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OBJECTIVES/GOALS: Electronic cigarettes have become increasingly popular, with various combustion products generated in the process. Dihydroxyacetone (DHA), a carbohydrate made during the heating process. Exposures may reach high micromolar to low millimolar doses of DHA per day and no studies have been done to understand the effects of DHA in the heart. METHODS/STUDY POPULATION: Here, we examine if DHA contributes to these using rat cardiomyocytes, H9c2 cells, and rat cardiac tissues to DHA evaluating metabolic and mitochondrial effects. Using the cells, we will investigate metabolic and mitochondrial pathways using Seahorse, protein expression changes in nutrient sensing pathways, and understand dose-dependent effects of DHA in the heart. Metabolite pools will also be evaluated to understand the changes promoted by DHA. Oxidative stress as previously observed in other cell models will also be measured. Key findings in the cardiac cells will be investigated in the cardiac tissues exposed to DHA. RESULTS/ANTICIPATED RESULTS: We have previously shown DHA induces oxidative stress, metabolic changes, and mitochondrial dysfunction in various cell line models. Interestingly, these effects are highly cell-type dependent. E-cigarettes are known to have toxic cardiac effects, including arterial stiffness, endothelial dysfunction, vascular injury, and oxidative stress. Changes in glycolytic, fatty acid synthesis, and the citric acid cycle enzymes and metabolites were found in the H9c2 cells. We also observed increased mitochondrial ROS and fuel changes due to DHA exposure. In DHA exposed cardiac tissues, we observed oxidative stress and mitochondrial fission and fusion dynamics altered. DISCUSSION/SIGNIFICANCE: These data suggest further study at physiologically relevant doses is warranted to understand how DHA inhaled impacts the long-term health of vapers. As well as the regulation of DHA in e-cigarettes as it has been deemed as safe for topical applications and warned against inhalation.

The data on the growth of prices for Arctic fish species in 2015, 2018, compared to 2013, the period of the relatively “hard” ruble, are presented. The reasons for the price increase are shown. An important one is the replacement of the “historical” method of providing biological resources to fishermen with the “auction” one, since it is associated with payment for the right to harvest. This leads to an increase in production costs and prices for fish products, as well as to a decrease in fish consumption by the popula-tion. Objectives of the article: to develop proposals to increase the supply of products from Arctic fish to Russian markets (primarily to the markets of the North-West of the country) and to reduce their prices. The relevance of the article is due to the lack of practical measures to reduce the prices of Arctic fish products and increase consumption. The most important results: the author's proposals to stimulate increased sales of fish products in Russia provided by the fish products of the Northern basin are substantiated. Practical significance: it is shown that the use of the developed proposals will reduce consumer prices for fish products, an increase in visits of fishing vessels to Arctic ports and unloading of fish products will lead to a multiplier effect by improving the activities of fish processing enterprises and servicing the fishing fleet.

Abstract In this study we map the dualities observed in the framework of integrable probabilities into the dualities familiar in a realm of integrable many-body systems. The dualities between the pairs of stochastic processes involve one representative from Macdonald-Schur family, while the second representative is from stochastic higher spin six-vertex model of TASEP family. We argue that these dualities are counterparts and generalizations of the familiar quantum-quantum (QQ) dualities between pairs of integrable systems. One integrable system from QQ dual pair belongs to the family of inhomogeneous XXZ spin chains, while the second to the Calogero-Moser-Ruijsenaars-Schneider (CM-RS) family. The wave functions of the Hamiltonian system from CM-RS family are known to be related to solutions to (q)KZ equations at the inhomogeneous spin chain side. When the wave function gets substituted by the measure, bilinear in wave functions, a similar correspondence holds true. As an example, we have elaborated in some details a new duality between the discrete-time inhomogeneous multispecies TASEP model on the circle and the quantum Goldfish model from the RS family. We present the precise map of the inhomogeneous multispecies TASEP and 5-vertex model to the trigonometric and rational Goldfish models respectively, where the TASEP local jump rates get identified as the coordinates in the Goldfish model. Some comments concerning the relation of dualities in the stochastic processes with the dualities in SUSY gauge models with surface operators included are made.

