gunson, Rory, additional, Schwarze, Jürgen, additional, and Sheikh, Aziz, additional

Published
2017
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