14 results on '"M. Cangelosi"'
Search Results
2. LB01 SIX WEEKS OF SOFOSBUVIR/LEDIPASVIR TREATMENT OF ACUTE HEPATITIS C VIRUS GENOTYPE 1 MONOINFECTION: FINAL RESULTS OF THE THE GERMAN HEPNET ACUTE HCV IV STUDY
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K. Deterding, C.D. Spinner, E. Schott, T.M. Welzel, G. Gerken, H. Klinker, U. Spengler, J. Wiegand, J. Schulze zur Wiesch, A. Pathil, M. Cornberg, A. Umgelter, C. Zöllner, S. Zeuzem, A. Papkalla, K. Weber, S. Hardtke, H. Leyen, A. Koch, D. Witzendorff, M. Manns, H. Wedemeyer, C.M. Preda, C.P. Popescu, C. Baicus, M. Manuc, R. Voiosu, E. Ceausu, L. Fulger, A. Nisanian, C.S. Pop, A. Oproiu, A. Arezzo, R. Passera, A. Bullano, Y. Mintz, A. KEDAR, L. Boni, E. Cassinotti, R. Rosati, U. Fumagalli, M. Sorrentino, M. Brizzolari, N. Di Lorenzo, A.L. Gaspari, D. Andreone, E. De Stefani, G. Navarra, S. Lazzara, M. Degiuli, K. Shishin, I. Khatkov, I. Kazakov, R. Schrittwieser, T. Carus, A. Corradi, G. Sitzman, A. Lacy, S. Uranues, A. Szold, M.A. Bonino, M. Morino, J. Strömberg, G. Sandblom, R. Coelen, M. Gaspersz, T. Labeur, J. Vugt, S. Dieren, F. Willemssen, C.Y. Nio, J. IJzermans, H.‐J. Klümpen, B. Groot Koerkamp, T. Gulik, R. Sturgess, D. Palmer, J. Trojan, A. Hoffmeister, B. Neu, S. Kasper, A. Dechêne, C. Jürgensen, J. Schirra, R. Jakobs, A. Høgset, L. Finnesand, A.E. Abd Elrazek, S. Saab, T. Salem, M. Abdel‐Aty, B. Hawary, A. Ismail, M. Zayied, M. Alboraie, R. Orenstein, E. Dubberke, C.H. Lee, S. Khanna, G. Hecht, S. Wong, T. Kwong, X. Wang, R.S.Y. Tang, S.C. Ng, J.J.Y. Sung, J. Yu, S. Ott, G.H. Waetzig, A. Rehmann, J. Moltzau‐Anderson, R. Bharti, J.A. Grasis, L. Cassidy, A. Tholey, H. Fickenscher, D. Seegert, P. Rosenstiel, S. Schreiber, T. Mazzawi, G.A. Lied, M. El‐Salhy, O.H. Gilja, J.G. Hatlebakk, T. Hausken, S.T. Witt, O. Bednarska, A. Icenhour, S. Elsenbruch, M. Ström, J.D. Söderholm, M. Engström, E.A. Mayer, Å. Keita, S. Walter, P.K. Kump, P. Wurm, H.P. Gröchenig, H.H. Wenzl, W. Petritsch, B. Halwachs, M. Wagner, V. Stadlbauer‐Köllner, A.J. Eherer, K.M. Hoffmann, A. Deutschmann, G. Reicht, L. Reiter, P. Slawitsch, G. Gorkiewicz, C. Hoegenauer, Y. Zhou, R. Kakuturu, D. Jung, K.K. Jørgensen, I.C. Olsen, G.L. Goll, M. Lorentzen, N. Bolstad, E.A. Haavardsholm, K.E. Lundin, C. Mørk, J. Jahnsen, T.K. Kvien, B.G. Feagan, B.E. Sands, G. Rossiter, X. Li, K. Usiskin, X. Zhan, J.‐F. Colombel, W.J. Sandborn, J. Panés, M. Ferrante, E. Louis, G. D'Haens, D. Franchimont, A. Kaser, O. Dewit, U. Seidler, K.‐J. Kim, M.F. Neurath, P. Scholl, S. Visvanathan, S.J. Padula, I. Herichova, N. Sha, D. Hall, W.O. Böcher, F. Bloemendaal, A. Levin, M. Wildenberg, P. Koelink, S. Verbeek, J. Claassens, B. Mcrae, G. Vidarsson, G.R. Brink, M. Badke, S. Rose‐John, M.E. Spehlmann, L. Peyrin‐Biroulet, J. Gatlin, M. Soloman, D. Unett, H. Al‐Shamma, D. Behan, J. Langhorst, J. Boone, A. Rueffer, G. Dobos, K. Beiderwellen, T. Lauenstein, W.S. Ngu, R. Bevan, Z.P. Tsiamoulos, P. Bassett, Z. Hoare, M. Rutter, N. Totton, T.J. Lee, A.V. Ramadas, J. Silcock, J. Painter, L.J. Neilson, B.P. Saunders, C.J. Rees, A. Schmidt, S. Goelder, H. Messmann, M. Goetz, T. Kratt, A. Meining, M. Birk, J. Delius, M. Albert, J.Y.W. Escher, A. Lau, R. Hoffman, K. Wiest, null Caca, A. Siddiqui, D. Wilson, M. Cangelosi, R. Rameshshanker, P. Wall, K. Cocks, T. Doulton, A. Yusuf, C. Hancock, R. Valori, A. Aravani, J. Rashbass, S. Vernon, E.J.A. Morris, J.H. ‐Choi, D.‐W. Seo, T.J. Song, D.H. Park, S.S. Lee, S.K. Lee, ‐H. Kim, P. Somani, and M. Sharma
