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1. Fluid stewardship in intensive care: clinical pharmacist’s actions analysis

Author

Elivelton Jesus CERQUEIRA, Alisson Menezes LIMA, José Alcântara NETO, Ingrid Peixoto FURTADO, João Antonio SOUSA, Luciana Mabel FELIX, and Renan Morais SILVA

Subjects
Public aspects of medicine, RA1-1270, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950
Abstract

Objective: To describe and analyze the pharmaceutical interventions performed by clinical intensivist pharmacists in the management of fluid therapy. Methods: This is an observational, retrospective, descriptive study conducted in a clinical ICU of a tertiary teaching hospital from January 2018 to December 2022. The study evaluated the classification according to the “four rights of fluid therapy” adapted from Hawkins14 (right drug, right dose, right route, and right patient); the acceptability of pharmaceutical interventions; the classification of interventions involving hidden fluids, and the medications involved in this classification. Results: The study included 415 patients, the majority of whom were male, 51% (213). The mean age was 57.4 ± 17.2 years. A total of 993 pharmaceutical interventions related to fluids were performed, comprising 12.2% of the interventions during the study period and corresponding to 2.4 per patient. The acceptability rate was 90% (894). Of the cited interventions, the majority (591) were related to the “right dose” (59.4%). The other interventions were: 167 (16.9%) related to the “right drug,” 163 (16.4%) to the “right route,” and 72 (7.2%) to the “right patient.” The management of hidden fluids was present in 722 (72.7%) interventions, with a focus on antimicrobials, totaling 256 (35.4%); followed by electrolytes and vitamins with 229 (31.7%), and antiulcer agents with 124 (17.2%). Conclusion: The pharmaceutical interventions analyzed were related to the “four rights of fluid therapy” and had high acceptability from the team. There was significant demand for pharmaceutical intervention in fluid management. The findings indicate the potential role of the clinical intensivist pharmacist as a key player in the fluid therapy management of critically ill patients.

Published
2024
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4. PRINCÍPIOS DE ECONOMIA CIRCULAR PARA O APROVEITAMENTO DOS RESÍDUOS SÓLIDOS DE ROCHAS ORNAMENTAIS NO DESENVOLVIMENTO DE PISOS DRENANTES

Author

Thiara Cezana Gomes, Nataly Senna Gerhardt Barraqui, and Luciana Belmira Felix dos Santos Soares

Subjects
Medical Terminology, Medical Assisting and Transcription
Abstract

No cenário atual de crescimento populacional e intenso desgaste dos recursos naturais, torna-se indispensável o uso de práticas mais sustentáveis. Nesse sentido, cresce a necessidade de um modelo econômico circular, no qual todos os tipos de materiais são desenvolvidos para serem recolocados na produção de forma eficiente. Assim, este artigo objetiva agregar princípios de economia circular no processo de desenvolvimento de um piso drenante que utiliza como matérias-primas os resíduos sólidos de marmorarias e pedreiras. A metodologia contemplou uma revisão da literatura com auxílio do Proknow-C, análises do mercado de rochas ornamentais no Brasil, obtenção de dados de resíduos sólidos gerados por marmorarias e pedreiras e, posteriormente, a discussão da proposta de reuso destes resíduos para produção de pisos drenantes.

Published
2022
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7. Meio Ambiente em Foco - Volume 2

