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1. Design and methods of the REMOVAL-HD study: a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients

Author

R. Krishnasamy, C. M. Hawley, M. J. Jardine, M. A. Roberts, Y. J. Cho, M. G. Wong, A. Heath, C. L. Nelson, S. Sen, P. F. Mount, E. M. Pascoe, D. Darssan, L. A. Vergara, P. A. Paul-Brent, N. D. Toussaint, D. W. Johnson, and C. A. Hutchison

Subjects
Albumin, Dialyser, Mid cut-off membrane, Efficacy, Free light chains, Haemodialysis, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Removal of uraemic toxins is inadequate using current dialysis strategies. A new class of dialysis membranes have been developed that allow clearance of larger middle molecules. The REMOVAL-HD study (a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients) will address safety, efficacy and the impact on patient-centred outcomes with the use of a mid cut-off (MCO) dialyser in a chronic haemodialysis (HD) population. Methods REMOVAL-HD is an open label, prospective, non-randomised, single-arm, multi-centre device study in 85 chronic HD participants. All visits will be conducted during regular HD sessions and participants will undergo a 1 month wash-in period using a standardised high flux dialyser, 6 months of intervention with a MCO dialyser and 1 month of wash-out using a high flux dialyser. The primary endpoint is change in pre-dialysis concentrations of serum albumin, with secondary endpoints including the efficacy of clearance of free light chains and β-2 microglobulin, and patient-centred outcomes including quality of life, symptom burden, functional status, nutritional status, hospitalisation and death. Discussion MCO dialysers are a novel form of HD membrane. The REMOVAL-HD study is a pivotal study designed to monitor the immediate and medium-term effects following exposure to this dialyser. Trial registration Australian New Zealand Clinical Trials Registry Number (ANZCTRN) 12616000804482. Date of registration - 21/06/2016.