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0301 basic medicine ,Ledipasvir ,Sofosbuvir ,business.industry ,Gastroenterology ,Virology ,Virus ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,Oncology ,chemistry ,Genotype ,Medicine ,030211 gastroenterology & hepatology ,Acute hepatitis C ,business ,medicine.drug - Published
- 2016
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3. PSU23 TRENDS IN ENDOBRONCHIAL ULTRASOUND AND MEDIASTINOSCOPY FOR SAMPLE ACQUISITION OF THORACIC LYMPH NODES IN LUNG CANCER AMONG A COMMERCIAL POPULATION
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G. Cramer, M. Cangelosi, S. Lee, and M. Wahidi
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medicine.medical_specialty ,Thoracic lymph node ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Health Policy ,Population ,Public Health, Environmental and Occupational Health ,Sample (statistics) ,medicine.disease ,Mediastinoscopy ,medicine ,Radiology ,Endobronchial ultrasound ,Lung cancer ,business ,education - Published
- 2020
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4. 10. Lead(II) Binding in Natural and Artificial Proteins
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Leela Ruckthong, Virginia M. Cangelosi, and Vincent L. Pecoraro
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chemistry.chemical_classification ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Biomolecule ,Protein design ,Trigonal pyramidal molecular geometry ,Nuclear magnetic resonance spectroscopy ,010501 environmental sciences ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Protein structure ,Homoleptic ,Binding site ,0105 earth and related environmental sciences ,Cysteine - Abstract
This article describes recent attempts to understand the biological chemistry of lead using a synthetic biology approach. Lead binds to a variety of different biomolecules ranging from enzymes to regulatory and signaling proteins to bone matrix. We have focused on the interactions of this element in thiolate-rich sites that are found in metalloregulatory proteins such as Pbr, Znt, and CadC and in enzymes such as δ-aminolevulinic acid dehydratase (ALAD). In these proteins, Pb(II) is often found as a homoleptic and hemidirectic Pb(II)(SR)3- complex. Using first principles of biophysics, we have developed relatively short peptides that can associate into three-stranded coiled coils (3SCCs), in which a cysteine group is incorporated into the hydrophobic core to generate a (cysteine)3 binding site. We describe how lead may be sequestered into these sites, the characteristic spectral features may be observed for such systems and we provide crystallographic insight on metal binding. The Pb(II)(SR)3- that is revealed within these α-helical assemblies forms a trigonal pyramidal structure (having an endo orientation) with distinct conformations than are also found in natural proteins (having an exo conformation). This structural insight, combined with 207Pb NMR spectroscopy, suggests that while Pb(II) prefers hemidirected Pb(II)(SR)3- scaffolds regardless of the protein fold, the way this is achieved within α-helical systems is different than in β-sheet or loop regions of proteins. These interactions between metal coordination preference and protein structural preference undoubtedly are exploited in natural systems to allow for protein conformation changes that define function. Thus, using a design approach that separates the numerous factors that lead to stable natural proteins allows us to extract fundamental concepts on how metals behave in biological systems.
