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O presente artigo tem por fundamento descrever acerca do clima organizacional, principalmente, apontando possíveis problemas que interferem no ambiente de trabalho e suas complicações para o contexto organizacional. O início foi apresentado conceitos de gestão de pessoas, clima organizacional, etc. A metodologia utilizada para a pesquisa, foi a qualitativa estruturada, por intermédio de questionário estruturado e desenvolvido com 38 questões contendo de 4 à 6 opções de respostas. Pesquisou opiniões de pessoas do ambiente público e privado, descrevendo empresas privadas e órgãos públicos. Objetivou-se neste, de uma forma geral, analisar o que é clima organizacional e quais as situações que atrapalham o ambiente de trabalho, no demais, de maneira mais específica: apresentou resultados de pesquisa de clima organizacional; apontou alguns fatores que influenciam o clima no ambiente de trabalho, e, analisou-se por intermédio da pesquisa, se existem casos de danos ao clima organizacional. O problema centrou-se no questionamento sobre como o clima organizacional interfere no ambiente de trabalho? A análise acerca da temática foi abordada tanto as questões relacionadas ao clima organizacional, bem como a análise acerca de pontos positivos e negativos. Foram consultadas 102 pessoas e por intermédio desta análise foram verificadas se pertencem a esfera pública ou privada, o sexo, quais as situações interferem nas relações de trabalho e se estão felizes ou não no ambiente onde estão inseridas. The present article has as basis to describe about the organizational climate, mainly, pointing out possible problems that interfere in the work environment and its complications for the organizational context. The beginning was presented concepts of people management, organizational climate, etc. The methodology used for the research was the structured qualitative, through a structured questionnaire and developed with 38 questions containing from 4 to 6 response options. He researched people's opinions from the public and private environment, describing private companies and public agencies. The objective was to analyze, in a general way, what is the organizational climate and what are the situations that disrupt the work environment, in the others, in a more specific way: presented results of research on organizational climate; pointed out some factors that influence the climate in the work environment, and it was analyzed through the research, if there are cases of damages to the organizational climate. Has the problem centered on the questioning of how the organizational climate interferes with the work environment? The analysis on the subject was approached both the issues related to the organizational climate, as well as the analysis on the positives and negatives. 102 people were consulted and through this analysis were verified whether they belong to the public or private sphere, sex, which situations interfere in the labor relations and whether they are happy or not in the environment where they are inserted.

Purpose: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. Methods: We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, hematology and histopathology were used to validate the treatments. Results: All animals survived. A gradual weight gain in all groups was observed, with no significant difference (p>0.05). The oral administration of ACE and ACE+vincristine 50% significantly reduced breast tumors incidence examined with PET-18FDG and fluorescence (p

Submitted by Wiqlifi Bruno de Freitas Melo (wbruno@ufersa.edu.br) on 2019-02-06T11:16:51Z No. of bitstreams: 1 RobsonLM_DISSERT.pdf: 1770953 bytes, checksum: 812a0080441123387e5ba468bcc11be0 (MD5) Approved for entry into archive by Vanessa Christiane (referencia@ufersa.edu.br) on 2019-02-15T16:18:39Z (GMT) No. of bitstreams: 1 RobsonLM_DISSERT.pdf: 1770953 bytes, checksum: 812a0080441123387e5ba468bcc11be0 (MD5) Approved for entry into archive by Vanessa Christiane (referencia@ufersa.edu.br) on 2019-02-15T16:18:47Z (GMT) No. of bitstreams: 1 RobsonLM_DISSERT.pdf: 1770953 bytes, checksum: 812a0080441123387e5ba468bcc11be0 (MD5) Made available in DSpace on 2019-02-15T16:18:54Z (GMT). No. of bitstreams: 1 RobsonLM_DISSERT.pdf: 1770953 bytes, checksum: 812a0080441123387e5ba468bcc11be0 (MD5) Previous issue date: 2018-03-28 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES Projetos arquiteturais de software tendem a evoluir priorizando o reuso de seus componentes, de modo a promover a evolução dos artefatos de código livre de refatorações não esperadas. No entanto, este reuso nem sempre acontece como esperado, devido principalmente a problemas estruturais dos projetos, oriundos de falta de planejamento e constantes refatorações. Problemas estruturais, em sua maioria, estão relacionados à existência de anomalias arquiteturais e ao escopo crescente de seus componentes. O escopo de um componente arquitetural refere-se ao percentual de dependência que ele possui em relação aos demais componentes do sistema. Infelizmente, existe uma carência de estudos que abordam a priorização de anomalias arquiteturais como forma de minimizar operações indesejadas de refatoração de código. Sabe-se que a ordem de tratamento das anomalias interfere diretamente no número de operações de refatoração. Neste contexto, há uma demanda crescente por estratégias capazes de priorizar o tratamento de anomalias arquiteturais de modo a minimizar o número de operações de refatoração. Este trabalho de pesquisa de mestrado analisou três sistemas de software em evolução, com o objetivo de prover suporte a priorização do tratamento de anomalias de modo a interferir na refatoração de elementos de código de sistemas de software em evolução. Neste contexto, emergem as contribuições: (i) Definição de mecanismos capazes de relacionar a ocorrência de anomalias arquiteturais com o número de operações de refatoração que acontecem no código, (ii) Desenvolvimento de uma solução computacional e (iii) resultados empíricos. Entendemos que os mecanismos para relação das anomalias arquiteturais com as operações de refatoração no código em (i) e o desenvolvimento de uma solução computacional em (ii), serão úteis para apoiar desenvolvedores e arquitetos na tomada de decisão acerca da priorização no tratamento de anomalias arquiteturais. Para as três aplicações avaliadas, o escopo mostrou ser um forte indicador para priorização no tratamento de anomalias para projetos arquiteturais menos refatorados. Ao priorizar adequadamente o tratamento de anomalias arquiteturais espera-se contribuir para a construção de projetos arquiteturais com menos problemas estruturais Software architectural projects tend to evolve prioritizing the reuse of their components in order to avoid code refactoring. However, this reuse does not always happen as expected, mainly due to structural problems of the projects, lack of planning and constant refactorings. In general, structural problems are related to the existence of architectural anomalies and to the increasing scope of its components. The scope of an architectural component refers to the percentage of dependence that it has in relation to the other components of the system. Unfortunately, there is a lack of studies that address the prioritization of architectural anomalies as a way to minimize unwanted code refactoring operations. It is known that anomalies treatment order impacts directly on the number of refactoring operations. In this context, there is a growing demand for strategies capable of prioritizing the treatment of architectural anomalies in order to minimize the number of refactoring operations. This master’s research work analyzed three evolving software systems, with the objective of providing support for the prioritization of the handling of anomalies in order to interfere in the refactoring of code elements of evolving software systems. In this context, the contributions emerge: (i) Definition of mechanisms capable of relating the occurrence of architectural anomalies with the number of refactoring operations that occur in the code, (ii) development of a computational solution, and (iii) empirical results. We understand that the mechanisms for relation of architectural anomalies with code refactoring operations in (i) and the development of a computational solution in (ii), will be useful to support developers and architects in the decision making about prioritization in the treatment of anomalies architecture. For the three applications evaluated, the scope proved to be a strong indicator for prioritization in the treatment of anomalies for less refactored architectural projects. When properly prioritizing the treatment of architectural anomalies, it is expected to contribute to the construction of architectural projects with fewer structural problems