The authors present the volume of Atlantic salmon farming in the world and in the Russian Arctic. It shows the reasons that hamper the development of salmonid mariculture in the Russian Arctic: the lack of own planting material adapted to Arctic waters, high-quality fodder, fish diseases and others. Objectives of the article: to show the peculiarities of natural and socio-economic conditions of mariculture development in the Russian Arctic and the impact of Atlantic salmon mariculture on import substitution. Relevance stems from the need to substantiate the sources of import substitution of salmon products. The most important results: the main factors that reduce the economic efficiency of growing and selling products were found; the possible causes of salmon diseases in the Russian Arctic and their impact on production processes were systematized, the possible impact of caged fish farming on the environment and on the population of salmon in the Arctic zone was shown. Practical significance: the article shows the influence of possible escapes of farmed salmon on the socio-economic conditions of the population of the Terskiy coast of the Murmansk region and the White Sea basin. It is proposed to introduce Atlantic GM salmon into the composition of genetically modified products. It is shown that import substitution is fully provided by Atlantic salmon mariculture and the supply of wild salmon from the Far East to the European part of Russia.

Increase in the number of acute and chronic diseases is a global trend. On the one hand, the emergence of new types of viruses, their active mutation, an increase in antibiotic-resistant bacterial strains, a high frequency of immunodeficiency and allergic diseases contribute to this. On the other hand is inadequate treatment of inflammatory diseases of the upper respiratory tract, widespread use of systemic antibiotics without indications. The use of bioregulatory medicines with proven efficacy in the complex treatment can reduce the drug load on the body, reduce the bacterial complications and side effects. Traumeel®S joins the physiological course of inflammation and activates pro-resolving mediators, contributes to its faster completion and tissue repair. The efficacy and safety of Traumeel®S has been confirmed in many randomized clinical trials. The drug has proven its value in almost any inflammatory pathology of the upper respiratory tract and ear. The drug Lymphomyosot®, a multicomponent agent with lymphatic drainage action, has proven itself perfectly in the complex therapy of chronic tonsillitis. In November 2019, the Council of Experts of the National Medical Association of Otorhinolaryngologists on the problems of pathology of the lympharyngeal ring was held. It is recommended to use the multicomponent bioregulatory preparation Traumeel®S to correct the inflammatory process, which has shown in studies a modulating effect on inflammatory mediators without suppressing COX-2 (prostaglandins). With exacerbation of chronic tonsillitis and lymphadenitis of nonspecific etiology, it is possible to use the multicomponent preparation Lymphomyosot®, which helps to improve the drainage and detoxification function of the lymphatic system.

Purpose: scientific and technical basis of the technology of applying mineral fertilizers against the background of precision irrigation during winter wheat cultivation in the south of Russia. Materials and methods. For assessing the precision irrigation technology efficiency in 2019, a two-factor field experiment was carried out at the fields of Biryuchekutskaya vegetable selection experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal Vegetable Research Center” using the example of winter wheat. The influence of different mineral fertilizers availability at different irrigation technologies on winter wheat productivity was studied. Results. The following technical characteristics have been determined: yield, total water consumption, irrigation rate and water balance coefficients for the options of the experiment. On the basis of technical characteristics, empirical dependences of winter wheat productivity on the applied fertilizers total doses used by zonal farming systems and with precision irrigation, as well as the empirical dependence of the dynamics of potato productivity on the sum of the mineral fertilizers rate of application and water consumption during precision irrigation, described by the surface equation, were revealed. The specified yield increase due to fertilizers in variants with precision fertilization (A2B3 and A3B3) was 6.2 and 6.7 t/ha (or 94.4 and 124.1 %), which is 1.2 and 1.5 t/ha higher in comparison with the recommended climatic cropping pattern (CCP) (A2B2 and A3B2), respectively. Water consumption of winter wheat in variants without irrigation (A1B1, A1B2, A1B3) ranged from 3371 to 3525 m³/ha, and in variants with the technology recommended by CCP (A2B1, A2B2 and A2B3), varied from 5702 to 6162 m³/ha and varied from 5639 to 6066 m³/ha in variants of the experiment with precision irrigation (A3B1, A3B2 and A3B3). Conclusions. The analysis of the results of field studies made it possible to conclude that the technology of precision application of mineral fertilizers against the background of precision irrigation has shown high efficiency.

Purpose: to analyze domestic and foreign experience in the application of systems or individual elements of precision irrigation. The analysis of literary sources, scientific and technical information on the development and use in agricultural production of technical and technological means for precision irrigation technology, including the work of foreign researchers is presented. As a result of the work carried out, it was found that most authors agree that the use of precision farming is impossible without the development of methods for remote sensing of the agricultural complex, improving the quality of spectral survey. Conclusions. Against the background of the analysis and consideration of the work of various researchers, it is concluded that the complex of technical and technological means (solutions) of sprinkling equipment for precision irrigation proposed by the staff of the Russian Scientific Research Institute of Land Improvement Problems is an advanced development and can be used as part of modern sprinkler machines. The essence of the development is as follows: the obtained data of remote sensing, the object of which is the moisture content of plants by field segments and the data on the positioning of the sprinkler on the field allow the processor installed on the machine to process the data and implement precision irrigation technology, in which the dosed volume of water is supplied for each field segment with the calculation of soil moisture levelling throughout the field at each irrigation.

