1. Acute Cardiac Events During COVID-19-Associated Hospitalizations.
- Author
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Woodruff, Rebecca, Garg, Shikha, George, Mary, Patel, Kadam, Jackson, Sandra, Loustalot, Fleetwood, Wortham, Jonathan, Taylor, Christopher, Whitaker, Michael, Alden, Nisha, Meek, James, Anderson, Evan, Weigel, Andy, Henderson, Justin, Bye, Erica, Davis, Sarah, Barney, Grant, Bennett, Nancy, Shiltz, Eli, Sutton, Melissa, Talbot, H, Price, Andrea, Sperling, Laurence, Havers, Fiona, and Reingold, Arthur
- Subjects
COVID-19 ,SARS-CoV-2 ,United States ,adults ,heart diseases ,hospitalization ,Adult ,Humans ,COVID-19 ,SARS-CoV-2 ,Hospital Mortality ,Hospitalization ,Heart Diseases - Abstract
BACKGROUND: COVID-19 is associated with cardiac complications. OBJECTIVES: The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults. METHODS: During January 2021 to November 2021, medical chart abstraction was conducted on a probability sample of adults hospitalized with laboratory-confirmed SARS-CoV-2 infection identified from 99 U.S. counties in 14 U.S. states in the COVID-19-Associated Hospitalization Surveillance Network. We calculated the prevalence of acute cardiac events (identified by International Classification of Diseases-10th Revision-Clinical Modification codes) by history of underlying cardiac disease and examined associated risk factors and disease outcomes. RESULTS: Among 8,460 adults, 11.4% (95% CI: 10.1%-12.9%) experienced an acute cardiac event during a COVID-19-associated hospitalization. Prevalence was higher among adults who had underlying cardiac disease (23.4%; 95% CI: 20.7%-26.3%) compared with those who did not (6.2%; 95% CI: 5.1%-7.6%). Acute ischemic heart disease (5.5%; 95% CI: 4.5%-6.5%) and acute heart failure (5.4%; 95% CI: 4.4%-6.6%) were the most prevalent events; 0.3% (95% CI: 0.1%-0.5%) experienced acute myocarditis or pericarditis. Risk factors varied by underlying cardiac disease status. Patients with ≥1 acute cardiac event had greater risk of intensive care unit admission (adjusted risk ratio: 1.9; 95% CI: 1.8-2.1) and in-hospital death (adjusted risk ratio: 1.7; 95% CI: 1.3-2.1) compared with those who did not. CONCLUSIONS: Acute cardiac events were common during COVID-19-associated hospitalizations, particularly among patients with underlying cardiac disease, and are associated with severe disease outcomes. Persons at greater risk for experiencing acute cardiac events during COVID-19-associated hospitalizations might benefit from more intensive clinical evaluation and monitoring during hospitalization.
- Published
- 2023