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3. Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy

Author

Wang Qiuye, Cui Haijing, Gan Ning, Ma Xuehua, Ren Wenzhi, and Wu Aiguo

Subjects
matrix metalloproteinases, enzyme-responsive, cancer, diagnosis, therapy, Chemistry, QD1-999
Abstract

Matrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue of the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function of elaborately designed enzyme-responsive nanoprobes, which is expected to realize precise diagnosis and treatment of cancer. This review systematically summarizes the classifications of MMPs, their substrates and recognized sequences, and overexpressed tumor types. The advances of MMPs-responsive nanoprobes for cancer diagnosis and therapy are focused, including trigger mechanism, design principle, and various imaging or therapy modes. Finally, this review analyzes the challenges of MMPs-responsive nanoprobes in clinical application, and provides constructive opinions for future study.

Published
2022
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16. sj-pdf-1-imr-10.1177_03000605211027774 - Supplemental material for Sporadic hemangioblastoma of the kidney: a clinicopathologic study of three cases and a literature review

Author

Xu, Yanmei, Ma, Xuehua, Ma, Yong, Li, Juan, Zhang, Renya, and Li, Xiaomei

Subjects
111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-imr-10.1177_03000605211027774 for Sporadic hemangioblastoma of the kidney: a clinicopathologic study of three cases and a literature review by Yanmei Xu, Xuehua Ma, Yong Ma, Juan Li, Renya Zhang and Xiaomei Li in Journal of International Medical Research

Published
2021
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22. Silica functionalized ultra small iron oxide nanoparticles (IONPs) for T1-weighted magnetic resonance imaging (MRI) contrast agent

Author

Ma Xuehua, Iqbal Muhammad Zubair, Ren Wenzhi, and Wu Aiguo

Subjects
Histology, Materials science, medicine.diagnostic_test, MRI contrast agent, Biomedical Engineering, Bioengineering, Magnetic resonance imaging, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, T1 weighted, medicine, Iron oxide nanoparticles, Biotechnology
Published
2016

27. Gd2O3/b‐TiO2composite nanoprobes with ultra‐high photoconversion efficiency for MR image‐guided NIR‐II photothermal therapy

Author

Chen, Jia, Chen, Tianxiang, Fang, Qianlan, Pan, Chunshu, Akakuru, Ozioma Udochukwu, Ren, Wenzhi, Lin, Jie, Sheng, Aizhu, Ma, Xuehua, and Wu, Aiguo

Abstract

Photothermal therapy (PTT), as an important noninvasive and effective tumor treatment method, has been extensively developed into a powerful cancer therapeutic technique. Nevertheless, the low photothermal conversion efficiency and the limited tissue penetration of typical photothermal therapeutic agents in the first near‐infrared (NIR‐I) region (700–950 nm) are still the major barriers for further clinical application. Here, we proposed an organic/inorganic dual‐PTT agent of synergistic property driven by polydopamine‐modified black‐titanium dioxide (b‐TiO2@PDA) with excellent photoconversion efficiency in the second NIR (NIR‐II) region (1000–1500 nm). More specifically, the b‐TiO2treated with sodium borohydride produced excessive oxygen vacancies resulting in oxygen vacancy band that narrowed the b‐TiO2band gap, and the small band gap led to NIR‐II region wavelength (1064 nm) absorbance. Furthermore, the combination of defect energy level trapping carrier recombination heat generation and conjugate heat generation mechanism, significantly improved the photothermal performance of the PTT agent based on b‐TiO2. The photothermal properties characterization indicated that the proposed dual‐PTT agent possesses excellent photothermal performance and ultra‐high photoconversion efficiency of 64.9% under 1064 nm laser irradiation, which can completely kill esophageal squamous cells. Meanwhile, Gd2O3nanoparticles, an excellent magnetic resonance imaging (MRI) agent, were introduced into the nanosystem with similar dotted core–shell structure to enable the nanosystem achieve real‐time MRI‐monitored cancer therapeutic performance. We believe that this integrated nanotherapeutic system can not only solve the application of PTT in the NIR‐II region, but also provide certain theoretical guidance for the clinical diagnosis and treatment of esophageal cancer. Low photoconversion efficiency and limited tissue penetration are the major barriers for photothermal therapy (PTT) agent application. Here, an efficient organic/inorganic dual‐PTT agent guided by MRI was proposed. It is proved the oxygen vacancy band narrowed its band gap that led to NIR‐II region absorb. Furthermore, the defect energy level trapping carrier and conjugate synergistic heat generation result in high photoconversion efficiency.

Published
2022
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32. Gd 2 O 3 /b-TiO 2 composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy.

Author

Chen J, Chen T, Fang Q, Pan C, Akakuru OU, Ren W, Lin J, Sheng A, Ma X, and Wu A

Abstract

Photothermal therapy (PTT), as an important noninvasive and effective tumor treatment method, has been extensively developed into a powerful cancer therapeutic technique. Nevertheless, the low photothermal conversion efficiency and the limited tissue penetration of typical photothermal therapeutic agents in the first near-infrared (NIR-I) region (700-950 nm) are still the major barriers for further clinical application. Here, we proposed an organic/inorganic dual-PTT agent of synergistic property driven by polydopamine-modified black-titanium dioxide (b-TiO 2 @PDA) with excellent photoconversion efficiency in the second NIR (NIR-II) region (1000-1500 nm). More specifically, the b-TiO 2 treated with sodium borohydride produced excessive oxygen vacancies resulting in oxygen vacancy band that narrowed the b-TiO 2 band gap, and the small band gap led to NIR-II region wavelength (1064 nm) absorbance. Furthermore, the combination of defect energy level trapping carrier recombination heat generation and conjugate heat generation mechanism, significantly improved the photothermal performance of the PTT agent based on b-TiO 2 . The photothermal properties characterization indicated that the proposed dual-PTT agent possesses excellent photothermal performance and ultra-high photoconversion efficiency of 64.9% under 1064 nm laser irradiation, which can completely kill esophageal squamous cells. Meanwhile, Gd 2 O 3 nanoparticles, an excellent magnetic resonance imaging (MRI) agent, were introduced into the nanosystem with similar dotted core-shell structure to enable the nanosystem achieve real-time MRI-monitored cancer therapeutic performance. We believe that this integrated nanotherapeutic system can not only solve the application of PTT in the NIR-II region, but also provide certain theoretical guidance for the clinical diagnosis and treatment of esophageal cancer., Competing Interests: Aiguo Wu is a member of the Exploration editorial board. The authors declare no conflict of interest., (© 2022 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.)

Published
2022
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