This paper presents the past, present and future status of the Russian VLBI network “Quasar”. This network has been developed for at least 20 years by the Institute of Applied Astronomy of the Russian Academy of Sciences (IAA RAS). The equipment installed currently at each “Quasar” station and the facilities for processing observational data are described briefly. The latest results are presented, including the Earth orientation parameters (EOP) determined from the “Quasar” VLBI data and comparison with those from other processing centers. Our future plans to extend the “Quasar” VLBI network to the east and to the west will be carried out by establishing the Ussurijsk station in the Far East and the Russian-Cuban station in the west. They are considered in the context of the Russian section activity in the GGOS project. The expected improvement of the EOP determination accuracy can be obtained within the future configuration of the “Quasar” network, which is proved by simulation. Keywords: Russian VLBI network “Quasar”, VLBI co-location station, Space geodesy technique, Global Geodetic Observing System (GGOS)

Purpose: to study the influence of the water head in the upstream and the backwater on the part of the downstream on the seasonal storage dam, built in a mountainous area. Materials and methods: complex geological conditions of anchoring a responsible in terms of safety structure in a mountainous area prompted us to a more detailed study of the issue of its stress-strain state with the ability to offer designers in detail the limits of possible changes in the parameters of the displacement of the seasonal storage dam foundation. The need for the dam construction in the mountainous area is due to several factors. First of all, it is a fundamental need to accumulate water on the Black Sea coast of the North Caucasus, where there is an ever-increasing deficit both for the needs of agricultural producers and for public water supply, while in the autumn-winter period, precipitation falls in the region even in abundance, as it is evidenced by flood control costs. Secondly, the mountainous relief and their gorges is the nature-created volume for water accumulation. Thirdly, the lands of mountain gorges are the most unsuitable for agricultural use lands, in contrast to the lands of the valleys, where reservoirs are currently located. Results: the study of the influence of the water head in the upstream and the backwater from the downstream on the dam was carried out using numerical modeling using the Midas and Maxima software products, which made it possible to cover the entire range of actions necessary for solving such problems. Conclusions: it was found that in the range of backwater changes in the headwater of the dam from 0.6 to 2.8 m, displacements at the dam foundation have extreme values at constant values of the head at the dam of 1.0; 5.0 and 10.0 m. In general, the largest displacement values at the dam foundation are observed at the highest head of the dam in the upstream, equal to 10.0 m.

We establish a remarkable relationship between the quantum Gaudin models with boundary and the classical many-body integrable systems of Calogero-Moser type associated with the root systems of classical Lie algebras (B, C and D). We show that under identification of spectra of the Gaudin Hamiltonians HjG with particles velocities q˙j of the classical model all integrals of motion of the latter take zero values. This is the generalization of the quantum-classical duality observed earlier for Gaudin models with periodic boundary conditions and Calogero-Moser models associated with the root system of the type A.

The aim of the study was to determine the effectiveness of groundwater treatment through filter-sorption loading by choosing the optimal ratio of its components and loading height. Material and Methods: the rounded (natural) quartz sand with a particle size of 0.8–2.0 mm and activated carbon on a coal-mining basis with a particle size of 1.5–2.8 mm was used as components of the filter-sorption loading in the given studies. During the research various ratios of these components with different loading heights were used. Results: the existence of a functional relationship between several filtration loading components ratio options and its height is determined during the experimental data analysis. The obtained experimental dependences show at what filter load and loading height the process of groundwater treatment was most effective. At a maximum loading height of 0.8 m, the water treatment efficiency increases to 99 %, but the filtering speed decreases to 0.7 m/h. Conclusion: there is a decrease in the iron concentration from 0.64 to 0.18 milligrams per cubic decimeter, manganese from 2.25 to 0.38 milligrams per cubic decimeter, stiffness from 22.6 to 18.2 °dH and suspended solids from 1.2 to 1.1 milligrams per cubic decimeter in relation to the source groundwater, with all variants of the filter loading ratio. This justifies the effectiveness of the developed filter-sorption loading. As a result of the studies the high purification efficiency was observed at a loading ratio of 3:1. The decrease in iron concentration reached 72 %, manganese – 86 %, hardness – 30 %, suspended solids – 10 %. Laboratory experiments have shown that a decrease in the amount of iron, manganese and suspended solids in water depends on the filter loading height and the filtration rate. Thus, the best option is a loading height of 0.5 to 0.7 m with a filtration rate of 3.7 to 2.4 m per h with a ratio of 3:1.