A compreensão da “tragédia dos comuns” de Garret Hardin (1968) aponta para a necessidade de se efetivar o ato ou efeito de gerir os recursos naturais disponíveis, possibilitando a projeção de um futuro mais sustentável para a presente e futuras gerações. Nesse sentido, este trabalho apresenta uma breve caracterização de iniciativas locais de aproveitamento de água de chuva nas ilhas da cidade de Belém do Pará, proporciona a sistematização de dados e informações considerando aspectos diversos relacionados ao uso da água, afirmando que é impossível se construir práticas sustentáveis tratando das questões ambientais de forma isolada. Para tanto, a presente pesquisa traz como produto de dissertação um ATLAS das iniciativas de aproveitamento da água da chuva na região estuaria de Belém, considerando questões relacionadas ao uso da água nas diversas formas de apropriação desse recurso natural essencial à promoção do desenvolvimento local. O ATLAS é constituído de diagnóstico apresentado por meio de mapas temáticos, trazendo a discussão questões relacionadas a “Distribuição espacial de iniciativas de aproveitamento de água da chuva; Sistematização de dados com uso de Sistema de Informação Geográfica (SIG); Gestão da informação e qualidade ambiental; Gestão de recursos naturais e tecnologias sociais”. A pesquisa considerou como objeto de análise, iniciativas de aproveitamento de água de chuva no contexto de 9 (nove) ilhas de Belém. Localiza e descreve 4 (quatro) modelos diferentes de captação de água de chuva, em meio a uma população de aproximadamente 3.046 habitantes, dos quais 90% não tem acesso à serviços públicos básicos como abastecimento de água via rede geral, coleta de lixo doméstico e sistemas de esgotamento sanitário via rede geral. Também apresenta modelos de utilização de água de chuva integrados ao uso de água do rio e de poços localizados em regiões próximas às ilhas, mostrando importante exemplo de gestão sistêmica de recursos hídricos, ações alinhadas, conscientemente ou não, a Política Nacional de Recursos Hídricos. Conclui que as iniciativas identificadas estão alinhadas aos objetivos e diretrizes propostos no Plano Diretor Municipal de Belém e apresenta diagnóstico temático que revela uma situação de risco social e ambiental pela falta de serviços de saneamento básico à comunidade local. Como contribuição, além de disponibilizar o Atlas em formato sigweb, essa pesquisa propõe o uso do Atlas como ferramenta de auxílio a instrumentos de gestão ambiental, demonstrando como o uso de SIG por meio do Atlas pode contribuir na gestão de recursos naturais considerando as diversas temáticas que envolvem o uso de tecnologias sociais na busca da sustentabilidade no consumo de águas na cidade de Belém do Pará. Garret Hardin's (1968) understanding of the "tragedy of the commons" points to the need to effect the act or effect of managing the available natural resources, enabling the projection of a more sustainable future for present and future generations. In this sense, this work presents a brief characterization of local initiatives for the use of rainwater in the islands of the city of Belém do Pará, provides the systematization of data and information considering various aspects related to water use, stating that it is impossible to construct practices Addressing environmental issues in isolation. Therefore, the present research brings as an dissertation an ATLAS of the initiatives of use of rainwater in the estuary of Belém, considering issues related to the use of water in the various forms of appropriation of this natural resource essential to the promotion of local development. The ATLAS is constituted of a diagnosis presented by means of thematic maps, bringing the discussion questions related to "Spatial distribution of initiatives of use of rainwater; Systematization of data using the Geographic Information System (GIS); Information management and environmental quality; Management of natural resources and social technologies ". The study considered as an object of analysis, initiatives for the use of rainwater in the context of 9 (nine) islands of Belém. It locates and describes 4 different models of rainwater harvesting, among a population of approximately 3,046 Inhabitants, of which 90% do not have access to basic public services such as water supply through the general network, domestic waste collection and sewage systems via the general network. It also presents models of rainwater use integrated with the use of river water and wells located in regions close to the islands, showing an important example of systemic management of water resources, actions aligned, consciously or not, with the National Water Resources Policy. It concludes that the initiatives identified are in line with the objectives and guidelines proposed in the Municipal Master Plan of Belém and presents a thematic diagnosis that reveals a situation of social and environmental risk due to the lack of basic sanitation services to the local community. As a contribution, in addition to providing the Atlas in sigweb format, this research proposes the use of the Atlas as a tool to assist environmental management instruments, demonstrating how the use of GIS through the Atlas can contribute to the management of natural resources considering the various themes Which involve the use of social technologies in the search for sustainability in water consumption in the city of Belém do Pará.