Published
2018
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2. Reviews: The Study of History: A Bibliographical Guide, the English Idea of History from Coleridge to Collingwood, the Changing Face of English Local History, Arthur and the English: The Arthurian Legend in Medieval English Life and Literature, Enacting Gender on the English Renaissance Stage, Shakespeare's Feminine Endings, Writing the English Republic: Poetry, Rhetoric and Politics 1627–1660, New Stories for Old: Biblical Patterns in the Novel, Catholicism and Anti-Catholicism in Early Modern English Texts, Primogeniture and Entail in England: A Survey of Their History and Representation in Literature, the English Civil War Through the Restoration in Fiction: An Annotated Bibliography, Diana, Self-Interest, and British National Identity, Dryden and the Traces of Classical Rome, between the Ancients and the Moderns: Baroque Culture in Restoration England, Bacchus in Romantic England: Writers and Drink, 1780–1830, Misogynous Economies: The Business of Literature in Eighteenth-Century Britain, the House of Forgery in Eighteenth-Century Britain, the Clothes That Wear Us, An Oxford Companion to the Romantic Age: British Culture, 1776–1832, Domestic Space: Reading the Nineteenth-Century Interior, Victorians in Theory: From Derrida to Browning, the Age of Virtue: British Culture from the Restoration to Romanticism, Woeful Afflictions: Disability and Sentimentality in Victorian America, Women Writers of the First World War: An Annotated Bibliography, the Pub in Literature, British Industrial Fictions, the Insatiability of Human Wants: Economics and Aesthetics in Market SocietyRichardsonR. C., The Study of History: A Bibliographical Guide , 2nd ed., Manchester University Press, 2000, pp. xiv + 140, £40.00.ParkerChristopher, The English Idea of History from Coleridge to Collingwood , Ashgate Publishing, 2000, pp. vii + 244, £45.RichardsonR. C. (ed.), The Changing Face of English Local History , Ashgate, 2000, pp. viii + 218, £45.00.BarronW. R. J. (ed.), Arthur and the English: The Arthurian Legend in Medieval English Life and Literature , University of Wales Press, 1999, pp. 398, £35.00.ComensoliViviana and RussellAnne (eds), Enacting Gender on the English Renaissance Stage , University of Illinois Press, 1999, pp. 270, £18.95; SaundersEve Rachel, Gender and Literacy on Stage in Early Modern England , Cambridge University Press, 1999, pp. 260, £35.BerryPhilippa, Shakespeare's Feminine Endings , Routledge, 1999, pp. 197, £15.99 pb.; BellIlona, Elizabethan Women and the Poetry of Courtship , Cambridge University Press, 1998, pp. 262, £35.00.NorbrookDavid, Writing the English Republic: Poetry, Rhetoric and Politics 1627–1660 , Cambridge University Press, 1999, pp. xiii + 509, £40.FischHarold, New Stories for Old: Biblical Patterns in the Novel , Macmillan, 1998, pp. x + 236, £42.50; FischHarold, The Biblical Presence in Shakespeare, Milton and Blake , Clarendon Press, 1999, pp. xi + 330, £45.MarottiArthur F. (ed.), Catholicism and Anti-Catholicism in Early Modern English Texts , Macmillan, 1999, pp. xvii + 266, £47.50; ShellAlison, Catholicism, Controversy and the English Literary Imagination, 1558–1660 , Cambridge University Press, 1999, pp. xi + 309, £37.50.JamoussiZouheir, Primogeniture and Entail in England: A Survey of their History and Representation in Literature , Centre de Publication Universitaire, Tunis, 1999, pp. 293, 8 DT.MurphRoxane C., The English Civil War through the Restoration in Fiction: An Annotated Bibliography , Greenwood Press, Westport, CT., 2000, pp. viii + 349, £63.95.HammondPaul, Dryden and the Traces of Classical Rome , Clarendon Press, Oxford, 1999, pp. 305, £45.00.LevineJoseph M., Between the Ancients and the Moderns: Baroque Culture in Restoration England , Yale University Press, 1999, pp. xiv + 279, £27.50.TaylorAnya, Bacchus in Romantic England: Writers and Drink, 1780–1830 , Macmillan, 1999, pp. xi + 264, £47.50.MandellLaura, Misogynous Economies: The Business of Literature in Eighteenth-century Britain , University of Kentucky, 1999, pp. x + 228, $42.00.BainesPaul, The House of Forgery in Eighteenth-century Britain , Ashgate, 1999, pp. viii + 195, £47.50.MunnsJessica and RichardsPenny (eds), The Clothes that Wear Us , Newark, University of Delaware Press, 1999, pp. 362, £37.McCalmanIain (ed.), An Oxford Companion to the Romantic Age: British Culture, 1776–1832 , Oxford University Press, 1999, p. xii + 780, £85.BrydenInga and FloydJanet (eds), Domestic Space: Reading the Nineteenth-century Interior , Manchester University Press, 1999, pp. xii + 219, £40.00; KiddAlan and NichollsDavid (eds), Gender, Civic Culture and Consumerism: Middle-class Identity in Britain 1800–1940 , Manchester University Press, 1999, pp. xiv + 223, £46.00, pb. £14.99.SchadJohn Victorians in Theory: From Derrida to Browning , Manchester University Press, 1999, pp. x + 180, £40.MorseDavid, The Age of Virtue: British Culture from the Restoration to Romanticism , Macmillan, 2000, pp. viii + 330, £45.KlagesMary, Woeful Afflictions: Disability and Sentimentality in Victorian America , University of Pennsylvania Press, 1999, pp. 211, $36.50.OudittSharon, Women Writers of the First World War: An Annotated Bibliography , Routledge, 2000, pp. 230, £75; TyleeClaire with TurnerElaine and CardinalAgnes (eds), War Plays by Women: An International Anthology , Routledge, 2000, pp. 225, £16.99 pb.TaylorJohn A., Diana, Self-Interest, and British National Identity , Praeger, 2000, pp. 169, £44.95.EarnshawSteven, The Pub in Literature , Manchester University Press, 2000, pp. x + 294, £45 and £15.99 pb.KlausH. Gustav and KnightS. (eds), British Industrial Fictions , University of Wales Press, 2000, pp. viii + 212, £14.99 pb.; BalchJack S., Lamps at High Noon , University of Illinois Press, 2000, pp. xl + 404, $19.45 pb.; ConroyJack, A World to Win , University of Illinois Press, 2000, pp. xxxv + 348, $17.95 pb.GagnierRegenia, The Insatiability of Human Wants: Economics and Aesthetics in Market Society , University of Chicago Press, 2000, pp. 352, £10.50 pb

Author

Paul Hyland, R. C. Richardson, Ivan Roots, Elizabeth Truax, Stevie Simkin, Kate McLuskie, William Lamont, Geoffrey M. Ridden, Keith Lindley, Joan Thirsk, Alan Marshall, Jeremy Gregory, W. A. Speck, Bridget Hill, Irene Collins, Lynn Schibeci, Terence Rodgers, Myron D. Yeager, Joyce K. Bibber, Mary Joannou, Jude Davies, Robert Poole, M. J. Jardine, and David Watson

Subjects
Literature, History, Annotated bibliography, Literature and Literary Theory, business.industry, First world war, History of literature, English literature, Premise, Narrative, Performance art, business, Gray (horse)
Abstract

‘The conviviality of the narrative premise’ is Steven Earnshaw’s felicitous phrase for the theme that suffuses this book. It is ‘a crawl through the drinking places of English literary history,’ in the company of Chaucer, Langland, Shakespeare, Dekker, Jonson, Pepys, Ned Ward (author of The London Spy), Goldsmith, Gray, Fielding, Cowper, Crabbe, Dickens, Eliot (G.), Hardy, Eliot (T. S.), Coppard, Hampson, Hamilton, Orwell and Amis (M.). It also ‘attempts to weave a pattern out of the strands of “pub”, English literature and England’. It is a labour of love, the product of years of hoarded references and inspired cups and we must be grateful. It will become a standard resort for literary scholars seeking quotable material on pubs (Piers Plowman ‘pissed a pottel in a pater-noster while’), and for anyone who likes to savour ‘the pub moment’ through the medium of print.

Published
2001

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