The current situation in the world draws public attention to the problems of building the armed forces and keeping their readiness to provide defense and security of the country. Rigid centralization of military construction in such collective bodies as the State Defense Committee, the General Headquarters of the Supreme Commander, determination and meticulous work of folk commissioners and the General Staff to identify areas of building and resource mobilization for the implementation of decisions taken can serve as a guide for solving similar problems in our days. Balanced development of the armed forces, technical equipment of modern weapons, timely replacement of losses, creation and transfer of reserves, training in a rigid time limit - it is not a complete list of the problems of military development, which made the success and victory in the war possible. On the eve of the 70th anniversary of the Soviet victory in this war it is not only important not to forget about the titanic work done, dedication and heroism of the older generation of our compatriots, the generation of victors, but also to reflect on the acute problems of the present, in order to be worthy of the glory of our ancestors and preserve their honor to future generations of Russians.

The current situation in the world draws public attention to the problems of building the armed forces and keeping their readiness to provide defense and security of the country. Rigid centralization of military construction in such collective bodies as the State Defense Committee, the General Headquarters of the Supreme Commander, determination and meticulous work of folk commissioners and the General Staff to identify areas of building and resource mobilization for the implementation of decisions taken can serve as a guide for solving similar problems in our days. Balanced development of the armed forces, technical equipment of modern weapons, timely replacement of losses, creation and transfer of reserves, training in a rigid time limit - it is not a complete list of the problems of military development, which made the success and victory in the war possible. On the eve of the 70th anniversary of the Soviet victory in this war it is not only important not to forget about the titanic work done, dedication and heroism of the older generation of our compatriots, the generation of victors, but also to reflect on the acute problems of the present, in order to be worthy of the glory of our ancestors and preserve their honor to future generations of Russians.

Ukraine is the largest consumer of hydrocarbons per unit of production in Europe (Ukraine policy review, 2006). The most important point is a reduction of energy consumption in chemical and metallurgical industries as a biggest consumer. This paper deals with energy savings potential of light hydrocarbons separation process. Energy consumption of light hydrocarbons separation process processes typical of Eastern European countries were analysed. Process Integration (PI) was used to perform a preliminary analysis of different units and fulfil the retrofit project of Total Site Integration (TSI). A new heat exchanger network (HEN) were developed and the equipment was calculated with use of the Pinch principles. A complex method was developed and applied to integrate several units at the enterprise site demonstrating the possibility to use heat pumps. Heat pump integration increases heat recovery and offers a solution in order to increase energy savings and project profitability. The heat transfer area and number of heat exchangers for a retrofitted heat exchanger network have been identified. The estimated payback period for integration Heat Pump of Gas Separation Enterprise is about 127 days and the pathways of plant modernization have been also proposed.

The process of benzene distillation and process of coal tar distillation being typical for East European countries is analyzed in this paper. The pinch analysis method was selected to perform a reconstruction project. According to principles of pinch analysis, new network diagrams are designed and capacity of heat-exchange equipment is calculated. The using of «Total Site Profiles» showed the feasibility of heat pump integration. Heat pump integration allowed to reduce the external hot utilities usage on 368 kW and cold utilities usage on 368 kW. This project let to decrease the external hot utilities usage on 23 % and cold utilities usage on 24,13 %, and also offered the way of step-by-step retrofit of the plant.

The purpose of the article is to show the necessity of reducing wholesale domestic prices for Arctic fish and to propose economic methods for solving this problem. The relevance is associated with an un-reasonable increase in wholesale prices, which are the basis of retail prices, resulting in a decrease in the consumption of local fish. The increase in wholesale prices of fisheries in 2014-2015 and in the subsequent period is analyzed. The fundamentals of the world doctrines of cost and value are given, and the absence of factors to justify the increase in wholesale prices on the basis of the labor theory of value is shown. The data on the unreasonably close relationship between wholesale prices for fish in the domestic market of Russia and the exchange prices at which fish products exported to the European Union countries are presented. The possibility of reducing wholesale domestic prices by increasing the supply of fish to the domestic market of Russia in order to achieve the threshold values of the figures indicated in the Doctrine of Food Security is shown. In order to replace exchange foreign prices used in the domestic market of Russia, the need to develop a methodology for determining wholesale prices for the main types of Arctic fish, primarily currency-intensive ones, is substantiated.