Author

Paulo André da Silva Martins, Carlos Alexandre dos Santos Querino, Juliane Kayse Albuquerque da Silva Querino, Aryanne Resende de Melo Moura, Sara Angélica Santos de Souza, Carlos Alexandre Santos Querino, Altemar Lopes Pedreira Junior, Luiz Octavio Fabricio dos Santos, Ariele Luckwü Mendes, Roberta Monique da Silva Santos, Luciana Melo Felix da Silva, Lara Patricia dos Santos Chaves, Danielle Ivana Pereira dos Santos, Francimara Souza da Costa, Ísis Ribeiro do Nascimento, Hyago Mardone Maciel, Juliana Gervasio Nunes, Alexandro Relvas Pereira, Maria Ferreira de Oliveira Filha, Janaína Zildeia da Silva Paiva, Dorinethe dos Santos Bentes, Francisco Das Chagas Melo Benevides, Sebastião Ferreira Lisboa Neto, Julian Oliveira Gama, Clayssa Picanço de Lima, Débora Cristina Bandeira Rodrigues, Joel Nunes Rodrigues, Barbara Gabriella Oliveira Chaves, Sara Fontinelli Laurido, Tony Marcos Porto Braga, Sharles Gabriel de Souza Borges, Letícia Santos Silva, Ana Karolline Soares Alves, Larissa Lorrana Silva, Chryss Ferreira Macêdo, Allan Guilherme Rodrigues de Souza, Sharles Gabriel de Sousa Borges, Daíse Araújo Soares de Souza, Lucirene Aguiar Souza, Fabíola de Souza Barão, Carlos Edwar de Carvalho Freitas, Fabíola Esquerdo De Souza, Solange Santos Costa, Elizia Raquel Cunha, Uarlisson da Silva Machado, Vanderlea Castro Bezerra, Luiz Octavio Fabrício Santos, Robson Lima Da Silva, Maximillian Nascimento Da Costa, Jean Carlos Oliveira Coelho, Karine Canani De Oliveira, Thiago de Sá Sena, Anderson Oliveira de Sousa, Bruno Menezes da Cunha Gomes, Felipe Augusto da Silva Santos, Lucas Moura Delfino, Luiz Ricardo da Silva Linhares, Manoel Leandro Araújo e Farias, Antonio Jorge Barbosa da Silva, Ygor Felipe Távora da Silva, Guilherme Augusto Bentes Furtado Neto, Isaque dos Santos Sousa, and Susane Patrícia Melo de Lima

Published
2018
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8. 1-Substituted β-Carbolines by a Pictet—Spengler Cyclization with Thioortho Esters and Carbon—Carbon Bond Formation via N-Sulfonyl Iminium Ions Generated from N,S-Sulfonyl Acetals

Author

Antonio L. Braga, Luciana A. Felix, Teodoro S. Kaufman, and Claudio C. Silveira

Subjects
Sulfonyl, chemistry.chemical_classification, chemistry, Silylation, Carbon–carbon bond, Reagent, Iminium, Organic chemistry, General Medicine, Lewis acids and bases, Ion
Abstract

The reaction of N-tosyltryptamines with thioortho esters, leading to 1-thiosubstituted tetrahydro-β-carbolines under modified Pictet−Spengler conditions, is described. The 1-heterosubstituted β-carbolines furnished 1-substituted β-carbolines upon reaction with Grignard reagents and silyl derivatives under Lewis acid promotion.

Published
2006
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9. Stereoselective Suzuki—Miyaura Cross-Coupling Reactions of Potassium Alkenyltrifluoroborates with Alkenyl Bromides

Author

Luciana A. Felix and Gary A. Molander and

Subjects
Stereochemistry, Chemistry, Potassium, Organic Chemistry, Cross reactions, chemistry.chemical_element, Stereoisomerism, General Medicine, Alkenes, Conjugated system, Bromine, Medicinal chemistry, Catalysis, Coupling reaction, Chemical coupling, Borates, Stereoselectivity
Abstract

[reaction: see text] The stereoselective synthesis of conjugated dienes using air-stable potassium alkenyltrifluoroborates as coupling partners is described. The palladium-catalyzed cross-coupling reaction of potassium (E)- and (Z)-alkenyltrifluoroborates with either (E)- or (Z)-alkenyl bromides proceeds readily with moderate to excellent yields to give the corresponding (E,E)-, (E,Z)-, (Z,E)-, or (Z,Z)-conjugated dienes stereospecifically. The cross-coupling can generally be effected using 5 mol % of Pd(OAc)2, 10 mol % of PPh3, and 3 equiv of Cs2CO3 in THF-H2O (10:1). A variety of functional groups are tolerated in both coupling partners.

Published
2005
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