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- 2017
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5. Protein Design: Toward Functional Metalloenzymes
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Vincent L. Pecoraro, Hira Qayyum, Virginia M. Cangelosi, Alison G. Tebo, Jefferson S. Plegaria, Melissa L. Zastrow, Catherine S. Mocny, Matteo Tegoni, Leela Ruckthong, and Fangting Yu
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Adenosine Deaminase ,Chemistry ,Protein design ,Zinc Fingers ,DNA ,Heme ,General Chemistry ,Alkenes ,Protein Engineering ,Article ,Protein Structure, Tertiary ,Biochemistry ,Metals, Heavy ,Metalloproteins ,Animals ,Protein Binding - Published
- 2014
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6. A de novo designed metalloenzyme for the hydration of CO2
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Virginia M. Cangelosi, Vincent L. Pecoraro, James E. Penner-Hahn, and Aniruddha Deb
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chemistry.chemical_classification ,Models, Molecular ,Binding Sites ,biology ,Protein design ,General Chemistry ,General Medicine ,Carbon Dioxide ,Combinatorial chemistry ,Small molecule ,Catalysis ,Article ,Structure-Activity Relationship ,Enzyme ,chemistry ,Biochemistry ,Carbonic anhydrase ,Metalloproteins ,Metalloprotein ,biology.protein ,Structure–activity relationship ,Binding site ,Carbonic Anhydrases - Abstract
Protein design will ultimately allow for the creation of artificial enzymes with novel functions and unprecedented stability. To test our current mastery of nature's approach to catalysis, a Zn(II) metalloenzyme was prepared using de novo design. α3DH3 folds into a stable single-stranded three-helix bundle and binds Zn(II) with high affinity using His3 O coordination. The resulting metalloenzyme catalyzes the hydration of CO2 better than any small molecule model of carbonic anhydrase and with an efficiency within 1400-fold of the fastest carbonic anhydrase isoform, CAII, and 11-fold of CAIII.
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- 2014
7. Socioeconomic status, linguistic skills and language background differentially relate to preschoolers' emotional and behavioural profile.
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Bonifacci P, Ravaldini V, Cangelosi M, and Tobia V
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Background: Proximal and distal factors interact to shape children's development and well-being. The present study aimed to examine socioeconomic status (SES), linguistic skills, and language background as concurrent predictors of socio-emotional and behavioural outcomes in heritage bilingual and monolingual children attending preschool., Methods: Parents of 1810 children (mean age = 63.42 months ± 7.36), attending preschool in Italy, completed the Four Factor Index of SES and the Strengths and Difficulties Questionnaire (SDQ). Teachers (n = 99) completed a questionnaire on children's linguistic skills and emotional and behavioural profiles. A subsample of 995 children was administered an expressive vocabulary task in Italian., Results: Regression analyses showed that linguistic skills were the only concurrent predictor of conduct problems, as well as the dominant predictor of hyperactivity/impulsivity, peer problems, and better prosocial behaviour. SES was negatively related to ADHD traits, peer problems, and prosocial behaviour. Finally, heritage bilingualism background was associated, although not as a primary predictor, with increased emotional problems, peer relationship problems, and lower teacher-rated emotional and behavioural skills. However, it was the main factor positively associated with prosocial behaviour., Conclusions: The implications of these findings for research in this area and for educational policy are discussed, highlighting the need for a multidimensional perspective that includes linguistic skills and SES in the assessment of children's emotional and behavioural outcomes., (© 2024. The Author(s).)
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- 2024
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8. Parents' and Children's Emotional Well-Being and Language Beliefs in Heritage Bilingual Families.
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Bonifacci P, Borghetti C, and Cangelosi M
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The present study aimed to examine how parents' psychological characteristics and positive beliefs about multilingualism predict children's emotional well-being in 51 multilingual families with an immigrant background. Parents were interviewed to assess their beliefs about multilingualism and completed a battery of questionnaires assessing depression, anxiety, psychological distress, parental competence, quality of life, and acculturative stress. They also completed the Strengths and Difficulties Questionnaire (SDQ), which assessed their children's socio-emotional and behavioral characteristics. The results from regression analyses showed that parents' depressive symptoms were significant concurrent predictors of children's conduct problems. In contrast, higher acculturation stress was associated with more emotional problems and better prosociality in children, although the stronger predictor for the latter variable was parents' self-efficacy. Positive beliefs about bilingualism were not related to children's well-being. The discussion highlights the importance of targeting parents' depressive traits and acculturation stress as possible risk factors for children's emotional and behavioral problems. Conversely, fostering parental self-efficacy may promote children's prosociality.
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- 2024
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9. Development of a Telehealth Simulation Using Intraprofessional Collaboration.
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Rumsey K, Joy S, More D, Cangelosi M, Feng J, and Touw M
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Abstract: Telehealth allows access to high-quality, holistic patient care, including diagnosis, interventions, treatments, monitoring, and patient education. As the use of telehealth continues to increase, faculty considered the need for entry-level nursing students to be introduced to telehealth and its services. Faculty from the medical-surgical II and mental health courses developed a learning experience for students that blends concepts from both courses, as patients often present with multiple problems. The telehealth experience helped students utilize assessment skills, learn delegation, and connect concepts from two courses to provide care for a patient remotely., Competing Interests: The authors have declared no conflict of interest., (Copyright © 2024 National League for Nursing.)