Chamber exposures are commonly used to evaluate the physiological and pathophysiological consequences of intermittent hypoxia in animal models. Researchers in this field use both commercial and custom-built chambers in their experiments. The purpose of this Cores of Reproducibility in Physiology paper is to demonstrate potential sources of variability in these systems that researchers should consider. Evaluating the relationship between arterial oxygen saturation and inspired oxygen concentration, we found that there are important sex-dependent differences in the commonly used C57BL6/J mouse model. The time delay of the oxygen sensor that provides feedback to the system during the ramp-down and ramp-up phases was different, limiting the number of cycles per hour that can be conducted and the overall stability of the oxygen concentration. The time to reach the hypoxic and normoxic hold stages, and the overall oxygen concentration, were impacted by the cycle number. These variables were further impacted by whether there are animals present in the chamber, highlighting the importance of verifying the cycling frequency with animals in the chamber. At ≤14 cycles/h, instability in the chamber oxygen concentration did not impact arterial oxygen saturation but may be important at higher cycle numbers. Taken together, these data demonstrate the important sources of variability that justify reporting and verifying the target oxygen concentration, cycling frequency, and arterial oxygen concentration, particularly when comparing different animal models and chamber configurations. NEW & NOTEWORTHY Intermittent hypoxia exposures are commonly used in physiology and many investigators use chamber systems to perform these studies. Because of the variety of chamber systems and protocols used, it is important to understand the sources of variability in intermittent hypoxia experiments that can impact reproducibility. We demonstrate sources of variability that come from the animal model, the intermittent hypoxia protocol, and the chamber system that can impact reproducibility.

We discuss the design, fabrication, and characterization of silicon-nitride microring resonators for nonlinear-photonic and biosensing device applications. The first part presents new theoretical and experimental results that overcome highly normal dispersion of silicon-nitride microresonators by adding a dispersive coupler. The latter parts review our work on highly efficient second-order nonlinear interaction in a hybrid silicon-nitride slot waveguide with nonlinear polymer cladding and silicon-nitride microring application as a biosensor for human stress indicator neuropeptide Y at the nanomolar level.

This review article considers the latest developments in the field of inorganic scintillation materials. Modern trends in the improvement of inorganic scintillation materials are based on engineering their features at the nanoscale level. The essential challenges to the fundamental steps of the technology of inorganic glass, glass ceramics, and ceramic scintillation materials are discussed. The advantage of co-precipitation over the solid-state synthesis of the raw material compositions, particularly those which include high vapor components is described. Methods to improve the scintillation parameters of the glass to the level of single crystals are considered. The move to crystalline systems with the compositional disorder to improve their scintillation properties is justified both theoretically and practically. A benefit of the implementation of the discussed matters into the technology of well-known glass and crystalline scintillation materials is demonstrated.

The mitochondria play a vital role in controlling cell metabolism and regulating crucial cellular outcomes. We previously demonstrated that chronic inhibition of the mitochondrial complex III in rats by Antimycin A (AA) induced sustained pulmonary vasoconstriction. On the metabolic level, AA-induced mitochondrial dysfunction resulted in a glycolytic shift that was reported as the primary contributor to pulmonary hypertension pathogenesis. However, the regulatory proteins driving this metabolic shift with complex III inhibition are yet to be explored. Therefore, to delineate the mechanisms, we followed changes in the rat lung mitochondrial proteome throughout AA treatment. Rats treated with AA for up to 24 days showed a disturbed mitochondrial proteome with significant changes in 28 proteins ( p < 0.05). We observed a time-dependent decrease in the expression of key proteins that regulate fatty acid oxidation, the tricarboxylic acid cycle, the electron transport chain, and amino acid metabolism, indicating a correlation with diminished mitochondrial function. We also found a significant dysregulation in proteins that controls the protein import machinery and the clearance and detoxification of oxidatively damaged peptides via proteolysis and mitophagy. This could potentially lead to the onset of mitochondrial toxicity due to misfolded protein stress. We propose that chronic inhibition of mitochondrial complex III attenuates mitochondrial function by disruption of the global mitochondrial metabolism. This potentially aggravates cellular proliferation by initiating a glycolytic switch and thereby leads to pulmonary hypertension.