ObjectivesThe purpose of this study was to assess coronary arterial remodeling as a marker of subclinical atherosclerosis using coronary wall magnetic resonance imaging (MRI) in an asymptomatic population-based cohort.BackgroundIn early atherosclerosis, compensatory enlargement of both the outer wall of the vessel as well as the lumen, termed compensatory enlargement or positive remodeling, occurs before luminal narrowing.MethodsOne hundred seventy-nine participants in the MESA (Multi-Ethnic Study of Atherosclerosis) trial were evaluated using black-blood coronary wall MRI. Coronary cross-sectional area (vessel size), lumen area, and mean wall thickness of the proximal coronary arteries were measured.ResultsMen had a greater vessel size, lumen area, and mean wall thickness than women (38.3 ± 11.3 mm2vs. 32.6 ± 9.4 mm2, 6.7 ± 3.2 mm2vs. 5.3 ± 2.4 mm2, and 2.0 ± 0.3 mm vs. 1.9 ± 0.3 mm, respectively, p < 0.05). No significant coronary artery narrowing was present by magnetic resonance angiography. Overall, coronary vessel size increased 25.9 mm2per millimeter increase in coronary wall thickness, whereas lumen area increased only slightly at 3.1 mm2for every millimeter increase in wall thickness (difference in slopes, p < 0.0001). Adjusting for age and sex, participants with an Agatston score >0 were more likely to have wall thickness >2.0 mm (odds ratio: 2.0, 95% confidence interval: 1.01 to 3.84).ConclusionsCoronary wall MRI detected positive arterial remodeling in asymptomatic men and women with subclinical atherosclerosis.

ObjectivesThe purpose of this study was to determine the extent of left ventricular (LV) involvement in individuals predisposed to developing arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), and to investigate novel morphologic variants of ARVD/C.BackgroundThe discovery of desmosomal mutations associated with ARVD/C has led researchers to hypothesize equal right ventricular (RV) and LV affliction in the disease process.MethodsThirty-eight (age 30 ± 17 years; 18 males) family members of 12 desmosomal mutation-carrying ARVD/C probands underwent genotyping and cardiac magnetic resonance imaging (CMR). The CMR investigators were blinded to clinical and genetic data.ResultsTwenty-five individuals had mutations in PKP2, DSP, and/or DSG2genes. RV abnormalities were associated with the presence of mutation(s) and with disease severity determined by criteria (minor = 1; major = 2) points for ARVD/C diagnosis. The only LV abnormality detected, the presence of intramyocardial fat, was present in 4 individuals. Each of these individuals was a mutation carrier, whereas 1 had no previously described ARVD/C-related abnormality. On detailed CMR, a focal “crinkling” of the RV outflow tract and subtricuspid regions (“accordion sign”) was observed in 60% of the mutation carriers and none of the noncarriers (p < 0.001). The sign was present in 0%, 37%, 71%, and 75% of individuals who met 1, 2, 3, and 4+ criteria points, respectively (p < 0.01).ConclusionsDespite a possible LV involvement in ARVD/C, the overall LV structure and function are well preserved. Independent LV involvement is of rare occurrence. The accordion sign is a promising tool for early diagnosis of ARVD/C. Its diagnostic utility should be confirmed in larger cohorts.