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- 2024
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10. Evolving Use of Health Technology Assessment in Medical Device Procurement-Global Systematic Review: An ISPOR Special Interest Group Report.
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Cangelosi M, Chahar A, and Eggington S
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- Humans, Delivery of Health Care, Hospitals, Technology Assessment, Biomedical, Public Opinion
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Objectives: To review the current academic evidence describing how data from health technology assessments (HTAs) informs procurement decisions for medical devices., Methods: A systematic literature review was performed to identify relevant studies and criteria used in medical device purchasing or procurement decisions. Included articles were screened for relevancy and risk of bias. The included studies were summarized qualitatively., Results: A total of 292 studies were screened, of which 11 matched the inclusion criteria. Included studies' geographies and HTA maturity varied. Some studies described hospital-level HTA processes, whereas others focused on national-level recommendations. Criteria for procurement decisions included standard HTA factors, such as efficacy, cost, cost-effectiveness, and budget impact; broader issues were also noted, including impact on the organization, ethical aspects, staff workload, and volume. There was little consideration of device-specific characteristics, such as life cycle, learning curve, or incremental technical innovation. Few decisions referred to HTA reports as part of the procurement decision; similarly, few HTA reports included a procurement perspective to help guide the procurement bodies., Conclusions: There is minimal evidence that notes HTA influencing medical device procurement. Procurement bodies and hospitals may not be incentivized to publish their work and transparency could be improved; further research would better describe the link between HTA and procurement. Such research would enable the HTA agencies to meaningfully assess devices to target procurement bodies and allow device sponsors to prioritize evidence. This could limit redundancy, improve evidence, and ultimately promote savings to healthcare systems and expand access., (Copyright © 2023. Published by Elsevier Inc.)
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- 2023
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11. Role of Whole-Body MR with DWIBS in child's Bartonellosis.
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Rossi E, Perrone A, Narese D, Cangelosi M, Sollai S, Semeraro A, Mortilla M, and Defilippi C
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- Animals, Bartonella henselae, Cats, Child, Humans, Male, Bartonella Infections diagnostic imaging, Cat-Scratch Disease diagnostic imaging, Diffusion Magnetic Resonance Imaging methods, Whole Body Imaging methods
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Cat-scratch disease (CSD) is a zoonosis in children, result of infection by Bartonella henselae, a gram-negative bacillus. Infection is generally characterized by regional and self-limited lymphadenopathy after exposure to a scratch or bite from a cat. Rarely, B. henselae is cause of fever of unknown origin (FUO), with dissemination to various organs, most often involving the reticuloendothelial system (liver, spleen, bone marrow), mimicking an inflammatory rather than a lymphoproliferative disease. Whole-body Magnetic Resonance Imaging (WBMRI), in association with diffusion-weighted imaging (DWIBS), allows a comprehensive evaluation of pediatric patients, without the risks inherent to ionizing radiation. It is a rapid and sensitive method for detecting and monitoring multifocal lesions such as proliferative or inflammatory and infectious processes. We report a case of systemic CDS in an immunocompetent young boy with fever of unknown origin, without history of cat contact, investigated by WBMRI.
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- 2016
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12. Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical Prediction Model Database.
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Wessler BS, Lai Yh L, Kramer W, Cangelosi M, Raman G, Lutz JS, and Kent DM
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- Global Health, Humans, Morbidity trends, Risk Factors, Cardiovascular Diseases epidemiology, Models, Theoretical, Risk Assessment methods
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Background: Clinical prediction models (CPMs) estimate the probability of clinical outcomes and hold the potential to improve decision making and individualize care. For patients with cardiovascular disease, there are numerous CPMs available although the extent of this literature is not well described., Methods and Results: We conducted a systematic review for articles containing CPMs for cardiovascular disease published between January 1990 and May 2012. Cardiovascular disease includes coronary heart disease, heart failure, arrhythmias, stroke, venous thromboembolism, and peripheral vascular disease. We created a novel database and characterized CPMs based on the stage of development, population under study, performance, covariates, and predicted outcomes. There are 796 models included in this database. The number of CPMs published each year is increasing steadily over time. Seven hundred seventeen (90%) are de novo CPMs, 21 (3%) are CPM recalibrations, and 58 (7%) are CPM adaptations. This database contains CPMs for 31 index conditions, including 215 CPMs for patients with coronary artery disease, 168 CPMs for population samples, and 79 models for patients with heart failure. There are 77 distinct index/outcome pairings. Of the de novo models in this database, 450 (63%) report a c-statistic and 259 (36%) report some information on calibration., Conclusions: There is an abundance of CPMs available for a wide assortment of cardiovascular disease conditions, with substantial redundancy in the literature. The comparative performance of these models, the consistency of effects and risk estimates across models and the actual and potential clinical impact of this body of literature is poorly understood., (© 2015 American Heart Association, Inc.)
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- 2015
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13. "GIOCAMPUS" - An effective school-based intervention for breakfast promotion and overweight risk reduction.
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Vanelli M, Monti G, Volta E, Finestrella V, Gkliati D, Cangelosi M, Caragnulo R, Vitale M, Ingrosso L, and Scazzina F
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- Child, Edible Grain, Feeding Behavior, Female, Fruit, Humans, Italy epidemiology, Male, Overweight epidemiology, Overweight prevention & control, Breakfast, Health Promotion, Pediatric Obesity prevention & control, Risk Reduction Behavior, School Health Services
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The aim of this study was to evaluate the efficacy of a campaign promoting breakfast in primary school-children from the city of Parma, Italy, where 22 % of peer school-children had reported in 2005 to skip breakfast. Two groups of children were interviewed by a multiple choice questionnaire on their breakfast habits. Group 1 counted only the children who underwent the intensive campaign (n. 341), and Group 2 a number of matched peers who did not attend any breakfast-promoting program (n. 291). Children who did not eat breakfast were found to be more numerous in Group 2 (17.5 %) than in Group 1 (8.0 %; p=0.0001). In the Group 2 the percentage of overweight (18.4 %) was higher compared to Group 1 patients (11.7 %; p=0.022). No significant difference in obesity percentage (8.9 vs 5.0 %; p=0.071). Seventy five percent of children in Group I and the 25% of children in Group 2 (p=0.031) had one or two parents who had reported to skip routinely breakfast. Children with one or both parents used to skip breakfast had a greater odds ratio of 3.04 and 3 respectively of skipping breakfast compared to the children with parents who had regularly breakfast (p=0.0002). Compared to the children tested in 2005, children admitted to the Giocampus program showed: a significant decrease in breakfasting (22 vs 8 %; p=0.0001), a significant decrease in overweight (18.5 vs 11.7 %; p=0.003) but not in obesity (7.5 vs 5.0 %; p=0.138) status; a significant increase in consumption of cereals (p=0.0001) and fruit (p=0.0001). In conclusion, an intensive breakfast-centred strategy seems to be effective in breakfast promotion and in overweight risk decrease.
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- 2014
14. Decreased nocturnal systolic blood pressure fall in older subjects with depression.
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Scuteri A, Spalletta G, Cangelosi M, Gianni W, Assisi A, Brancati AM, Modestino A, Caltagirone C, and Volpe M
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- Aged, Aged, 80 and over, Blood Pressure Monitoring, Ambulatory, Female, Heart Rate physiology, Humans, Hypertension epidemiology, Male, Monitoring, Ambulatory methods, Oscillometry, Prognosis, Sex Characteristics, Circadian Rhythm physiology, Depression physiopathology, Depressive Disorder physiopathology, Systole physiology
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Depressed subjects have a two-fold increased risk of CV events than non-depressed ones. Altered blood pressure (BP) circadian profile may be one mechanism underlying this association. We studied 135 elderly subjects (mean age 78+/-6 yrs, range 69- 93; 30 M, 87 F). On the basis of the 15-items Geriatric Depression Scale (GDS), score>5 identified subjects with depressive symptoms. Based upon 24-h Ambulatory BP Monitoring (Spacelabs 90207), the following BP circadian profile measures were examined: SD of 24-h, day, and night SBP, DBP, MBP; 24-h, day, and night SBP and DBP load; night SBP and DBP decline; dipping status for SBP and DBP. Compared with non-depressed subjects (n=61), depressed subjects (n=74) were similar in age and more likely to be women. No significant differences in traditional CV risk factors or in medication use were observed between the two groups. After controlling for age, sex, and traditional CV risk factors, subjects with depressive symptoms presented a significantly lower night-time SBP fall than non-depressed ones (average, -4.4 mmHg for SBP) with a significantly higher occurrence of non-dipper status. The GDS score was an independent significant inverse determinant of 24-h SD of SBP. Depressive symptoms in older subjects are accompanied by lower nocturnal BP fall and are significant independent determinants of SBP variability.
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- 2009
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